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    New substd. pyridine cpds.
    43.
    发明专利
    New substd. pyridine cpds. 未知

    公开(公告)号：DE4344958A1

    公开(公告)日：1995-07-06

    申请号：DE4344958

    申请日：1993-12-30

    Applicant: HOECHST AG

    Inventor： WEIDMANN KLAUS DR ,  BARINGHAUS KARL-HEINZ DR ,  TSCHANK GEORG DR ,  BICKEL MARTIN DR

    IPC: C07D213/81 ,  C07D213/89 ,  C07D215/48 ,  C07K5/078 ,  C07D213/79 ,  A61K31/44 ,  A61K31/50

    Abstract: Substd. pyridine cpds. of formula (I) and their salts and prodrugs, with the exception of 3-hydroxypyridine-2-carboxylic acid-N-(carboxymethyl)amide, are new: Qx = O or S; X = O or S; Y = N or CR ; m = 0 or 1; A = (1-4C) alkylene, or CHR ; R = a natural alpha amino acid; B = CO2H, CONHCOR"', CONHSOR'", CONHSO2R"', NHSO2CF3, tetrazolyl, imidazolyl or 3-hydroxyisoxazolyl; R"' = aryl, heteroaryl, 3-7C cycloalkyl or opt. monosubstd. U; R , R , R = H, OH, halo, CN, CF3, NO2, COOH, 1-20C alkyl, 3-8C cycloalkyl, Ar, etc.; or R +R or R +R = a chain (CH2)o, in which 1-2 CH2 gps. are opt. replaced by O, S, SO, SO2 or NR' and the chain may contain a C=C double bond; or R +R = 5-6 membered aromatic carbocyclic or heterocyclic ring; Ar = 6-12C aryl; or R + R or R + R = a chain (CH2)o, in which 1-12 CH2 gp. is opt. replaced by O, S, SO, SO2 or NR' and the chain may contain a C-c double bond; or R +R = 5-6 membered aromatic carbocyclic or heterocyclic ring; Ar = 6-12C aryl; R' = H, Ar, 1-8C alkyl, 1-8C alkoxy(1-8C)alkyl, 7-12C aralkoxy(1-8C)alkyl, etc.; R = H; o = 3-5; x = 0-3;T = 1-6C alkyl; U = 1-4C alkyl.

    50.
    发明专利
    未知

    公开(公告)号：DE59005328D1

    公开(公告)日：1994-05-19

    申请号：DE59005328

    申请日：1990-07-14

    Applicant: HOECHST AG

    Inventor： BAADER EKKEHARD DR ,  BICKEL MARTIN DR ,  GUENZLER-PUKALL VOLKMAR DR

    IPC: C07D213/81 ,  A61K31/44 ,  A61K31/455 ,  A61P37/06 ,  C07D213/82

    Abstract: N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxylic acid diamides of the formula I where R is linear or branched C1-C4-alkanediyl, R is unbranched C1-C4-alkyl or hydrogen and n is 1 or 2 and R , R and n' have the same meanings as R , R and n, where R and R , R and R , and n and n' are identical or different, and their physiologically acceptable salts with the exception of N,N'-bis(2-methoxyethyl)pyridine-2,4-dicarboxylic acid diamide and N,N'-bis(2-hydroxyethyl)pyridine-2,4-dicarboxylic acid diamide. The compounds of the formula I inhibit prolin hydroxylase and lysin hydroxylase and are suitable as fibrosuppressants and immunosuppressants.

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