公开(公告)号：WO1994023024A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003441

申请日：1994-04-07

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  FRITZINGER, David, C. ,  BREDEHORST, Reinhard ,  VOGEL, Carl-Wilhelm

IPC: C12N15/07

CPC classification number: C07K14/46 ,  C07K19/00

Abstract: DNA sequences encoding cobra C3, CVF1, and CVF2, as well as plasmids and transformed hosts comprising such DNA sequences, are provided.

Abstract translation: 提供了编码眼镜蛇C3，CVF1和CVF2的DNA序列，以及包含这种DNA序列的质粒和转化宿主。

公开(公告)号：WO1994016701A1

公开(公告)日：1994-08-04

申请号：PCT/US1994001006

申请日：1994-01-27

Applicant: SEPRACOR, INC. ,  GEORGETOWN UNIVERSITY

Inventor： SEPRACOR, INC. ,  GEORGETOWN UNIVERSITY ,  GRAY, Nancy, M. ,  WOOSLEY, Raymond, L.

IPC: A61K31/495

CPC classification number: A61K31/495

Abstract: Methods and compositions are disclosed uitlizing the optically pure (2S, 4R) isomer of itraconazole. This compound is a potent drug for the treatment of local and systemic fungal, yeast, and dermatophyte infections, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of itraconazole.

Abstract translation: 公开了将伊曲康唑的光学纯（2S，4R）异构体取代的方法和组合物。 该化合物是治疗局部和全身真菌，酵母和皮肤癣菌感染的有效药物，同时避免与伊曲康唑外消旋混合物相关的副作用的伴随责任。

公开(公告)号：WO1993018751A1

公开(公告)日：1993-09-30

申请号：PCT/US1993002439

申请日：1993-03-23

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  RAHMAN, Aquilar ,  RAFAELOFF, Rafael ,  HUSAIN, Syed, Rafat

IPC: A61K09/127

CPC classification number: A61K31/335 ,  A61K9/127 ,  A61K31/337 ,  A61K31/70 ,  B82Y5/00 ,  Y10T428/2984 ,  A61K2300/00

Abstract: Liposomal-encapsulated taxol or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer, and which may be used advantageously in combination with hyperthermia. The liposomes confer enhanced stability and solubility to taxol or derivatives thereof.

Abstract translation: 提供了脂质体包封的紫杉醇或其抗肿瘤衍生物或其混合物，其用于实现治疗性增强的治疗癌症的方法，并且其可有利地与热疗相结合使用。 脂质体赋予紫杉醇或其衍生物更高的稳定性和溶解性。

公开(公告)号：WO1993013417A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011093

申请日：1992-12-30

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  BANO, Mozeena ,  DICKSON, Robert, B. ,  KIDWELL, William, R.

IPC: G01N33/53

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K47/6835 ,  C07K16/22

Abstract: An antibody which is immunoreactive against mammary-derived growth factor 1 (MDGF1) and related growth factors. A new growth factor/growth factor receptor-oncogene family. New therapeutic agents based on this system for treatment of disease.

Abstract translation: 对乳腺来源的生长因子1（MDGF1）和相关生长因子具有免疫反应性的抗体。 一种新的生长因子/生长因子受体癌基因家族。 基于该系统治疗疾病的新型治疗剂。

公开(公告)号：WO1993013416A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011092

申请日：1992-12-30

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  BANO, Mozeena ,  DICKSON, Robert, B. ,  KIDWELL, William, R.

IPC: G01N33/53

CPC classification number: G01N33/6872 ,  G01N33/57415

Abstract: A method for detecting MDGF1 as a diagnostic or prognostic variable for breast cancer or other disease in a mammal, which comprises: a) contacting a portion of a tissue sample or body fluid from the mammal with one or more antibodies directed against MDGF1, and detecting the presence of MDGF1 by a quantitative assay, or b) detecting functional receptors in tissue membrane fractions by ligand binding and by determining phosphotyrosine accumulation on a specific protein, or both.

Abstract translation: 一种用于检测MDGF1作为哺乳动物乳腺癌或其他疾病的诊断或预后变量的方法，其包括：a）使来自哺乳动物的组织样品或体液的一部分与一种或多种针对MDGF1的抗体接触，并检测 通过定量测定法存在MDGF1，或b）通过配体结合检测组织膜级分中的功能性受体并通过测定特异性蛋白上的磷酸酪氨酸积累，或两者兼有。

公开(公告)号：WO1991018921A1

公开(公告)日：1991-12-12

申请号：PCT/US1991003443

申请日：1991-05-22

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  LIPPMAN, Marc ,  LUPU, Ruth

IPC: C07K09/00

CPC classification number: C07K19/00 ,  A61K38/00 ,  C07K14/495

Abstract: A method for inhibiting the growth of adenocarcinoma cells in a human, which cells overexpress the oncogene erbB-2, which entails administering to said human an amount of a 30 Kd glycoprotein effective to inhibit the growth of said cells.

Abstract translation: 一种抑制人类腺癌细胞生长的方法，其中细胞过表达癌基因erbB-2，其需要向所述人施用一定量的有效抑制所述细胞生长的30Kd糖蛋白。

公开(公告)号：WO1991011957A1

公开(公告)日：1991-08-22

申请号：PCT/US1991000888

申请日：1991-02-14

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  McRAE, Donald, A.

IPC: A61B05/05

CPC classification number: A61F7/00 ,  A61B5/053 ,  A61B5/0535 ,  A61N1/403

Abstract: A method of evaluating tissue changes in a mammal occurring durint therapeutic hyperthermia, comprising: a) applying therapeutic hyperthermia to said mammal and monitoring the changes in tissue electrical impendance before, during and after said therapeutic hyperthermia, or any combination thereof, and b) determining the extent of tissue change in said mammal from the changes in tissue electrical impedance.

公开(公告)号：WO1990010621A1

公开(公告)日：1990-09-20

申请号：PCT/US1990001201

申请日：1990-03-13

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  ZARA, Jane, J. ,  WOOD, Richard, D. ,  BREDEHORST, Reinhard ,  VOGEL, Carl-Wilhelm

IPC: C07D207/46

CPC classification number: C07D213/71 ,  C07C323/59 ,  G01N33/54353

Abstract: Site-specific heterobifunctional crosslinkers of the formula: X-COCH(NH2)-Y-Z, where X is a carbonyl reactive group, Y is a variable length spacer, and Z is a thiol reactive group, are useful for the specific labelling of biomolecules or bioaffecting molecules.

公开(公告)号：WO1989011292A1

公开(公告)日：1989-11-30

申请号：PCT/US1989002173

申请日：1989-05-23

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  RAHMAN, Aquilur

IPC: A61K37/22

CPC classification number: A61K31/475 ,  A61K9/127 ,  Y10S514/883 ,  Y10S514/908 ,  Y10T428/2984

Abstract: A composition made up of a liposome-encapsulated vinca alkaloid and the method for using a liposome-encapsulated vinca alkaloid to treat tumors is disclosed. This composition possesses an antitumor activity and a lower toxicity as compared to nonencapsulated drug.

公开(公告)号：WO1989000575A1

公开(公告)日：1989-01-26

申请号：PCT/US1988002354

申请日：1988-07-18

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  TALEBIAN, Abdolhossen ,  GREEN, Dianna, C. ,  HAMMER, Charles, F. ,  SCHEIN, Philip, S.

IPC: C07H11/00

CPC classification number: C07H23/00 ,  C07F15/0093

Abstract: Compounds of formula (I), wherein each of R1 and R2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R1 and R2 together is a multifunctional carboxylic acid residue which forms a ring with the platinum atom through two oxygens of said multifunctional carboxylic acid; and R3 is a deoxy mono or disaccharide or a derivative thereof; and R4 is selected from the group consisting of hydrogen, C1-4-alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl, wherein substituents are selected from the group consisting of halogen, nitro, C1-2-alkoxy, carboxy, carbonyl ester or phenyl or a pharmaceutically acceptable salt thereof are disclosed. Compositions containing these compounds and methods using these compounds are also discussed.