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    NEW ENAMEL-DENTIN ADHESIVES BASED ON CHEMICALLY MODIFIED NATURAL POLYSACCHARIDES
    41.
    发明申请
    NEW ENAMEL-DENTIN ADHESIVES BASED ON CHEMICALLY MODIFIED NATURAL POLYSACCHARIDES 审中-公开
    基于化学修饰的天然多糖的新型ENAMEL-DENTIN粘合剂

    公开(公告)号：WO2015128415A1

    公开(公告)日：2015-09-03

    申请号：PCT/EP2015/054014

    申请日：2015-02-26

    Applicant: UNIVERSITA' DEGLI STUDI DI TRIESTE

    Inventor： PAOLETTI, Sergio ,  DI LENARDA, Roberto ,  BRESCHI, Lorenzo ,  CADENARO, Milena ,  DIOLOSA', Marina ,  TURCO, Gianluca ,  DONATI, Ivan

    IPC: C08B37/08 ,  A61K6/097 ,  A61L24/08

    CPC classification number: C08B37/003 ,  A61K6/083 ,  A61K6/097 ,  A61L24/08 ,  C08L33/08 ,  C08L5/08

    Abstract: The present invention concerns the preparation of chemically modified derivatives of chitosan with acrylic groups and their use in the field of enamel-dentin adhesives. Chitosan derivatives have physical-chemical features (hydrophilicity, presence of electrical charges on the chain) which allow them to interact with the organic part of the demineralized tooth. At the same time, the acrylic groups incorporated in the polymer chain allow the formation of a covalent bond with the restorative material used in the dental field that is typically composed of acrylic resins. By combining the adhesion to the tooth surface and the bond with the restorative material, the chemically modified chitosan described herein is able to increase the lifespan of the dental restoration and can thus find use in the field of adhesives, in particular enamel-dentin adhesives.

    Abstract translation: 本发明涉及具有丙烯酸基团的壳聚糖的化学改性衍生物的制备及其在釉 - 牙本质粘合剂领域中的应用。 壳聚糖衍生物具有物理化学特征（亲水性，在链上存在电荷），这使得它们与去矿质化牙齿的有机部分相互作用。 同时，掺入聚合物链中的丙烯酸基允许与通常由丙烯酸树脂组成的牙科领域中使用的修复材料形成共价键。 通过结合与牙齿表面的粘附和与修复材料的粘合，本文所述的化学改性的壳聚糖能够增加牙齿修复体的寿命，因此可用于粘合剂领域，特别是牙釉质 - 牙本质粘合剂领域。

    METHOD FOR COVALENT IMMOBILIZATION OF ENZYMES ON FUNCTIONALIZED SOLID POLYMERIC SUPPORTS
    42.
    发明申请
    METHOD FOR COVALENT IMMOBILIZATION OF ENZYMES ON FUNCTIONALIZED SOLID POLYMERIC SUPPORTS 审中-公开
    功能性固体聚合物支持物的酶的固定化方法

    公开(公告)号：WO2012085206A1

    公开(公告)日：2012-06-28

    申请号：PCT/EP2011/073794

    申请日：2011-12-22

    Applicant: SPRIN S.P.A. ,  UNIVERSITA' DEGLI STUDI DI TRIESTE ,  GARDOSSI, Lucia ,  SPIZZO, Patrizia ,  FATTOR, Diana ,  SINIGOI, Loris

    Inventor： GARDOSSI, Lucia ,  SPIZZO, Patrizia ,  FATTOR, Diana ,  SINIGOI, Loris

    IPC: C12N11/02 ,  C12N11/04

    CPC classification number: C12N11/08 ,  C12N9/20

    Abstract: It is herein described a method of immobilization of enzymes, in particular enzymes that are active at the interface with hydrophobic phases as lipases, on porous solid polymeric supports, in which there is formation of a stable covalent bond between the support and the enzyme and in which a hydrophobic "interface" forms around the solid support that allows the enzyme, dissolved in a minimum aqueous phase, to pass from the closed/inactive conformation (which prevails when the enzyme is in aqueous phase) to the open/activated conformation (which prevails when the enzyme comes into contact with a hydrophobic phase) and to adopt an optimum orientation, turning the opening of the hydrophobic active site towards the hydrophobic organic phase.

    Abstract translation: 本文描述了一种固定酶的方法，特别是在与疏水相作为脂肪酶的界面处活性的酶在多孔固体聚合物载体上固定，其中在载体和酶之间形成稳定的共价键，并且在 其在固体支持物周围形成疏水性“界面”，其允许溶解在最小水相中的酶从封闭/不活动构象（其在酶处于水相时占优势）传递至开放/活化构象（其中 当酶与疏水相接触时占优势）并采取最佳取向，将疏水活性位点的开口转向疏水性有机相。

    3D MATRICES OF HUMAN ELASTIN-LIKE POLYPEPTIDES AND METHOD OF PREPARATION THEREOF
    43.
    发明申请
    3D MATRICES OF HUMAN ELASTIN-LIKE POLYPEPTIDES AND METHOD OF PREPARATION THEREOF 审中-公开
    人类弹力素多聚体的三维矩阵及其制备方法

    公开(公告)号：WO2010119420A1

    公开(公告)日：2010-10-21

    申请号：PCT/IB2010/051642

    申请日：2010-04-15

    Applicant: UNIVERSITA' DEGLI STUDI DI TRIESTE ,  BANDIERA, Antonella

    Inventor： BANDIERA, Antonella

    IPC: C07K14/78 ,  A61K38/39 ,  A61L27/52

    CPC classification number: C07K14/78 ,  A61L27/227 ,  A61L27/52

    Abstract: 3D matrices or hydrogels made of human elastin-like polypeptides and their preparation are described. Said matrices can be obtained by enzymatic cross- linking of such polypeptides and can be used in the biomedical and pharmaceutical fields as support the growth of cells, isolated or as multicellular association, both on the surface and inside the matrix. Said matrices can also deliver pharmacologically active molecules, which are incorporated and then released in a controlled manner.

    Abstract translation: 描述了由人弹性蛋白样多肽制成的3D基质或水凝胶及其制备方法。 所述基质可以通过这种多肽的酶交联获得，并且可以用于生物医学和药物领域，以支持在基质的表面和内部的细胞生长，分离或多细胞关联。 所述基质还可以递送药理活性分子，其被并入并随后以受控的方式释放。

    THREE-DIMENSIONAL NANOCOMPOSITE MATERIALS CONSISTING OF A POLYSACCHARIDIC MATRIX AND METALLIC NANOPARTICLES, PREPARATION AND USE THEREOF
    44.
    发明申请
    THREE-DIMENSIONAL NANOCOMPOSITE MATERIALS CONSISTING OF A POLYSACCHARIDIC MATRIX AND METALLIC NANOPARTICLES, PREPARATION AND USE THEREOF 审中-公开
    三维纳米复合材料包含多晶基质和金属纳米颗粒，其制备和使用

    公开(公告)号：WO2010010123A1

    公开(公告)日：2010-01-28

    申请号：PCT/EP2009/059432

    申请日：2009-07-22

    Applicant: UNIVERSITA' DEGLI STUDI DI TRIESTE ,  DONATI, Ivan ,  MARSICH, Eleonora ,  TRAVAN, Andrea ,  PAOLETTI, Sergio

    Inventor： DONATI, Ivan ,  MARSICH, Eleonora ,  TRAVAN, Andrea ,  PAOLETTI, Sergio

    IPC: C08L5/00 ,  C08B37/00

    CPC classification number: C08L5/08 ,  C08B37/003 ,  C08L5/04

    Abstract: In the present invention nanocomposite materials in form of three-dimensional structure formed by a polymeric matrix consisting of a polysaccharidic composition of neutral or anionic polysaccharides and a branched cationic polysaccharides, in which metallic nanoparticles are uniformly dispersed and stabilized, are described. Using appropriate techniques of gelification or by means of an appropriate dehydration, the nanocomposite materials are three-dimensional matrices having different shapes in hydrated form as hydrogels, or in non-hydrated form. These nanocomposite materials have a broad-spectrum of strong bactericidal activity, but do not show any cytotoxicity. The particular antibacterial properties associated with metallic particle nano-scale and the presence of biological signals on the polymeric chains along with the lack of cytotoxicity may be exploited in developing new-generation biomaterials provided with antimicrobial properties and for many other applications in biomedical, pharmaceutical and food field.

    Abstract translation: 在本发明中，描述了由由中性或阴离子多糖的多糖组合物和支化阳离子多糖组成的聚合物基质形成的纳米复合材料，其中金属纳米颗粒均匀分散和稳定。 使用合适的凝胶化技术或通过合适的脱水技术，纳米复合材料是具有水合形式不同形状作为水凝胶或非水合形式的三维基质。 这些纳米复合材料具有广谱的强杀菌活性，但不显示任何细胞毒性。 与金属颗粒纳米尺度相关的特定抗菌性能以及聚合物链上的生物信号的存在以及缺乏细胞毒性可以用于开发具有抗微生物性质的新一代生物材料，并且可用于生物医药，制药和 食品领域。

    METHOD AND SYSTEM FOR GENETIC PATTERN RECOGNITION
    46.
    发明申请
    METHOD AND SYSTEM FOR GENETIC PATTERN RECOGNITION 审中-公开
    用于遗传图案识别的方法和系统

    公开(公告)号：WO2007068719A1

    公开(公告)日：2007-06-21

    申请号：PCT/EP2006/069659

    申请日：2006-12-13

    Applicant: UNIVERSITA' DEGLI STUDI DI TRIESTE ,  SCUOR, Nicola

    Inventor： SCUOR, Nicola

    IPC: C12Q1/68 ,  G01N27/22

    CPC classification number: C12Q1/6825 ,  G01N27/3276 ,  Y10T436/143333

    Abstract: A method and an system for the detection of nucleic acid oligonucleotides is characterized in that said detection corresponds to a capacitive reading of the melting point of complexes obtained by hybridization of said oligonucleotides and suitably modified molecules of oligonucleotide probes.

    Abstract translation: 用于检测核酸寡核苷酸的方法和系统的特征在于所述检测对应于通过所述寡核苷酸和适当修饰的寡核苷酸探针分子的杂交获得的复合物的熔点的电容读数。

    PROCESS FOR ENZYMATIC SYNTHESIS OF β-LACTAM ANTIBIOTICS
    50.
    发明申请
    PROCESS FOR ENZYMATIC SYNTHESIS OF β-LACTAM ANTIBIOTICS 审中-公开
    β-LACTAM抗生素的酶促合成方法

    公开(公告)号：WO2004062558A2

    公开(公告)日：2004-07-29

    申请号：PCT/EP2004/000182

    申请日：2004-01-14

    Applicant: UNIVERSITA' DEGLI STUDI DI TRIESTE ,  LINDA, Paolo ,  GARDOSSI, Lucia ,  TONIUTTI, Micaela

    Inventor： LINDA, Paolo ,  GARDOSSI, Lucia ,  TONIUTTI, Micaela

    IPC: A61K

    CPC classification number: C12P37/04 ,  C12P35/04

    Abstract: The present invention describes a process for the preparation of β-lactam antibiotics, cephalexin and ampicillin, wherein the β-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyzed by a catalytic enzyme. The acylation reaction is carried out in solid phase in solvent free systems (water or organic solvents) for the dispersion of reagents and at controlled temperatures.

    Abstract translation: 本发明描述了制备β-内酰胺抗生素，头孢氨苄和氨苄青霉素的方法，其中通过催化酶生物催化的反应，用酰化剂D-苯基甘氨酸酰化β-内酰胺核。 酰化反应在无溶剂系统（水或有机溶剂）中以固相的形式进行，用于分散试剂和控制温度。

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