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    2- OR 4-Hydroxy-3,5-dihalo-benzylamines and salts thereof
    41.
    发明授权
    2- OR 4-Hydroxy-3,5-dihalo-benzylamines and salts thereof 失效
    2-或4-羟基-3,5-二卤代苄胺及其盐

    公开(公告)号：US4113777A

    公开(公告)日：1978-09-12

    申请号：US812325

    申请日：1977-07-01

    Applicant: Johannes Keck ,  Sigfrid Puschmann ,  Gerd Kruger ,  Klaus-Reinhold Noll ,  Matyas Leitold ,  Helmut Pieper

    Inventor： Johannes Keck ,  Sigfrid Puschmann ,  Gerd Kruger ,  Klaus-Reinhold Noll ,  Matyas Leitold ,  Helmut Pieper

    IPC: A61K31/135 ,  C07C87/28

    CPC classification number: A61K31/135 ,  Y10S514/849 ,  Y10S514/925

    Abstract: Compounds of the formula ##STR1## wherein X and R.sub.1 are each chlorine or bromine;R.sub.2 is isopropyl; tert.butyl; tert.pentyl; mono-, di- or tri-hydroxy-substituted branched alkyl of 3 to 5 carbon atoms; cyclohexyl; or hydroxycyclohexyl; andR.sub.3 is alkyl of 1 to 4 carbon atoms or, when R.sub.2 is other than cyclohexyl, also hydrogen;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as secretolytics, antitussives, anti-ulcerogenics and stimulants for the production of the surfactant or antiatelectasis factor of the alveoli.

    Abstract translation: 其中X和R 1各自为氯或溴的式“IMAGE”的化合物; R2是异丙基; 叔丁基 叔戊基 3至5个碳原子的单，二或三羟基取代的支链烷基; 环己基 或羟基环己基; 并且R 3是1至4个碳原子的烷基，或者当R 2不是环己基时，也是氢; 和非毒性，药理学上可接受的酸添加量; 化合物作为其生物利用作为秘密，抗生素，抗生素和抗生素用于生产ALVEOLI的表面活性剂或抗原决定因子。

    Electrical glass melting furnace
    42.
    发明授权
    Electrical glass melting furnace 失效
    电炉玻璃熔化炉

    公开(公告)号：US4107447A

    公开(公告)日：1978-08-15

    申请号：US804405

    申请日：1977-06-07

    Applicant: Helmut Pieper

    Inventor： Helmut Pieper

    IPC: C03B5/027 ,  H05B3/00 ,  C03B5/02

    CPC classification number: H05B3/0023 ,  C03B5/0275

    Abstract: An electrical glass melting furnace having a refractory tank, wherein the batch glass is fed onto the surface of a bath of molten glass therein and refined glass is withdrawn from a lower portion thereof. Electric heating power is supplied, in the form of three-phase AC, through two levels of peripherally spaced electrodes. The secondary coils of the transformers employed each feed an electrode or electrode pair and the output of each secondary coil is additionally connected to the input of one of the other secondary coils in the system.

    Abstract translation: 一种具有耐火罐的电熔玻璃熔炉，其中分批玻璃被送入其中的熔融玻璃浴表面，精炼玻璃从其下部排出。 以三相AC的形式通过两层外围间隔的电极提供电加热功率。 所采用的变压器的次级线圈每个馈送电极或电极对，并且每个次级线圈的输出额外地连接到系统中其他次级线圈之一的输入端。

    Pharmaceutical compositions containing an aminobenzyl-amine and method of use
    44.
    发明授权
    Pharmaceutical compositions containing an aminobenzyl-amine and method of use 失效
    含氨基苄基胺的药物组合物及其使用方法

    公开(公告)号：US4006246A

    公开(公告)日：1977-02-01

    申请号：US649481

    申请日：1976-01-15

    Applicant: Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

    Inventor： Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

    IPC: A61K31/135 ,  A61K31/19 ,  A61K31/24

    CPC classification number: A61K31/19 ,  A61K31/135

    Abstract: Pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl, benzoyl or halobenzoyl,R.sub.2 is hydrogen, chlorine or bromine,R.sub.3 is carboxyl or lower carbalkoxy, andR.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy-(alkyl of 1 to 5 carbon atoms), alkenyl or 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy-(cycloalkyl of 5 to 7 carbon atoms) or benzyl,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as anti-ulcerogenics, secretolytics, antitussives, and stimulants of the production of the surfactant or antiatelectasis factor of the alveoli.

    Abstract translation: 含有下式化合物作为活性成分的药物剂量单位组合物，其中R 1是氢，低级烷酰基，苯甲酰基或卤代苯甲酰基，R 2是氢，氯或溴，R 3是羧基或低级烷氧羰基，R 4和R 5各自是 氢，1至5个碳原子的烷基，一或二羟基 - （1至5个碳原子的烷基），烯基或2至4个碳原子，5至7个碳原子的环烷基，一或二羟基 - （5至7个碳原子的环烷基）或苄基，或非毒性，药理学上可接受的酸添加盐; 以及使用它们作为抗生素，秘密，抗生素和生物活性物质的抗生素或抗原决定因子的方法。

    Method of operation of a glass melting furnace and a glass melting furnace for the practice of the method
    46.
    发明授权
    Method of operation of a glass melting furnace and a glass melting furnace for the practice of the method 失效
    一种玻璃熔炉和玻璃熔炉的操作方法

    公开(公告)号：US6154481A

    公开(公告)日：2000-11-28

    申请号：US286741

    申请日：1999-04-06

    Applicant: Helmut Sorg ,  Helmut Pieper

    Inventor： Helmut Sorg ,  Helmut Pieper

    IPC: C03B5/04 ,  C03B5/182 ,  C03B5/185 ,  C03B5/193 ,  C03B5/20 ,  C03B5/225 ,  C03B5/027

    CPC classification number: C03B5/182 ,  C03B5/04 ,  C03B5/185 ,  C03B5/193 ,  C03B5/20 ,  C03B5/225

    Abstract: In a glass melting furnace, a radiation screen wall is installed between a melting area and a refining area with a refining bank. This radiation screen wall leaves a flow path above the melt surface of the glass bath for the return flow of at least part of the combustion gases from the refining area to the melting area. In order to suppress a return flow of already refined and very hot glass melt from the refining area into a melting area, but still allow the charging material to melt completely as early as possible, the furnace is operated to produce at least one upward current between the middle of the melting area and the front face of the refining bank in the glass melt. Within the glass melt and before the melt surface is reached, this upward current is divided into a first partial current which flows upstream into the melting area and a second partial current which flows downstream over the refining bank, whereby a return current of the glass melt from the refining area into the melting area is prevented by the second partial current flowing downstream. This upward current is achieved by the use of one or more of the following arrangements: a row of bubblers; a step projecting upwards from the furnace bottom; and/or at least two heating electrodes which are installed before the front face of the refining bank.

    Abstract translation: 在玻璃熔炉中，在熔化区域和精炼区域之间安装有辐射屏蔽壁与精炼库。 该辐射屏蔽壁在玻璃浴的熔融表面之上留下流动路径，用于使至少部分燃烧气体从精炼区域返回到熔化区域。 为了抑制已经精炼和非常热的玻璃熔体从精炼区域到熔化区域的回流，但是仍然允许充电材料尽可能早地完全熔化，炉子被操作以产生至少一个向上的电流， 熔化区的中间和玻璃熔体中的精炼库的前面。 在玻璃熔体内并且在熔体表面达到之前，该向上的电流被分成在熔融区域上游流动的第一部分电流和在精炼库上游流动的第二部分电流，由此玻璃熔体的回流 从精炼区域进入熔化区域被第二部分电流流向下游。 该向上的电流通过使用以下一种或多种布置来实现：一排起泡器; 从炉底向上突出的台阶; 和/或至少两个加热电极，其安装在精炼库的前表面之前。

    Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
    49.
    发明授权
    Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them 失效
    哌嗪衍生物，含有这些化合物的药物组合物，其用途和制备方法

    公开(公告)号：US5700801A

    公开(公告)日：1997-12-23

    申请号：US572256

    申请日：1995-12-13

    Applicant: Helmut Pieper ,  Volkhard Austel ,  Frank Himmelsbach ,  Gunter Linz ,  Brian Guth ,  Johannes Weisenberger

    Inventor： Helmut Pieper ,  Volkhard Austel ,  Frank Himmelsbach ,  Gunter Linz ,  Brian Guth ,  Johannes Weisenberger

    IPC: C07D295/18 ,  A61K31/495 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/34 ,  C07D211/58 ,  C07D213/74 ,  C07D213/78 ,  C07D401/12 ,  C07D211/18

    CPC classification number: C07D213/74 ,  C07D211/34 ,  C07D211/58 ,  C07D401/12

    Abstract: Piperazine derivatives useful in the treatment or prevention of inflammation, bone degradation, thrombosis and tumor metastasis. Exemplary species are: (a) �4-trans-�3-�4-(4-Pyridyl)-piperazin-1-yl!propionyl!amino!-cyclohexanecarboxylic acid, (b) 3-�4-trans-�4-(4-Pyridyl)-piperazin-1-yl!carbonylamino!-cyclohexylpropionic acid, (c) 3-�4-trans-�4-(4-Pyridyl)-piperazin-1-yl!malonylamino!cyclohexylcarboxylic acid, (d) Methyl �4-trans-�3-�4-(4-pyridyl)-piperazin-1-yl!-propionyl!-amino!cyclohexane carboxylate, (e) Methyl 3-�4-trans-�4-(4-pyridyl)-piperazin-1-yl!-carbonylamino!cyclohexyl propionate, (f) Methyl �4-trans-�4-(4-pyridyl)-piperazin-1-yl!-malonylamino!-cyclohexyl carboxylate, (g) Cyclohexyl �4-trans-��4-(4-pyridyl)-piperazin-1-yl!-acetyl!-amino!-cyclohexane carboxylate, and (h) Isobutyl �4-trans-��4-(4-pyridyl)-piperazin-1-yl!-acetyl!-amino!-cyclohexane carboxylate.

    Abstract translation: 哌嗪衍生物可用于治疗或预防炎症，骨退化，血栓形成和肿瘤转移。 示例性物质是：（a）[4-反式 - [3- [4-（4-吡啶基） - 哌嗪-1-基]丙酰基]氨基] - 环己烷甲酸，（b）3- [4-反式 - [4 - （4-吡啶基） - 哌嗪-1-基]羰基氨基] - 环己基丙酸，（c）3- [4-反式 - [4-（4-吡啶基） - 哌嗪-1-基]丙二酰氨基]环己基羧酸， d）[4-反式 - [3- [4-（4-吡啶基） - 哌嗪-1-基] - 丙酰基] - 氨基]环己烷羧酸甲酯，（e）3- [4-反式 - [4- 4-吡啶基） - 哌嗪-1-基] - 羰基氨基]环己基丙酸酯，（f）[4-反式 - [4-（4-吡啶基） - 哌嗪-1-基] - 丙酰基氨基] ）[4-反式 - [[4-（4-吡啶基） - 哌嗪-1-基] - 乙酰基] - 氨基] - 环己烷羧酸环己酯和（h）[4-反式 - [[4- 吡啶基） - 哌嗪-1-基] - 乙酰基] - 氨基] - 环己烷羧酸酯。

    Method and apparatus for separating out gall during glass melting processes
    50.
    发明授权
    Method and apparatus for separating out gall during glass melting processes 失效
    玻璃熔化过程中分离出胆汁的方法和装置

    公开(公告)号：US5683484A

    公开(公告)日：1997-11-04

    申请号：US574389

    申请日：1995-12-18

    Applicant: Helmut Pieper ,  Lothar Rott ,  Matjaz Bucar

    Inventor： Helmut Pieper ,  Lothar Rott ,  Matjaz Bucar

    IPC: B09B3/00 ,  C03B5/00 ,  C03B5/193 ,  C03B5/20 ,  C03B5/26

    CPC classification number: C03B5/262 ,  B09B3/0066 ,  C03B5/005 ,  C03B5/193 ,  Y02P40/52 ,  Y10S588/90

    Abstract: An electrically heated tank furnace is used to melt glass whereby a floating gall layer is formed on the melt, in particular during the vitrification of hazardous materials such as asbestos, fly ash, filter dust, whereby the tank of the furnace is fitted with a discharge outlet for the melt and an overflow channel with an inlet for the gall. A stream of ascending gas bubbles is produced in the melt. In order to promote better and automatic draining of the gall the stream of gas bubbles is produced directly in front of the overflow channel which thereby maintains a layer of liquid gall in the overflow channel and a layer of molten glass retained by a weir on the bottom of the overflow channel. The temperature in the overflow channel is chosen to be above the melting temperature of the gall, whilst the bottom layer of glass is maintained at a temperature at which the viscosity of the glass is so high that the glass does not drain out the overflow channel.

    Abstract translation: 特别是在诸如石棉，飞灰，过滤灰尘的危险物质的玻璃化过程中，熔融玻璃上形成浮动的胆汁层，由此炉子的炉子装有放电 用于熔体的出口和具有胆汁入口的溢流通道。 在熔体中产生上升的气泡流。 为了促进更好和自动排出胆汁，气泡直接在溢流通道的前面产生，从而在溢流通道中保持一层液体胆汁，并在底部保留有一个堰的熔融玻璃层 的溢出通道。 溢流通道中的温度选择为高于胆汁的熔化温度，而玻璃底层保持在玻璃的粘度如此高以至于玻璃不会排出溢流通道的温度。

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