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公开(公告)号：US20230129380A1
公开(公告)日：2023-04-27
申请号：US17912382
申请日：2021-03-19
Inventor： Leroy Cronin
Abstract: The present invention provides a method for estimating the molecular complexity of a sample, for example to determine whether biotic or synthetic components are present in the sample. The method comprises the steps of (a) performing one of MS/MS, NMR or IR on a sample; (b) determining the unique peaks in the resulting spectrum; and (c) calculating the molecular assembly index of the sample based on the number of unique peaks in the spectrum.
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公开(公告)号：US11506477B2
公开(公告)日：2022-11-22
申请号：US17008070
申请日：2020-08-31
Applicant: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE , The University Court of the University of Glasgow
Inventor： Mehedi Islam , Piotr Roztocki , Michael Kues , Christian Reimer , Bennet Fisher , Stefania Sciara , Robin Helsten , Yanbing Zhang , Yoann Jestin , Roberto Morandotti
IPC: G01B9/02015 , G01B9/02001
Abstract: A system and a method for phase extraction of a multi-path interferometer, the method comprising generating a reference signal of a coherence length longer than an arm length difference of the multi-path interferometer; splitting the reference signal into a frequency shifted reference signal and an unshifted reference signal; recombining the frequency shifted reference signal and the unshifted reference signal into a polarization- and frequency-multiplexed reference signal, and feeding the polarization- and frequency-multiplexed reference signal to the multi-path interferometer; detecting frequency shifted and unshifted output signals of the multi-path interferometer; and determining the interferometer phase from the detected signal.
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公开(公告)号：US11260081B2
公开(公告)日：2022-03-01
申请号：US16313060
申请日：2017-06-29
Inventor： Oded Rechavi , Shahar Bracha , Lilach Sheiner
Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.
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公开(公告)号：US20210349367A1
公开(公告)日：2021-11-11
申请号：US17272616
申请日：2019-08-30
Inventor： Emily Rose Adams , David John Adams
IPC: G02F1/1516 , C09K9/02
Abstract: Provided are novel naphthalene diimide (NDI) compound of Formula 1. The compounds may exhibit colour change from substantially transparent to substantially black upon electrochemical or photochemical stimulus and may be useful in smart windows.
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公开(公告)号：US20210233620A1
公开(公告)日：2021-07-29
申请号：US17257227
申请日：2019-07-04
Inventor： Leroy CRONIN
Abstract: The present invention provides a method to generate a predictive model for a reaction set, which reaction set is the sum of the reaction outcomes for a plurality of chemical inputs. Also provided is a system for generating a predictive model for a reaction set, which system may be used in the method. The system comprises a synthesiser for conducting reactions, which synthesiser is an automated synthesiser, an analytical unit for monitoring reactions performed by the synthesiser, and a control unit suitably programmed with a machine learning algorithm, for analysing analytical data from the analytical unit, and for controlling the synthesiser.
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Patent Agency Ranking
公开(公告)号：US20210032762A1
公开(公告)日：2021-02-04
申请号：US16964557
申请日：2019-01-24
Inventor： Leroy Cronin , Mark Symes , Jia-Jia Chen
Abstract: The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.
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公开(公告)号：US20200249175A1
公开(公告)日：2020-08-06
申请号：US16616765
申请日：2018-05-23
Inventor： David Robert Sime CUMMING , Chunxiao HU , Mohammed AL-RAWHANI , Boon Chong CHEAH
IPC: G01N21/80 , G01N27/414
Abstract: A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.
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公开(公告)号：US10604852B2
公开(公告)日：2020-03-31
申请号：US14357066
申请日：2012-11-08
Inventor： Leroy Cronin , Mark Symes
Abstract: The invention provides methods for producing hydrogen and oxygen, comprising the steps of: (i) oxidising a mediator at a working electrode to yield an oxidised mediator, and reducing protons at a counter electrode to yield hydrogen; and (ii) reducing an oxidised mediator at a working electrode to yield a mediator, and oxidising water at a counter electrode to yield oxygen, wherein the oxygen generation step is performed non-simultaneously to the hydrogen generation step, and the oxidised mediator of step (i) is used as the oxidised mediator of step (ii), or the mediator of step (ii) is used as the mediator of step (i), and the mediator has a reversible redox wave lying between the onset of the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER).
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公开(公告)号：US20200016279A1
公开(公告)日：2020-01-16
申请号：US16497277
申请日：2018-03-23
Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
Inventor： Adrian BIRD , Rebekah TILLOTSON , Stuart Robert COBB , Ralph David HECTOR
Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5′ to 3′: a 5′ transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3′ untranslated region (3′UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes. The nucleic acid molecules and viral vectors disclosed herein provide novel tools for expressing MeCP2 and are of particular value in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome.
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公开(公告)号：US10248032B1
公开(公告)日：2019-04-02
申请号：US15955428
申请日：2018-04-17
Inventor： Peter Edward MacKay , Jonathan Gavin Ironside-Smith , Sonja Franke-Arnold , Neal Matthew Radwell
Abstract: A cone-based polarizer includes a beam splitter including a front side (FS) and a back side (BS) part for receiving a first and a second beam portion, respectively. The FS part includes two prisms including parallel first and second FS hypotenuses, and the BS part includes two prisms including parallel first and second BS hypotenuses. A first TIR cone is on top and a second TIR cone is on a bottom of the beam splitter. The first and second TIR cones are aligned to have an essentially common cone axis direction and are configured to add a structured polarization upon retroreflecting. The first and second FS hypotenuses have a FS TIR interface in-between and are angled at about 45 degrees relative to the cone axis direction. The first and second BS hypotenuses have a BS TIR interface in-between and are angled at about 90 degrees relative to the FS hypotenuses.
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