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    41.
    发明专利
    未知

    公开(公告)号：AT277883T

    公开(公告)日：2004-10-15

    申请号：AT02025292

    申请日：2002-11-13

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  ERHARDT MELANIE

    IPC: C07D339/04 ,  C07C67/30 ,  C07C67/31 ,  C07C67/317 ,  C07C67/32 ,  C07C69/66 ,  C07C69/675

    Abstract: Production of dihydroxycarboxylic acid esters, by reaction of hydroxycarboxylic acid diesters with complex hydrides, is conducted in the absence of a solvent. Production of dihydroxycarboxylic acid esters of formula (I) by reaction of hydroxycarboxylic acid diesters of formula (II) with complex hydrides is conducted in the absence of a solvent. n = 1, 2, 3, 4, 5, 6 or 7; and R and R = optionally substituted 1-20C alkyl, 2-20C alkenyl or alkynyl, 3-8C cycloalkyl, aralkyl, aryl, hetarylalkyl or hetaryl An Independent claim is included for production of R-(+)- alpha -lipoic acid of formula (III) from (I) obtained as above (i.e. in the absence of solvent) by: (1) converting (I) to its bis-sulfonic ester by reaction in an organic solvent with a sulfonic acid chloride and a tertiary nitrogen base; (2) converting the ester thus obtained to R- alpha -lipoic acid ester by reaction in a polar solvent with sulfur and an alkali metal disulfide; and then (3) converting the ester to the required product.

    METHOD FOR THE PURIFICATION OF LIPONIC ACID
    42.
    发明专利
    METHOD FOR THE PURIFICATION OF LIPONIC ACID 未知

    公开(公告)号：AU2003288079A1

    公开(公告)日：2004-06-18

    申请号：AU2003288079

    申请日：2003-11-17

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  MAIER ULRIKE

    IPC: A61P5/50 ,  C07D339/04 ,  A61K31/385

    Abstract: The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

    43.
    发明专利
    未知

    公开(公告)号：DE10160149A1

    公开(公告)日：2003-06-18

    申请号：DE10160149

    申请日：2001-12-07

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  ERHARDT MELANIE

    IPC: C07D339/04 ,  C07C67/30 ,  C07C67/31 ,  C07C67/317 ,  C07C67/32 ,  C07C69/66 ,  C07C69/675

    Abstract: Production of dihydroxycarboxylic acid esters, by reaction of hydroxycarboxylic acid diesters with complex hydrides, is conducted in the absence of a solvent. Production of dihydroxycarboxylic acid esters of formula (I) by reaction of hydroxycarboxylic acid diesters of formula (II) with complex hydrides is conducted in the absence of a solvent. n = 1, 2, 3, 4, 5, 6 or 7; and R and R = optionally substituted 1-20C alkyl, 2-20C alkenyl or alkynyl, 3-8C cycloalkyl, aralkyl, aryl, hetarylalkyl or hetaryl An Independent claim is included for production of R-(+)- alpha -lipoic acid of formula (III) from (I) obtained as above (i.e. in the absence of solvent) by: (1) converting (I) to its bis-sulfonic ester by reaction in an organic solvent with a sulfonic acid chloride and a tertiary nitrogen base; (2) converting the ester thus obtained to R- alpha -lipoic acid ester by reaction in a polar solvent with sulfur and an alkali metal disulfide; and then (3) converting the ester to the required product.

    48.
    发明专利
    未知

    公开(公告)号：DE19845517A1

    公开(公告)日：2000-04-06

    申请号：DE19845517

    申请日：1998-10-02

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KLATT MARTIN JOCHEN ,  BOERMER ARMIN ,  HOLZ JENS ,  VOSS GUDRUN

    IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C67/297 ,  C07C67/31 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732 ,  C07C67/313

    Abstract: Enantiomerically pure beta -hydroxyesters (I) are prepared by asymmetric hydrogenation of a beta -hydroxyester (II) over a ruthenium complex catalyst (III) containing an optically active bidentate bis-phospholane ligand. Preparation of enantiomerically pure beta -hydroxyesters (I) involves reacting a beta -hydroxyester (II) with hydrogen in presence of a ruthenium complex catalyst of formula (III): LRuX2 (III) X = halo, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate; L = bidentate bis-phospholane ligand of formula (A) : Y = bridging group providing 1-5C between the two P atoms; R1 = H, 1-6C alkyl, aryl, alkaryl or Si(R2)3; R2 = alkyl or aryl; m = 0 and R3 = OR4; or m = 1 and R3 = H; R4 = as R1.

    50.
    发明专利
    未知

    公开(公告)号：AT328878T

    公开(公告)日：2006-06-15

    申请号：AT03779948

    申请日：2003-11-17

    Applicant: BASF AG

    Inventor： MAIER ULRIKE ,  KLATT MARTIN JOCHEN

    IPC: A61P5/50 ,  C07D339/04 ,  A61K31/385

    Abstract: The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

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