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公开(公告)号：KR1020180025536A
公开(公告)日：2018-03-09
申请号：KR1020160112312
申请日：2016-09-01
Applicant: 충남대학교산학협력단 , 한국교통대학교산학협력단
IPC: C01B21/064 , B82Y20/00 , B82Y15/00
CPC classification number: C01B21/0648 , B82Y15/00 , B82Y20/00 , C01P2004/20
Abstract: 본발명은육방정질화붕소나노시트및 이의제조방법에관한것으로, 보다상세하게는형광성을이용하여생체분자탐지하기위한육방정질화붕소나노시트의대규모의박리화및 기능화를최적화한제조방법에관한것이다. 본발명에따르면, hBN으로부터 hBN-OH 나노시트를만들기위한편리한공정을최적화하였으며, 대량생산에도유리한효과가있다. 또한 hBN-OH 나노시트는푸른형광방출(blue emission)을보이기때문에세포를이미징할수 있고전기화학분석을통해생체분자를탐지하는데사용될수 있다.
Abstract translation: 本发明是六方氮化硼纳米片，并涉及其制造方法，更具体地涉及一种用于制备用于优化大规模分离筛制备，与六方晶系氮化硼纳米片的官能化通过荧光检测生物分子 会的。 根据本发明，优化是从六方氮化硼，在大规模生产具有有利的影响制备的hBN-OH纳米片的便利方法。 也可以图像，因为六方氮化硼-OH纳米片的细胞是示出蓝色荧光发射（蓝色发光），可用于通过电化学分析以检测生物分子。
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Patent Agency Ranking
公开(公告)号：KR101764746B1
公开(公告)日：2017-08-04
申请号：KR1020160040033
申请日：2016-04-01
Applicant: 충남대학교산학협력단
CPC classification number: C08L5/08 , C08J3/075 , C08J2205/022 , C08L71/02
Abstract: 본발명은폴록사머기반의하이드로젤시스템이갖는문제점을보완하여물성과안정성을강화한하이드로젤형성용조성물에관한것이다. 본발명에따르면, 물리적인가교구조로이루어지는마이셀패킹으로인해다량의물이있는환경에서쉽게분해되어기계적물성이저하되는폴록사머의문제점이글리콜키토산유도체첨가에의해현저히개선될수 있다. 따라서이렇게물성이강화된하이드로젤형성용조성물은생체주입형시스템으로이용시체내에서머무르는시간이길어져생체재료로써응용범위가넓어질수 있다.
Abstract translation: 本发明涉及用于水凝胶形成的组合物，其通过补充基于泊洛沙姆的水凝胶体系的问题来改善物理性质和稳定性。 根据本发明，所述泊洛沙姆是由于物理问题胶束填料制成两两分区容易分解，其中大量的水环境中的机械特性劣化可以通过添加乙二醇脱乙酰壳多糖衍生物的显着提高。 因此，由此增强的水凝胶组合物的用于形成但也可以是更广泛的应用作为生物材料的物理性质是留在所述驱动体在体内注射模具系统变得更长的时间。
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公开(公告)号：KR1020130103948A
公开(公告)日：2013-09-25
申请号：KR1020120024997
申请日：2012-03-12
Applicant: 충남대학교산학협력단
CPC classification number: A61K9/5192 , A61K9/513 , A61K31/41
Abstract: PURPOSE: A solid nanodispersion of pranlukast is provided to improve solubility, to prevent recrystallization after the solid nanodispersion is redispersed in a solvent, and to increase initial dissolution rate, thereby showing equal or better effects using a small amount of pranlukast. CONSTITUTION: A method for preparing a solid nanodispersion of pranlukast comprises the steps of: uniformly mixing 1g of pranlukast, 0.5-2.0 g of a soluble polymer, and 0.1-3 g of a poloxamer surfactant; fusing and primarily drying the mixture to obtain a primary dry material; dissolving the primary dry material in a solvent and removing the solvent to obtain a secondary dry material; and redissolving and spray-drying the secondary dry material.
Abstract translation: 目的：提供普兰司特的固体纳米分散体，以改善溶解性，防止固体纳米分散体再分散在溶剂中后的再结晶，并提高初始溶解速率，从而使用少量的普鲁卡斯特显示相同或更好的效果。 构成：制备普鲁司特固体纳米分散体的方法包括以下步骤：将1g普罗司特，0.5-2.0g可溶性聚合物和0.1-3g泊洛沙姆表面活性剂均匀混合; 熔融并主要干燥混合物以获得初级干燥材料; 将初级干物质溶解在溶剂中并除去溶剂以获得第二干料; 并再次溶解和喷雾干燥二次干燥材料。
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公开(公告)号：KR101262056B1
公开(公告)日：2013-05-08
申请号：KR1020100083967
申请日：2010-08-30
Applicant: 충남대학교산학협력단
CPC classification number: C08B37/003 , A61K47/36 , C08L5/08
Abstract: 본발명은글리콜키토산유도체, 이의제조방법및 이를포함하는약물전달체에관한것으로, 보다상세하게는나노크기의자기집합체를형성할수 있고, 온도감응성과생분해성을동시에가져약물전달체로사용되기에적합한특성을갖는글리콜키토산유도체, 이의제조방법및 이를포함하는약물전달체에관한것이다.
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公开(公告)号：KR1020110095445A
公开(公告)日：2011-08-25
申请号：KR1020100014915
申请日：2010-02-19
Applicant: 충남대학교산학협력단
CPC classification number: A61K47/32 , A61K9/06 , A61K2121/00
Abstract: PURPOSE: A method for manufacturing pH-sensitive hydrogel is provided to use the hydrogel as a drug carrier which is disintegrated and released in the small intestine and large intestine. CONSTITUTION: A method for manufacturing pH-sensitive hydrogel comprises: a step of adding polymeric hydrogel and sodium compounds to a reaction solvent and stirring to prepare a porous hydrogel; a step of swelling the porous hydrogel; and a step of coating the porous hydrogel with a intestine-targeting coating solution. The polymeric hydrogel is glycol chitosan-glycidyl (meth)acrylate hydrogel. The coating solution is methacrylic acid copolymers, shellac, cellulose acetate phthalate, polyvinyl acetate phthalate, or hydroxypropyl methylcellulose phthalate. A drug delivery system contains the pH-sensitive hydrogel as an drug carrier.
Abstract translation: 目的：提供一种制造pH敏感性水凝胶的方法，使用水凝胶作为药物载体，其在小肠和大肠中分解释放。 构成：用于制造pH敏感性水凝胶的方法包括：将聚合物水凝胶和钠化合物加入到反应溶剂中并搅拌以制备多孔水凝胶的步骤; 膨胀多孔水凝胶的步骤; 以及用肠对向涂层溶液涂覆多孔水凝胶的步骤。 聚合物水凝胶是乙二醇壳聚糖 - （甲基）丙烯酸缩水甘油酯水凝胶。 涂布溶液是甲基丙烯酸共聚物，虫胶，邻苯二甲酸乙酸纤维素，聚醋酸乙烯邻苯二甲酸酯，或羟丙基甲基纤维素邻苯二甲酸酯。 药物递送系统含有pH敏感的水凝胶作为药物载体。
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公开(公告)号：KR1020100082937A
公开(公告)日：2010-07-21
申请号：KR1020090002236
申请日：2009-01-12
Applicant: 충남대학교산학협력단
Abstract: PURPOSE: A surface modifying method of a polyacrylonitrile hollow fiber membrane is provided to prevent degradation of filtering performance for a long time and to improve good water separation performance. CONSTITUTION: A surface modifying method of a polyacrylonitrile hollow fiber membrane includes the following steps: processing atmospheric pressure plasma after mounting the polyacrylonitrile hollow fiber membrane to a reactor; reacting the hollow fiber membrane with oxygen gas; reacting mixed gas of inert gas and florin with the hollow fiber membrane; and modifying the surface of the polyacrylonitrile hollow fiber membrane to hydrophilic property. An atmospheric pressure plasma process is performed for 10 ~ 100 seconds.
Abstract translation: 目的：提供聚丙烯腈中空纤维膜的表面改性方法，以防止长时间的过滤性能下降，提高良好的水分离性能。 构成：聚丙烯腈中空纤维膜的表面改性方法包括以下步骤：在将聚丙烯腈中空纤维膜安装到反应器之后处理大气压等离子体; 中空纤维膜与氧气反应; 使惰性气体和氟里芬的混合气体与中空纤维膜反应; 并将聚丙烯腈中空纤维膜的表面改性为亲水性。 进行大气压等离子体处理10〜100秒。
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