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    Azaindazoles as kinase inhibitors and use thereof
    44.
    发明授权
    Azaindazoles as kinase inhibitors and use thereof 有权
    阿魏唑作为激酶抑制剂及其应用

    公开(公告)号：US08846673B2

    公开(公告)日：2014-09-30

    申请号：US13388700

    申请日：2010-08-11

    Applicant: Jingwu Duan ,  Bin Jiang ,  Zhonghui Lu

    Inventor： Jingwu Duan ,  Bin Jiang ,  Zhonghui Lu

    IPC: A61K31/535 ,  C07D471/04

    CPC classification number: C07D471/04

    Abstract: Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, (I) are useful as kinase modulators, including Btk modulation, wherein A1, A2, A3, R4 are as defined herein.

    Abstract translation: 具有式（I）的化合物及其对映异构体和非对映异构体，药学上可接受的盐，（I）可用作激酶调节剂，包括Btk调节，其中A1，A2，A3，R4如本文所定义。

    MOS TRANSISTOR USING STRESS CONCENTRATION EFFECT FOR ENHANCING STRESS IN CHANNEL AREA
    46.
    发明申请
    MOS TRANSISTOR USING STRESS CONCENTRATION EFFECT FOR ENHANCING STRESS IN CHANNEL AREA 审中-公开
    使用应力集中效应的MOS晶体管增强通道的应力

    公开(公告)号：US20130137235A1

    公开(公告)日：2013-05-30

    申请号：US13512415

    申请日：2011-04-22

    Applicant: Qi Yu ,  Xiangzhan Wang ,  Ning Ning ,  Jingchun Li ,  Hongdong Yang ,  Xianwei Ying ,  Weijie Zhou ,  Bin Jiang ,  Yong Wang

    Inventor： Qi Yu ,  Xiangzhan Wang ,  Ning Ning ,  Jingchun Li ,  Hongdong Yang ,  Xianwei Ying ,  Weijie Zhou ,  Bin Jiang ,  Yong Wang

    IPC: H01L29/66

    CPC classification number: H01L29/4983 ,  H01L21/823807 ,  H01L21/823828 ,  H01L21/823864 ,  H01L29/0649 ,  H01L29/0653 ,  H01L29/7842 ,  H01L29/7843 ,  H01L29/7845 ,  H01L29/7848 ,  H01L29/7849

    Abstract: A MOS transistor (60, 62) is provided. The structure of the transistor (60, 62) includes: a semiconductor substrate (10), a channel area (20, 24), source/drain regions (22, 26), a gate (30, 32), a gate insulating layer (11), a shallow trench isolation region (12), a passive layer (50, 52), and holes (40, 42) formed with a certain distance to the gate insulating layer (11). Wherein both the shapes of the holes (40, 42) and the Young's modulus' difference between the material in the holes (40, 42) and that around the holes (40, 42) contribute to the stress concentration effect, thus the stress in the channel area (20, 24) is enhanced. The structure of the transistor (60, 62) can greatly reduce the stress attenuation during the transmission from stress resource to the sensitive region, and concentrate the stress in the sensitive region. The structure can be involved in large size device, especially.

    Abstract translation: 提供了MOS晶体管（60,62）。 晶体管（60,62）的结构包括：半导体衬底（10），沟道区（20,24），源极/漏极区（22,26），栅极（30,32），栅极绝缘层 （11），浅沟槽隔离区（12），钝化层（50,52）和与栅绝缘层（11）形成一定距离的孔（40,42）。 其中孔（40,42）的形状和孔（40,42）中的材料与孔（40,42）周围的材料之间的杨氏模量差都有助于应力集中效应，因此应力 增加了通道区域（20,24）。 晶体管（60,62）的结构可以大大降低从应力资源向敏感区域传输过程中的应力衰减，并将应力集中在敏感区域。 该结构可以涉及大尺寸装置，特别是。

    Fused heteroaryl modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
    47.
    发明授权
    Fused heteroaryl modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof 有权
    糖皮质激素受体，AP-1和/或NF-κB活性的融合杂芳基调节剂及其用途

    公开(公告)号：US08304539B2

    公开(公告)日：2012-11-06

    申请号：US12866270

    申请日：2009-02-05

    Applicant: Jingwu Duan ,  David S. Weinstein ,  Bin Jiang

    Inventor： Jingwu Duan ,  David S. Weinstein ,  Bin Jiang

    IPC: C07D491/147 ,  C07D413/00

    CPC classification number: C07D491/147

    Abstract: Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or taυtomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; •A is a S- to 8-membered carbocyclic ring or a S- to 8-membered heterocyclic ring; B1 and B2 rings are pyridyl rings, wherein the B1 and B2 rings are each fused to the A ring and the B1 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R1, R2, and R4, and the B2 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R5, R7, and R3 J1, J2, and J3 are at each occurrence the same or different and are independently -A1QA2-; Q is a bond, O, S, S(O), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3 alkylene, substituted C1-3 alkylene, C2-4 alkenylene, and substituted C2-4 alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein.

    Abstract translation: 提供新的非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病或病症，包括具有结构的代谢和炎症和免疫疾病或病症 式（I）的化合物：其对映异构体，非对映异构体或其互变异构体或其前药酯或其药学上可接受的盐，其中：Z是杂环基或杂芳基; A是5至8元碳环或5至8元杂环; B1和B2环是吡啶环，其中B1和B2环各自与A环稠合，B1环任选被一至三个相同或不同并且独立地选自R 1，R 2和R 4的基团取代 并且B2环任选被一至三个相同或不同并且独立地选自R5，R7和R8的基团取代，J1，J2和J3在每次出现时相同或不同，并且独立地为-A 1 QA 2 - ; Q是键，O，S，S（O）或S（O）2; A1和A2相同或不同，并且在每次出现时独立地选自键，C1-3亚烷基，取代的C1-3亚烷基，C2-4亚烯基和取代的C2-4亚烯基，条件是A1和A2被选择为 该环A为5-至8-元碳环或杂环; R1至R11如本文所定义。

    Spectrum verification imaging system and method
    49.
    发明授权
    Spectrum verification imaging system and method 有权
    频谱验证成像系统及方法

    公开(公告)号：US07773224B2

    公开(公告)日：2010-08-10

    申请号：US11863424

    申请日：2007-09-28

    Applicant: Fan He ,  Shumin Cheng ,  Michael Frenzer ,  Bin Jiang ,  Vahid Goudarzi

    Inventor： Fan He ,  Shumin Cheng ,  Michael Frenzer ,  Bin Jiang ,  Vahid Goudarzi

    IPC: G01J3/51

    CPC classification number: G01J1/124 ,  G01J2003/466

    Abstract: A system (200) and method (800) for determining whether a sample object (203) has a color that is within a predetermined range is provided. The system (200) includes a light source (201) capable of projecting lights having different light wavelength spectrum upon the sample object (203). A controller (222) causes the light source (201) to project a first light wavelength spectrum upon the sample object (203), then another, then another, and so forth. While each light is projecting upon the object, a monochromatic image capture device (202) captures an image having luminous intensity information. The luminous intensity information, or a subset thereof selected by an image selection tool (232) is then compared to the statistical range, which is derived from a plurality of images taken of a reference object (403).

    Abstract translation: 提供了一种用于确定样本对象（203）是否具有在预定范围内的颜色的系统（200）和方法（800）。 系统（200）包括能够将具有不同光波长光谱的光投射到样本物体（203）上的光源（201）。 控制器（222）使得光源（201）将样品（203）上的第一光波长谱投影到另一个，另一个则另一个等等。 当每个光投射在物体上时，单色图像捕获装置（202）捕获具有发光强度信息的图像。 然后将由图像选择工具（232）选择的发光强度信息或其子集与从参考对象（403）拍摄的多个图像导出的统计范围进行比较。

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