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    PRODUCTION OF INDOLE DERIVATIVE
    41.
    发明专利
    PRODUCTION OF INDOLE DERIVATIVE 失效

    公开(公告)号：JPH09176117A

    公开(公告)日：1997-07-08

    申请号：JP33684495

    申请日：1995-12-25

    Applicant: KOWA CO

    Inventor： KYOTANI YOSHINORI ,  SHIMIZU NOBORU ,  SATO SEIICHI ,  YAMAGUCHI TAKASHI ,  KITAMURA TAKAHIRO ,  OGIYA TADAAKI ,  KAWAMINE KATSUMI

    IPC: C07D209/34 ,  B01J31/24 ,  C07B61/00 ,  C07F7/10

    Abstract: PROBLEM TO BE SOLVED: To produce an indole derivative useful as a synthetic intermediate for a furo[2,3-e]indole derivative having treating action on cardiac diseases under mild reaction condition in high yield. SOLUTION: The objective indole derivative expressed by the formula I [R and R are each a (substituted)alkyl; R is an alkyl or an aralkyl; R and R are each H, a halogen, etc.; R is H, sec-butyl, etc.] can be produced by cyclizing a compound of the formula II (R is sec-butyl, t-butyl, etc.; X is a halogen) in the presence of a metal (e.g. copper or iron) or a metal complex (e.g. a palladium complex). The amounts of the metal catalyst and the metal complex in the reaction are preferably 1-2mol-equivalent and 0.01-0.1 mol- equivalent based on the compound of the formula II, respectively.

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