公开(公告)号：WO2009133325A3

公开(公告)日：2010-01-28

申请号：PCT/FR2009000493

申请日：2009-04-28

Applicant: SERVIER LAB ,  COMMISSARIAT ENERGIE ATOMIQUE ,  OGIER JULIEN ,  DORIS ERIC ,  LEFOULON FRANCOIS ,  ARNAULD THOMAS

Inventor： OGIER JULIEN ,  DORIS ERIC ,  LEFOULON FRANCOIS ,  ARNAULD THOMAS

IPC: A61K9/51

CPC classification number: A61K9/1075 ,  A61K9/5138

Abstract: The invention relates to polymerized micelles including polymerized amphiphilic molecules obtained from amphiphilic molecules including one or two lipid chains, each including one or two polymerizable motifs connected to a polar head. The invention can be used in drugs.

Abstract translation: 本发明涉及聚合胶束，包括从包括一个或两个脂质链的两亲分子获得的聚合的两亲分子，每个包含一个或两个连接到极性头的可聚合基序。 本发明可用于药物。

公开(公告)号：WO2009022065A3

公开(公告)日：2009-04-16

申请号：PCT/FR2008000934

申请日：2008-07-01

Applicant: SERVIER LAB ,  YOUS SAID ,  ETTAOUSSI MOHAMED ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

Inventor： YOUS SAID ,  ETTAOUSSI MOHAMED ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

IPC: C07C233/18 ,  A61K31/165 ,  A61P25/00

CPC classification number: C07C233/18

Abstract: Compounds of formula (I): in which: R1 is an alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, and R2 and R3 are a hydrogen atom or an alkyl group. Medicaments.

Abstract translation: 式（I）化合物：其中：R1是烷基，烯基，卤代烷基，多卤代烷基，环烷基，环烷基烷基，芳基，芳基烷基，杂芳基或杂芳基烷基，R2和R3是氢原子或烷基。 药物。

公开(公告)号：WO2009022064A3

公开(公告)日：2009-04-16

申请号：PCT/FR2008000933

申请日：2008-07-01

Applicant: SERVIER LAB ,  YOUS SAID ,  ETTAOUSSI MOHAMED ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

Inventor： YOUS SAID ,  ETTAOUSSI MOHAMED ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

IPC: C07C233/18 ,  A61K31/165 ,  A61P25/00 ,  C07C233/60

CPC classification number: C07C233/18 ,  C07C233/60 ,  C07C2601/02 ,  C07C2601/04

Abstract: Compounds of formula (I): in which: R1 is alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, and R2 is a fluorine atom or an alkyl group substituted with one or more fluorine atoms. Medicaments.

Abstract translation: 式（I）的化合物：其中：R1是烷基，烯基，卤代烷基，多卤代烷基，环烷基，环烷基烷基，芳基，芳烷基，杂芳基或杂芳基烷基，R2是氟原子或被一个或多个氟原子取代的烷基。 药物。

公开(公告)号：WO2008099083A3

公开(公告)日：2008-12-11

申请号：PCT/FR2008000014

申请日：2008-01-04

Applicant: SERVIER LAB ,  LE RIDANT ALAIN ,  HARPEY CATHERINE

Inventor： LE RIDANT ALAIN ,  HARPEY CATHERINE

IPC: A61K31/437 ,  A61K31/4439 ,  A61K31/553 ,  A61P25/00 ,  C07D401/12 ,  C07D487/06

CPC classification number: C07D487/06 ,  C07D401/12

Abstract: The invention relates to the use of neuroprotective compounds for obtaining drugs for the curative treatment of neurodegenerative diseases and/or for preventing the occurrence of problems resulting from said diseases.

Abstract translation: 本发明涉及神经保护性化合物用于获得用于治疗性治疗神经变性疾病和/或用于预防由所述疾病引起的问题的发生的药物的用途。

公开(公告)号：WO2007144512A3

公开(公告)日：2008-03-20

申请号：PCT/FR2007000989

申请日：2007-06-14

Applicant: SERVIER LAB ,  CORDI ALEXIS ,  HABERKORN LAURE ,  VERBEUREN TONY ,  COURCHAY CHRISTINE ,  SIMONET SERGE

Inventor： CORDI ALEXIS ,  HABERKORN LAURE ,  VERBEUREN TONY ,  COURCHAY CHRISTINE ,  SIMONET SERGE

IPC: C07D257/04 ,  A61K31/41 ,  A61P9/00 ,  A61P9/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14

CPC classification number: C07D257/04 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14

Abstract: The invention relates to compounds of formula (I): in which: R 1 is an alkanoyl group, R 2 is an alkyl group substituted with a group G, or R 1 and R 2 form, together with the nitrogen atom which bears them, an imidazolyl or benzimidazolyl group, substituted with a group G, and G is a -(CH 2 ) n -A-(CH 2 ) m -(CR 4 R 5 ) P -(CH 2 ) O -R 3 group in which n, m, p, o, R 4 , R 5 and A are as defined in the description, and R 3 is a group of formula (II) or formula (III). The invention also relates to the use of said compounds as angiotensin receptor antagonists and as NO donors, in the fields of hypertension and cardiovascular pathologies.

Abstract translation: 本发明涉及式（I）的化合物：其中：R 1是烷酰基，R 2是被基团G取代的烷基， 与它们的氮原子一起形成与基团G取代的咪唑基或苯并咪唑基，并且G是 - （CH 2）n - 2 ）_{名词 -A-（CH 2 ）米 - （CR 4 - [R}

公开(公告)号：WO2006103342A9

公开(公告)日：2007-10-25

申请号：PCT/FR2006000673

申请日：2006-03-29

Applicant: SERVIER LAB ,  DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  GLOANEC PHILIPPE ,  MILLAN MARK ,  ORTUNO JEAN-CLAUDE ,  MANNOURY LA COUR CLOTILDE ,  GOBERT ALAIN

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  GLOANEC PHILIPPE ,  MILLAN MARK ,  ORTUNO JEAN-CLAUDE ,  MANNOURY LA COUR CLOTILDE ,  GOBERT ALAIN

IPC: C07D295/08 ,  A61K31/495 ,  A61P1/08 ,  A61P3/04 ,  A61P25/08 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30 ,  C07D213/40 ,  C07D295/12 ,  C07D295/14 ,  C07D333/20

CPC classification number: C07D213/40 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D333/20

Abstract: The invention concerns a compound of formula (I), wherein: R 3 represents a hydrogen atom; and R 1 and R 2 form together, with the carbon atoms bearing them, a benzene, naphthalene or quinoline ring, each of said rings being optionally substituted, or R 1 represents a hydrogen atom, and R 2 and R 3 form together, with the atoms bearing them, a benzene, naphthalene or quinoline ring, each of said rings being optionally substituted; n represents 1 or 2; -X- represents a group selected among -(CH2) m -O-Ak-, -(CH 2 ) m -NR 4 -Ak-, - (CO)-NR 4 -Ak- and -(CH 2 ) m -NR 4 -(CO)-; m represents an integer between 1 and 6 inclusive; Ak represents an optionally substituted alkylene chain; and R 4 represents a hydrogen atom or an alkyl group; Ar represents an aryl or heteroaryl group; its optical isomers, as well as a pharmaceutically acceptable acid-addition salt thereof. The invention is applicable to medicines.

Abstract translation: 本发明涉及式（I）化合物，其中：R 3表示氢原子; 和R 1和R 2 2一起形成带有它们的碳原子，苯，萘或喹啉环，每个所述环任选被取代，或R _{1 表示氢原子，并且R 2和R 3和它们的原子一起形成苯，萘或喹啉环，每个 所述环任选被取代; n表示1或2; -X-表示选自以下的基团： - （CH 2）m -O-Ak-， - （CH 2 CH 2）m -N > - > - （ - ）（CO）-NR 4 -A - 和 - （CH 2 CH 2）m -NR 4 - （CO） - ; m表示1〜6的整数， Ak表示任选取代的亚烷基链; R 4表示氢原子或烷基; Ar表示芳基或杂芳基; 其光学异构体，以及其药学上可接受的酸加成盐。 本发明适用于药物。}

公开(公告)号：WO2007017585A3

公开(公告)日：2007-04-12

申请号：PCT/FR2006001901

申请日：2006-08-04

Applicant: SERVIER LAB ,  LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: C07D491/22 ,  A61K31/4745 ,  A61P35/00 ,  C07D471/14

CPC classification number: C07D471/14

Abstract: Compounds of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 80 , R 90 , R 81 , R 91 , AIk and G are such as defined in the description, can be used for drugs.

Abstract translation: 式（I）化合物，其中R 1，R 2，R 3，R 4，R 4， 80以下，R 80，R 90，R 81，R 91，Alk和 G在描述中定义，可用于药物。

公开(公告)号：WO2007015004A2

公开(公告)日：2007-02-08

申请号：PCT/FR2006001869

申请日：2006-08-02

Applicant: SERVIER LAB ,  COQUEREL GERARD ,  LINOL JULIE ,  SOUVIE JEAN-CLAUDE

Inventor： COQUEREL GERARD ,  LINOL JULIE ,  SOUVIE JEAN-CLAUDE

IPC: C07C233/18 ,  A61K31/165 ,  A61P25/00 ,  C07C231/24

CPC classification number: C07C231/24 ,  C07C233/18 ,  C07C2602/10

Abstract: The crystalline form V of a compound of formula (I) is characterised by the X diffraction diagram thereof on a powder.

Abstract translation: 式（I）化合物的结晶形式V的特征在于其在粉末上的X衍射图。

公开(公告)号：WO2006079719A3

公开(公告)日：2006-09-28

申请号：PCT/FR2006000174

申请日：2006-01-26

Applicant: SERVIER LAB ,  PARMENON CECILE ,  VIAUD-MASSUARD MARIE-CLAUDE ,  GUILLARD JEROME ,  DACQUET CATHERINE ,  KTORZA ALAIN ,  CAIGNARD DANIEL-HENRI

Inventor： PARMENON CECILE ,  VIAUD-MASSUARD MARIE-CLAUDE ,  GUILLARD JEROME ,  DACQUET CATHERINE ,  KTORZA ALAIN ,  CAIGNARD DANIEL-HENRI

IPC: C07D215/06 ,  A61K31/4709 ,  A61P3/04 ,  C07D215/58

CPC classification number: C07D215/12

Abstract: The invention concerns compounds of formula (I), wherein: R 1 , R 2 , R 3 , R 4 and X are such as defined in the description; A represents an alkylene chain such as defined in the description; B represents an alkyl or alkenyl group substituted by a group (II) or R 7 , or B represents a group (III) or R 7 . The invention is applicable to preparation of medicines.

Abstract translation: 本发明涉及式（I）的化合物，其中：R 1，R 2，R 3，R 4， >和X是在描述中定义的; A表示亚烷基链，如描述中所定义; B表示被基团（II）或R 7取代的烷基或链烯基，或B表示基团（III）或R 7。 本发明适用于药物的制备。

公开(公告)号：WO2006027474A2

公开(公告)日：2006-03-16

申请号：PCT/FR2005002162

申请日：2005-08-30

Applicant: SERVIER LAB ,  GUILLAUMET GERALD ,  BERTEINA-RABOIN SABINE ,  EL KAZZOULI SAID ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： GUILLAUMET GERALD ,  BERTEINA-RABOIN SABINE ,  EL KAZZOULI SAID ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: The invention relates to compounds of formula (I), wherein A is an -NHCOR

Abstract translation: 本发明涉及式（I）化合物，其中A是-NHCOR