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41.发明公开오수유 추출물 또는 이로부터 분리된 루타에카르핀 또는 리모시트린 3-루티노시드를 유효성분으로 함유하는 세포 노화 억제용 조성물 有权用于抑制包含EVODIA OFFICINALIS或RUTAECARPINE或LIMOCITRIN 3-O-抗坏血酸酯从其中分离的提取物的细胞感觉的组合物
公开(公告)号：KR1020150024607A
公开(公告)日：2015-03-09
申请号：KR1020130101711
申请日：2013-08-27
Applicant: 영남대학교 산학협력단
IPC: A61K36/754 , A61K31/519 , A61K31/7048 , A61P17/00
CPC classification number: A61K36/754 , A23L33/105 , A23V2200/302 , A23V2200/306 , A23V2200/308 , A61K8/97 , A61K2236/33 , A61Q19/08 , Y10S514/824 , Y10S514/844
Abstract: The present invention relates to a composition for inhibiting cellular senescence comprising extracts of Evodia officinalis or limocitrin 3-O-rutinoside isolated from the same as an active ingredient. More specifically, provided is a composition for inhibiting cellular senescence derived from Adriamycin. The composition can be used for treating diseases such as skin aging, rheumatic arthritis, ostarthritis, hepatitis, chronic skin injury, artery hardening, prostatic hyperplasia, liver cancer, etc by inhibiting cellular senescence of fibroblast or umbilical vein endothelial cell. Also, the composition can be utilized for developing antiaging functional foods, anti-vein aging drugs, and cosmetics which can inhibit cellular senescence.
Abstract translation: 本发明涉及一种用于抑制细胞衰老的组合物，其包含从其分离自作为活性成分的伊曲他丹或五味噌啉3-O-芸香苷的提取物。 更具体地，提供了用于抑制源自阿霉素的细胞衰老的组合物。 该组合物可用于通过抑制成纤维细胞或脐静脉内皮细胞的细胞衰老来治疗皮肤老化，风湿性关节炎，骨关节炎，肝炎，慢性皮肤损伤，动脉硬化，前列腺增生，肝癌等疾病。 此外，该组合物可用于开发可抑制细胞衰老的抗衰老功能食品，抗静脉老化药物和化妆品。
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公开(公告)号：KR1020150024605A
公开(公告)日：2015-03-09
申请号：KR1020130101709
申请日：2013-08-27
Applicant: 영남대학교 산학협력단
CPC classification number: A61K36/36 , A23L33/105 , A23V2200/302 , A23V2200/306 , A23V2200/308 , A61K8/97 , A61K2236/33 , A61Q19/08 , Y10S514/824 , Y10S514/844
Abstract: 본 발명은 장구채 추출물 또는 이로부터 분리된 (-)-보르네시톨((-)-bornesitol)을 유효성분으로 함유하는 세포 노화 억제용 조성물에 관한 것으로, 아드리아마이신에 의해 유도되는 것을 특징으로 하는 세포 노화 억제용 약학 조성물을 제공한다. 이렇게 섬유아세포 또는 제대정맥혈관내피세포의 세포노화 과정을 억제함으로써 노화관련 질환, 예를 들어 피부노화, 류마티스성 관절염, 골관절염, 간염, 만성 피부손상 조직, 동맥경화, 전립샘 증식증 및 간암 등과 같은 질환 치료에 유용하게 사용될 수 있다. 또한 세포노화를 저해할 수 있는 항노화 기능성 식품, 항혈관노화 약물 개발, 화장품 개발에 활용될 수 있을 것으로 기대된다.
Abstract translation: 本发明涉及一种用于抑制细胞衰老的组合物，其包含从其相同的活性成分中分离出的Melandrium firmum Rohrbach或（ - ） - 甘露糖醇的提取物。 更具体地，提供了用于抑制源自阿霉素的细胞衰老的组合物。 该组合物可用于通过抑制成纤维细胞或脐静脉内皮细胞的细胞衰老来治疗皮肤老化，风湿性关节炎，骨关节炎，肝炎，慢性皮肤损伤，动脉硬化，前列腺增生，肝癌等疾病。 此外，该组合物可用于开发可抑制细胞衰老的抗衰老功能食品，抗静脉老化药物和化妆品。
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公开(公告)号：KR1020140112636A
公开(公告)日：2014-09-24
申请号：KR1020130026226
申请日：2013-03-12
Applicant: 영남대학교 산학협력단
IPC: A61K36/28 , A61K31/343 , A61P19/02 , A61P17/00
CPC classification number: A61K36/28 , A61K31/343 , Y10S514/825
Abstract: The present invention relates to a pharmaceutical composition for inhibiting the aging of fibroblasts, containing, as an active ingredient, an Inula japonica thunberg extract, britanin isolated therefrom, or a mixture thereof, and provides a pharmaceutical composition induced by Adriamycin for inhibiting the aging of fibroblasts. As such, the composition of the present invention can be useful to treat diseases, such as age-related diseases including skin aging, rheumatoid arthritis, osteoarthritis, hepatitis, chronic skin tissue damage, arteriosclerosis, prostatic hyperplasia, and liver cancer, by inhibiting the cell aging process of human fibroblasts. Further, the composition of the present invention is expected to be used for the development of functional anti-aging food, a vessel anti-aging drug, and cosmetics, which can inhibit cell aging.
Abstract translation: 本发明涉及一种用于抑制成纤维细胞衰老的药物组合物，其含有作为活性成分的日本粳稻提取物，从其中分离出的丝氨酸蛋白酶或其混合物，并提供由阿霉素诱导的用于抑制老化的药物组合物 成纤维细胞。 因此，本发明的组合物可用于治疗诸如年龄相关疾病，包括皮肤老化，类风湿性关节炎，骨关节炎，肝炎，慢性皮肤组织损伤，动脉硬化，前列腺增生和肝癌等疾病，通过抑制 人成纤维细胞的细胞衰老过程。 此外，本发明的组合物预期用于开发可抑制细胞衰老的功能性抗衰老食品，血管抗衰老药物和化妆品。
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44.发明公开선복화 추출물 또는 이로부터 분리된 퀘르세타제틴 3,4''-디메틸 에테르를 유효성분으로 함유하는 세포 노화 억제용 조성물 有权用于抑制包含A ICA TH ING ING ING ING ING ING TING TING TING TING TING TING AME AME AME AME AME AME AME AME AME AME AME AME AME AME AME AME AME AME AME AME AME
公开(公告)号：KR1020140111830A
公开(公告)日：2014-09-22
申请号：KR1020130026225
申请日：2013-03-12
Applicant: 영남대학교 산학협력단
IPC: A61K36/28 , A61K31/352 , A61K31/35 , A61P17/00
CPC classification number: A61K36/28 , A23L33/105 , A23V2200/302 , A23V2200/306 , A23V2200/308 , A61K8/97 , A61K2236/33 , A61Q19/08 , Y10S514/824 , Y10S514/844
Abstract: The present invention relates to a pharmaceutical composition for inhibiting the aging of umbilical vein endothelial cells, containing, as an active ingredient, an Inula japonica thunberg extract or quercetagetin 3,4′-dimethyl ether isolated therefrom and represented by chemical formula 1, and provides a pharmaceutical composition for inhibiting the aging of umbilical vein endothelial cells induced by Adriamycin. As such, the composition of the present invention can be useful to treat diseases, such as age-related diseases including skin aging, rheumatoid arthritis, osteoarthritis, hepatitis, chronic skin tissue damage, arteriosclerosis, prostatic hyperplasia, and liver cancer, by inhibiting the cell aging process of human umbilical vein endothelial cells. Further, the composition of the present invention is expected to be used for the development of a functional anti-aging food, a vessel anti-aging drug, and cosmetics, which can inhibit cell aging.
Abstract translation: 本发明涉及一种用于抑制脐静脉内皮细胞老化的药物组合物，其含有由化学式1分离并由其分离的ula粳提取物或槲皮素3,4'-二甲醚作为活性成分，并提供 用于抑制阿霉素诱导的脐静脉内皮细胞老化的药物组合物。 因此，本发明的组合物可用于治疗诸如年龄相关疾病，包括皮肤老化，类风湿性关节炎，骨关节炎，肝炎，慢性皮肤组织损伤，动脉硬化，前列腺增生和肝癌等疾病，通过抑制 人脐静脉内皮细胞的细胞衰老过程。 此外，本发明的组合物预期用于开发可抑制细胞衰老的功能性抗衰老食品，血管抗衰老药物和化妆品。
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公开(公告)号：KR101062616B1
公开(公告)日：2011-09-05
申请号：KR1020090098670
申请日：2009-10-16
Applicant: 영남대학교 산학협력단
IPC: A61K31/56 , A61K36/185 , A61P39/06 , A23L1/30
Abstract: 본 발명은 유근피(
Salicis radicis cortex)로부터 분리한 테르펜계 화합물 또는 카테킨 글리코사이드계 화합물 중 하나 또는 둘 이상의 화합물을 유효성분으로 함유하는 노화 억제용 약학조성물에 관한 것으로, 특히 에피프리에델라놀 (epifriedelanol)은 아드리아마이신에 의한 세포노화를 억제하고, 이러한 세포노화 과정에서 발현이 증가하는 p53 단백질 발현을 억제함으로써 노화 관련 질환, 예를들어 피부노화, 류마티스성 관절염, 골관절염, 간염, 만성 피부손상 조직, 동맥경화, 전립샘 증식증 및 간암 등과 같은 질환 치료에 유용하게 사용될 수 있다.
유근피, 에피프리에델라놀, 아드리아마이신, 노화-
Patent Agency Ranking46.发明公开
公开(公告)号：KR1020100121904A
公开(公告)日：2010-11-19
申请号：KR1020090040826
申请日：2009-05-11
Applicant: 영남대학교 산학협력단
Abstract: PURPOSE: A biomarker for diagnosing metabolic syndrome using a parameter of serum or lipoprotein fraction is provided to predict or diagnose metabolic syndrome occurrence. CONSTITUTION: A method for diagnosing metabolic syndrome comprises: a step of preparing serum sample; a step of isolating lipoprotein from the serum sample; and a step of evaluating isolated lipoprotein fraction. The parameter of serum is serum cholesterol concentration, serum triglyceride(TG) concentration, serum uric concentration or serum apoA-I concentration. A biomarker for diagnosing metabolic syndrome is used by the serum parameter or lipoprotein HDL fraction parameter.
Abstract translation: 目的：提供使用血清或脂蛋白分数参数诊断代谢综合征的生物标志物，以预测或诊断代谢综合征发生。 构成：诊断代谢综合征的方法包括：制备血清样品的步骤; 从血清样品中分离脂蛋白的步骤; 和评估分离的脂蛋白部分的步骤。 血清参数为血清胆固醇浓度，血清甘油三酯（TG）浓度，血清尿酸浓度或血清apoA-I浓度。 用于诊断代谢综合征的生物标志物由血清参数或脂蛋白HDL级分参数使用。
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公开(公告)号：KR1020100103174A
公开(公告)日：2010-09-27
申请号：KR1020090021652
申请日：2009-03-13
Applicant: 영남대학교 산학협력단
IPC: C07C69/675 , C07C69/34 , A61P9/10 , A61P3/10
CPC classification number: C07C69/675 , C07C69/34
Abstract: PURPOSE: Functional lipid is provided to prevent the defects of cooking oil or functional oil, to prevent or cure chronic metabolic disease, and to apply the lipid for cosmetics. CONSTITUTION: Functional lipid is marked with chemical formula 1. The first location of monoacylglycerol is combined with fatty acid. In the chemical formula 1, R is oleic acid, palmitic acid, or stearic acid. An anti-arteriosclerosis composition or an antidiabetic composition contains the functional lipid as an active ingredient.
Abstract translation: 目的：提供功能性脂质，以防止烹饪油或功能性油的缺陷，预防或治疗慢性代谢疾病，并将化学物质应用于脂质。 构成：功能性脂质用化学式1表示。单酰基甘油的第一个位置与脂肪酸结合。 在化学式1中，R是油酸，棕榈酸或硬脂酸。 抗动脉硬化组合物或抗糖尿病组合物含有功能性脂质作为活性成分。
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49.发明授权
公开(公告)号：KR101834615B1
公开(公告)日：2018-03-07
申请号：KR1020150093429
申请日：2015-06-30
Applicant: 영남대학교 산학협력단
IPC: G01N33/68 , A61K39/395 , A23L1/305
Abstract: 본발명은 CD9에특이적으로결합하는항체를유효성분으로함유하는세포노화또는노화관련질환예방또는치료용약학조성물에관한것으로, 보다상세하게는 CD9 특이적항체는세포표면에노출되어있는 CD9 항원의세포외영역과특이적으로결합함으로써, 노화된세포에서 CD9의발현을감소시켜세포노화를억제하고, 노화와관련된혈관질환인죽상경화병변을감소시키는효과를나타내었다. 따라서, 본발명의 CD9은세포노화또는노화관련질환의바이오마커조성물로사용될수 있으며, CD9 특이적항체를유효성분으로함유하는조성물을세포노화를억제또는노화관련질환을예방하거나치료할수 있는약학조성물또는건강식품조성물로유용하게사용할수 있다.
Abstract translation: 本发明涉及一种细胞衰老或衰老相关的疾病的预防或治疗，其包含结合到CD9 eteuk转移作为活性成分，并且其在细胞表面上CD9暴露CD9抗原的更具体的特异性抗体的抗体的药物组合物 通过与细胞外区域特异性结合，老化细胞中CD9的表达减少，由此抑制细胞衰老并减少动脉粥样硬化病变（与衰老相关的血管疾病）。 因此，本发明的CD9可以与细胞衰老或生物标志物，与年龄有关的疾病的组合物中使用，CD9特异性抗体的组合物中的细胞，其可以预防或治疗抑制老化或与年龄有关的疾病，含有作为活性成分的药物组合物 或作为保健食品组合物。
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公开(公告)号：KR1020170115321A
公开(公告)日：2017-10-17
申请号：KR1020160042824
申请日：2016-04-07
Applicant: 영남대학교 산학협력단
IPC: G03F7/00
Abstract: 본발명은유체의입출이이루어지는관통공이챔버의일측편으로편심형성되는챔버의형상에의해세포의이동이없는데드스페이스가발생하지않고, 미세채널에인접하는챔버들의내측모서리가 R값을갖지않고직각으로형성하여, 챔버와채널간의경계선상에그림자가발생하지않는실리콘마이크로칩및 그제조방법을제공한다.
Abstract translation: 本发明是通过包括具有相邻的，而不会造成死空间的室的内边缘的一个的R值的球的流体的出纳员，没有细胞，微通道通过其中在所述腔室的一方的侧板形成有偏心的腔室的形状的移动 并且在腔室和通道之间的边界线上不产生阴影，以及制造该阴影的方法。
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