公开(公告)号：KR1020080006737A

公开(公告)日：2008-01-17

申请号：KR1020060065840

申请日：2006-07-13

Applicant: (주)아모레퍼시픽 ,  에스비사이언스(주)

Inventor： 김형준 ,  김광미 ,  김혁 ,  성기사 ,  김대권 ,  박종희 ,  조선아 ,  이창훈 ,  김정주 ,  신재민 ,  조두호

IPC: A61K31/131 ,  A61P17/02

Abstract: A pharmaceutical composition is provided to effectively inhibit cell proliferation, inflammatory reaction, histamine secretion or itch caused by the function of sphingosylphosphorylcholine without side effects, thereby being usefully used for inhibiting scar formation after wound and preventing and treating inflammation, pruritus and skin inflammatory diseases. A pharmaceutical composition for inhibiting the function of sphingosylphosphorylcholine comprises 2-amino-2-octyloxymethyl-propane-1,3-diol represented by the formula(1) or a pharmaceutically acceptable salt thereof. The composition further comprises a carrier, an excipient or a diluent.

Abstract translation: 提供药物组合物以有效地抑制由鞘脂酰磷酰胆碱的功能引起的细胞增殖，炎症反应，组胺分泌或瘙痒，无副作用，从而有效地用于抑制伤口后的瘢痕形成，预防和治疗炎症，瘙痒和皮肤炎症性疾病。 用于抑制鞘糖基磷酰胆碱功能的药物组合物包含由式（1）表示的2-氨基-2-辛氧基甲基 - 丙烷-1,3-二醇或其药学上可接受的盐。 组合物还包含载体，赋形剂或稀释剂。