-
公开(公告)号：US20190314561A1
公开(公告)日：2019-10-17
申请号：US16346840
申请日：2017-11-03
Inventor： Peter RHEE , Andrew TANG , Kevin OKARSKI
Abstract: A needle assembly includes an outer cannula having a distal end portion, the distal end portion comprising a sharp bevel facilitating insertion of the needle assembly into a subject. The needle assembly further includes an inner cannula slidably disposed coaxially in the lumen of the outer cannula and movable between an extended position and a retracted position, the inner cannula having a blunt distal end portion extending beyond the sharp bevel of the outer cannula whenever the inner cannula is in the extended position. The needle assembly further includes a bias coupled to the inner cannula in a manner favoring automatic positioning of the inner cannula at the extended position. The needle assembly includes a valve located in fluid communication with the lumen of the inner cannula to allow fluid to exit the subject through the inner cannula, and to prevent ingress of fluid into the subject.
-
42.发明授权公开(公告)号：US10428115B2
公开(公告)日：2019-10-01
申请号：US14893800
申请日：2014-05-23
Inventor： Yeon Sun Lee , Victor J. Hruby , Frank Porreca , Josephine Lai
Abstract: Described are Dynorphin A analog compounds and uses thereof for treating pain in humans and lower animals by administering to a human or lower animal in need of treatment. The compounds interact with the bradykinin receptor to relieve pain. Preferred compounds are amphipathic [Des-Arg7]-dynorphin A peptide analogs and specific cyclic dynorphin A peptide analogs.
-
公开(公告)号：US20190263857A1
公开(公告)日：2019-08-29
申请号：US16150496
申请日：2018-10-03
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , UNIVERSITY OF SOUTH FLORIDA
Inventor： David L. Morse , Josef Vagner , Mark McLaughlin , Robert Gillies , Amanda Huynh , Michael Doligalski
Abstract: Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.
-
公开(公告)号：US20190153512A1
公开(公告)日：2019-05-23
申请号：US16197319
申请日：2018-11-20
Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventor： Muhammed MURTAZA , Mehreen KISAT , Ahuva ODENHEIMER-BERGMAN
IPC: C12Q1/6806 , C12Q1/6869
Abstract: Methods are provided for detecting non-human candidate DNA within a plasma sample from a human subject. A method of diagnosing and characterizing a bacterial infection may include the steps of obtaining a plasma sample from a subject suspected of having a bacterial infection, extracting cell-free DNA (cfDNA) from the plasma sample, performing whole genome sequencing on the cfDNA to obtain sequencing data, aligning the sequencing data with a human genome to identify human DNA and non-human DNA, removing the human DNA from the sequencing data, assigning the non-human DNA to a candidate pathogen DNA, selecting a subset of the non-human DNA based on a fragment length of the non-human DNA, and determining the presence of the candidate pathogen DNA within the subset of the non-human DNA.
-
公开(公告)号：US10281723B2
公开(公告)日：2019-05-07
申请号：US14953563
申请日：2015-11-30
Applicant: The Arizona Board of Regents on behalf of the University of Arizona , BEIJING INSTITUTE OF TECHNOLOGY
Inventor： Dewen Cheng , Yongtian Wang , Hong Hua
Abstract: A tiled head-mounted display device, comprising: an optical component including a plurality of prisms with free-form surfaces, each prism being a wedge prism comprising a first optical surface, a second optical surface and a third optical surface; and a display component including a plurality of micro-displays, wherein the number of the micro-displays and the number of the prisms with free-form surfaces is identical. The tiled head-mounted display device according to the present invention is compact and light, provides wide field of view and high resolution, especially for the optical tiling head-mounted display device, the exit pupil planes of each display channels are coincident, thus avoiding pupil aberration and keeping exit pupil diameter and eye clearance same as the single ocular. There is no resolution variance throughout the entire field of view, thus preventing extra trapezoid distortion. The tiled head-mounted display device according to the present invention can be readily applicable to augmented environments applications by simply adding an auxiliary free-form lens behind the free-form prism.
-
Patent Agency Ranking
公开(公告)号：US20180346415A1
公开(公告)日：2018-12-06
申请号：US15779132
申请日：2016-11-30
Inventor： Laurence HURLEY , Vijay GOKHALE , HyunJin KANG , Kui WU
IPC: C07C275/54 , C07D401/12 , C07D239/52 , C07D239/34 , C07D403/04 , C07D241/18 , C07D295/088 , C07D219/08 , A61P35/00
CPC classification number: C07C275/54 , A61K31/17 , A61K31/4402 , A61K31/4995 , A61K31/505 , A61K31/5377 , A61P35/00 , C07D219/08 , C07D239/34 , C07D239/52 , C07D241/18 , C07D295/088 , C07D401/12 , C07D403/04
Abstract: The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.
-
47.发明申请公开(公告)号：US20180344680A1
公开(公告)日：2018-12-06
申请号：US16060742
申请日：2016-12-07
Inventor： Donna D. Zhang , Georg T. Wondrak
IPC: A61K31/26 , A61K31/11 , A61P17/02 , A61K31/522 , A61K31/4709 , A61K31/4365 , A61K31/235 , A61K38/18
CPC classification number: G01N33/6872 , A61K9/0014 , A61K31/05 , A61K31/11 , A61K31/12 , A61K31/192 , A61K31/232 , A61K31/26 , A61K31/277 , A61K31/343 , A61K31/4365 , A61K31/4709 , A61K31/522 , A61K31/616 , A61K38/00 , A61K2300/00
Abstract: Compositions and methods are provided for treating, ameliorating, and preventing diabetes-related skin ulcers in a mammalian subject comprising administering to the subject an effective amount of an NRF2 activating agent.
-
公开(公告)号：US20180298382A1
公开(公告)日：2018-10-18
申请号：US15764255
申请日：2016-10-05
Applicant: The Regents of the University of California , The Arizona Board of Regents on Behalf of The University of Arizona
Inventor： Martha R. Stampfer , James C. Garbe , Lukas Vrba , Bernard W. Futscher
IPC: C12N15/113 , C12N15/88 , C12N15/79 , C12N5/09
Abstract: Aspects of the present disclosure include RNAs that confer a mortal phenotype and nucleic acids encoding same. Liposomes, recombinant cells, and pharmaceutical compositions that include the RNAs or nucleic acids encoding same are also provided. Further provided are methods involving quantifying MORT RNAs and/or determining the methylation status of the MORT promoter, as well as methods that employ the RNAs or nucleic acids encoding same.
-
公开(公告)号：US20180280696A1
公开(公告)日：2018-10-04
申请号：US15762626
申请日：2016-09-23
Inventor： Marvin J. Slepian , David G. Armstrong , Bijan Najafi
IPC: A61N1/36 , A61B5/103 , A61B5/0205 , A61B5/00 , A61B5/145 , A61B5/026 , A61F5/01 , A61H23/00 , A61H7/00 , A43B7/14
Abstract: A sensor interface device (e.g., orthotic device or immobilization device) is disclosed. More specifically, described is an individualized sensor device and system to prevent tissue damage resulting from, for example, pressure, torsion, temperature, shear, altered blood flow, reduced oxygen tension, pH levels, tissue conductivity, tissue viscoelasticity, infection and sweat chloride levels. In particular embodiments, the systems, devices and related methods are used for preventing ambulation and mobility related plantar tissue related damage and immobilizing tissues.
-
公开(公告)号：US20180243190A1
公开(公告)日：2018-08-30
申请号：US15753514
申请日：2016-08-17
Inventor： Georg T. WONDRAK , Donna D. ZHANG
CPC classification number: A61K8/37 , A61K8/86 , A61K31/202 , A61K33/24 , A61K33/30 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
Abstract: Provided herein are methods for preventing conditions related to UV-radiation exposure in subjects at risk for exposure to UV-radiation. In particular, the invention relates to compositions comprising specific formulations of dietary carotenoids (e.g., bixin) which function as activators of NRF2 pathway related activity, and related methods for the protection of mammalian skin against UV-radiation.
-
-
-
-
-
-
-
-
-
Search Results
799
records
(took 0.07 seconds)
