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公开(公告)号：US20240140918A1
公开(公告)日：2024-05-02
申请号：US18263513
申请日：2022-01-28
Inventor： Isamu SHIINA , Motoyuki SHIMONAKA , Takatsugu MURATA , Yuuki OBATA , Toshirou NISHIDA , Koji OKAMOTO
IPC: C07D263/32 , C07D213/56 , C07D277/30
CPC classification number: C07D263/32 , C07D213/56 , C07D277/30
Abstract: A compound represented by formula (1) below, useful for treating cancer. In the formula, R1 and R3-R8 each independently represents a hydrogen atom or an alkyl group, R2 represents a hydrogen atom or a group represented by —ORa, R9 represents a group represented by —C(O)NRcRf, Ra, Re, and Rf each independently represents a hydrogen atom, an arylalkyl group that may have a substituent, or a heteroarylalkyl group. A production method that enables the compound to be produced with high efficiency, and a pharmaceutical composition containing the compound as an active ingredient
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42.发明公开公开(公告)号：US20240110922A1
公开(公告)日：2024-04-04
申请号：US18241473
申请日：2023-09-01
Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION , JEOL Ltd.
Inventor： Tatsuya Higashi , Masaki Takiwaki , Koji Takahashi , Seketsu Fukuzawa
IPC: G01N33/68
CPC classification number: G01N33/6848
Abstract: An estrogen derivatization method uses a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1):
where in Formula (1), X is a quaternary cation. A mass spectrometry method includes derivatizing estrogen by the above estrogen derivatization method. A derivatization reagent derivatizing estrogen includes a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1), where in Formula (1), X is a quaternary cation.-
公开(公告)号：US11932666B2
公开(公告)日：2024-03-19
申请号：US17965125
申请日：2022-10-13
Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor： Takeshi Wada , Tatsuya Saito , Yuka Ishii , Yohei Nukaga
IPC: C07H19/073 , C07F5/02 , C07F9/6558 , C07F9/6584 , C07H19/173 , C07H21/00 , C12N15/113
CPC classification number: C07H19/173 , C07F5/02 , C07F9/6558 , C07F9/6584 , C07H19/073 , C07H21/00 , C12N15/113 , C12N2310/11 , C12N2310/31 , C12N2310/321 , Y02P20/55
Abstract: Provided is a polymerizable compound represented by a Formula E-1 or Formula E-2 shown in the description. In Formula E-1 or Formula E-2, R1 represents an alkoxy group, —NRN2, a hydroxy group, an aryl group, or an alkyl group, wherein RN each independently represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms; n represents an integer from 1 to 5; R3 represents a hydrogen atom, an acetyl group, a phenoxyacetyl group, a pivaloyl group, a benzyl group, a 4-methoxybenzyl group, a benzoyl group, a triphenylmethyl group, a 4,4′-dimethoxytrityl (DMTr) group, a 4-methoxytrityl (MMTr) group, a 9-phenylxanthenyl group, a trimethylsilyl group, a cyanomethoxymethyl group, a 2-(cyanoethoxy)ethyl group, or a cyanoethoxymethyl group; and X represents a structure represented by any one of Formula B-1 to Formula B-5 shown in the description.
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公开(公告)号：US11920045B2
公开(公告)日：2024-03-05
申请号：US16837153
申请日：2020-04-01
Inventor： Soh Noguchi , Mitsunobu Morita , Takashi Okada , Tatsuki Yamaguchi , Koji Arimitsu
IPC: C09D11/10 , B33Y70/00 , C09D11/101 , C09D11/38 , B29C64/112 , B33Y10/00
CPC classification number: C09D11/101 , B33Y70/00 , C09D11/38 , B29C64/112 , B33Y10/00
Abstract: To provide an active-energy-ray-curable composition including a compound represented by General Formula (I) below:
where in the General Formula (I), R is hydrogen or a methyl group; A is a structure expressed by one selected from the group consisting of Structural Formulas (II) to (VII) below, each of which may have a substituent such as an alkyl group or an alkoxy group, or both; j and k in the Structural Formulas (VI) and (VII) are an integer of 0 or more; X denotes a substituent including a heteroatom; n is an integer of 0 or more, m is an integer of 1 or more, and n+m is 3 or more, or n is an integer of 0 and m is an integer of 2; and wavy lines in the Structural Formulas (II) to (VII) each independently denote a bond with X or a (meth)acryloyl group (H2C═CR—C(═O)—):-
公开(公告)号：US11919932B2
公开(公告)日：2024-03-05
申请号：US18092737
申请日：2023-01-03
Applicant: The University of Tokyo , ONO PHARMACEUTICAL CO., LTD. , TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor： Kouji Matsushima , Satoshi Ueha , Shungo Deshimaru , Chang-Yu Chen , Shoji Yokochi , Yoshiro Ishiwata , Shiro Shibayama
Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.
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Patent Agency Ranking
46.发明公开公开(公告)号：US20230218175A1
公开(公告)日：2023-07-13
申请号：US18007367
申请日：2021-07-30
Applicant: Tokyo University of Science Foundation , RIKEN
Inventor： Hiroshi Takemura , Kohei Soga , Reiichirou Ike , Toshihiro Takamatsu , Hiroaki Ikematsu , Hideo Yokota
CPC classification number: A61B5/0086 , G06T7/0012 , A61B5/004 , A61B5/7267 , G06T2207/30096 , G06T2207/30028 , G06T2207/10068 , G06T2207/10048 , G06T2207/20081 , G06T2207/30061
Abstract: An image processing device acquires an image obtained by irradiating an area of a living body with light having a wavelength of 955 [nm] to 2025 [nm]. The image processing device inputs the acquired image to a learned model or a statistical model generated in advance for detecting, from the image, a tumor present in the area, and determines whether or not a tumor is present at each point in the image.
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公开(公告)号：US20230212345A1
公开(公告)日：2023-07-06
申请号：US17270974
申请日：2019-08-27
Applicant: Tokyo University of Science Foundation
Inventor： Koji Arimitsu
CPC classification number: C08G18/161 , C08G18/1841 , C08G18/2072 , C08G18/2081 , C08G18/3206 , C08G18/581 , C08G18/584 , C08G18/7642 , C08J5/18 , C08J2375/04
Abstract: One embodiment of the present invention provides a curable composition, including a polyfunctional isocyanate compound, a compound selected from the group consisting of a multivalent alcohol and an epoxy compound, and a base amplifier.
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公开(公告)号：US11637230B2
公开(公告)日：2023-04-25
申请号：US17254434
申请日：2019-06-28
Inventor： Junichi Uchida , Yuki Haijima , Yuki Sueuchi , Tsutomu Iida
IPC: H10N10/855 , C01B33/06 , H10N10/01 , H01L35/22 , H01L35/34
Abstract: The purpose of the present invention is to provide a thermoelectric conversion element having a film which not only maintains sufficient adhesion even when exposed to a high temperature but also exhibits excellent oxidation resistance and crack resistance. The problem is solved by a thermoelectric conversion element including a thermoelectric conversion component, in which the thermoelectric conversion component contains magnesium silicide and/or manganese silicide and is covered with a film containing Si and Zr.
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公开(公告)号：US20230089021A1
公开(公告)日：2023-03-23
申请号：US17788770
申请日：2020-12-24
Applicant: Tokyo University of Science Foundation
Inventor： Koji Arimitsu
IPC: G03F7/004 , C07D213/75 , C08K5/3432
Abstract: A photobase generator, includes a compound including a first skeleton represented by the following formula (a); and a second skeleton including a nitrogen atom bonding to a bonding position of the first skeleton to form an amide group, and a pyridine skeleton in addition to the nitrogen atom, in which the compound generates a base in which a hydrogen atom is bonded with the nitrogen atom of the second skeleton by light irradiation. In formula (a), G is a divalent aromatic group, and * represents the bonding position with the nitrogen atom.
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公开(公告)号：US11572393B2
公开(公告)日：2023-02-07
申请号：US16978633
申请日：2019-03-07
Applicant: The University of Tokyo , ONO PHARMACEUTICAL CO., LTD. , TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor： Kouji Matsushima , Satoshi Ueha , Shungo Deshimaru , Chang-Yu Chen , Shoji Yokochi , Yoshiro Ishiwata , Shiro Shibayama
Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.
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