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公开(公告)号：KR100842012B1
公开(公告)日：2008-06-27
申请号：KR1020060088257
申请日：2006-09-12
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 나이벡
IPC: A61F2/28
CPC classification number: A61L27/365 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/4649 , A61L27/3608 , A61L27/3683 , A61L27/54 , A61L2300/102 , A61L2300/112 , A61L2300/402 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2430/02
Abstract: 본 발명은 말뼈를 이용한 골이식재의 제조 방법에 관한 것으로, 더욱 자세하게는 말뼈를 차아염소산나트륨으로 처리, 121℃ 이상의 가압수열처리 및 500℃ 이상의 고온에서 열처리하여 제조하는 방법으로, 기존의 이종골 이식에 많이 사용되었던 소뼈를 사용할 시에 우려되었던 광우병 감염의 위험이 없으며, 이종간의 면역반응을 일으키지 않는 안전한 골이식재를 제조하는 방법에 관한 것이다.
본 발명에 따르면, 사람의 뼈와 그 구조가 매우 유사한 말의 뼈에서 지방질과 유기질을 효과적으로 제거하여 인체에 이식하였을 때 면역반응을 일으키지 않으며, 광우병의 원인인 변성 프라이온 프로테인 등 유기질의 병원성 물질의 감염위험이 없는 골이식재를 간단한 방법으로 제조할 수 있다.
골이식재, 말뼈, 차아염소산나트륨, 이종골이식, Bone Grafting Substitute-
公开(公告)号：KR1020140102514A
公开(公告)日：2014-08-22
申请号：KR1020130015954
申请日：2013-02-14
Applicant: 주식회사 나이벡
Abstract: The present invention relates to a bioactive peptide self-assembled gel-type scaffold and a method for manufacturing the same and, more specifically, to a gel-type scaffold in which bioactive peptide is self-assembled to differentiate a mesenchymal stem cell into a bone tissue and to a method for manufacturing the scaffold. The scaffold according to the present invention can be coated on the surface of various medical devices like an implant, and can be applied by being mixed with a particulate bone grafting material to improve the therapeutic effect of an existing medical device not only in dental field, but also for repairing bone tissues of a tumor patient, and even in an orthopedic and plastic surgical field to have an effect of maximizing tissue regeneration.
Abstract translation: 本发明涉及生物活性肽自组装凝胶型支架及其制造方法，更具体地说，涉及一种凝胶型支架，其中生物活性肽被自组装以将间充质干细胞分化为骨 组织和制造支架的方法。 根据本发明的支架可以涂覆在诸如植入物的各种医疗装置的表面上，并且可以通过与颗粒状骨移植材料混合来应用，以改善现有医疗装置的治疗效果，不仅在牙科领域， 而且还用于修复肿瘤患者的骨组织，甚至在整形外科手术领域中具有使组织再生最大化的作用。
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公开(公告)号：KR1020140039347A
公开(公告)日：2014-04-02
申请号：KR1020120103620
申请日：2012-09-18
Applicant: 서울대학교산학협력단 , 주식회사 나이벡
IPC: C07K14/435 , A61K49/14 , A61K47/48 , A61P35/00
CPC classification number: A61K47/64 , A61K31/704 , A61K38/00 , A61K49/0056 , C07K7/08 , C07K14/47 , C07K2319/10 , C12Q1/26 , C12Q1/58 , C12Q1/66 , C12Y301/13 , G01N33/574 , C07K14/435 , A61K47/50 , A61K49/14
Abstract: The present invention relates to a peptide having a tumor selective permeability and a use thereof, and more specifically, to a VPTD (VEGF binding protein transduction domain) peptide selectively combining with a heparin and VEGF specifically overly distributed in a tumor cell or a tumor tissue, and represented by sequence number one, or a HPTD (Heparin binding protein transduction domain) peptide represented by sequence number two; and a complex combining a drug with the peptide. The tumor permeability peptide and the tumor permeability peptide-drug complex according to the present invention selectively combine with a tumor cell or a tumor tissue and are accumulated to be used for an accurate diagnosis and treatment of cancer, as preventing an aspecific distribution of the administered peptide or the complex in a body, at the same time, to minimize side effects occurred in the body, and therefore, are useful in the diagnosis and treatment of cancer.
Abstract translation: 本发明涉及具有肿瘤选择性渗透性的肽及其用途，更具体地，涉及与特异性过度分布在肿瘤细胞或肿瘤组织中的肝素和VEGF选择性结合的VPTD（VEGF结合蛋白转导结构域） ，由序列号1表示，或以序列号2表示的HPTD（肝素结合蛋白转导结构域）肽; 以及将药物与肽组合的复合物。 根据本发明的肿瘤渗透性肽和肿瘤渗透性肽 - 药物复合物选择性地与肿瘤细胞或肿瘤组织结合，并且被累积以用于癌症的准确诊断和治疗，因为防止施用的特异性分布 肽或复合物在体内，同时减少身体发生的副作用，因此可用于诊断和治疗癌症。
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公开(公告)号：KR1020110137235A
公开(公告)日：2011-12-22
申请号：KR1020100118184
申请日：2010-11-25
Applicant: 주식회사 나이벡
CPC classification number: C07K14/4723 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/17 , A61K38/1729 , A61K38/18 , A61K38/1808 , A61K38/1858
Abstract: PURPOSE: A peptide and a pharmaceutical composition containing the same are provided to treat atopic dermatitis, psoriasis, and arthritis. CONSTITUTION: A human beta-defensin-2-derived peptide with antibacterial or anti-inflammatory activity contains an amino acid sequence of sequence number 1. An antibacterial composition contains the peptides as an active ingredient. A composition for treating inflammation contains the peptides as an active ingredient. The inflammation includes psoriasis, arthritis, allergy, asteoarthritis, rhinitis, tympanitis, sore throat, tonsillitis, cystitis or nephritis.
Abstract translation: 目的：提供一种肽和含有该组合物的药物组合物以治疗特应性皮炎，牛皮癣和关节炎。 构成：具有抗菌或抗炎活性的人β-防御素-2衍生肽含有序列号1的氨基酸序列。抗菌组合物含有肽作为活性成分。 用于治疗炎症的组合物含有肽作为活性成分。 炎症包括牛皮癣，关节炎，过敏，骨关节炎，鼻炎，鼓膜炎，喉咙痛，扁桃体炎，膀胱炎或肾炎。
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公开(公告)号：KR1020100039750A
公开(公告)日：2010-04-16
申请号：KR1020080098832
申请日：2008-10-08
Applicant: 서울대학교산학협력단 , 주식회사 나이벡
CPC classification number: A61K6/08 , A61K6/0017 , C08L71/02 , C08L1/08 , C08L29/04 , C08L35/08 , C08L39/06
Abstract: PURPOSE: A composition for preventing hemodia is provided to maintain use of treating agent for hemodia and to quickly prevent hemodia. CONSTITUTION: A composition for preventing hemodia contains 100 weight parts of adhesive polymer for coating teeth, 2-3 weight parts of activating material for preventing hemodia, 2-10 weight parts of material for promoting filtration of the active material, 4-10 weight parts of activating material for relieving sensitive nerve, and 2-3 weight parts of pH adjusting agent. The activating material for preventing hemodia is potassium nitrate, stannous fluoride(SnF2), sodium monofluoride phosphate(MFP), sodium fluoride(NaF), sodium silicofluoride(Na2SiF6), potassium oxalete(K2C2O4), or strontium chloride(SrCl2). The material promoting infiltration of the activating material is a peptide of 80-90% of alginine.
Abstract translation: 目的：提供用于预防血液透析的组合物，以维持血液透析治疗剂的使用并快速预防血液透析。 构成：用于预防血液透析的组合物含有100重量份用于涂覆牙齿的粘合剂聚合物，2-3重量份用于防止血液透析的活化材料，2-10重量份用于促进活性物质过滤的材料，4-10重量份 用于缓解敏感神经的活化材料和2-3重量份的pH调节剂。 用于预防血液透析的活化材料是硝酸钾，氟化亚锡（SnF 2），单氟磷酸钠（MFP），氟化钠（NaF），氟化硅钠（Na 2 SiF 6），草酸钾（K 2 C 2 O 4）或氯化锶（SrCl 2）。 促进活化材料渗透的物质是80-90％的精氨酸的肽。
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Patent Agency Ranking
公开(公告)号：KR102210543B1
公开(公告)日：2021-02-01
申请号：KR1020180122816
申请日：2018-10-15
Applicant: 주식회사 나이벡 , 충북대학교 산학협력단 , 서울대학교산학협력단
IPC: G01N33/569 , G01N33/68
Abstract: 본발명은고효율줄기세포선별을위한 GRP78 유래펩타이드및 그이용에관한것으로, 보다자세하게는세포표면의 GRP78 단백질의결합부위 (binding domain)에결합할수 있는 GRP78 유래펩타이드를표지자로활용하여고효율의줄기세포선별에관한것이다. 본발명에따른 GRP78의아미노산서열중, 고효율의줄기세포를인식할수 있는특정아미노산서열을포함하는 GRP78 유래펩타이드는노화되지않은고효율의줄기세포만을선별하는것이가능하다. 또한, GRP78 유래펩타이드를줄기세포에처리또는도입하면줄기세포의효율을증진시킬수 있으므로, 치료효능이우수한줄기세포치료제제조에유용하다.
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公开(公告)号：KR102129380B1
公开(公告)日：2020-07-02
申请号：KR1020180122736
申请日：2018-10-15
Applicant: 주식회사 나이벡 , 충북대학교 산학협력단 , 서울대학교산학협력단
IPC: G01N33/569 , G01N33/68 , C12Q1/6881
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公开(公告)号：KR101693533B1
公开(公告)日：2017-01-06
申请号：KR1020150042700
申请日：2015-03-26
Applicant: 서울대학교산학협력단 , 주식회사 나이벡
Abstract: 본발명은종양조직내에존재하는암 줄기세포의증식억제및 세포사멸을유도하는펩타이드를포함하는항종양조성물에관한것으로, 보다상세하게는종양내에존재하는암줄기세포에특이적으로과발현되어있는 NF-κB의활성을저해하는항암기능성펩타이드에관한것이다. 본발명에따른암줄기세포증식억제및 세포사멸유도용펩타이드는암줄기세포내 NF-κB 단백질의핵 내이동을저해하여암줄기세포의성장억제및 세포사멸을유도할수 있으므로, 항암치료용조성물로유용하게사용될수 있다.
Abstract translation: 本发明涉及包含抑制肿瘤组织中存在的癌干细胞增殖并诱导这种癌干细胞凋亡的肽的抗癌成分，更具体地，涉及抑制NF-κB活性的抗癌肽， 特异性地在肿瘤中存在的癌干细胞中过度表达。
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公开(公告)号：KR1020160119580A
公开(公告)日：2016-10-14
申请号：KR1020150048441
申请日：2015-04-06
Applicant: 서울대학교산학협력단 , 주식회사 나이벡
CPC classification number: A61L27/04 , A61L27/00 , A61L27/306 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2430/02 , A61L2430/12 , C07K7/00 , C07K7/08 , C07K19/00 , C07K2319/00 , C07K2319/20
Abstract: 본발명은지르코니아무기질표면에특이적으로결합하는펩타이드에관한것으로, 더욱상세하게는상기펩타이드에기능성약물을추가도입하여지르코니아표면에안정하게고정시켜약물의활성을장기간유지시키도록하는연결펩타이드에관한것이다. 본발명에따른지르코니아에결합하는펩타이드는지르코니아표면에안정적으로고정됨으로써, 상기펩타이드에도입된생리활성물질의활성을지르코니아표면에서안정하게장기간동안유지시킬수 있으므로, 이를이용한외과적재생치료에유용하다.
Abstract translation: 本发明涉及特异性地结合到氧化锆无机表面，并且更具体地涉及一种连接肽，以氧化锆稳定地固定化的表面的很长一段时间维持药物的另外的活性引入的功能性物质与肽的肽 会的。 的是，根据本发明结合到氧化锆的肽被稳定地固定在氧化锆表面上，以稳定的生理活性物质的活性，在氧化锆表面的肽被引入，所以sikilsu保持使用相同的很长一段时间，可用于外科再生治疗。
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公开(公告)号：KR1020130067239A
公开(公告)日：2013-06-21
申请号：KR1020120145576
申请日：2012-12-13
Applicant: 주식회사 나이벡
CPC classification number: G01N33/54306 , C07K1/047 , G01N33/54313 , G01N33/6845 , G01N2500/20
Abstract: PURPOSE: A method for discovering a physiologically active peptide is provided to quickly identify a peptide containing 20 or more amino acids, and to develop a medicinal product and a medical device by searching the physiologically active peptide which is attached to a certain biomaterial and regenerates a tissue. CONSTITUTION: A method for discovering a physiologically active peptide comprises: a step of adding bead resin to each well of a well plate, synthesizing a peptide containing a protein fragment with physiological activity onto the surface of a bead to prepare a physiologically active peptide library; and a step of sorting a peptide with physiological activity in the peptide library using an antibody or a quenching dye and a fluorescent material. The antibody is conjugated with phosphatase or peroxidase. [Reference numerals] (1) Establish a peptide library; (2) Screen peptide; (3) Verify the effectiveness of the peptide; (4) Mass-produce the peptide (Develop a target functionalized peptide medicine); (AA) Natural protein; (BB) Natural protein; (CC) Peptide library; (DD) Become database (The database is always updated and can be variously used for any peptide screening); (EE) Synthesize peptide by a non-natural method; (FF) Selectively combine reactant and the peptide; (GG) Select peptide by fluorescent and color expression; (HH) Separate and confirm the peptide; (II) Separate the peptide and confirm sequences; (JJ) Verify effectiveness to a cell and animal experiment model; (KK) Mass-produce the peptide by non-natural synthesis method
Abstract translation: 目的：提供一种用于发现生理活性肽的方法，用于快速鉴定含有20个或更多个氨基酸的肽，并通过搜索附着于某种生物材料的生理活性肽并再生一种生物活性肽来开发药用产品和医疗器械 组织。 构成：用于发现生理活性肽的方法包括：向孔板的每个孔中加入珠粒树脂的步骤，将含有具有生理活性的蛋白质片段的肽合成到珠粒表面上以制备生理活性肽文库; 以及使用抗体或淬灭染料和荧光材料在肽文库中分选具有生理活性的肽的步骤。 抗体与磷酸酶或过氧化物酶缀合。 （附图标记）（1）建立肽文库; （2）筛选肽; （3）验证肽的有效性; （4）大量生产肽（开发靶功能化肽药）; （AA）天然蛋白; （BB）天然蛋白; （CC）肽库; （DD）成为数据库（数据库总是更新，可以多种多样地用于任何肽筛选）; （EE）通过非天然方法合成肽; （FF）选择性地组合反应物和肽; （GG）通过荧光和颜色表达选择肽; （HH）分离并确认肽; （II）分离肽并确认序列; （JJ）验证细胞和动物实验模型的有效性; （KK）通过非天然合成法大量生产肽
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