公开(公告)号：EP2381843B1

公开(公告)日：2016-06-01

申请号：EP10731004.7

申请日：2010-01-15

Applicant: St. Michael's Hospital

Inventor： SINDERBY, Christer ,  BECK, Jennifer

IPC: A61B5/08 ,  A61B5/0488 ,  A61B5/091

CPC classification number: A61B5/091 ,  A61B5/037 ,  A61B5/0488 ,  A61B5/087

公开(公告)号：EP2779896A1

公开(公告)日：2014-09-24

申请号：EP12848806.1

申请日：2012-11-16

Applicant: St. Michael's Hospital

Inventor： SINDERBY, Christer ,  COMTOIS, Norman ,  BECK, Jennifer ,  EMTELL, Pär ,  KOCK, Michael

IPC: A61B5/08 ,  A61B5/0488 ,  A61M16/00

CPC classification number: A61M16/0051 ,  A61B5/04001 ,  A61B5/04884 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/742 ,  A61M16/00 ,  A61M16/0069 ,  A61M16/021 ,  A61M2016/0021 ,  A61M2205/502 ,  A61M2210/1014 ,  A61M2230/40 ,  A61M2230/60

Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.

公开(公告)号：EP2320793A1

公开(公告)日：2011-05-18

申请号：EP09809154.9

申请日：2009-08-26

Applicant: St. Michael's Hospital

Inventor： SINDERBY, Christer

IPC: A61B5/091 ,  A61M16/00

CPC classification number: A61B5/08 ,  A61B5/0488 ,  A61B5/087 ,  A61B5/687 ,  A61M16/021 ,  A61M2016/0039 ,  A61M2230/60 ,  A61M2230/005

Abstract: The present invention relates to a system and method for determining a patient-ventilator breath contribution index in a spontaneously breathing, mechanically ventilated patient. A patient's efficiency to generate an inspiratory volume without mechanical ventilatory assist and a patient's efficiency to generate an inspiratory volume with mechanical ventilatory assist are calculated and used to determine the patient-ventilator breath contribution index.

公开(公告)号：EP3469623A2

公开(公告)日：2019-04-17

申请号：EP17812350.1

申请日：2017-06-09

Applicant: University Health Network ,  St. Michael's Hospital

Inventor： ZARRINE-AFSAR, Arash ,  GINSBERG, Howard Joeseph ,  WOOLMAN, Michael

IPC: H01J49/10 ,  H01J27/24 ,  H01J49/04

公开(公告)号：EP2983695A1

公开(公告)日：2016-02-17

申请号：EP14783323.0

申请日：2014-03-19

Applicant: Sunnybrook Research Institute ,  St. Michael's Hospital

Inventor： DUMONT, Daniel ,  VAN SLYKE, Paul ,  LEE, Warren

IPC: A61K38/18 ,  A61K31/13 ,  A61K31/195 ,  A61K31/216 ,  A61K31/351 ,  A61K31/7056 ,  A61K39/395 ,  A61K47/48 ,  A61P31/16

CPC classification number: A61K38/08 ,  A61K31/13 ,  A61K31/195 ,  A61K31/215 ,  A61K31/7012 ,  A61K31/7056 ,  A61K38/00 ,  A61K45/06 ,  A61K47/60 ,  C07K14/515 ,  A61K2300/00

Abstract: The present disclosure provides methods and uses of Tie2 agonists alone or in combination with antiviral agents. In particular, the present disclosure provides methods and uses for treating influenza, treating a bacterial superinfection associated with influenza and decreasing lung endothelial leakage. The disclosure also provides compositions comprising (a) a Tie2 agonist and (b) an antiviral agent and methods and uses thereof.

Abstract translation: 本公开提供了Tie2激动剂单独或与抗病毒剂组合的方法和用途。 具体而言，本公开提供了治疗流感，治疗与流感相关的细菌重复感染和减少肺内皮渗漏的方法和用途。 本公开还提供了包含（a）Tie2激动剂和（b）抗病毒剂的组合物及其方法和用途。

公开(公告)号：EP2588177A1

公开(公告)日：2013-05-08

申请号：EP11800020.7

申请日：2011-06-29

Applicant: St. Michael's Hospital

Inventor： SINDERBY, Christer ,  BECK, Jennifer

IPC: A61M16/00 ,  A61M16/04

Abstract: A ventilatory assist system and method are disclosed. The system comprises a tube for connection to a patient's airway, inspiratory and expiratory tube lumens connected to the tube, an inspiratory air source connected to the inspiration tube lumen, and a controller of air pressure in the expiratory tube lumen. The pressure controller is responsive to a physiological breathing signal representative of patient's inspiratory effort to allow air flow through the expiratory tube lumen during a patient's expiration phase, partially restricting the air flow through the expiratory tube lumen to a so minimum air flow during a patient's inspiration phase. During both respiratory phases, a unidirectional air flow is produced through the inspiratory and expiratory tube lumens to prevent air expired by the patient from being breathed again. The physiological breathing signal allows synchronization of the ventilatory assist with breathing efforts of the patient.

公开(公告)号：EP2381992A1

公开(公告)日：2011-11-02

申请号：EP10730997.3

申请日：2010-01-14

Applicant: St. Michael's Hospital

Inventor： SINDERBY, Christer ,  BECK, Jennifer

IPC: A61M16/00 ,  A61B5/0448 ,  A61B5/08

CPC classification number: A61M16/0051 ,  A61B5/0488 ,  A61B5/08 ,  A61M16/026 ,  A61M2016/0027

Abstract: A method and device determine a level of mechanical ventilatory assist to be delivered to a patient. A patient's neural respiratory drive is measured and multiplied by an existing amplification factor to obtain an existing predicted ventilatory pressure. A mechanical ventilator is controlled accordingly. An existing resulting pressure is measured. The patient's neural respiratory drive is multiplied by a modified amplification factor to obtain a new predicted pressure. The existing and new predicted pressures are compared to determine an anticipated change in pressure. The mechanical ventilator is now controlled according to the new predicted pressure. A new resulting pressure is measured. The existing and new resulting pressures are compared to determine an actual change in pressure. The anticipated and actual changes in pressure are compared. The amplification factor is increased, maintained or decreased in response to the comparison between the anticipated and actual changes in pressure.

公开(公告)号：EP2381843A1

公开(公告)日：2011-11-02

申请号：EP10731004.7

申请日：2010-01-15

Applicant: St. Michael's Hospital

Inventor： SINDERBY, Christer ,  BECK, Jennifer

IPC: A61B5/08 ,  A61B5/0488 ,  A61B5/091

CPC classification number: A61B5/091 ,  A61B5/037 ,  A61B5/0488 ,  A61B5/087

Abstract: A method and system for measuring changes in inspiratory load of a patient's respiratory system during mechanical ventilation. The method and system calculate a first relation between a measured inspiratory airway pressure and a measured electrical activity of respiratory muscle, and a second relation between a measured inspiratory volume and the measured electrical activity. A load index is calculated from the first and second relations. Changes in inspiratory load are determined based on the load index.

公开(公告)号：EP2375977A1

公开(公告)日：2011-10-19

申请号：EP10730988.2

申请日：2010-01-07

Applicant: St. Michael's Hospital

Inventor： SINDERBY, Christer ,  BECK, Jennifer ,  COMTOIS, Norman ,  GRASSELLI, Giacomo

IPC: A61B5/091 ,  A61M16/00

CPC classification number: A61M16/0051 ,  A61B5/091 ,  A61M16/0003 ,  A61M16/024 ,  A61M2016/003 ,  A61M2016/0036

Abstract: A method and device for determining dynamic hyperinflation during mechanical ventilation of a spontaneously breathing patient, wherein mechanical ventilation is removed during one breath of the patient, inspiratory and expiratory volumes of the patient are measured during the one breath, and a difference between the inspiratory and expiratory volumes measured during the one breath is calculated. Dynamic hyperinflation of the patient's lungs is indicated in relation to the calculated difference.

公开(公告)号：EP3086831B1

公开(公告)日：2020-09-23

申请号：EP14875136.5

申请日：2014-12-23

Applicant: St. Michael's Hospital

Inventor： SINDERBY, Christer ,  BECK, Jennifer ,  COMTOIS, Norman

IPC: A61M16/20 ,  A61M16/04 ,  A61M16/08