-
公开(公告)号：US20190153512A1
公开(公告)日：2019-05-23
申请号：US16197319
申请日：2018-11-20
Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventor： Muhammed MURTAZA , Mehreen KISAT , Ahuva ODENHEIMER-BERGMAN
IPC: C12Q1/6806 , C12Q1/6869
Abstract: Methods are provided for detecting non-human candidate DNA within a plasma sample from a human subject. A method of diagnosing and characterizing a bacterial infection may include the steps of obtaining a plasma sample from a subject suspected of having a bacterial infection, extracting cell-free DNA (cfDNA) from the plasma sample, performing whole genome sequencing on the cfDNA to obtain sequencing data, aligning the sequencing data with a human genome to identify human DNA and non-human DNA, removing the human DNA from the sequencing data, assigning the non-human DNA to a candidate pathogen DNA, selecting a subset of the non-human DNA based on a fragment length of the non-human DNA, and determining the presence of the candidate pathogen DNA within the subset of the non-human DNA.
-
公开(公告)号：US10281723B2
公开(公告)日：2019-05-07
申请号：US14953563
申请日：2015-11-30
Applicant: The Arizona Board of Regents on behalf of the University of Arizona , BEIJING INSTITUTE OF TECHNOLOGY
Inventor： Dewen Cheng , Yongtian Wang , Hong Hua
Abstract: A tiled head-mounted display device, comprising: an optical component including a plurality of prisms with free-form surfaces, each prism being a wedge prism comprising a first optical surface, a second optical surface and a third optical surface; and a display component including a plurality of micro-displays, wherein the number of the micro-displays and the number of the prisms with free-form surfaces is identical. The tiled head-mounted display device according to the present invention is compact and light, provides wide field of view and high resolution, especially for the optical tiling head-mounted display device, the exit pupil planes of each display channels are coincident, thus avoiding pupil aberration and keeping exit pupil diameter and eye clearance same as the single ocular. There is no resolution variance throughout the entire field of view, thus preventing extra trapezoid distortion. The tiled head-mounted display device according to the present invention can be readily applicable to augmented environments applications by simply adding an auxiliary free-form lens behind the free-form prism.
-
43.发明申请公开(公告)号：US20180344680A1
公开(公告)日：2018-12-06
申请号：US16060742
申请日：2016-12-07
Inventor： Donna D. Zhang , Georg T. Wondrak
IPC: A61K31/26 , A61K31/11 , A61P17/02 , A61K31/522 , A61K31/4709 , A61K31/4365 , A61K31/235 , A61K38/18
CPC classification number: G01N33/6872 , A61K9/0014 , A61K31/05 , A61K31/11 , A61K31/12 , A61K31/192 , A61K31/232 , A61K31/26 , A61K31/277 , A61K31/343 , A61K31/4365 , A61K31/4709 , A61K31/522 , A61K31/616 , A61K38/00 , A61K2300/00
Abstract: Compositions and methods are provided for treating, ameliorating, and preventing diabetes-related skin ulcers in a mammalian subject comprising administering to the subject an effective amount of an NRF2 activating agent.
-
公开(公告)号：US20180298382A1
公开(公告)日：2018-10-18
申请号：US15764255
申请日：2016-10-05
Applicant: The Regents of the University of California , The Arizona Board of Regents on Behalf of The University of Arizona
Inventor： Martha R. Stampfer , James C. Garbe , Lukas Vrba , Bernard W. Futscher
IPC: C12N15/113 , C12N15/88 , C12N15/79 , C12N5/09
Abstract: Aspects of the present disclosure include RNAs that confer a mortal phenotype and nucleic acids encoding same. Liposomes, recombinant cells, and pharmaceutical compositions that include the RNAs or nucleic acids encoding same are also provided. Further provided are methods involving quantifying MORT RNAs and/or determining the methylation status of the MORT promoter, as well as methods that employ the RNAs or nucleic acids encoding same.
-
公开(公告)号：US20180280696A1
公开(公告)日：2018-10-04
申请号：US15762626
申请日：2016-09-23
Inventor： Marvin J. Slepian , David G. Armstrong , Bijan Najafi
IPC: A61N1/36 , A61B5/103 , A61B5/0205 , A61B5/00 , A61B5/145 , A61B5/026 , A61F5/01 , A61H23/00 , A61H7/00 , A43B7/14
Abstract: A sensor interface device (e.g., orthotic device or immobilization device) is disclosed. More specifically, described is an individualized sensor device and system to prevent tissue damage resulting from, for example, pressure, torsion, temperature, shear, altered blood flow, reduced oxygen tension, pH levels, tissue conductivity, tissue viscoelasticity, infection and sweat chloride levels. In particular embodiments, the systems, devices and related methods are used for preventing ambulation and mobility related plantar tissue related damage and immobilizing tissues.
-
Patent Agency Ranking
公开(公告)号：US20180243190A1
公开(公告)日：2018-08-30
申请号：US15753514
申请日：2016-08-17
Inventor： Georg T. WONDRAK , Donna D. ZHANG
CPC classification number: A61K8/37 , A61K8/86 , A61K31/202 , A61K33/24 , A61K33/30 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
Abstract: Provided herein are methods for preventing conditions related to UV-radiation exposure in subjects at risk for exposure to UV-radiation. In particular, the invention relates to compositions comprising specific formulations of dietary carotenoids (e.g., bixin) which function as activators of NRF2 pathway related activity, and related methods for the protection of mammalian skin against UV-radiation.
-
公开(公告)号：US10013743B2
公开(公告)日：2018-07-03
申请号：US15308310
申请日：2015-04-30
Inventor： Phillip H. Kuo , Bijan Najafi , Matthew A. Kupinski
CPC classification number: G06T5/005 , G06T5/002 , G06T5/50 , G06T2200/04 , G06T2207/10104 , G06T2207/10108 , G06T2207/20182 , G06T2207/30016 , G06T2207/30061
Abstract: The present invention provides methods and devices for correcting motion related imaging artifacts. In particular, the methods include positioning a device configured to detect motion at a region of interest on an object, simultaneously obtaining an image data set of the region of interest and a motion data set at the region of interest with the device, and correcting motion related imaging artifacts with an algorithm configured to identify time periods of motion from the motion data set, and correct the image data set corresponding to the identified time periods of motion.
-
公开(公告)号：US09988371B2
公开(公告)日：2018-06-05
申请号：US15315490
申请日：2015-06-03
Applicant: The Arizona Board of Regents, on Behalf of the University of Arizona , Universita' Federico II
Inventor： Hong-yu Li , Brendan Frett , Massimo Santoro , Francesca Carlomagno
IPC: C07D413/12 , C07D413/14 , A61K31/422 , A61K45/06 , A61K31/4439 , A61K31/5377 , A61K31/506 , C12N9/12
CPC classification number: C07D413/14 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/12 , C12N9/12 , C12Y207/10002
Abstract: The invention relates to compounds of the formula (VIII) wherein the moieties R1, R2, R3, R4, and R5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.
-
公开(公告)号：US20180140677A1
公开(公告)日：2018-05-24
申请号：US15574794
申请日：2016-05-18
Inventor： Victor J. Hruby , Minying Cai
CPC classification number: A61K38/34 , A61K8/64 , A61K38/00 , A61K38/10 , A61Q19/04 , C07K7/08 , C07K14/685 , C07K14/69
Abstract: A gamma-melanocyte stimulating hormone (γ-MSH) derivative having improved stability, selectivity and bioavailabilty. The γ-MSH derivative is selective for the melanocortin-1 receptor (MC1 R) and is deliverable to skin cells via topical or transdermal delivery. The γ-MSH derivative is made up of naturally occurring amino acids for stimulating melanin from within for photoprotection of human skin against ultraviolet radiation damage.
-
公开(公告)号：US09962256B2
公开(公告)日：2018-05-08
申请号：US14421731
申请日：2013-08-15
Inventor： Sean J. McCafferty
IPC: A61F2/16
CPC classification number: A61F2/16 , A61F2/1624 , A61F2/1635 , A61F2002/1681 , A61F2002/1682 , A61F2002/1689 , A61F2002/169 , A61F2210/0014
Abstract: A haptic supporting an intraocular lens (IOL) in the eye permits radial tension from ciliary muscle relaxation rather than contraction to alter the lens power. The IOL is supported by the overlying tissue in the eye such as iris root, sclera and ciliary process, so that anterior and posterior forces on IOL are balanced, and buckling or displacement of lens in the eye or haptic is reduced or prevented. The haptic is of a thickness so as to increase stiffness and to reduce or prevent IOL buckling or displacement.
-
-
-
-
-
-
-
-
-
Search Results
785
records
(took 0.079 seconds)
