-
公开(公告)号：KR100864677B1
公开(公告)日：2008-10-23
申请号：KR1020070029255
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07C233/07 , C07C233/10
Abstract: 본 발명은 항비만 효과를 나타내는 하기 화학식 1로 표시되는 3,5-디히드록시벤조산 유도체 화합물 및 이의 제조방법에 관한 것이다:
[화학식 1]
상기 식 중, R은 아다만틸, 시클로헥실 또는 헥실이다.
3,5-디히드록시벤조산 유도체, 항비만, 루시퍼라아제, IDH3α, CPT1, 혈당-
公开(公告)号：KR100851044B1
公开(公告)日：2008-08-12
申请号：KR1020070083905
申请日：2007-08-21
Applicant: (주)아모레퍼시픽
Abstract: 3,5-Dihydroxy benzamide derivatives are provided to whiten the skin due to a depigmenting activity and improve stability in aqueous solution and organic solvent in formulation by inhibiting structure change. A cosmetic composition for whitening the skin comprises 0.01-20 wt.% of 3,5-dihydroxy benzamide derivatives represented by a formula(1), wherein a hydroxyl group is located in the 2,3-, 2,4-, 2,5-, 3,4- or 3,5-site, and is used in forms of emulsion, cream, cosmetic lotion, essence, pack, gel, powder, makeup base, foundation, lotion, ointment, patch, beauty solution, cleansing foam, cleansing cream, cleansing water, body lotion, body cream, body oil, body essence, shampoo, rinse, body cleanser, soap, hair dye or spray.
Abstract translation: 提供3,5-二羟基苯甲酰胺衍生物，由于脱色活性而使皮肤变白，并通过抑制结构变化提高配方中水溶液和有机溶剂的稳定性。 用于使皮肤美白的化妆品组合物包含0.01-20重量％的由式（1）表示的3,5-二羟基苯甲酰胺衍生物，其中羟基位于2,3-，2,4-， 5-，3,4-或3,5-位，并以乳液，霜剂，化妆水，精华，包装，凝胶，粉末，化妆底，粉底，洗剂，软膏，贴片，美容液，清洁剂的形式使用 泡沫，清洁霜，清洁水，身体乳液，身体霜，身体油，身体精华，洗发水，漂洗，身体清洁剂，肥皂，染发剂或喷雾剂。
-
公开(公告)号：KR100845511B1
公开(公告)日：2008-07-10
申请号：KR1020070029253
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07D317/68 , A61K31/357
Abstract: A hydroxamic acid derivative is provided to induce the activity increase of each promoter of IDH3alpha and CPT1 involving with energy consumption metabolism, thereby being usefully used for preventing or treating diseases related to dyslipidemia such as obesity, hyperlipidemia and diabetes. A hydroxamic acid is represented by a formula(1), wherein R1 is CONH, NHCO, CONR4 or NR4CO(where R4 is H or C1-10 alkyl); R2 is -(CH2)n-(where n is 0 or 1); and R3 is H or C1-10 alkyl. A method for preparing the hydroxamic acid comprises the steps of: (a) reacting an anhydrous compound synthesized by reacting ethyl chloroformate with piperonic acid using pyridine or N-methyl morpholine as a solvent with methyl 4-amino benzoate or 4-amino phenyl acetic acid ethyl ester at a temperature of 10-20 deg.C using pyridine or N-methyl morpholine as a solvent to prepare a benzamide compound; (b) reacting the benzamide with an alkyl halide selected from the group consisting of bromomethane, bromoethane, bromopropane, bromo isopropane, bromo butane, and bromo tert-butane to substitute an amide bond of the benzamide with an alkyl group; (c) hydrolyzing methyl ester in the benzamide obtained from the step(a) or the benzamide compound obtained from the step(b) to prepare an acid and reacting the acid with ethyl chloroformate using pyridine or N-methyl morpholine as a solvent to covert the acid into an anhydrous compound; and (d) reacting the anhydrous compound with hydroxyl amine chloride or N-methyl hydroxyl amine chloride at a temperature of 0-10 deg.C using pyridine or N-methyl morpholine as a solvent to obtain the product of the formula(1). An agent for anti-obese, treating diabetes or hyperlipidemia comprises the hydroxamic acid.
Abstract translation: 提供异羟肟酸衍生物以诱导与能量代谢相关的IDH3α和CPT1的每种启动子的活性增加，从而有效地用于预防或治疗与脂肪血症如肥胖症，高脂血症和糖尿病有关的疾病。 异羟肟酸由式（1）表示，其中R1是CONH，NHCO，CONR4或NR4CO（其中R4是H或C1-10烷基）; R2是 - （CH2）n-（其中n是0或1）; 并且R 3是H或C 1-10烷基。 制备异羟肟酸的方法包括以下步骤：（a）使吡啶或N-甲基吗啉作为溶剂与4-氨基苯甲酸甲酯或4-氨基苯基乙酸反应，使氯甲酸乙酯与胡椒酸反应合成的无水化合物 乙酯，使用吡啶或N-甲基吗啉作为溶剂，在10-20℃的温度下制备苯甲酰胺化合物; （b）使苯甲酰胺与选自溴甲烷，溴乙烷，溴丙烷，溴异丙烷，溴丁烷和溴叔丁烷的烷基卤反应，以苯甲酰胺与烷基取代; （c）水解由步骤（a）获得的苯甲酰胺中的甲酯或由步骤（b）获得的苯甲酰胺化合物制备酸，并使用吡啶或N-甲基吗啉作为溶剂使酸与氯甲酸乙酯反应，从而使 将酸变成无水化合物; 和（d）使用吡啶或N-甲基吗啉作为溶剂，在0-10℃的温度下使无水化合物与羟胺或N-甲基羟胺氯化物反应，得到式（1）的产物。 用于抗肥胖，治疗糖尿病或高脂血症的药物包括异羟肟酸。
-
公开(公告)号：KR100837186B1
公开(公告)日：2008-06-13
申请号：KR1020060095279
申请日：2006-09-29
Applicant: (주)아모레퍼시픽
IPC: C07C233/11 , C07C233/21
Abstract: 본 발명은 하기 화학식 1로 표시되는 항노화 효과를 나타내는 레티노익산(Retinoic acid) 유도체 및 이의 제조방법에 관한 것이다:
[화학식 1]
[상기 화학식 1에서, R
1 은 수소, 직쇄 또는 분쇄의 (C
1 -C
7 )알킬 또는 (C
3 -C
7 )시클로알킬이고; R
2 는 히드록시, 1~4개의 히드록시기가 치환된 직쇄 또는 분쇄의 (C
1 -C
7 )알킬 또는 히드록시피라논이 치환된 직쇄 또는 분쇄의 (C
1 -C
5 )알킬이다.]
또한 본 발명은 상기 화학식 1의 레티노익산 유도체를 유효성분으로 함유하는 피부노화 방지용 피부 외용제 조성물에 관한 것이다.
레티노익산 * 레티노익산 수용체 * 항노화 * 콜라겐 * 콜라게나아제 발현억제 * 주름 개선 * 피부 외용제-
公开(公告)号：KR100803577B1
公开(公告)日：2008-02-15
申请号：KR1020050115649
申请日：2005-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/498 , A61K8/602 , A61K2800/522 , A61Q19/02 , A61Q19/08
Abstract: 본 발명은 이카린의 가수분해물을 함유하는 화장료용 조성물에 관한 것으로, 보다 구체적으로는 이카린의 가수분해물인 이카리틴, 이카리시드 I 및 이카리시드 II를 함유하는 화장료에 관한 것이고, 상기 이카린(icariin)의 가수분해물은 (a) 식물로부터 물 또는 유기용매를 이용하여 이카린을 함유하는 식물 추출물을 수득하는 단계; 및 (b) 상기 수득된 식물 추출물을 산, 염기, 효소 또는 상기 효소를 생산하는 미생물을 이용하여 가수분해하는 단계를 포함하는 방법에 의해 제조될 수 있다.
본 발명에 따른 화장료용 조성물은 항산화, 항노화, 미백 또는 주름 개선용으로 적용될 수 있다.
에피메디움, 이카리틴, 이카리시드 I, 이카리시드 II, 이카린, 항산화, 미백, 주름 개선, 항노화, 화장료-
Patent Agency Ranking
公开(公告)号：KR100787879B1
公开(公告)日：2007-12-27
申请号：KR1020020010512
申请日：2002-02-27
Applicant: (주)아모레퍼시픽
IPC: C07D311/72
Abstract: 본 발명은 항산화 효과를 나타내는, 하기 화학식 1로 표시되는 신규 토코페롤 유도체 및 이의 제조방법, 이를 함유하는 화장료 조성물에 관한 것이다.
[화학식 1]
상기 식 중에서
R
1 , R
2 , R
3 는 H 또는 메틸기로서, 토코페롤의 상기 5, 7 또는 8번 위치에 적어도 하나 이상의 메틸기를 가지며, A는 CH
2 -CH(CH
3 )- 또는 CH=C(CH
3 )-이다.
R
4 는 CH
2 -CH
2 , CH=CH, CH
2 -CH
2 -CH
2 , CH
2 -CH(CH
3 )-CH
2 또는 CH
2 -C(CH
3 )
2 -CH
2 이다.
R
5 는 디에탄올 아민, 트리스 히드록시 아민 또는 N-메틸 글루카민이다.
토코페롤 유도체 * 토코페롤숙신산 * 토코페롤말레인산 * 토코페롤 글루타르산 * 염화토코페롤숙신산 * 염화토코페롤말레인산 * 염화토코페롤글루타르산 * 화장료 조성물 * 항산화-
47.发明授权엘라스테아제 저해 효과를 갖는 3,5-디히드록시벤조산유도체 화합물과 그 제조방법 및 이를 함유하는 항노화화장료 조성물 有权,5-라스테아제저해효과를갖갖갖는,5- ,5- 3 3 3 3 3 3 3 3 3 3 3 3
公开(公告)号：KR100726280B1
公开(公告)日：2007-06-11
申请号：KR1020060035603
申请日：2006-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C233/65 , C07C235/64
Abstract: Provided is a 3,5-dihydroxybenzoic acid derivative, which shows an elastase inhibitory effect and an excellent effect of scavenging free radicals generated by UV irradiation, has an excellent anti-aging effect, and is useful for an anti-aging cosmetic composition. The 3,5-dihydroxybenzoic acid derivative is a compound represented by a formula 1, substituted with hydroxyl groups at 3,5-position thereof and the amide group being substituted with a bulky substituent. The 3,5-dihydroxybenzoic acid derivative is obtained by the method comprising the steps of: (A) reacting 3,5-dihydroxybenzoic acid with acetic anhydride to form 3,5-diacetyloxybenzoic acid; (B) forming an amide compound from the 3,5-diacetyloxybenzoic acid by using ethyl chloroformate and an oleophilic group; and (C) hydrolyzing the acetyl group of the amide compound to provide a 3,5-dihydroxybenzoic acid derivative.
Abstract translation: 本发明提供一种3,5-二羟基苯甲酸衍生物，其显示出弹性蛋白酶抑制作用，并且通过UV照射产生的清除自由基的优异效果，具有优异的抗老化作用，并且可用于抗老化化妆品组合物。 3,5-二羟基苯甲酸衍生物是由式3表示的化合物，其3,5-位被羟基取代且酰胺基被大体积取代基取代。 3,5-二羟基苯甲酸衍生物通过包括以下步骤的方法获得：（A）使3,5-二羟基苯甲酸与乙酸酐反应形成3,5-二乙酰氧基苯甲酸; （B）通过使用氯甲酸乙酯和亲油基团由3,5-二乙酰氧基苯甲酸形成酰胺化合物; 和（C）水解酰胺化合物的乙酰基得到3,5-二羟基苯甲酸衍生物。
-
公开(公告)号：KR1020070013482A
公开(公告)日：2007-01-31
申请号：KR1020050067815
申请日：2005-07-26
Applicant: (주)아모레퍼시픽
IPC: C07D317/64
Abstract: Sesamol derivatives and a process for preparing the same compounds are provided to improve anti-oxidizing activity and stability of sesamol, recover the skin damaged by reactive oxygen species, prevent aging of biological membranes, and inhibit production of peroxides of unsaturated fatty acid and its derivatives. The sesamol derivatives represented by the formula(1) are provided, wherein the sesamol derivatives are prepared by reacting sesamol with adamantanol in an equivalence ratio of 1:1.0~1.3 under acid condition, and recrystallizing the resulting product in polar solvent; the acid is hydrochloric acid, nitric acid, sulfuric acid, p-toluenesulfonic acid, benzene sulfonic acid, acetic acid, trichloroacetic acid or trifluoroacetic acid; the solvent used in the reaction is dichloromethane, tetrahydrofuran, ethyl acetate, acetonitrile, chloroform, ethyl ether, trichloro ethylene, benzene or toluene; and the polar solvent is methanol, ethanol, isopropanol, acetone, acetonitrile or water.
Abstract translation: 提供了芝麻酚衍生物和制备相同化合物的方法，以提高芝麻素的抗氧化活性和稳定性，回收活性氧损伤的皮肤，防止生物膜老化，抑制不饱和脂肪酸及其衍生物过氧化物的产生 。 提供由式（1）表示的芝麻酚衍生物，其中芝麻酚衍生物通过在酸性条件下使芝麻酚与当量比为1：1.0〜1.3的金刚烷醇反应制备，并将所得产物在极性溶剂中重结晶; 酸是盐酸，硝酸，硫酸，对甲苯磺酸，苯磺酸，乙酸，三氯乙酸或三氟乙酸; 反应中使用的溶剂是二氯甲烷，四氢呋喃，乙酸乙酯，乙腈，氯仿，乙醚，三氯乙烯，苯或甲苯; 极性溶剂为甲醇，乙醇，异丙醇，丙酮，乙腈或水。
-
公开(公告)号：KR100643514B1
公开(公告)日：2006-11-23
申请号：KR1020050041060
申请日：2005-05-17
Applicant: (주)아모레퍼시픽
IPC: C07C233/64 , A61K8/368
Abstract: Provided are a hydroxybenzoic acid amide compound which suppresses the generation of melanin, its preparation method, and a whitening cosmetic composition containing the compound. The hydroxybenzoic acid amide compound is represented by the formula 1, wherein R1 and R2 are H or OH. The method comprises the steps of dissolving hydroxybenzoic acid in a solvent, adding a catalyst and a base drop by drop, and reacting it with acetic anhydride to prepare an acetylated compound represented by the formula II; dissolving the acetylated compound of the formula II in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare an amide compound represented by the formula III; and reacting the amine compound of the formula III with a base to hydrolyze it (See the reaction scheme 1), wherein R3 and R4 is H or an acetoxy group.
Abstract translation: 本发明提供抑制黑色素生成的羟基苯甲酸酰胺化合物及其制备方法和含有该化合物的美白化妆品组合物。 羟基苯甲酸酰胺化合物由式1表示，其中R 1和R 2是H或OH。 该方法包括以下步骤：将羟基苯甲酸溶解在溶剂中，逐滴加入催化剂和碱，并使其与乙酸酐反应以制备式II表示的乙酰化化合物; 将式II的乙酰化的化合物溶解在溶剂中并加入碱，氯甲酸乙酯和金刚烷胺以制备式III表示的酰胺化合物; 和使式III的胺化合物与碱反应以水解（参见反应方案1），其中R 3和R 4是H或乙酰氧基。
-
公开(公告)号：KR100636737B1
公开(公告)日：2006-10-20
申请号：KR1020050032607
申请日：2005-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C225/20
Abstract: Provided are a gallic acid adamantamine amide compound which inhibits the generation of melanin, a method for preparing the compound, and a cosmetic composition containing the compound. The gallic acid adamantamine amide compound is represented by the formula 1. The method comprises the steps of dissolving gallic acid in a solvent, adding a catalyst and a base to the solution drop by drop, and reacting it with acetic anhydride to prepare the acetylated compound represented by the formula II (See the reaction scheme 1); dissolving the acetylated compound in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare the amide compound represented by the formula III; and reacting the obtained amide compound with a base to hydrolyze it, thereby preparing the gallic acid adamantamine amide compound represented by the formula 1. Preferably the catalyst is dimethyl aminopyridine; and the base is triethylamine.
Abstract translation: 本发明提供抑制黑色素生成的没食子酸金刚胺酰胺化合物，其制备方法以及含有该化合物的化妆品组合物。 没食子酸金刚烷胺酰胺化合物由式1表示。该方法包括以下步骤：将没食子酸溶解在溶剂中，逐滴向溶液中加入催化剂和碱，并使其与乙酸酐反应以制备乙酰化的化合物 由式II表示（参见反应方案1）; 将乙酰化的化合物溶解在溶剂中，加入碱，氯甲酸乙酯和金刚烷胺制备式III所示的酰胺化合物; 并使所得酰胺化合物与碱反应以将其水解，从而制备式1代表的没食子酸金刚烷胺酰胺化合物。优选该催化剂是二甲基氨基吡啶; 碱是三乙胺。
-
-
-
-
-
-
-
-
-
Search Results
186
records
(took 0.032 seconds)
