公开(公告)号：WO2015107214A1

公开(公告)日：2015-07-23

申请号：PCT/EP2015/050988

申请日：2015-01-20

Applicant: EVEON ,  UCB PHARMA SA

Inventor： PAYET-BURIN, Xavier

IPC: A61K9/19

CPC classification number: A61K9/0095 ,  A61K9/19 ,  A61K47/60

Abstract: The invention relates to a process for reconstitution of a solid form of a pharmaceutical composition, comprising the following successive steps: (i) providing the solid form of the pharmaceutical composition in a sealed container, the pressure within the container being an initial pressure (p i ,) comprised between 0.5 Pa and 1.2x10 5 Pa; (ii) at a first time point (t 0 ) introducing the solvent into said sealed container and maintaining the resulting pressure (p r ) within the container during a controlled time Δt 1 ; and (iii) at a second time point (t 2 ) increasing the pressure within the container to a controlled pressure (p 2 ) higher than said resulting pressure (p r ) until complete reconstitution.

Abstract translation: 本发明涉及重组固体形式的药物组合物的方法，其包括以下连续步骤：（i）将药物组合物的固体形式提供在密封容器中，容器内的压力为初始压力（pi ，）包含在0.5Pa和1.2×10 5 Pa之间; （ii）在第一时间点（t0）将溶剂引入所述​​密封容器中并在受控时间Δt1期间将所得压力（pr）保持在容器内; 和（iii）在第二时间点（t2）将容器内的压力增加到高于所述所得压力（pr）的受控压力（p2），直到完全重构。

公开(公告)号：WO2012164389A3

公开(公告)日：2013-04-11

申请号：PCT/IB2012001147

申请日：2012-06-04

Applicant: UCB PHARMA SA ,  MCLOUGHLIN MARTIN J

Inventor： MCLOUGHLIN MARTIN J

IPC: A61M5/20 ,  A61M5/32

CPC classification number: A61M5/14546 ,  A61M5/1452 ,  A61M5/158 ,  A61M5/172 ,  A61M5/20 ,  A61M5/3129 ,  A61M5/3134 ,  A61M5/3137 ,  A61M5/31511 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/3213 ,  A61M5/326 ,  A61M5/5086 ,  A61M2005/206 ,  A61M2005/3139 ,  A61M2005/3152 ,  A61M2005/3215 ,  A61M2202/04 ,  A61M2205/27 ,  A61M2205/276 ,  A61M2205/33 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/586 ,  A61M2205/8206 ,  F04C2270/0421

Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit has a housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity is arranged for receipt of a syringe suitable for use in the injected delivery of drug to a patient. The syringe has a barrel for containing a volume of a liquid drug formulation, the barrel defining an end flange at the rear end thereof and a forward shoulder at the forward end thereof. The cassette unit includes a sleeve form adapter arranged for receipt by the syringe barrel and to fit at least partly over the end flange of the syringe barrel. Accommodation of different syringe sizes within the same cassette unit geometry is achievable by selecting a sleeve form adapter tailored to the particular sizing of the barrel of each different syringe.

Abstract translation: 提供了适用于具有电动驱动单元的自动注射器的盒单元。 盒单元具有限定盒单元容纳腔和针投影孔的壳体。 壳体空腔布置成接收适合用于将药物注射到患者体内的注射器。 注射器具有用于容纳一定体积的液体药物制剂的桶，所述筒在其后端处限定端部凸缘和在其前端处的前肩。 盒单元包括套筒形适配器，其布置成被注射器筒收到并且至少部分地装配在注射器筒的端部凸缘上。 通过选择针对每个不同注射器的筒的特定尺寸调整的套筒形式适配器，可以在同一盒单元几何形状内容纳不同注射器尺寸。

公开(公告)号：WO2012013930A3

公开(公告)日：2012-05-03

申请号：PCT/GB2011001129

申请日：2011-07-27

Applicant: UCB PHARMA SA ,  WILD GAVIN BARRY

Inventor： WILD GAVIN BARRY

IPC: C07K1/30 ,  C07K14/245 ,  C07K16/24

CPC classification number: C07K16/00 ,  C07K1/30 ,  C07K16/241 ,  C07K2317/14 ,  C07K2317/55 ,  C12N9/90 ,  C12P21/00

Abstract: The present invention provides method for purifying a recombinant protein from a gram-negative bacterial host cell sample or extract thereof wherein said host cell expresses a recombinant protein and a recombinant disulphide isomerase DsbC; comprising: a. adjusting the pH of the host cell sample or extract thereof to a pH of 5 or less to precipitate the recombinant disulphide isomerase; and b. separating precipitated recombinant disulphide isomerase DsbC from the recombinant protein to produce a recombinant protein sample.

Abstract translation: 本发明提供从革兰氏阴性细菌宿主细胞样品或其提取物中纯化重组蛋白的方法，其中所述宿主细胞表达重组蛋白和重组二硫异构酶DsbC; 包括：a。 将宿主细胞样品或其提取物的pH调节至5以下的pH以沉淀重组二硫异构酶; 和b。 从重组蛋白中分离沉淀的重组二硫化异构酶DsbC以产生重组蛋白质样品。

公开(公告)号：WO2011117648A3

公开(公告)日：2011-11-17

申请号：PCT/GB2011050608

申请日：2011-03-25

Applicant: UCB PHARMA SA ,  HUMPHREYS DAVID PAUL

Inventor： HUMPHREYS DAVID PAUL

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/46

CPC classification number: C07K16/00 ,  C07K2317/55 ,  C07K2317/94

Abstract: Disulfide Stabilised Antibodies and Fragments Thereof The present disclosure provides an antibody or antibody fragment comprising at least one Fab molecule, wherein the light chain variable region, VL and the heavy chain region, VH of the Fab molecule are linked by one or more disulfide bonds, and use of the same in treatment or prophylaxis.

Abstract translation: 二硫化物稳定的抗体及其片段本公开提供了包含至少一个Fab分子的抗体或抗体片段，其中Fab分子的轻链可变区，VL和重链区VH通过一个或多个二硫键连接， 并将其用于治疗或预防。

公开(公告)号：WO2008128919A2

公开(公告)日：2008-10-30

申请号：PCT/EP2008054496

申请日：2008-04-14

Applicant: UCB PHARMA SA ,  CELANIRE SYLVAIN ,  DENONNE FREDERIC ,  VALADE ANNE

Inventor： CELANIRE SYLVAIN ,  DENONNE FREDERIC ,  VALADE ANNE

IPC: C07D401/12 ,  A61K31/4453 ,  A61P25/00 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D207/26 ,  C07D265/32 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to compounds comprising a cyclobutoxy group, processes for preparing them, pharmaceutical compositions comprising said compounds and their use as pharmaceuticals.

Abstract translation: 本发明涉及包含环丁氧基的化合物，其制备方法，包含所述化合物的药物组合物及其作为药物的用途。

公开(公告)号：WO2007003898A8

公开(公告)日：2008-10-09

申请号：PCT/GB2006002416

申请日：2006-06-29

Applicant: UCB PHARMA SA ,  HEYWOOD SAM PHILIP

Inventor： HEYWOOD SAM PHILIP

IPC: A61K39/395 ,  A61K47/48

CPC classification number: A61K47/60 ,  C07K2317/55

Abstract: The present invention provides a process for attaching one or more effector molecules to one or more cysteines in a protein comprising: a) activating one or more cysteines in the protein by diafiltering the protein against a monothiol reducing agent or a multi-thiol reducing agent which is incapable of forming intramolecular disulphide bonds and b) reacting the treated protein with an effector molecule.

Abstract translation: 本发明提供了将一种或多种效应分子连接到蛋白质中的一个或多个半胱氨酸的方法，其包括：a）通过将蛋白质反渗透单硫醇还原剂或多硫醇还原剂来活化蛋白质中的一个或多个半胱氨酸 不能形成分子内二硫键，和b）使经处理的蛋白质与效应分子反应。

公开(公告)号：WO2014066256A1

公开(公告)日：2014-05-01

申请号：PCT/US2013/065954

申请日：2013-10-21

Applicant: UCB PHARMA SA ,  MCLOUGHLIN, Martin, John ,  HEALD, Michael, James, David ,  CHARLES, Cameron, Townley ,  GARRETT, Dylan, Sanders ,  LOZEAU, Kevin, Richard

Inventor： MCLOUGHLIN, Martin, John ,  HEALD, Michael, James, David ,  CHARLES, Cameron, Townley ,  GARRETT, Dylan, Sanders ,  LOZEAU, Kevin, Richard

IPC: A61M5/20

CPC classification number: A61M5/20 ,  A61M5/002 ,  A61M5/3134 ,  A61M5/31505 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/2013 ,  A61M2005/206 ,  A61M2005/208 ,  A61M2005/2477 ,  A61M2205/13 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/586 ,  A61M2205/8206 ,  H05K1/0298 ,  H05K1/189 ,  H05K2201/052 ,  H05K2201/10151 ,  H05K2201/2009

Abstract: Provided is a drive unit for an auto-injector having a drive unit housing arranged for docking receipt of a syringe or of a cassette unit comprising a syringe movable from a rest position, in which a needle tip of the syringe is within the drive unit housing to a use position, in which the needle tip protrudes from a needle delivery aperture; and a drive arrangement including one or more electrically powered sources of axial drive; a first drive transfer element for advancing the syringe to said use position; and a second drive transfer element for moving a plunger into the barrel of the syringe to eject liquid contents thereof. The drive unit housing is provided with a skin sensor arrangement having an array of plural skin sensor electrodes located about the needle delivery aperture.

Abstract translation: 本发明提供一种用于自动注射器的驱动单元，其具有驱动单元壳体，该驱动单元壳体被布置成用于对接接收注射器或包括可从静止位置移动的注射器的盒单元，其中注射器的针尖位于驱动单元壳体内 到针尖从针传送孔突出的使用位置; 以及驱动装置，其包括一个或多个电动轴向驱动源; 用于将注射器推进到所述使用位置的第一驱动传递元件; 以及用于将柱塞移动到注射器的筒中以喷射其液体内容物的第二驱动传递元件。 驱动单元壳体设置有皮肤传感器装置，其具有围绕针传送孔定位的多个皮肤传感器电极的阵列。

公开(公告)号：WO2013024291A2

公开(公告)日：2013-02-21

申请号：PCT/GB2012051992

申请日：2012-08-15

Applicant: UCB PHARMA SA ,  UNIV LEUVEN KATH ,  BROOKINGS DANIEL CHRISTOPHER ,  FORD DANIEL JAMES ,  GHAWALKAR ANANT RAMRAO ,  HERMAN JEAN ,  HUANG QIUYA ,  KULISA CLAIRE LOUISE ,  LOUAT THIERRY ,  NEUSS JUDI CHARLOTTE ,  REUBERSON JAMES THOMAS ,  VANDERHOYDONCK BART

Inventor： BROOKINGS DANIEL CHRISTOPHER ,  FORD DANIEL JAMES ,  GHAWALKAR ANANT RAMRAO ,  HERMAN JEAN ,  HUANG QIUYA ,  KULISA CLAIRE LOUISE ,  LOUAT THIERRY ,  NEUSS JUDI CHARLOTTE ,  REUBERSON JAMES THOMAS ,  VANDERHOYDONCK BART

IPC: C07D495/04 ,  A61K31/519 ,  A61P29/00 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D495/04 ,  A61K31/519 ,  C07D513/04 ,  C07D519/00

Abstract: A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

Abstract translation: 一系列单环或双环二胺取代的噻吩并[2,3-d]嘧啶和异噻唑并[5,4-d]嘧啶衍生物有益于治疗和/或预防各种人类疾病，包括炎症，自身免疫和肿瘤疾病 ; 病毒性疾病; 和器官和细胞移植排斥反应。

公开(公告)号：WO2012164402A3

公开(公告)日：2013-01-31

申请号：PCT/IB2012001394

申请日：2012-06-04

Applicant: UCB PHARMA SA ,  MCLOUGHLIN MARTIN J

Inventor： MCLOUGHLIN MARTIN J

IPC: A61M5/20 ,  A61M5/32

CPC classification number: A61M5/14546 ,  A61M5/1452 ,  A61M5/158 ,  A61M5/172 ,  A61M5/20 ,  A61M5/3129 ,  A61M5/3134 ,  A61M5/3137 ,  A61M5/31511 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/3213 ,  A61M5/326 ,  A61M5/5086 ,  A61M2005/206 ,  A61M2005/3139 ,  A61M2005/3152 ,  A61M2005/3215 ,  A61M2202/04 ,  A61M2205/27 ,  A61M2205/276 ,  A61M2205/33 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/586 ,  A61M2205/8206 ,  F04C2270/0421

Abstract: There is provided an auto-injector for a syringe that is suitable for use in the injected delivery of drug to a patient. The auto-injector comprises a cassette unit arranged for receipt of a syringe provided with a needle cover and removable cap. The auto-injector also comprises a drive unit arranged for docking receipt of the cassette unit at a docking position and a drive arrangement. The drive unit is provided with a timer that starts a time count on removal of the removable cap and needle cover from the cassette unit.

Abstract translation: 提供了一种用于注射器的自动注射器，其适用于将药物注射到患者体内。 自动注射器包括盒单元，其被布置成用于接收设置有针盖和可移除盖的注射器。 自动注射器还包括驱动单元，该驱动单元布置成用于对接在对接位置处的盒单元的接收和驱动装置。 驱动单元设置有定时器，其启动从盒单元去除可移除盖和针盖的时间计数。

公开(公告)号：WO2008132139A3

公开(公告)日：2008-12-31

申请号：PCT/EP2008055016

申请日：2008-04-24

Applicant: UCB PHARMA SA ,  KENDA BENOIT ,  TURET LAURENT ,  QUESNEL LAURENT ,  MICHEL PHILIPPE

Inventor： KENDA BENOIT ,  TURET LAURENT ,  QUESNEL LAURENT ,  MICHEL PHILIPPE

IPC: A61K31/4015 ,  A61K31/407 ,  A61K31/4162 ,  A61K31/417 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/45 ,  A61K31/4704 ,  A61K31/472 ,  A61K31/55 ,  C07D207/38 ,  C07D215/22 ,  C07D233/32

CPC classification number: C07D233/32 ,  A61K31/4015 ,  A61K31/407 ,  A61K31/4162 ,  A61K31/417 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/45 ,  A61K31/4704 ,  A61K31/472 ,  A61K31/55 ,  C07D215/227 ,  C07D217/24 ,  C07D263/20 ,  C07D263/22 ,  C07D263/38 ,  C07D277/14 ,  C07D277/34 ,  C07D277/68 ,  C07D401/06 ,  C07D403/06 ,  C07D417/06 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present invention relates to new compounds, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract translation: 本发明涉及新化合物，其制备方法，含有它们的药物组合物以及它们作为药物的用途。