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41.发明申请
公开(公告)号：WO2017013537A1
公开(公告)日：2017-01-26
申请号：PCT/IB2016/054176
申请日：2016-07-13
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ALSALMI, Wadad
IPC: C07K14/005
CPC classification number: C07K14/005 , A61K9/7023 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/627 , C07K1/22 , C07K1/36 , C07K14/162 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C07K2319/50 , C12N7/00 , C12N2740/16022 , C12N2740/16043 , C12N2740/16051 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234
Abstract: An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a 5 binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
Abstract translation: 开发了生产模仿天然HIV-1包膜三聚体的重组三聚体的方法。 形成重组三聚体的重组蛋白包含通过重组HIV-1 gp140的C-末端的接头与标签融合的重组HIV-1 gp140。 接头足够长，使得标签可通过结合在固体基质上的5结合分子进行结合。 在细胞中表达后，将重组蛋白分泌到培养基中并在其中组装成重组三聚体。 重组三聚体可以从培养基中直接纯化。 产生来自不同进化枝病毒的切割和未切割的三聚体。
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公开(公告)号：WO2014083518A2
公开(公告)日：2014-06-05
申请号：PCT/IB2013/060453
申请日：2013-11-27
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , GAO, Guofen
IPC: C07K19/00 , C07K14/155 , C12N15/62
CPC classification number: C07K14/005 , C07K2319/35 , C07K2319/70 , C07K2319/735 , C12N7/00 , C12N7/02 , C12N2740/16122 , C12N2740/16222 , C12N2795/10122 , C12N2795/10123
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公开(公告)号：WO2010042264A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/051215
申请日：2009-07-21
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA , RAMELLA-ROMAN, Jessica, C. , MIROTZNIK, Mark , MATHEWS, Scott, A.
Inventor： RAMELLA-ROMAN, Jessica, C. , MIROTZNIK, Mark , MATHEWS, Scott, A.
IPC: A61B3/10
CPC classification number: A61B5/14555 , G02B3/0056 , G02B5/201 , G02B27/28
Abstract: The multi-aperture system of the present invention provides a retinal oximetry apparatus for determining the level of oxygen saturation in retinal vessels using a lenslet array comprising at least seven lenses for the simultaneous measurement of reflected light with at least three wavelengths and at least four polarization states. The multi-aperture system of the present invention further provides an apparatus for determining the level of oxygen saturation in retinal vessels using a lenslet array comprising at least ten lenses for the simultaneous measurement of reflected light with at least three wavelengths for oxygen measurement, at least three wavelengths for melanin content, and at least four polarization states. Methods of operating the same are also provided.
Abstract translation: 本发明的多孔径系统提供了一种用于使用包括至少七个透镜的小透镜阵列来确定视网膜血管中的氧饱和度水平的视网膜血氧测定装置，用于同时测量具有至少三个波长的反射光和至少四个极化 状态。 本发明的多孔径系统还提供了一种用于使用包括至少十个透镜的小透镜阵列来确定视网膜血管中的氧饱和度的装置，用于同时测量具有至少三个波长的用于氧测量的反射光，至少 三个波长的黑色素含量和至少四个极化状态。 还提供了其操作方法。
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公开(公告)号：WO1993024067A1
公开(公告)日：1993-12-09
申请号：PCT/US1992004196
申请日：1992-05-27
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
IPC: A61B19/00
CPC classification number: A61N1/16
Abstract: An arrangement for inhibiting the adverse effect of an ambient time varying field having an electric component of 5 Kv/M or less and/or a magnetic component of 500 mu T or less on a living system. To provide protection, at least one of the characteristic parameters of said field to which the living system is exposed is changed within time intervals of less than 10 seconds.
Abstract translation: 一种用于抑制具有5Kv / M以下的电气成分和500mT以下的磁性成分的环境时变场对生活系统的不利影响的装置。 为了提供保护，在小于10秒的时间间隔内改变生物系统所暴露的所述场的特征参数中的至少一个。
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公开(公告)号：WO2020021451A1
公开(公告)日：2020-01-30
申请号：PCT/IB2019/056288
申请日：2019-07-23
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： GONG, Weiliang , XU, Hui , LUTZE, Werner , PEGG, Ian L.
Abstract: A geopolymer thermal energy storage (TES) concrete product comprising at least one binder; at least one alkali activator; at least one fine aggregate with high thermal conductivity and heat capacity; and at least one coarse aggregate with high thermal conductivity and heat capacity.
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Patent Agency Ranking46.发明申请
公开(公告)号：WO2017013567A1
公开(公告)日：2017-01-26
申请号：PCT/IB2016/054260
申请日：2016-07-18
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ALSALMI, Wadad
IPC: C12N15/63 , C12P21/00 , C07K14/005
CPC classification number: C07K14/005 , A61K9/7023 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/627 , C07K1/22 , C07K1/36 , C07K14/162 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C07K2319/50 , C12N7/00 , C12N2740/16022 , C12N2740/16043 , C12N2740/16051 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234
Abstract: An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
Abstract translation: 开发了生产模仿天然HIV-1包膜三聚体的重组三聚体的方法。 形成重组三聚体的重组蛋白包含通过重组HIV-1 gp140的C-末端的接头与标签融合的重组HIV-1 gp140。 接头足够长，使得标签可通过结合在固体基质上的结合分子进行结合。 在细胞中表达后，将重组蛋白分泌到培养基中并在其中组装成重组三聚体。 重组三聚体可以从培养基中直接纯化。 产生来自不同进化枝病毒的切割和未切割的三聚体。
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公开(公告)号：WO2014141051A1
公开(公告)日：2014-09-18
申请号：PCT/IB2014/059599
申请日：2014-03-10
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： GONG, Weiliang , LUTZE, Werner , PEGG, Ian L.
CPC classification number: C04B38/02 , C04B28/006 , Y02P40/165 , Y02W30/92 , Y02W30/94 , Y02W30/95 , C04B12/04 , C04B14/06 , C04B14/106 , C04B14/28 , C04B14/303 , C04B18/08 , C04B18/141 , C04B18/162 , C04B20/002 , C04B20/0048 , C04B20/008 , C04B22/04 , C04B22/06 , C04B38/08 , C04B2103/0088 , C04B2103/22 , C04B2103/58
Abstract: A composite binder comprises: one or more Class F fly ash materials, one or more gelation enhancers, and one or more hardening enhancers, wherein each of the one or more Class F fly ash materials comprises 15 wt.% or less calcium oxide, and wherein the composite binder is a Portland cement-free binder for concrete. Also provided are Geopolymer Composite Cellular Concretes (GCCCs) including the composite binder and methods of making these GCCCs.
Abstract translation: 复合粘合剂包括：一种或多种F类飞灰材料，一种或多种胶凝增强剂和一种或多种硬化增强剂，其中所述一种或多种F级飞灰材料中的每一种包含15重量％或更少的氧化钙，以及 其中复合粘合剂是用于混凝土的波特兰无水泥粘合剂。 还提供了包括复合粘合剂的地质聚合物复合蜂窝混凝土（GCCC）和制备这些GCCC的方法。
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48.发明申请POLYMERS GRAFTED WITH ORGANIC PHOSPHOROUS COMPOUNDS FOR EXTRACTING URANIUM FROM SOLUTIONS 审中-公开与有机磷化合物接触的聚合物，用于从溶液中萃取铀
公开(公告)号：WO2014031702A1
公开(公告)日：2014-02-27
申请号：PCT/US2013/055885
申请日：2013-08-20
Applicant: UNIVERSITY OF MARYLAND , THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： TISSOT, Chanel , BARKATT, Aaron , AL-SHEIKHLY, Dr. Mohamad I.
CPC classification number: B01J20/3085 , B01J20/264 , B01J20/265 , B01J20/28023 , B01J20/28038 , B01J20/2804 , B01J20/321 , B01J20/3212 , B01J20/3278 , B01J20/3425 , B01J20/3475 , C02F1/285 , C02F1/683 , C02F2101/006 , C02F2103/08 , C02F2303/16 , C08G69/00 , C22B60/0265 , G21F9/12
Abstract: Complexing or chelating agents that offer strong, selective bonding with uranium as well as a broad pH range of effectiveness, specifically including the pH range around 8.2, together with the acrylic double bonds required for radiation-induced grafting on polymers to remove uranium from a solution such as seawater. The novel adsorbing species are phosphorus-containing molecules, in particular organic phosphates, phosphonates and phosphoric acids. Organic phosphorus compounds, for example, organic phosphates, phosphonates, and phosphoric acids, are attached to polymer fibers to form fibers, fiber fabrics or membranes that are effective, or show activity, in uranium adsorption.
Abstract translation: 提供强大的选择性结合铀的复合或螯合剂以及广泛的pH范围的有效性，特别是包括pH范围在8.2左右，以及辐射诱导接枝聚合物从溶液中除去铀所需的丙烯酸双键 如海水。 新颖的吸附物质是含磷分子，特别是有机磷酸盐，膦酸盐和磷酸。 将有机磷化合物，例如有机磷酸盐，膦酸盐和磷酸连接到聚合物纤维上以形成在铀吸附中有效或显示活性的纤维，纤维织物或膜。
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49.发明申请SYSTEMS AND METHODS FOR IMPROVING THE ACCURACY OF DAY-AHEAD LOAD FORECASTS ON AN ELECTRIC UTILITY GRID 审中-公开用于提高电力实用网格中日间负载预测精度的系统和方法
公开(公告)号：WO2012138688A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032062
申请日：2012-04-04
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA , FORBES, Kevin, F. , ZAMPELLI, Ernest, M. , ST.CYR, O., Chris
Inventor： FORBES, Kevin, F. , ZAMPELLI, Ernest, M. , ST.CYR, O., Chris
IPC: G06F11/30
CPC classification number: G06Q30/0202 , G06Q10/04 , G06Q50/06 , Y04S10/54 , Y04S50/14
Abstract: Systems and methods improve the forecast of electricity consumption, and/or refining such predictions. Predictions may be refined by accounting for factors such as preliminary predictions, pricing and cost information associated with future supply of energy, the extent of anticipated changes in the predictions, the time of day and/or anticipated daylight for the period of time. Coefficient values are calculated for a forecast error model that takes into account factors related to electricity consumption using existing historical electrical grid data. Using the calculated values, the forecast error model may be applied to current electricity demand forecasts.
Abstract translation: 系统和方法提高了用电量的预测和/或改进了这些预测。 可以通过考虑与未来能源供应相关的初步预测，定价和成本信息，预测的预期变化程度，时间和/或期望的预期日光等因素来改进预测。 对于使用现有历史电网数据考虑与电力消耗相关的因素的预测误差模型，计算系数值。 使用计算值，预测误差模型可能适用于当前的电力需求预测。
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50.发明申请PROTEIN AND NUCLEIC ACID DELIVERY VEHICLES, COMPONENTS AND MECHANISMS THEREOF 审中-公开蛋白质和核酸递送机构，其组成和机理
公开(公告)号：WO2011125054A2
公开(公告)日：2011-10-13
申请号：PCT/IB2011/051533
申请日：2011-04-08
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA , RAO, Venigalla
Inventor： RAO, Venigalla
CPC classification number: C12N15/86 , A61K31/7088 , A61K31/711 , A61K47/48776 , A61K47/6901 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/87 , C12N15/88 , C12N2795/10042 , C12N2795/10122 , C12N2795/10142 , C12N2795/10152
Abstract: Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
Abstract translation: 复杂病毒通过顺序和不可逆组装由简单蛋白质亚基组装。 在噬菌体的基因组包装过程中，一个强大的分子马达组装在一个空头颅的特殊门户顶点，开始包装。 本发明的一个方面涉及高度混杂的噬菌体T4包装机，将DNA转运到成品噬菌体头以及pro头中。 单个电机可以将外源DNA以与头孢子相同的速率强制进入噬菌体头，噬菌体头经历反复的引发，将多个DNA分子包装在相同的头部。 这表明噬菌体DNA包装机具有不寻常的构象可塑性，将DNA提供到明显被动的衣壳容器中，包括高度稳定的病毒壳，直至其充满。 这些特征允许设计一种新型的纳米框输送车辆。
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