公开(公告)号：ZA7108537B

公开(公告)日：1972-09-27

申请号：ZA7108537

申请日：1971-12-21

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  QUITT P ,  VOGLER K ,  LANZ P

IPC: C07D499/12 ,  A61K31/431 ,  A61P31/04 ,  C07D207/28 ,  C07D207/34 ,  C07D213/78 ,  C07D213/79 ,  C07D213/89 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/54 ,  C07D239/557 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D309/12 ,  C07D333/38 ,  C07D499/00 ,  C07D499/56 ,  C07D499/60 ,  C07D

CPC classification number: C07D213/78 ,  C07D207/28 ,  C07D207/34 ,  C07D213/79 ,  C07D213/89 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/557 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68 ,  C07D309/12 ,  C07D333/38 ,  C07D499/00 ,  Y02P20/55 ,  Y10S514/962

公开(公告)号：DK117490B

公开(公告)日：1970-05-04

申请号：DK86068

申请日：1968-03-01

Applicant: HOFFMANN LA ROCHE

Inventor： VOGLER K ,  ZANETTI G

IPC: C07D499/00 ,  C07D499/46 ,  C07D499/48 ,  C07D99/14

Abstract: Acyl derivatives of 6-amino penicillanic acid of general formula (I) and their addition salts. (I) R1, R2, R3 and R4 = H-, hal-, C1-7 alkyl-, C1-7 alkenyl-, cycloalkyl-, cycloalkenyl-, aralkyl-, opt. substd. aryl-, cyano-, carboxyl-, carbalkoxy-, hydroxy-, C1-7 alkoxy-, C1-7 alkylthio-, C1-7 alkyl-sulphonyl-, nitro-, nitroso-, azido-, amino-, C1-7 alkylamino-, di-C1-7 alkylamino-, carbamino-, formyl-, hal-C1-7 alkyl-, C1-7 alkoxy-C1-7 alkyl-, hydroxy-C1-7 alkyl-, amino-C1-7alkyl-, C1-7 alkylamino-C1-7alkyl-, di-C1-7alkylamino-C1-7 alkyl-, acyl-, opt. substd. sulphamido- or a heterocyclic group. R5 = H-, C1-7 alkyl-, hal-C1-7alkyl-, cyano-C1-7 alkyl-, amino-C1-7alkyl-, hydroxy-C1-7 alkyl, carboxy-C1-7 alkyl-, C1-7 alkylamino-C1-7 alkyl-, carbalkoxy -C1-7 alkyl-, C1-7 alkenyl-, cycloalkyl-, cycloalkenyl-, aralkyl, opt. substd. aryl-, aryl-sulphonylamino-C1-7 alkyl-, C1-7 alkylsulphonylamino-C1-7 alkyl-, carbalkoxy- particularly (2-nitropyrrol-1-yl-methyl) penicillin. Antibiotics.