公开(公告)号：WO2003003984A8

公开(公告)日：2003-01-16

申请号：PCT/US2002/021268

申请日：2002-07-03

Applicant: CURAGEN CORPORATION ,  FERNANDES, Elma, R. ,  VERNET, Corine, A., M. ,  SHIMKETS, Richard, A. ,  ANDERSON, David, W. ,  PADIGARU, Muralidhara ,  BOLDOG, Ferenc, L. ,  LI, Li ,  SHENOY, Suresh, G. ,  CASMAN, Stacie, J. ,  RASTELLI, Luca ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GROSSE, William, M. ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LIU, Xiaohong ,  MEZICK, Amanda, J. ,  PATTURAJAN, Meera ,  SHEN, Lei ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  ZERHUSEN, Bryan, D. ,  VOSS, Edward, Z.

Inventor： FERNANDES, Elma, R. ,  VERNET, Corine, A., M. ,  SHIMKETS, Richard, A. ,  ANDERSON, David, W. ,  PADIGARU, Muralidhara ,  BOLDOG, Ferenc, L. ,  LI, Li ,  SHENOY, Suresh, G. ,  CASMAN, Stacie, J. ,  RASTELLI, Luca ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GROSSE, William, M. ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LIU, Xiaohong ,  MEZICK, Amanda, J. ,  PATTURAJAN, Meera ,  SHEN, Lei ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  ZERHUSEN, Bryan, D. ,  VOSS, Edward, Z.

IPC: G01N33/53 ,  C12N5/00 ,  C07K14/00 ,  A61K38/00

公开(公告)号：WO2003000918A2

公开(公告)日：2003-01-03

申请号：PCT/US2002/019650

申请日：2002-06-21

Applicant: CURAGEN CORPORATION ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  BURGESS, Catherine, E. ,  BADER, Joel, S. ,  BANSAL, Aruna ,  PENA, Carol, E., A. ,  SHIMKETS, Richard, A.

Inventor： GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  BURGESS, Catherine, E. ,  BADER, Joel, S. ,  BANSAL, Aruna ,  PENA, Carol, E., A. ,  SHIMKETS, Richard, A.

IPC: C12Q

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

Abstract: Disclosed herein is a nucleic acid sequence that encodes a novel polypeptide. Also disclosed is a polypeptide encoded by the nucleic acid sequence, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving this novel human nucleic acid and protein. The invention also provides nucleic acids containing single-nucleotide polymorphisms identified for transcribed human sequnces, as well as methods of using the nucleic acids.

Abstract translation: 本文公开了编码新多肽的核酸序列。 还公开了由核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明进一步公开了涉及这种新型人核酸和蛋白质的疾病的诊断，治疗和预防的治疗，诊断和研究方法。 本发明还提供了含有针对转录人类序列鉴定的单核苷酸多态性的核酸，以及使用核酸的方法。

公开(公告)号：WO2002090568A3

公开(公告)日：2002-11-14

申请号：PCT/US2002/014341

申请日：2002-05-02

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit, R. ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUNTHER, Erik ,  HERRMANN, John, L. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LEWIN, David, A. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MEZES, Peter, D. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  MILLER, Charles, E.

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit, R. ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUNTHER, Erik ,  HERRMANN, John, L. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LEWIN, David, A. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MEZES, Peter, D. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  MILLER, Charles, E.

IPC: C07K14/00

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the-polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2002090568A2

公开(公告)日：2002-11-14

申请号：PCT/US2002/014341

申请日：2002-05-02

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit, R. ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUNTHER, Erik ,  HERRMANN, John, L. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LEWIN, David, A. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MEZES, Peter, D. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  MILLER, Charles, E.

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit, R. ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUNTHER, Erik ,  HERRMANN, John, L. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LEWIN, David, A. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MEZES, Peter, D. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  MILLER, Charles, E.

IPC: C12Q

CPC classification number: C07K14/705 ,  C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the-polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码G偶联的蛋白质 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2002090504A3

公开(公告)日：2002-11-14

申请号：PCT/US2002/014342

申请日：2002-05-02

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CHAPOVAL, Andrei ,  EDINGER, Schlomit ,  GERLACH, Valerie ,  GORMAN, Linda ,  GUNTHER, Erik ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SPYTEK, Kimberly, A. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D.

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CHAPOVAL, Andrei ,  EDINGER, Schlomit ,  GERLACH, Valerie ,  GORMAN, Linda ,  GUNTHER, Erik ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SPYTEK, Kimberly, A. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D.

IPC: C07H21/04

Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.

公开(公告)号：WO2002068649A3

公开(公告)日：2002-09-06

申请号：PCT/US2002/002785

申请日：2002-01-31

Applicant: CURAGEN CORPORATION ,  TCHERNEV, Velizar, T. ,  SPYTEK, Kimberly, A. ,  ZERHUSEN, Bryan, D. ,  PATTURAJAN, Meera ,  SHIMKETS, Richard, A. ,  LI, Li ,  GANGOLLI, Esha, A. ,  PADIGARU, Muralidhara ,  ANDERSON, David, W. ,  RASTELLI, Luca ,  MILLER, Charles, E. ,  GERLACH, Valerie, L. ,  TAUPIER, Raymond, J., Jr. ,  GUSEV, Vladimir, Y. ,  COLMAN, Steven, D. ,  WOLENC, Adam, R. ,  PENA, Carol, E., A. ,  FURTAK, Katarzyna ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  RIEGER, Daniel, K. ,  BURGESS, Catherine, E.

Inventor： TCHERNEV, Velizar, T. ,  SPYTEK, Kimberly, A. ,  ZERHUSEN, Bryan, D. ,  PATTURAJAN, Meera ,  SHIMKETS, Richard, A. ,  LI, Li ,  GANGOLLI, Esha, A. ,  PADIGARU, Muralidhara ,  ANDERSON, David, W. ,  RASTELLI, Luca ,  MILLER, Charles, E. ,  GERLACH, Valerie, L. ,  TAUPIER, Raymond, J., Jr. ,  GUSEV, Vladimir, Y. ,  COLMAN, Steven, D. ,  WOLENC, Adam, R. ,  PENA, Carol, E., A. ,  FURTAK, Katarzyna ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  RIEGER, Daniel, K. ,  BURGESS, Catherine, E.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2002068649A2

公开(公告)日：2002-09-06

申请号：PCT/US2002/002785

申请日：2002-01-31

Applicant: CURAGEN CORPORATION ,  TCHERNEV, Velizar, T. ,  SPYTEK, Kimberly, A. ,  ZERHUSEN, Bryan, D. ,  PATTURAJAN, Meera ,  SHIMKETS, Richard, A. ,  LI, Li ,  GANGOLLI, Esha, A. ,  PADIGARU, Muralidhara ,  ANDERSON, David, W. ,  RASTELLI, Luca ,  MILLER, Charles, E. ,  GERLACH, Valerie, L. ,  TAUPIER, Raymond, J., Jr. ,  GUSEV, Vladimir, Y. ,  COLMAN, Steven, D. ,  WOLENC, Adam, R. ,  PENA, Carol, E., A. ,  FURTAK, Katarzyna ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  RIEGER, Daniel, K. ,  BURGESS, Catherine, E.

Inventor： TCHERNEV, Velizar, T. ,  SPYTEK, Kimberly, A. ,  ZERHUSEN, Bryan, D. ,  PATTURAJAN, Meera ,  SHIMKETS, Richard, A. ,  LI, Li ,  GANGOLLI, Esha, A. ,  PADIGARU, Muralidhara ,  ANDERSON, David, W. ,  RASTELLI, Luca ,  MILLER, Charles, E. ,  GERLACH, Valerie, L. ,  TAUPIER, Raymond, J., Jr. ,  GUSEV, Vladimir, Y. ,  COLMAN, Steven, D. ,  WOLENC, Adam, R. ,  PENA, Carol, E., A. ,  FURTAK, Katarzyna ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  RIEGER, Daniel, K. ,  BURGESS, Catherine, E.

IPC: C12N15/12

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003099201A3

公开(公告)日：2003-12-04

申请号：PCT/US2003/014692

申请日：2003-05-09

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ALVAREZ, Enrique ,  ANDERSON, David, W. ,  BADER, Joel, S. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHILLAKURU, Rajeev, A. ,  DEEGLER, Lisa ,  EDINGER, Shlomit, R. ,  FERNANDES, Elma, R. ,  GORMAN, Linda ,  GROSSE, William, M. ,  HERRMANN, John, L. ,  JEFFERS, Michael, E. ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LICHENSTEIN, Henri, S. ,  NAMDEV, Kumar ,  PADIGARU, Muralidhara ,  PENA, Carol, E. A. ,  PRAYAGA, Sudhirdas, K. ,  RIEGER, Daniel, K. ,  SHIMKETS, Richard, A. ,  VALAX, Pascal ,  YANG, Meijia ,  YIM, Zachary ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ALVAREZ, Enrique ,  ANDERSON, David, W. ,  BADER, Joel, S. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHILLAKURU, Rajeev, A. ,  DEEGLER, Lisa ,  EDINGER, Shlomit, R. ,  FERNANDES, Elma, R. ,  GORMAN, Linda ,  GROSSE, William, M. ,  HERRMANN, John, L. ,  JEFFERS, Michael, E. ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LICHENSTEIN, Henri, S. ,  NAMDEV, Kumar ,  PADIGARU, Muralidhara ,  PENA, Carol, E. A. ,  PRAYAGA, Sudhirdas, K. ,  RIEGER, Daniel, K. ,  SHIMKETS, Richard, A. ,  VALAX, Pascal ,  YANG, Meijia ,  YIM, Zachary ,  ZHONG, Mei

IPC: A61K38/00

Abstract: In methods of using a fibroblast growth factor, such as for treating, preventing or delaying a proliferation-associated disorder, steps are provided to administer to a subject a therapeutically effective amount of a particular fibroblast growth factor polypeptide, or variant or fragment thereof.

公开(公告)号：WO2003099201A2

公开(公告)日：2003-12-04

申请号：PCT/US2003/014692

申请日：2003-05-09

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ALVAREZ, Enrique ,  ANDERSON, David, W. ,  BADER, Joel, S. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHILLAKURU, Rajeev, A. ,  DEEGLER, Lisa ,  EDINGER, Shlomit, R. ,  FERNANDES, Elma, R. ,  GORMAN, Linda ,  GROSSE, William, M. ,  HERRMANN, John, L. ,  JEFFERS, Michael, E. ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LICHENSTEIN, Henri, S. ,  NAMDEV, Kumar ,  PADIGARU, Muralidhara ,  PENA, Carol, E. A. ,  PRAYAGA, Sudhirdas, K. ,  RIEGER, Daniel, K. ,  SHIMKETS, Richard, A. ,  VALAX, Pascal ,  YANG, Meijia ,  YIM, Zachary ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ALVAREZ, Enrique ,  ANDERSON, David, W. ,  BADER, Joel, S. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHILLAKURU, Rajeev, A. ,  DEEGLER, Lisa ,  EDINGER, Shlomit, R. ,  FERNANDES, Elma, R. ,  GORMAN, Linda ,  GROSSE, William, M. ,  HERRMANN, John, L. ,  JEFFERS, Michael, E. ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LICHENSTEIN, Henri, S. ,  NAMDEV, Kumar ,  PADIGARU, Muralidhara ,  PENA, Carol, E. A. ,  PRAYAGA, Sudhirdas, K. ,  RIEGER, Daniel, K. ,  SHIMKETS, Richard, A. ,  VALAX, Pascal ,  YANG, Meijia ,  YIM, Zachary ,  ZHONG, Mei

IPC: A61K

CPC classification number: C07K14/50 ,  A61K38/1825

Abstract: In methods of using a fibroblast growth factor, such as for treating, preventing or delaying a proliferation-associated disorder, steps are provided to administer to a subject a therapeutically effective amount of a particular fibroblast growth factor polypeptide, or variant or fragment thereof.

Abstract translation: 在使用成纤维细胞生长因子（例如用于治疗，预防或延迟增殖相关病症）的方法中，提供了向受试者施用治疗有效量的特定成纤维细胞生长因子多肽或其变体或片段的步骤。

公开(公告)号：WO2003085096A2

公开(公告)日：2003-10-16

申请号：PCT/US2003/009929

申请日：2003-04-01

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUO, Xiajia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUO, Xiajia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

IPC: C12N

CPC classification number: A61K38/04 ,  A61K38/17 ,  C07H21/02 ,  C07K14/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/00 ,  C12N15/00 ,  C12P21/02 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/53

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.