公开(公告)号：KR1020100045046A

公开(公告)日：2010-05-03

申请号：KR1020080104069

申请日：2008-10-23

Applicant: 한국과학기술연구원

Inventor： 정봉철 ,  이정애

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/53

Abstract: PURPOSE: A method for measuring concentration of polyol in urine and a marker for diagnosing breast cancer are provided to accurately measure concentration of polyol with hihg sensitivity and to diagnose breast cancer. CONSTITUTION: A marker for diagnosing breast cancer comprises a polyol. The polyol is adonitol, arabitol, xylitol, glucose, mannitol, dulcitol, sorbitol, or inositol. The inositol is myo-inositol. The breast cancer is diagnosed when the concentration of urine arabitol of polyol is 1.3-10 times more than that of a normal group. A method for measuring concentration of polyl in urine comprises: a step of treating mixture solution of anhydrous acetylic acid and pyridine to urine sample; and a step of measuring the concentration of polyol through GC-MS(gas chromatography-mass spectrometry).

Abstract translation: 目的：提供测定尿中多元醇浓度的方法和诊断乳腺癌的标记物，以准确测定具有高敏感性的多元醇的浓度，并诊断乳腺癌。 构成：用于诊断乳腺癌的标记物包括多元醇。 多元醇是阿糖醇，阿糖醇，木糖醇，葡萄糖，甘露糖醇，曲醇醇，山梨糖醇或肌醇。 肌醇是肌醇。 当多元醇尿阿糖醇的浓度比正常组的浓度高1.3-10倍时，诊断出乳腺癌。 一种测定尿中polyl浓度的方法包括：将无水乙酸和吡啶的混合溶液处理至尿液样品的步骤; 以及通过GC-MS（气相色谱 - 质谱）测定多元醇浓度的步骤。