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公开(公告)号：KR1020080104751A
公开(公告)日：2008-12-03
申请号：KR1020070051974
申请日：2007-05-29
Applicant: 한국과학기술원
IPC: B81B1/00
Abstract: An apparatus and a method for driving microfluid using a light-emitting element are provided to form a protective layer for preventing electrolysis on a photoconductive layer so as to minimize damages due to electrolysis. An apparatus for driving microfluid using a light-emitting element includes a light-emitting element(10) emitting a laser beam, a photoconductive layer(30) having a region to which the laser beam is irradiated and a voltage is applied, a reference electrode layer(40) for forming an electric potential in the photoconductive layer, a microfluid flow channel(50) through which microfluid or particles(51) in the microfluid are moved with the voltage applied to the photoconductive layer, and a voltage supply unit(60) connected to the photoconductive layer and the reference voltage layer to apply a voltage thereto.
Abstract translation: 提供使用发光元件驱动微流体的装置和方法，以形成用于防止光电导层上的电解的保护层，从而最小化由于电解造成的损伤。 使用发光元件驱动微流体的装置包括发射激光的发光元件（10），具有照射激光束的区域和施加电压的光电导层（30），参考电极 用于在光电导层中形成电位的层（40），微流体通道（50），微流体中的微流体或微粒（51）通过施加到光电导层的电压而移动，以及电压供应单元 ）连接到光电导层和参考电压层以向其施加电压。
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公开(公告)号：KR100850235B1
公开(公告)日：2008-08-04
申请号：KR1020070016578
申请日：2007-02-16
Applicant: 한국과학기술원
Abstract: A microfluidic chip for particle focusing based on hydrophoresis are provided to allow it to be applied to a mobile flow cytometry where a cell analysis function is integrated and to omit the impressing or maintenance of additional external voltage. A microfluidic chip(1) for particle focusing based on hydrophoresis comprises a sample injection hole(10) which is formed on the upper surface of a microfluidic channel to inject a sample; a V-shaped microstructure(30) which is located at the upper and lower surfaces of the inside of the microfluidic channel and whose height is smaller than the height of the channel; and a sample discharge hole(20) which is formed on the upper surface of the microfluidic channel so as to allow the sample passed through the V-shaped microstructure to be discharged.
Abstract translation: 提供了一种用于基于疏水性的颗粒聚焦的微流控芯片，以将其应用于其中集成细胞分析功能的移动流式细胞术，并且省略额外的外部电压的压印或维护。 用于基于疏水性的颗粒聚焦的微流体芯片（1）包括样品注入孔（10），其形成在微流体通道的上表面上以注入样品; 位于微流体通道内部的上表面和下表面并且其高度小于通道高度的V形微结构（30）; 以及形成在微流体通道的上表面上以使得通过V形微结构的样品排出的样品排出孔（20）。
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公开(公告)号：KR100771522B1
公开(公告)日：2007-10-30
申请号：KR1020060113809
申请日：2006-11-17
Applicant: 한국과학기술원
CPC classification number: B29C33/3842 , A61B5/04
Abstract: A conductive polymer mirco-needle electrode sheet, and a manufacturing method thereof are provided to allow a mass production, and to improve industrial availability by simplifying the manufacturing process. A conductive polymer micro-needle electrode sheet(40) comprises a conductive polymer sheet(41) and a plurality of micro-needle electrodes(43). The plural micro-needle electrodes are projected from one side of the conductive polymer sheet. The conductive polymer sheet and the plural micro-needle electrodes are formed integrally by a conductive polymer. A diameter of each micro-needle electrode is in a range of 50~200 micrometers. A manufacturing process thereof includes a step of forming a solidified conductive polymer by solidifying molten conductive polymer; and a step of injection-molding a conductive polymer micro-needle electrode sheet by separating the solidified conductive polymer from a mold.
Abstract translation: 提供导电聚合物微针电极片及其制造方法以允许批量生产，并且通过简化制造工艺来提高工业可用性。 导电聚合物微针电极片（40）包括导电聚合物片（41）和多个微针电极（43）。 多个微针电极从导电性聚合物片的一侧突出。 导电聚合物片和多个微针电极由导电聚合物一体地形成。 每个微针电极的直径在50〜200微米的范围内。 其制造方法包括通过固化熔融的导电聚合物形成固化的导电聚合物的步骤; 以及通过将固化的导电性聚合物与模具分离而将导电性聚合物微针电极片注射成型的工序。
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公开(公告)号：KR1020060080353A
公开(公告)日：2006-07-10
申请号：KR1020050000720
申请日：2005-01-05
Applicant: 한국과학기술원
CPC classification number: G02B21/365 , G02B21/06 , G02B21/368 , G02B27/30 , H04Q9/00
Abstract: 본 발명은 렌즈(lens)를 사용하지 않는 광학 현미경 및 이를 이용한 영상 획득 시스템에 관한 것이다. 특히 디지털 영상 센서 앞에 수직에 가깝게 들어온 빛만 통과시키는 콜리메이터(collimator)를 이용하여 렌즈 없는 구조를 갖는 것을 특징으로 한다. 이 구조물은 나란한 관들의 집합으로써, 각 관의 관찰할 표본 쪽 끝에는 작은 구멍이 나있어서, 시료상의 한 점에서 영상 센서 위의 한 화소로 일대일 사영을 수행한다. 상을 확대, 축소하는 렌즈를 배제하였으므로 현미경의 제작비용이 절감되고 소형화가 가능하다.
칩 상의 현미경, 렌즈 없는 광학 현미경, 소형화, 휴대화, 내삽(interpolation), 디지털(digital), 형광.-
公开(公告)号：KR1020060018698A
公开(公告)日：2006-03-02
申请号：KR1020040067196
申请日：2004-08-25
Applicant: 한국과학기술원
CPC classification number: B01L3/502769 , B01L2300/0867 , B01L2300/0874 , B01L2300/0883 , G01N33/54306 , G01N33/573
Abstract: 본 발명은 미세 유체 채널 기술을 이용한 효소 활성도 분석용 칩에 관한 것으로서, 구체적으로는 측정시료 분배용 미세 유체 채널 부위(1), 반응시약 희석용 미세 유체 채널 부위(3) 및 시료와 시약의 반응 및 측정이 수행되는 반응 챔버 부위(2)로 구성된 모듈을 포함하는 효소 활성도 분석용 칩에 관한 것이다. 본 발명의 미세 유체 채널을 이용한 효소 활성도 분석용 칩은 서로 다른 기질 농도에서 효소-기질 반응이 가능하고, 상기 반응 결과를 ELISA로 측정함으로써, 효소 키네틱스 분석을 간단하게 수행할 수 있어, 효소 활성의 분석을 이용한 생화학 실험이나 질병의 예측에 유용하게 이용될 수 있다.
효소 활성도 분석, 미세 유체 채널, 칩-
Patent Agency Ranking
公开(公告)号：KR1020040100646A
公开(公告)日：2004-12-02
申请号：KR1020030033064
申请日：2003-05-23
Applicant: 주식회사 올메디쿠스 , 한국과학기술원
CPC classification number: B01L3/502707 , B01L2300/0645 , B01L2300/0896 , B82Y30/00 , G01N27/3277
Abstract: PURPOSE: A micro/nano fluidic three-dimensional electrode system is provided, thereby facilitating mixing effect of bio-fluid flowing the micro/nano-channels, and simultaneously measuring the oxidation and reduction of electrode activating materials with a high yield. CONSTITUTION: The micro/nano fluidic three-dimensional electrode system comprises the parts of: a first insulating substrate(1); a second insulating substrate(1) which faces to the first insulating substrate(1) with a certain distance to form micro/nano-channels; a plurality of electrodes(2) for oxidation which are formed perpendicularly to the micro/nano-channels on the first insulating substrate(1) with a certain distance, and are electrically connected each other; and a plurality of electrodes for reduction which are formed perpendicularly to the micro/nano-channels on the second insulating substrate(1) with a certain distance, and are electrically connected each other, wherein the oxidation electrodes and reduction electrodes are engaged each other in a zig-zag form.
Abstract translation: 目的：提供微/纳米流体三维电极系统，从而促进流经微/纳通道的生物流体的混合效应，同时以高产率测量电极活化材料的氧化和还原。 构成：微/纳米流体三维电极系统包括以下部分：第一绝缘基板（1）; 第二绝缘基板（1），其以一定距离面对第一绝缘基板（1）以形成微/纳通道; 多个用于氧化的电极（2），其在第一绝缘基板（1）上与微/纳通道垂直形成一定距离，并彼此电连接; 以及与所述第二绝缘基板（1）上的微/纳通道垂直形成一定距离的多个还原用电极，并且彼此电连接，其中所述氧化电极和还原电极彼此接合 一个曲折形式。
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公开(公告)号：KR1020170115388A
公开(公告)日：2017-10-17
申请号：KR1020160043014
申请日：2016-04-07
Applicant: 한국과학기술원
IPC: B01L3/00 , G01N33/569 , C08L1/18
CPC classification number: B01L3/5027 , B01L3/50273 , B01L2300/069 , B01L2300/0803 , B01L2300/0825 , B01L2300/0861 , B01L2300/12 , B01L2400/0406 , C08L1/18 , G01N33/5304 , G01N33/56911
Abstract: 본발명은섬유기반미세유체소자를위한다종유체이송시스템에관한것으로, 구체적으로다종의유체를필요에따라섬유기반미세유체소자를통해이동시켜목적하는다단계의화학적반응을손쉽게구현할수 있는섬유기반미세유체소자를위한다종유체이송시스템에관한것이다. 더욱상세하게는시료패드, 섬유기반의미세유체소자, 흡습패드, 상기구성의이동또는위치변경이가능하도록하는샘플층및 검출층을포함하는다종유체이송시스템에관한것이다.
Abstract translation: 本发明纤维所依据的宽的流体输送系统，用于在微流体装置上，特别是根据需要，在基于光纤的也可以通过微流体装置访问容易地实现所希望的多级的化学反应的各种流体的纤维为主细 用于流体装置的多流体传输系统。 更具体地，涉及包括将样品层和使所述样品垫，所述基于纤维的微流体装置，改变吸收垫，运动的结构或位置的检测层的多种类的流体输送系统。
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公开(公告)号：KR101575593B1
公开(公告)日：2015-12-10
申请号：KR1020140037744
申请日：2014-03-31
Applicant: 한국과학기술원
IPC: G01N33/538 , G01N33/569 , G01N35/08
Abstract: 본발명은섬유네트워크기반미세유체소자및 그용도에관한것으로, 더욱자세하게는섬유네트워크의크기를압력으로조절하여유체의유속을쉽게조절할수 있는미세유체소자및 그용도에관한것이다. 본발명에따르면, 섬유네트워크기반미세유체소자는유체의유속을쉽게조절함으로써다종의유체를순차적으로이송시킬수 있어, 이를통해세척과반응및 검출과정을한 번의로딩으로구현할수 있는효과로간이면역검사법을사용하는임신진단, 혈당검사및 유해미생물검출등의분야에서산업적규모로유용하게이용될수 있다.
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50.发明公开메쉬-그리드 미세액적 어레이를 이용한 단일 세포 기반 목적 유용효소 활성 탐색 방법 有权使用MESH-INTEGRATED MICRODROPLET ARRAY的单个基于细胞的筛选方法的有用的酶资源
公开(公告)号：KR1020140106933A
公开(公告)日：2014-09-04
申请号：KR1020130021247
申请日：2013-02-27
Abstract: The present invention relates to a method for manufacturing a picoliter-level microdroplet containing target cells in a single cell unit to analyze the activity of the single cell and to a method for screening interest useful enzyme activity using meshgrid-introduced microdroplet microwell array. The method for manufacturing the microdroplet increases microdroplet production efficiency by secondary crushing when microdroplet is manufactured. Microdroplet microwell array with open-structure using meshgrid method can easily capture and fuse droplets and provide a stable environment to be connected to additional manipulation and another device, which enables that various microorganisms, metagenome-derived metabolism and enzyme activity can be fast searched in the single cell level and is applied to study for interaction between microorganisms in various conditions.
Abstract translation: 本发明涉及在单细胞单元中制造含有靶细胞的皮升级微滴的方法，以分析单细胞的活性，以及使用引入网格丝的微滴微孔阵列筛选感兴趣的有用酶活性的方法。 制造微滴的方法通过二次破碎来提高微滴生产效率。 具有开放式结构的微滴微孔阵列可以容易地捕获和融合液滴，并提供稳定的环境以连接到额外的操作和另一种装置，这使得能够快速搜索各种微生物，来源于代谢物的代谢和酶活性 单细胞水平，并用于研究各种条件下微生物之间的相互作用。
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