公开(公告)号：WO03046123A2

公开(公告)日：2003-06-05

申请号：PCT/EP0212134

申请日：2002-10-31

Applicant: BASF AG ,  ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N15/11 ,  C07K14/34 ,  C12N1/21 ,  C12N15/63 ,  C12P13/08 ,  C12N

CPC classification number: C12P13/08 ,  C07K14/34

Abstract: The invention relates to novel nucleic acid molecules, the use thereof for the construction of genetically improved micro-organisms and methods for the production of fine chemicals, in particular amino acids by means of said genetically improved micro-organisms.

Abstract translation: 本发明涉及新的核酸分子，它们的遗传改良的微生物以及用于产生精细化学品，在使用这些遗传改良的微生物的特定氨基酸的方法的结构中使用。

公开(公告)号：WO03040293A2

公开(公告)日：2003-05-15

申请号：PCT/EP0212137

申请日：2002-10-31

Applicant: BASF AG ,  ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N1/21 ,  C12N15/31 ,  C12N

CPC classification number: C07K14/34

Abstract: The invention relates to novel nucleic acid molecules, the use thereof in the construction of bio-engineered improved microorganisms and to methods for the production of fine chemicals, especially amino acids, with the aid of said bio-engineered improved microorganisms.

Abstract translation: 本发明涉及新的核酸分子，它们的遗传改良的微生物以及用于产生精细化学品，在使用这些遗传改良的微生物的特定氨基酸的方法的结构中使用。

公开(公告)号：WO2003040292A2

公开(公告)日：2003-05-15

申请号：PCT/EP2002/012136

申请日：2002-10-31

Applicant: BASF AKTIENGESELLSCHAFT ,  ZELDER, Oskar ,  POMPEJUS, Markus ,  SCHRÖDER, Hartwig ,  KRÖGER, Burkhard ,  KLOPPROGGE, Corinna ,  HABERHAUER, Gregor

Inventor： ZELDER, Oskar ,  POMPEJUS, Markus ,  SCHRÖDER, Hartwig ,  KRÖGER, Burkhard ,  KLOPPROGGE, Corinna ,  HABERHAUER, Gregor

IPC: C12N

CPC classification number: C07K14/47 ,  C12N15/77 ,  C12P13/08

Abstract: Die Erfindung betrifft neue Nukleinsäuremoleküle, deren Verwendung zur Konstruktion von gentechnisch verbesserten Mikroorganismen und Verfahren zur Herstellung von Feinchemikalien, insbesondere Aminosäuren mit Hilfe dieser gentechnisch verbesserten Mikroorganismen.

Abstract translation: 本发明涉及新的核酸分子，它们的遗传改良的微生物以及用于产生精细化学品，在使用这些遗传改良的微生物的特定氨基酸的方法的结构中使用。

公开(公告)号：WO2003040290A2

公开(公告)日：2003-05-15

申请号：PCT/EP2002/012133

申请日：2002-10-31

Applicant: BASF AKTIENGESELLSCHAFT ,  ZELDER, Oskar ,  POMPEJUS, Markus ,  SCHRÖDER, Hartwig ,  KRÖGER, Burkhard ,  KLOPPROGGE, Corinna ,  HABERHAUER, Gregor

Inventor： ZELDER, Oskar ,  POMPEJUS, Markus ,  SCHRÖDER, Hartwig ,  KRÖGER, Burkhard ,  KLOPPROGGE, Corinna ,  HABERHAUER, Gregor

IPC: C12N

CPC classification number: C07K14/34 ,  C12P13/08

Abstract: Die Erfindung betrifft neue Nukleinsäuremoleküle, deren Verwendung zur Konstruktion von gentechnisch verbesserten Mikroorganismen und Verfahren zur Herstellung von Feinchemikalien, insbesondere Aminosäuren mit Hilfe dieser gentechnisch verbesserten Kikroorganismen.

Abstract translation: 本发明涉及新的核酸分子，它们的遗传改良的微生物以及用于产生精细化学品，在使用这些遗传改良Kikroorganismen特定氨基酸的方法的结构中使用。

公开(公告)号：WO03040181A2

公开(公告)日：2003-05-15

申请号：PCT/EP0212139

申请日：2002-10-31

Applicant: BASF AG ,  ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C07H21/04 ,  C07K14/34 ,  C12N1/21 ,  C12N9/12 ,  C12N9/16 ,  C12N9/90 ,  C12N15/31 ,  C12P13/08 ,  C12R1/15

CPC classification number: C12N9/1223 ,  C07H21/04 ,  C07K14/34 ,  C12N9/16 ,  C12N9/90 ,  C12P13/08 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, the use thereof in the construction of bio-engineered improved microorganisms and methods for the production of fine chemicals, especially amino acids with the aid of said bio-engineered improved microorganisms.

Abstract translation: 本发明涉及新的核酸分子，它们的遗传改良的微生物以及用于产生精细化学品，在使用这些遗传改良的微生物的特定氨基酸的方法的结构中使用。

公开(公告)号：WO2009133114A1

公开(公告)日：2009-11-05

申请号：PCT/EP2009/055146

申请日：2009-04-28

Applicant: BASF SE ,  HEROLD, Andrea ,  SCHRÖDER, Hartwig ,  JEONG, Weol Kyu ,  KLOPPROGGE, Corinna ,  ZELDER, Oskar ,  HAEFNER, Stefan ,  RICHTER, Ulrike ,  BECKER, Judith ,  WITTMANN, Christoph

Inventor： HEROLD, Andrea ,  SCHRÖDER, Hartwig ,  JEONG, Weol Kyu ,  KLOPPROGGE, Corinna ,  ZELDER, Oskar ,  HAEFNER, Stefan ,  RICHTER, Ulrike ,  BECKER, Judith ,  WITTMANN, Christoph

IPC: C12P13/00 ,  C12N9/04

CPC classification number: C12P13/001 ,  C12N9/0006 ,  C12P13/02 ,  C12P13/08 ,  C12P13/12 ,  C12P13/20

Abstract: The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.

Abstract translation: 本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产精细化学品的方法。 所述精细化学品可以是氨基酸，用于聚合物合成的单体，糖，脂质，油，脂肪酸或维生素，并且优选天冬氨酸家族的氨基酸，特别是甲硫氨酸或赖氨酸，或所述氨基酸的衍生物，特别是尸胺。 此外，本发明涉及与初始微生物相比具有降低的异柠檬酸脱氢酶活性的重组微生物，以及这些微生物在生产精细化学品如天冬氨酸家族氨基酸及其衍生物中的用途。

公开(公告)号：WO2009098046A1

公开(公告)日：2009-08-13

申请号：PCT/EP2009/000758

申请日：2009-02-04

Applicant: BASF SE ,  ZELDER, Oskar ,  JEONG, Weol Kyu ,  KLOPPROGGE, Corinna ,  HEROLD, Andrea ,  SCHRÖDER, Hartwig

Inventor： ZELDER, Oskar ,  JEONG, Weol Kyu ,  KLOPPROGGE, Corinna ,  HEROLD, Andrea ,  SCHRÖDER, Hartwig

IPC: C12P17/12 ,  C12N9/02

CPC classification number: C12P17/12 ,  C12N9/001

Abstract: The present invention relates to a novel method for the fermentative production of dipicolinate by cultivating a recombinant microorganism expressing an enzyme having dipicolinate synthetase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyester or polyamide copolymers making use of dipicolinate as obtained by fermentative production.

Abstract translation: 本发明涉及通过培养表达具有吡啶二羧酸合成酶活性的酶的重组微生物来发酵吡啶硫酸盐的新方法。 本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及使用通过发酵生产得到的吡啶二酸盐制备聚酯或聚酰胺共聚物的方法。

公开(公告)号：WO2008101857A3

公开(公告)日：2008-12-11

申请号：PCT/EP2008051795

申请日：2008-02-14

Applicant: EVONIK DEGUSSA GMBH ,  YOCUM R ROGERS ,  ZELDER OSKAR ,  SCHROEDER HARTWIG ,  KLOPPROGGE CORINNA ,  HEROLD ANDREA ,  HAEFNER STEFAN ,  PATTERSON THOMAS A ,  PERO JANICE G

Inventor： ZELDER OSKAR ,  SCHROEDER HARTWIG ,  KLOPPROGGE CORINNA ,  HEROLD ANDREA ,  HAEFNER STEFAN ,  PATTERSON THOMAS A ,  PERO JANICE G

IPC: C12P13/12 ,  C12N15/52 ,  C12N15/77

CPC classification number: C12P13/12 ,  C12N15/52

Abstract: The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N5, N10 -methylene-THF is increased. The present invention also relates to the use of such microorganisms for producing methionine.

Abstract translation: 本发明涉及增加N5，N10-亚甲基-THF的形成的微生物，特别是谷氨酸棒杆菌。 本发明还涉及这种微生物用于生产甲硫氨酸的用途。

公开(公告)号：WO2007051725A2

公开(公告)日：2007-05-10

申请号：PCT/EP2006/067680

申请日：2006-10-23

Applicant: BASF AG ,  ZELDER, Oskar ,  HEROLD, Andrea ,  KLOPPROGGE, Corinna ,  SCHRÖDER, Hartwig ,  HAEFNER, Stefan ,  HEINZLE, Elmar ,  WITTMANN, Christoph ,  KROEMER, Jens ,  PERO, Janice G. ,  YOCUM, R. Rogers ,  PATTERSON, Thomas A. ,  WILLIAMS, Mark ,  HERMAN, Theron

Inventor： ZELDER, Oskar ,  HEROLD, Andrea ,  KLOPPROGGE, Corinna ,  SCHRÖDER, Hartwig ,  HAEFNER, Stefan ,  HEINZLE, Elmar ,  WITTMANN, Christoph ,  KROEMER, Jens ,  PERO, Janice G. ,  YOCUM, R. Rogers ,  PATTERSON, Thomas A. ,  WILLIAMS, Mark ,  HERMAN, Theron

IPC: A23K1/00 ,  C12N15/22 ,  C12P13/12

CPC classification number: C12P13/12 ,  A23K10/16 ,  A23K20/142 ,  A23K40/10 ,  C12N15/52

Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.

Abstract translation: 本发明涉及有效制备L-氨基酸（例如L-蛋氨酸）的微生物和方法。 具体而言，本发明涉及其中降低和/或防止蛋氨酸途径中的高乳糖蛋氨酸的形成和/或积累的微生物和方法。

公开(公告)号：WO2005059093A3

公开(公告)日：2006-03-02

申请号：PCT/EP2004014266

申请日：2004-12-15

Applicant: BASF AG ,  KROEGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN

Inventor： KROEGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HAEFNER STEFAN

IPC: C07K14/34 ,  C12N20060101 ,  C12N1/00 ,  C12N15/63 ,  C12N15/67 ,  C12N15/77 ,  C12P1/00 ,  C12P13/08 ,  C12P13/12 ,  C12N1/21

CPC classification number: C07K14/34 ,  C12N15/77 ,  C12P13/08 ,  C12P13/12

Abstract: The invention relates to the use of nucleic acid sequences for regulating gene transcription and expression, said novel promoters and expression units, methods for modifying or inducing the gene transcription rate and/or expression rate, expression cassettes containing said expression units, genetically modified microorganisms having a modified or induced transcription rate and/or expression rate, and methods for producing biosynthetic products by cultivating said genetically modified microorganisms.

Abstract translation: 本发明涉及使用核酸序列的调节基因，所述新的启动子和表达单元本身的转录和表达，用于改变或引起转录和/或基因的表达率的速率的方法，含有该表达单元的表达盒，具有改变的遗传修饰的微生物或 引起转录速率和/或表达的速率以及通过培养遗传修饰的微生物的制备生物合成产物的方法。