公开(公告)号：AU3237993A

公开(公告)日：1993-06-28

申请号：AU3237993

申请日：1992-12-04

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： THOMAS L CASAVANT ,  SAMUEL A FINEBERG

IPC: G06F9/38 ,  G06F15/173 ,  G06F15/80

Abstract: A method and an apparatus for reconciling communication and locality by enabling a user/programmer to write programs in an extended procedural language which explicitly manipulate locality. The multiprocessor includes a plurality of processing elements connected to each other each processing element having a unique address and including a central processing unit for executing local CPU code and reading and writing local data and a locality manager for controlling data movement between processing elements which are cooperating on a single task by executing local locality manager code which indicates when shared data can be released and when non-local data is requested.

公开(公告)号：AU2171492A

公开(公告)日：1993-01-08

申请号：AU2171492

申请日：1992-05-27

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： JONATHAN S DORDICK ,  DAVID G RETHWISCH ,  DAMODAR R PATIL

IPC: C08F20/28 ,  C07H15/04 ,  C08B37/00 ,  C08F20/26 ,  C08G18/42 ,  C08G63/688 ,  C08G69/00 ,  C08G69/26 ,  C08G75/00 ,  C08G85/00 ,  C12P7/62 ,  C12P19/00 ,  C12P19/02 ,  C12P19/04 ,  C12P19/44

公开(公告)号：IL246118D0

公开(公告)日：2016-07-31

申请号：IL24611816

申请日：2016-06-08

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  BROAD INST INC

IPC: C12N20060101

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences especially for use as to nucleotide repeat disorders. Provided are delivery systems and tissues or organ which are targeted as sites for delivery especially for use as to nucleotide repeat disorders. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex or system especially for use as to nucleotide repeat disorders, as well as methods for the design and of such. Also provided are methods of directing CRISPR complex or system formation in eukaryotic cells especially for use as to nucleotide repeat disorders including with consideration of specificity for target recognition and avoidance of toxicity and editing or modifying a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

公开(公告)号：AU7619000A

公开(公告)日：2001-04-30

申请号：AU7619000

申请日：2000-09-27

Applicant: COLEY PHARM GMBH ,  COLEY PHARM GROUP INC ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION THE

Inventor： HARTMANN GUNTHER ,  BRATZLER ROBERT L ,  KRIEG ARTHUR

IPC: A61K31/7088 ,  A61K35/12 ,  A61K38/00 ,  A61K38/21 ,  A61P1/00 ,  A61P1/08 ,  A61P1/16 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  A61P43/00 ,  C12N5/0784 ,  C12N15/117 ,  A61K35/28 ,  A61K38/19 ,  C12N5/08

公开(公告)号：AU7615300A

公开(公告)日：2001-04-30

申请号：AU7615300

申请日：2000-09-25

Applicant: COLEY PHARM GMBH ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION THE

Inventor： KRIEG ARTHUR M ,  SCHETTER CHRISTIAN ,  VOLLMER JORG

IPC: C12N15/09 ,  A23L20060101 ,  A23L1/30 ,  A61K20060101 ,  A61K9/20 ,  A61K9/48 ,  A61K31/00 ,  A61K31/7088 ,  A61K31/7125 ,  A61K35/12 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/08 ,  A61K39/085 ,  A61K39/102 ,  A61K39/106 ,  A61K39/108 ,  A61K39/145 ,  A61K39/21 ,  A61K39/245 ,  A61K39/39 ,  A61K39/395 ,  A61K45/00 ,  A61K45/06 ,  A61K48/00 ,  A61P20060101 ,  A61P1/00 ,  A61P1/16 ,  A61P1/18 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P27/02 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/04 ,  A61P37/08 ,  C12N5/06

Abstract: The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25 % T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/or greater than 50 % c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.

公开(公告)号：AU5452000A

公开(公告)日：2001-03-13

申请号：AU5452000

申请日：2000-05-30

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION THE

Inventor： STONE EDWIN M ,  SHEFFIELD VAL C

IPC: A61P43/00 ,  C07K14/47 ,  C12Q1/68 ,  C12Q1/6883 ,  C12N15/62 ,  A01K67/027 ,  C12N5/10

公开(公告)号：AU5471600A

公开(公告)日：2001-01-02

申请号：AU5471600

申请日：2000-06-08

Applicant: LORENZ EVA ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION THE

Inventor： LORENZ EVA ,  SCHWARTZ DAVID A ,  SCHUTTE BRIAN C

IPC: C07K14/705 ,  C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/68 ,  A01K67/027

Abstract: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.

公开(公告)号：AU5454500A

公开(公告)日：2001-01-02

申请号：AU5454500

申请日：2000-06-15

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION THE

Inventor： AMARASINGHE SUDATH ,  MINTEER SHELLEY ,  ZOOK LOIS ANNE ,  DUNWOODY DREW C ,  SPOLAR CATHERINE ,  CHUNG HACHULL ,  LEDDY JOHNA

IPC: B01D49/00 ,  B03C1/00 ,  B03C1/01 ,  B03C1/023 ,  B03C1/025 ,  B03C1/035 ,  C23C6/00 ,  C23C24/08 ,  C23C30/00 ,  C25B11/00 ,  C25B13/00 ,  C25D3/54 ,  G21F9/12 ,  H01F1/00 ,  H01F10/00 ,  H01F41/24 ,  H01F41/26 ,  H01F41/30 ,  H01M4/02 ,  H01M4/36 ,  H01M4/86 ,  H01M4/88 ,  H01M4/90 ,  H01M4/92 ,  H01M8/00 ,  H01M8/04 ,  H01M8/10 ,  H01M8/24 ,  H01M10/42 ,  B01D35/06 ,  G01N33/553

Abstract: Materials and methods for making and using magnetically enhanced composite materials are provided. Surfaces coated with such composites can be used to improve fuel cells, material separators, and other applications. A variety of devices can incorporate such composites, including fuel cells, separators, batteries, and electrodes that effect electrolysis of magnetic species.

公开(公告)号：AU2614800A

公开(公告)日：2000-08-07

申请号：AU2614800

申请日：2000-01-19

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION THE

Inventor： SOLL DAVID R ,  SHUTT DAMON

IPC: A61K38/16 ,  A61K38/20 ,  A61K39/39 ,  A61P31/18 ,  C07K14/16 ,  A61K39/00

Abstract: The combination of HIV proteins Tat and Nef is chemotactic for CD4+ cells. Utilizing the capacity of Tat and Nef to modulate CD4+ cell trafficking and infiltration, the invention provides various treatment modes for individuals infected with HIV. The invention further provides treatment modes for other localized diseases by controlling CD4+ cell trafficking and infiltration. In particular, the invention provides methodology for promoting CD4+ cell chemotaxis to a localized site of infection as a means of augmenting the efficacy of extant chemotherapeutic methods. The invention further provides methodology for diverting CD4+ cell infiltration from a localized site where the presence of CD4+ cells is detrimental to the clinical outcome, by providing a composition comprising Tat and Nef at a distinct site, such as blood, within the individual where the accumulation of CD4+ cells is less detrimental.

公开(公告)号：AU2385200A

公开(公告)日：2000-07-31

申请号：AU2385200

申请日：1999-12-27

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION THE

Inventor： LINHARDT ROBERT J ,  BAZIN HELENE G

IPC: C07G3/00 ,  C07H1/00 ,  C07H13/04 ,  C07H15/12

Abstract: New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excellent surface-active properties.