公开(公告)号：WO2018236910A1

公开(公告)日：2018-12-27

申请号：PCT/US2018/038341

申请日：2018-06-19

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  SUN, Thomas W.

Inventor： SUN, Thomas W. ,  COHEN, Stanley N. ,  DENG, Ning ,  FENG, Yanan ,  CHENG, Tzu-Hao

IPC: A61K31/403 ,  C07D209/82

Abstract: Aspects of the present disclosure include methods of reducing the deleterious impact of a target gene in a cell, such as the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a tetrahydrocarbazolamine compound. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.

公开(公告)号：WO2011102946A8

公开(公告)日：2011-08-25

申请号：PCT/US2011/022754

申请日：2011-01-27

Applicant: EXXONMOBIL CHEMICAL PATENTS INC. ,  KOLB, Rainer ,  CHU, John W. ,  KISS, Gabor ,  REYNOLDS, Jr., Robert, P. ,  SCHAUDER, Jean-Roch ,  SUN, Thomas T.

Inventor： KOLB, Rainer ,  CHU, John W. ,  KISS, Gabor ,  REYNOLDS, Jr., Robert, P. ,  SCHAUDER, Jean-Roch ,  SUN, Thomas T.

IPC: C08L23/14

Abstract: Elastomeric polymer blends and processes for their production are described. Specifically, the polymer blends comprise a first polymer and a second polymer, where the first polymer comprises from 70 wt% to 90 wt% units derived from propylene and from 10 wt% to 30 wt% units derived from ethylene and/or a C 4 -C 10 alpha-olefin, and the second polymer comprises from 88 wt% to 98 wt% units derived from propylene and from 2 wt% to 12 wt% units derived from ethylene and/or a C 4 -C 10 alpha-olefin. The elastomeric polymer blends are further characterized by having two or more of the following properties: an overall propylene content of between 75 wt% and 90 wt%, a melting point between 110°C and 145°C, a Vicat softening point greater than 45°C, a tensile stress at 300% strain of less than 500 psi (3447 kPa), as determined by a stress strain test according to ASTM D412, or an average maximum force for pellet separation of less than 10 N in an accelerated storage stability test. The polymer blends are produced in a dual reactor process, in which the first polymer and the second polymer are prepared using differing catalyst systems.

公开(公告)号：WO2008121554A1

公开(公告)日：2008-10-09

申请号：PCT/US2008/057388

申请日：2008-03-19

Applicant: QUALCOMM Incorporated ,  KRISHNAMOORTHI, Raghuraman ,  SUN, Thomas ,  MANTRADAVI, Ashok

Inventor： KRISHNAMOORTHI, Raghuraman ,  SUN, Thomas ,  MANTRADAVI, Ashok

IPC: H04L1/20

CPC classification number: H04L1/206 ,  H04L1/24 ,  H04L27/2626 ,  H04L2001/0097

Abstract: Apparatus and methods are disclosed for testing or qualifying a repeater/transmitter in a multicarrier system by utilizing modulation error ratio (MER). In particular, a disclosed method includes determining an estimated effective modulation error ratio of an output of the repeater/transmitter. The estimated effective modulation error ratio is compared with a predetermined threshold, and the repeater/transmitter is qualified when the estimated effective modulation error ratio is greater than the predetermined threshold. Using an estimated modulation error ratio for repeater/transmitters, which can have non-flat modulation error ratios over a total number of subcarriers, affords an efficient method to test and qualify repeater/transmitters.

Abstract translation: 公开了用于通过利用调制误差比（MER）在多载波系统中测试或限定中继器/发射机的装置和方法。 具体地，所公开的方法包括确定中继器/发射机的输出的估计有效调制误差比。 将估计的有效调制误差比与预定阈值进行比较，并且当估计的有效调制误差比大于预定阈值时，中继器/发射机被限定。 对于可能在副载波总数上具有非平坦调制误差比的中继器/发射机使用估计的调制误差率，提供了测试和限定中继器/发射机的有效方法。

公开(公告)号：WO2007134153A3

公开(公告)日：2007-11-22

申请号：PCT/US2007/068641

申请日：2007-05-10

Applicant: QUALCOMM Incorporated ,  LING, Fuyun ,  SUN, Thomas ,  KRISHNAMOORTHI, Raghuraman ,  VAN VEEN, Durk L. ,  CHARI, Murali Ramaswamy

Inventor： LING, Fuyun ,  SUN, Thomas ,  KRISHNAMOORTHI, Raghuraman ,  VAN VEEN, Durk L. ,  CHARI, Murali Ramaswamy

IPC: H04B17/00 ,  H04L27/00

Abstract: The claimed subject matter relates to estimating noise variance associated with a transmitter. For example, the noise variance can be estimated in connection with determining performance parameters associated with a transmitter. Determining noise variance can include the acts of estimating phase alteration of a received signal through utilization of a least squares-based phase estimation algorithm. Determining noise variance can also include the act of determining an unbiased estimation of noise variance as a function of the estimated phase alteration.

公开(公告)号：WO2007131056A2

公开(公告)日：2007-11-15

申请号：PCT/US2007/068062

申请日：2007-05-02

Applicant: QUALCOMM Incorporated ,  SUN, Thomas ,  VAN VEEN, Durk, L. ,  LING, Fuyun ,  CHARI, Murali, Ramaswamy ,  KRISHNAMOORTHI, Raghuraman

Inventor： SUN, Thomas ,  VAN VEEN, Durk, L. ,  LING, Fuyun ,  CHARI, Murali, Ramaswamy ,  KRISHNAMOORTHI, Raghuraman

IPC: H04B17/00 ,  H04L1/20

CPC classification number: H04L27/2676 ,  H04B17/101 ,  H04B17/15 ,  H04L1/206 ,  H04L25/0232 ,  H04L25/0236 ,  H04L27/2657

Abstract: The claimed subject matter relates to analyzing performance of a transmitter. This can be accomplished, for instance, through partitioning a super frame into a plurality of segments, and thereafter estimating and correcting phase with respect to at least one of the plurality of segments. Thereafter, additive noise can be determined with respect to the at least one segment. For instance, the super frame can include multiple OFDM symbols, and the transmitter can be a FLO transmitter.

Abstract translation: 所要求保护的主题涉及分析发射机的性能。 这可以例如通过将超帧划分成多个段，然后相对于多个段中的至少一个来估计和校正相位来实现。 此后，可以相对于至少一个段确定加性噪声。 例如，超帧可以包括多个OFDM符号，并且发射机可以是FLO发射机。

公开(公告)号：WO2007118104A2

公开(公告)日：2007-10-18

申请号：PCT/US2007/065902

申请日：2007-04-03

Applicant: QUALCOMM Incorporated ,  SUN, Thomas ,  KRISHNAMOORTHI, Raghuraman

Inventor： SUN, Thomas ,  KRISHNAMOORTHI, Raghuraman

IPC: H04L27/26

CPC classification number: H04L27/2623

Abstract: The claimed subject matter relates to enforcing a threshold peak to average power while reducing affects associated with saturation. This can be accomplished, for instance, by accessing a piecewise linear approximation of an ideal saturation region, wherein the ideal saturation region is based at least in part upon the threshold peak to average ratio. Thereafter, a desirably transmitted signal can be saturated if power associated with the signal lies outside a region encompassed by the piecewise linear approximation.

Abstract translation: 所要求保护的主题涉及在减小与饱和度相关的影响的同时执行阈值峰值以达到平均功率。 这可以例如通过访问理想饱和区域的分段线性近似来实现，其中理想饱和区域至少部分地基于阈值峰均比。 此后，如果与信号相关联的功率位于由分段线性近似包围的区域之外，则期望发送的信号可以是饱和的。