公开(公告)号：CA3078348C

公开(公告)日：2022-03-08

申请号：CA3078348

申请日：2011-09-23

Applicant: MEDTRONIC MINIMED INC

Inventor： SMITH ROGER E ,  CAUSEY JAMES ,  GIBSON SCOTT R ,  HE TOM XIAOHAI ,  FOGARTY THOMAS G ,  RING LAWRENCE SCOTT ,  LOFTIN SCOTT M

IPC: A61M5/145 ,  A61M5/142 ,  A61M5/168

Abstract: Ambulatory infusion pumps, pump assemblies, cartridges, baseplates, cannulas, insertion tools, and related components as well as combinations thereof and related methods. An exemplary medicament cartridge may comprise: a barrel defining at least a substantial portion of a medicament reservoir that has a total filled volume; and a plunger movable with respect to the barrel to controllably dispense out of the reservoir an amount of medicament of 0.1% or less of the total filled volume of the reservoir and with a single-dose precision of better than plus or minus 20%; and the precision is obtained within a dispensing period of less than eight hours.

公开(公告)号：CA3060140C

公开(公告)日：2022-02-15

申请号：CA3060140

申请日：2018-04-27

Applicant: MEDTRONIC MINIMED INC

Inventor： AASMUL SOREN ,  SVENNING KRISTENSEN JESPER

IPC: G01N33/542 ,  C08B37/02 ,  G01N33/66

Abstract: The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.

公开(公告)号：CA3026437C

公开(公告)日：2021-11-02

申请号：CA3026437

申请日：2017-06-06

Applicant: MEDTRONIC MINIMED INC

Inventor： WANG JENN-HANN LARRY

IPC: C08G18/40 ,  A61B5/1486 ,  C08G18/44 ,  C08G18/50 ,  C08G18/61 ,  C12Q1/00 ,  C12Q1/54

Abstract: Embodiments of the invention provide compositions useful in analyte sensors as well as methods for making and using such compositions and sensors. In typical embodiments of the invention, the sensor is a glucose sensor having an analyte modulating membrane. The analyte modulating layer includes a biocompatible composition including a polyurea-urethane copolymer formed from a reaction mixture. The polyurea-urethane copolymer exhibits an improved thermal stability.

公开(公告)号：CA3046567C

公开(公告)日：2021-10-19

申请号：CA3046567

申请日：2018-08-31

Applicant: MEDTRONIC MINIMED INC

Inventor： AJEMBA PETER ,  NOGUEIRA KEITH ,  TSAI ANDY Y ,  MILLER MICHAEL E ,  JACKS STEVEN C ,  VARSAVSKY ANDREA ,  KANNARD BRIAN T ,  NISHIDA JEFFERY

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/1495

Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

公开(公告)号：CA3049716C

公开(公告)日：2021-08-03

申请号：CA3049716

申请日：2017-12-22

Applicant: MEDTRONIC MINIMED INC

Inventor： YAVORSKY MATTHEW WILLIAM ,  VAZQUEZ PABLO

IPC: A61M5/158 ,  A61M5/32 ,  A61M25/06

Abstract: Embodiments relate to a cannula that is provided for delivering a substance, such as a medicine (e.g., insulin) to a patient, where the cannula has reduced likelihood of kinking or occlusions when implanted in a patient. The cannula may have a reduced number of stress concentrations along its length, an angled tip and/or a curve in its length. The cannula may include other designs to reduce kinking, such as internal ribbing and/or a slit along its wall.

公开(公告)号：DK3572105T3

公开(公告)日：2021-07-05

申请号：DK19185515

申请日：2014-10-09

Applicant: MEDTRONIC MINIMED INC

Inventor： MONTALVO SUSAN MCCONNELL ,  CHONG COLIN A ,  LICKLITER HANS ,  BIKOVSKY RAFAEL

IPC: A61M5/142 ,  A61M5/158

公开(公告)号：CA2818677C

公开(公告)日：2021-06-22

申请号：CA2818677

申请日：2011-12-16

Applicant: MEDTRONIC MINIMED INC

Inventor： DESBOROUGH LANE ,  PALERM CESAR C

IPC: A61B5/145 ,  A61B5/00 ,  G16H20/10 ,  G16H40/63

Abstract: Disclosed are methods, apparatuses, etc. for determination and application of a unidimensional metric for assessing a patient's glycemic health. In one particular implementation, a computed metric may be used to balance short-term and long-term risks associated with a particular therapy. In another implementation, a computed unidimensional metric may be used to balance risks of hyperglycemia and hypoglycemia.

公开(公告)号：CA3046094C

公开(公告)日：2021-06-08

申请号：CA3046094

申请日：2017-12-15

Applicant: MEDTRONIC MINIMED INC

Inventor： CHIU CHIA-HUNG ,  SCHULTZ PETER ,  VOSKANYAN GAYANE R ,  WANG HSIFU ,  GOTTLIEB REBECCA K ,  WARNOCK KENNETH D ,  JUAREZ MARTINEZ RICARDO

IPC: A61M5/14 ,  A61B5/00 ,  A61M5/142 ,  A61M5/145 ,  A61M5/158 ,  A61M5/172

Abstract: Disclosed is a medical device component for delivering medication fluid to a patient. The medical device component includes a fluid infusion device to regulate delivery of medication fluid, a body-mountable base unit, and a top cover assembly that is removably couplable to the base unit and to the fluid infusion device. The base unit includes a cannula to deliver medication fluid under the control of the fluid infusion device, and a physiological analyte sensor to measure a physiological characteristic. The base unit also includes an electronics assembly electrically connected to sensor leads to obtain measurements in the analog domain, to convert measurements into digital sensor data, and to communicate conditioned digital sensor data to the fluid infusion device. The top cover assembly is configured to provide both fluid and electrical connections for the base unit, by way of an infusion tube having sensor conductors integrated therein or otherwise associated therewith.

公开(公告)号：CA2931955C

公开(公告)日：2021-04-27

申请号：CA2931955

申请日：2014-11-21

Applicant: MEDTRONIC MINIMED INC

Inventor： VARSAVSKY ANDREA ,  LI XIAOLONG ,  LIU MIKE C ,  ZHONG YUXIANG ,  YANG NING

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：CA3030922C

公开(公告)日：2021-02-02

申请号：CA3030922

申请日：2015-07-17

Applicant: MEDTRONIC MINIMED INC

Inventor： BAZARGAN AFSHIN ,  PANANEN JACOB E ,  ALDERETE JUAN M ,  ALI SHERIF M ,  GROVER BENJAMIN A ,  HALILI EDGARDO C ,  MONTALVO SUSAN MCCONNELL ,  NG ANTHONY C ,  RANKERS ULRICH H ,  SAKAE VAUGHN S ,  VAZQUEZ PABLO ,  WEAVER ANDREW E ,  YAVORSKY MATTHEW WILLIAM ,  YU EDMOND W ,  WAGNER JENNIFER L ,  LIN MARK ,  IBRANYAN ARSEN ,  TIECK R MARIE ,  TROCK ADAM S ,  LORENZEN ERIC M

IPC: A61M5/14 ,  A61M5/145 ,  A61M39/10 ,  A61M39/12

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.