公开(公告)号：US20170216265A1

公开(公告)日：2017-08-03

申请号：US15347587

申请日：2016-11-09

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Board of Regents of the University of Texas System

Inventor： Sanford Markowitz ,  Amar Desai ,  Stanton Gerson ,  Joseph Ready

IPC: A61K31/4365 ,  A61K31/495 ,  A61K38/19

CPC classification number: A61K31/4365 ,  A61K31/495 ,  A61K38/193

Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.

公开(公告)号：US20240068033A1

公开(公告)日：2024-02-29

申请号：US18261366

申请日：2022-01-14

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Helen Moinova ,  Joseph Willis ,  Bert Vogelstein ,  Kenneth Kinzler ,  Nickolas Papadopoulos ,  Chetan Bettewgowda ,  Christopher Douville

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: A method of detecting Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus, applying a Repetitive Element Aneuploidy Sequencing System (RealSeqS) methodology to a biological sample from the esophagus of the subject to detect Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus.

公开(公告)号：US20230285402A1

公开(公告)日：2023-09-14

申请号：US18117257

申请日：2023-03-03

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  James K. V. Willson ,  Bruce Posner ,  Joseph Ready ,  Monika Antczak ,  Yongyou Zhang ,  Amar Desai ,  Stanton Gerson ,  William Greenlee ,  Sung Yeun Yang ,  KiBeom Bae

IPC: A61K31/5377 ,  A61K31/4365 ,  C07D495/04 ,  A61K31/444 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519

CPC classification number: A61K31/5377 ,  A61K31/4365 ,  C07D495/04 ,  A61K31/444 ,  A61K31/437 ,  A61K31/496 ,  A61K31/519

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

公开(公告)号：US20230116062A1

公开(公告)日：2023-04-13

申请号：US17898776

申请日：2022-08-30

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Sanford Markowitz ,  Amar Desai ,  Joseph Ready

IPC: A61K31/4365 ,  A61K38/19 ,  A61K31/495 ,  A61K31/444 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/519 ,  A61K31/496

Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.

公开(公告)号：US11478458B2

公开(公告)日：2022-10-25

申请号：US16995878

申请日：2020-08-18

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Sanford Markowitz ,  Joseph Ready ,  Andrew Pieper

IPC: A61K31/4365 ,  A61P25/28 ,  A61K31/4375 ,  A61K31/437

Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

公开(公告)号：US20210386410A1

公开(公告)日：2021-12-16

申请号：US16902579

申请日：2020-06-16

Applicant: Case Western Reserve University

Inventor： Amitabh Chak ,  Sanford Markowitz ,  Dennis Siedlak ,  Joseph Willis ,  Lishan Aklog ,  Michael Boutillette ,  Richard Yazbeck

IPC: A61B10/02 ,  A61M25/10

Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.

公开(公告)号：US20210369256A1

公开(公告)日：2021-12-02

申请号：US17331375

申请日：2021-05-26

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Lishan Aklog ,  Richard Yazbeck ,  Michael Boutillette ,  Brian deGuzman ,  David Wurtman

IPC: A61B10/04

Abstract: A method for collecting a cell sample, including eosinophil white blood cells in a patient is provided. The method includes advancing to a location in an esophagus associated with eosinophilic esophagitis (EoE), a device provided with a collection portion having a first axial end portion and an inflatable second axial end portion. Thereafter, axially moving the second axial end portion, relative to the first axial end portion, from a collapsed position within the first axial end portion into an expanded position out from the first axial end portion. Once the second axial end portion is in the expanded position, allowing it to engage the location associated with EoE to collect a sample of cells.

公开(公告)号：US20210317132A1

公开(公告)日：2021-10-14

申请号：US16617137

申请日：2018-05-29

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Sanford Markowitz ,  Monika Antczak ,  Joseph Ready ,  Youngyou Zhang

IPC: C07D495/04 ,  C07D495/22

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

公开(公告)号：US20210100779A1

公开(公告)日：2021-04-08

申请号：US17044888

申请日：2019-04-04

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  INJE INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Sanford Markowitz ,  Ki Beom Bae ,  Hye Jung Kim ,  Sun-Hee Kim

IPC: A61K31/4365

Abstract: A method for preventing or treating renal ischemia reperfusion injury or acute kidney injury associated with renal ischemia reperfusion injury in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

公开(公告)号：US20210094968A1

公开(公告)日：2021-04-01

申请号：US16869879

申请日：2020-05-08

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Sanford Markowitz ,  Joseph Ready ,  Yongyou Zhang ,  Monika Antczak ,  James K.V. Willson ,  Bruce Posner ,  William Greenlee

IPC: C07D495/04 ,  A61K31/4365 ,  A61K31/395 ,  A61K31/519 ,  A61K31/5377 ,  A61P7/06 ,  A61P15/10 ,  A61P1/02 ,  A61P9/10 ,  A61P19/00 ,  A61P37/04 ,  A61P39/00 ,  A61P1/16 ,  A61P9/00 ,  A61P17/14 ,  A61P25/02 ,  A61P37/06 ,  A61P17/00 ,  A61P35/02 ,  A61P9/12 ,  A61P13/12 ,  A61P17/02 ,  A61P1/00 ,  A61P9/04 ,  A61P11/00 ,  A61P25/00 ,  A61P25/16 ,  A61P29/00 ,  A61P35/04 ,  A61P1/04 ,  A61P35/00 ,  A61K8/49 ,  A61K9/00 ,  A61K31/444 ,  A61K31/4545 ,  A61K35/28 ,  A61K38/19 ,  A61Q7/00 ,  A61Q19/04

Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.