公开(公告)号：US20170037478A1

公开(公告)日：2017-02-09

申请号：US15298728

申请日：2016-10-20

Applicant: DANA-FARBER CANCER INSTITUTE, INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  CHILDREN'S MEDICAL CENTER CORPORATION ,  THE TECHNICAL UNIVERSITY OF DENMARK

Inventor： Andrea L. Richardson ,  Zhigang C. Wang ,  Daniel P. Silver ,  Zoltan Szallasi ,  Nicolai Juul Birkbak ,  Aron Charles Eklund

IPC: C12Q1/68

Abstract: The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.

Abstract translation: 本发明部分地基于鉴定用于定义对抗癌药物的响应的预测生物标志物的新方法。

公开(公告)号：US20160318893A1

公开(公告)日：2016-11-03

申请号：US15103838

申请日：2014-12-19

Applicant: TECHNICAL UNIVERSITY OF DENMARK ,  UNIVERSITY OF COPENHAGEN

Inventor： Björn Hamberger ,  Eirini Pateraki ,  Birger Lindberg MØLLERø ,  Morten NØRHOLM ,  Morten Thrane Nielsen ,  Johan Andersen-Ranberg ,  Carl Jörg Bohlmann ,  Phillipp Zerbe

IPC: C07D311/92 ,  C12N9/88 ,  C12P17/06

CPC classification number: C07D311/92 ,  C07B2200/07 ,  C12N9/88 ,  C12N9/90 ,  C12N15/8243 ,  C12P17/06 ,  C12Y402/03 ,  C12Y505/01

Abstract: The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.

Abstract translation: 本发明涉及一种制备对映异构纯的（13R） - 马来酰氧化物的方法，所述方法包括以下步骤：将香叶基香叶基二磷酸酯（GGPP）与二级二萜合酶接触，得到实验部分13-en-8,15-二醇二磷酸酯 （LPP），然后使LPP与I类二萜合酶接触，得到（13R） - 马来酰氧基。 本发明还涉及通过本发明的方法获得的（13R） - 马来酰氧基氧化物。

公开(公告)号：US20160238679A1

公开(公告)日：2016-08-18

申请号：US15141257

申请日：2016-04-28

Applicant: Technical University of Denmark

Inventor： Vitaliy Zhurbenko

IPC: G01R33/34 ,  G01R33/345

CPC classification number: G01R33/34076 ,  G01R33/345 ,  G01R33/3628

Abstract: The present disclosure relates to a probe for use within the field of nuclear magnetic resonance, such as magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS)). One embodiment relates to an RF probe for magnetic resonance imaging and/or spectroscopy comprising a conductive non-magnetic hollow waveguide having an internal volume and at least one open end, one or more capacitors and at least a first conductive non-magnetic wire, wherein said first conductive wire connects at least one of said one or more capacitors to opposite walls of one open end of the waveguide and wherein said first conductive wire and said one or more capacitors are located outside of said internal volume, wherein the internal volume of the hollow waveguide defines an imaging volume or sample volume.

Abstract translation: 本公开内容涉及用于核磁共振领域的探针，例如磁共振成像（MRI）和磁共振波谱（MRS））。 一个实施例涉及用于磁共振成像和/或光谱的RF探针，其包括具有内部体积和至少一个开放端，一个或多个电容器和至少第一导电非磁性线的导电非磁性中空波导，其中 所述第一导线将所述一个或多个电容器中的至少一个连接到波导的一个开放端的相对壁，并且其中所述第一导线和所述一个或多个电容器位于所述内部体积的外部，其中， 空心波导定义成像体积或样本体积。

公开(公告)号：US20160076999A1

公开(公告)日：2016-03-17

申请号：US14888372

申请日：2014-03-18

Applicant: TECHNICAL UNIVERSITY OF DENMARK

Inventor： Henrik Schiøtt SØRENSEN ,  Thornas Martini JØRGENSEN

IPC: G01N21/45 ,  G01N21/85

CPC classification number: G01N21/45 ,  G01N21/85 ,  G01N2201/06113

Abstract: A refractive index based measurement of a property of a fluid is measured in an apparatus including a variable wavelength coherent light source, a sample chamber, a wavelength controller, a light sensor, a data recorder and a computation apparatus, by—directing coherent light having a wavelength along an input light path, —producing scattering of the light from each of a plurality of interfaces within the apparatus including interfaces between the fluid and a surface bounding the fluid, the scattering producing an interference pattern formed by the scattered light, —cyclically varying the wavelength of the light in the input light path over a 1 nm to 20 nm wide range of wavelengths a rate of from 10 Hz to 50 KHz, —recording variation of intensity of the interfering light with change in wavelength of the light at an angle of observation, and—calculating the property from the variation.

Abstract translation: 在包括可变波长相干光源，样品室，波长控制器，光传感器，数据记录器和计算装置的装置中测量基于折射率的液体性质测量，其包括相干光，其具有 沿着输入光路的波长，产生来自设备内的多个界面中的每一个的光的散射，包括流体和界定流体的表面之间的界面，散射产生由散射光形成的干涉图案，周期地 在10Hz至50KHz的波长范围内，在1nm至20nm宽的波长范围内改变输入光路中的光的波长， - 记录干扰光的强度随着光的波长变化的变化 观察角度，并根据变化计算属性。

公开(公告)号：US20150267228A1

公开(公告)日：2015-09-24

申请号：US14435111

申请日：2013-10-10

Applicant: TECHNICAL UNIVERSITY OF DENMARK

Inventor： Irina Borodina ,  Kanchana Rueksomtawin Kildegaard ,  Jochen Förster ,  Fredrik Öberg

IPC: C12P7/42 ,  C12N9/00 ,  C12N9/88 ,  C12N9/10 ,  C12N9/04

CPC classification number: C12P7/42 ,  C12N9/0006 ,  C12N9/1096 ,  C12N9/88 ,  C12N9/93 ,  C12P7/52 ,  C12Y101/01031 ,  C12Y101/01059 ,  C12Y206/01001 ,  C12Y401/01011 ,  C12Y401/01015 ,  C12Y604/01001

Abstract: A genetically modified Saccharomyces cerevisiae including an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.

Abstract translation: 包括产生3-HP的活性发酵途径的转基因酿酒酵母表达表达来自蜡状芽孢杆菌AH1272的氨基转移酶YhxA的外源基因，其催化β-丙氨酸和丙酮酸之间的转氨基反应以产生丙二酸半醛。 酵母还可以表达3-羟基异丁酸脱氢酶（HIBADH）和3-羟基丙酸脱氢酶（3-HPDH）和天冬氨酸1-脱羧酶。 此外，酵母可以表达丙酮酸羧化酶和天冬氨酸氨基转移酶。

公开(公告)号：US20150131100A1

公开(公告)日：2015-05-14

申请号：US14405938

申请日：2013-06-06

Applicant: Technical University of Denmark

Inventor： Kasper Reck ,  Christian Østergaard ,  Ole Hansen ,  Erik Vilain Thomsen

IPC: G01L1/24 ,  G02B6/10 ,  G01N21/55

CPC classification number: G01L1/246 ,  G01L11/02 ,  G01N21/55 ,  G01N2201/061 ,  G01N2201/0633 ,  G01N2201/084 ,  G02B6/10

Abstract: The present invention relates to an all-optical sensor utilizing effective index modulation of a waveguide and detection of a wavelength shift of reflected light and a force sensing system accommodating said optical sensor. One embodiment of the invention relates to a sensor system comprising at least one multimode light source, one or more optical sensors comprising a multimode sensor optical waveguide accommodating a distributed Bragg reflector, at least one transmitting optical waveguide for guiding light from said at least one light source to said one or more multimode sensor optical waveguides, a detector for measuring light reflected from said Bragg reflector in said one or more multimode sensor optical waveguides, and a data processor adapted for analyzing variations in the Bragg wavelength of at least one higher order mode of the reflected light.

Abstract translation: 本发明涉及利用波导的有效折射率调制和检测反射光的波长偏移的全光学传感器以及容纳所述光学传感器的力感测系统。 本发明的一个实施例涉及包括至少一个多模光源的传感器系统，一个或多个光学传感器，其包括容纳分布式布拉格反射器的多模传感器光波导，至少一个发射光波导，用于引导来自所述至少一个光的光 源到所述一个或多个多模传感器光波导，用于测量在所述一个或多个多模传感器光波导中从所述布拉格反射器反射的光的检测器，以及适于分析至少一个高阶模的布拉格波长的变化的数据处理器 的反射光。

公开(公告)号：US20150080671A1

公开(公告)日：2015-03-19

申请号：US14290402

申请日：2014-05-29

Applicant: Technical University of Denmark ,  Glostrup Hospital ,  H. Lundbeck A/S

Inventor： Julie Anja Engelhard Christensen ,  Lykke Kempfner ,  Poul Jørgen Jennum ,  Helge Bjarup Dissing Sørensen ,  Lars Arvastson ,  Søren Rahn Christensen

IPC: A61B5/00 ,  A61B5/11 ,  A61B5/0496 ,  A61B5/0476

CPC classification number: A61B5/4812 ,  A61B5/0476 ,  A61B5/0496 ,  A61B5/11 ,  A61B5/4082 ,  A61B5/4806 ,  A61B5/7264

Abstract: The present invention relates to the use of sleep spindles as a novel biomarker for early diagnosis of synucleinopathies, in particular Parkinson's disease (PD). The method is based on automatic detection of sleep spindles. The method may be combined with measurements of one or more further biomarkers derived from polysomnographic recordings.

Abstract translation: 本发明涉及睡眠心轴作为突触核蛋白病，特别是帕金森病（PD）的早期诊断的新型生物标志物的用途。 该方法基于睡眠主轴的自动检测。 该方法可以与衍生自多导睡眠摄影记录的一种或多种另外的生物标志物的测量结合。

公开(公告)号：US20140342426A1

公开(公告)日：2014-11-20

申请号：US14353299

申请日：2012-10-12

Applicant: TECHNICAL UNIVERSITY OF DENMARK ,  VESTFORSYNING A/S

Inventor： Irini Angelidaki ,  Poul Lyhne ,  Gang Luo

IPC: C12P5/02

CPC classification number: C12P5/023 ,  C12M21/04 ,  C12M29/16 ,  C12M43/00 ,  C12M43/08 ,  C12M47/18 ,  Y02E50/343

Abstract: The present invention relates to an anaerobic process for biogas upgrading and hydrogen utilization comprising the use of acidic waste as co-substrate. In this process, H2 and CO2 will be converted to CH4, which will result in lower CO2 content in the biogas. The invention relates to both in situ and ex situ methods of biogas upgrading. The invention further relates to a bioreactor comprising hollow fibre membranes.

Abstract translation: 本发明涉及一种用于生物气体升级和氢利用的厌氧方法，包括使用酸性废物作为辅助底物。 在此过程中，H2和CO2将转化为CH4，这将导致沼气中CO2含量降低。 本发明涉及沼气提质的原位和非原位方法。 本发明还涉及包含中空纤维膜的生物反应器。

公开(公告)号：US12226527B2

公开(公告)日：2025-02-18

申请号：US17350304

申请日：2021-06-17

Applicant: TECHNICAL UNIVERSITY OF DENMARK

Inventor： Thomas Lars Andresen ,  Linda Maria Bruun ,  Trine Bjørnbo Larsen ,  Rasmus Irming Jølck ,  Anders Elias Hansen

IPC: A61K9/06 ,  A61K9/00 ,  A61K47/26

Abstract: The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.

公开(公告)号：US11730917B2

公开(公告)日：2023-08-22

申请号：US17084275

申请日：2020-10-29

Applicant: Optoceutics ApS ,  Technical University of Denmark

Inventor： Marcus Carstensen ,  Paul Michael Petersen ,  Jes Broeng ,  Mark Henney ,  Ngoc Mai Nguyen ,  Robert Dobkin

IPC: A61M21/02 ,  G16H20/40 ,  G16H40/67 ,  G16H20/70 ,  G16H10/60 ,  A61B3/11 ,  A61B3/113 ,  A61B3/14 ,  A61M21/00

CPC classification number: A61M21/02 ,  G16H20/40 ,  G16H20/70 ,  G16H40/67 ,  A61B3/112 ,  A61B3/113 ,  A61B3/14 ,  A61M2021/0044 ,  A61M2205/3303 ,  A61M2205/583 ,  G16H10/60

Abstract: Gamma brain stimulation for preventing or treating Alzheimer's disease or sleeping disorders using light or sound is known. A strobing 40 Hz light source has been shown to cause positive effects due to the stimulation. It is an advantage to know the actual dosage of light that enters the person's eyes in order to understand the relationship between dosage and effectiveness. A camera is used to detect the subject's gaze angle, distance, pupil diameter and any other factors that affect the light power that enters the eye. A target dosage is first determined by a medical worker, such as to determine the effects of the exact same dosage on a group of similar persons, such as Alzheimer's patients. With deviations of gaze angle, distance, and pupil size from the ideal, the effective dosage is decreased. The disclosed system adjusts the actual dosage, such as session duration, based on such factors so that the final dosage received by the person is consistent and meets the target dosage.