公开(公告)号：ZA7208418B

公开(公告)日：1973-08-29

申请号：ZA7208418

申请日：1972-11-27

Applicant: HOFFMANN LA ROCHE

Inventor： LANZ P ,  REINER R ,  VOGLER K

IPC: C07D499/00 ,  C07D499/60 ,  C07D501/20 ,  C07D501/28 ,  C07D

CPC classification number: C07D499/00 ,  Y02P20/55

公开(公告)号：NZ198558A

公开(公告)日：1985-08-16

申请号：NZ19855881

申请日：1981-10-05

Applicant: HOFFMANN LA ROCHE

Inventor： REINER R

IPC: C07D293/06 ,  C07D501/20 ,  C07D501/24 ,  C07D505/00 ,  C07D501/00 ,  A61K31/545 ,  A61K31/555 ,  C07D498/00 ,  C07F11/00

公开(公告)号：ZA816068B

公开(公告)日：1983-02-23

申请号：ZA816068

申请日：1981-09-01

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D249/12 ,  C07D ,  A61K

公开(公告)号：SE8105628L

公开(公告)日：1983-01-18

申请号：SE8105628

申请日：1981-09-23

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K31/546 ,  C07D249/12 ,  C07D501/36

公开(公告)号：DK449981A

公开(公告)日：1982-04-11

申请号：DK449981

申请日：1981-10-09

Applicant: HOFFMANN LA ROCHE

Inventor： REINER R ,  WEISS U

IPC: C07D293/06 ,  C07D501/20 ,  C07D501/24 ,  C07D505/00 ,  C07D

公开(公告)号：DK379581A

公开(公告)日：1982-04-07

申请号：DK379581

申请日：1981-08-26

Applicant: HOFFMANN LA ROCHE

Inventor： REINER R

IPC: C07D253/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D253/075 ,  C07D501/00 ,  C07D501/18 ,  C07D501/36 ,  C07D

Abstract: There is presented compounds of the formula I wherein X represents the 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl group or its corresponding tautomeric form, the 2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl group, and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of the compounds and hydrates of the compounds of formula I or of their esters, ethers and salts. Also provided is a method of their manufacture and intermediates therefor as well as corresponding pharmaceutical preparations.

公开(公告)号：BE890460A

公开(公告)日：1982-03-23

申请号：BE206037

申请日：1981-09-23

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D249/12 ,  C07D

公开(公告)号：ZA807099B

公开(公告)日：1981-11-25

申请号：ZA807099

申请日：1980-11-14

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/16 ,  C07D501/36 ,  C07D501/46 ,  C07D

Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.

公开(公告)号：AU6851181A

公开(公告)日：1981-10-01

申请号：AU6851181

申请日：1981-03-18

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D249/12 ,  C07D253/075 ,  C07D501/36 ,  A61K31/545 ,  C07D201/18 ,  C07D253/06

公开(公告)号：DK496380A

公开(公告)日：1981-05-22

申请号：DK496380

申请日：1980-11-20

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/16 ,  C07D501/36 ,  C07D501/46 ,  C07D

Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.