Abstract:
본 발명은 피오글리타존을 이용한 F-18 FDG 양전자방출단층촬영에서 악성 종양과 염증 병변을 구분하여 악성 종양을 선택적으로 진단하는 방법에 관한 것으로, 상세하게는 F-18 FDG 양전자방출단층촬영에서 피오글리타존을 처리한 경우 피오글리타존을 처리하지 않은 경우에 비해 악성 종양 병변에서만 F-18 FDG의 섭취량을 증가시키고, 염증 병변에서는 F-18 FDG의 섭취량을 약간 증가시키거나 감소시킴으로써, 양전자방출단층촬영 영상 진단 시 악성 종양과 염증을 구분하여 악성 종양 병변만 선택적으로 진단하는 것을 특징으로 한다.
Abstract:
PURPOSE: An iron oxide nano particle in which non-polymer bio molecules are introduced to a surface modifier and a cancer diagnosis and treatment composition including thereof are provided to improve delivery of oxide nano particles to target organ. CONSTITUTION: An iron oxide nano particle comprises iron oxide based core particles, a shell coated with soluble material which is selected from ATP, NAD, ADP, AMP and NADP, and gluconic acid combined in surface of the shell. The soluble are ATP. Fluorescent probes are additionally combined with surfaces of the nano particles. The fluorescence probes are chlorotoxin. A weight ratio of the gluconic acid to the iron oxide based core particle which is coated with ATP is 1:0.3-1:3. A diameter of the nano particle is 5-300 nano meters.