公开(公告)号：AU2003260965A1

公开(公告)日：2004-04-23

申请号：AU2003260965

申请日：2003-09-12

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： KATAGIRI TOYOMASA ,  NAKAMURA YUSUKE

IPC: C12Q1/68

公开(公告)号：AU2003249012A8

公开(公告)日：2004-04-23

申请号：AU2003249012

申请日：2003-07-29

Applicant: JAPAN PRESIDENT UNIV TOKYO ,  UNIV TOKYO ,  ONCOTHERAPY SCIENCE INC

Inventor： KATAGIRI TOYOMASA ,  NAKAMURA YUSUKE

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/574 ,  C07K14/705 ,  C07K16/18 ,  G01N33/50 ,  A61K35/00

Abstract: Objective methods for detecting and diagnosing Chronic myeloid leukemia (CML) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of CML-associated gene that discriminate between CML and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of CML, methods of treating CML and method of vaccinating a subject against CML.

公开(公告)号：CA2500982A1

公开(公告)日：2004-04-15

申请号：CA2500982

申请日：2003-09-12

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: C12Q1/68

Abstract: Objective methods for detecting and diagnosing testicular seminoma (TS) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of TS -associated gene that discriminate between TS and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of TS, methods of treating TS and method of vaccinating a subject against TS.

公开(公告)号：CA2500859A1

公开(公告)日：2004-04-15

申请号：CA2500859

申请日：2003-09-22

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO

Inventor： NAKAGAWA HIDEWAKI ,  NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

IPC: C07K14/47 ,  C12Q1/68 ,  C12N15/12 ,  C07H21/00 ,  A61K48/00 ,  C12P21/02 ,  A61K38/17 ,  C07K16/18 ,  A61K39/395 ,  G01N33/53

Abstract: The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.

公开(公告)号：CA2497132A1

公开(公告)日：2004-03-25

申请号：CA2497132

申请日：2003-08-12

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P15/00 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/68 ,  G01N37/00

Abstract: Disclosed are methods of detecting ovarian endometriosis using differentiall y expressed genes. Also disclosed are methods of screening compounds serving a s agents for treating ovarian endometriosis, and methods of treating ovarian endometriosis and method or vaccinating a subject against ovarian endometriosis.

公开(公告)号：WO2007013670A3

公开(公告)日：2007-08-16

申请号：PCT/JP2006315341

申请日：2006-07-26

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO ,  NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

IPC: C12Q1/68 ,  C07K16/32 ,  C12N15/113

CPC classification number: C12N15/1137 ,  C12N15/1135 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: The present application provides novel human gene GALNT6 whose expression is markedly elevated in breast cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of breast cancers, as target molecules for developing drugs against the disease, such as siRNAS, and for attenuating cell growth of breast cancer.

Abstract translation: 本申请提供了在乳腺癌中表达显着升高的新型人基因GALNT6。 由该基因编码的基因和多肽可用于例如乳腺癌的诊断，作为用于开发针对该疾病的药物的靶分子，例如siRNAS，以及用于减弱乳腺癌的细胞生长。

公开(公告)号：WO2006085684A3

公开(公告)日：2007-03-29

申请号：PCT/JP2006302684

申请日：2006-02-09

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO ,  NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2500/00

Abstract: Objective methods for detecting and diagnosing bladder cancer (BLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BLC-associated gene that discriminates between BLC cells and normal cells. The present invention further provides means for predicting and preventing bladder cancer metastasis using BLC-associated genes having unique altered expression patterns in bladder cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of bladder cancer, methods of treating bladder cancer and method for vaccinating a subject against bladder cancer. In particular, the present application provides novel human genes C2093, B5860Ns and C6055s whose expression is markedly elevated in bladder cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of bladder cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of bladder cancer.

Abstract translation: 本文描述了膀胱癌（BLC）检测和诊断的客观方法。 在一个实施方案中，诊断方法涉及确定鉴别BLC细胞和正常细胞的BLC相关基因的表达水平。 本发明还提供了使用具有淋巴结转移的膀胱癌细胞中具有独特改变的表达模式的BLC相关基因来预测和预防膀胱癌转移的手段。 最后，本发明提供筛选可用于治疗膀胱癌的治疗剂，治疗膀胱癌的方法和接种疫苗接种膀胱癌的方法。 特别地，本申请提供了新的人基因C2093，B5860Ns和C6055，其表达在膀胱癌中显着升高。 由该基因编码的基因和多肽可用于例如膀胱癌的诊断，作为用于开发针对该疾病的药物的靶分子，以及用于减轻膀胱癌的细胞生长。

公开(公告)号：WO2005029089A9

公开(公告)日：2006-05-04

申请号：PCT/JP2004013718

申请日：2004-09-14

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO ,  NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: G01N33/574 ,  G01N33/68

CPC classification number: G01N33/689 ,  G01N2800/364

Abstract: Disclosed are methods of diagnosing ovarian endometriosis using an antibody against the TFPI-2 protein. According to the present invention, this protein is detected at higher levels in the serum of subjects suffering from endometriosis as compared to normal control subjects and thus may serve as diagnostic marker and therapeutic target for ovarian endometriosis. In addition to methods of diagnosing ovarian endometriosis, the present invention provides kits for performing the diagnosis.

Abstract translation: 公开了使用针对TFPI-2蛋白的抗体诊断卵巢子宫内膜异位症的方法。 根据本发明，与正常对照受试者相比，在患有子宫内膜异位症的受试者的血清中检测到该蛋白质较高，因此可作为卵巢子宫内膜异位症的诊断标志物和治疗靶标。 除了诊断卵巢子宫内膜异位症的方法之外，本发明提供用于进行诊断的试剂盒。

公开(公告)号：WO2005028676A3

公开(公告)日：2005-09-15

申请号：PCT/JP2004014438

申请日：2004-09-24

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO ,  NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

IPC: C07K14/47 ,  C12N9/10 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C07K14/4702 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2500/04

Abstract: Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.

Abstract translation: 本文描述了用于检测和诊断乳腺癌（BRC）的客观方法。 在一个实施方案中，诊断方法包括确定区分BRC细胞和正常细胞的BRC相关基因的表达水平。 在另一个实施方案中，诊断方法包括确定在DCIS和IDC细胞之间区分BRC细胞的BRC相关基因的表达水平。 本发明进一步提供了用于在具有淋巴结转移的乳腺癌细胞中使用具有独特改变的表达模式的BRC相关基因来预测和预防乳腺癌转移的手段。 最后，本发明提供筛选可用于治疗乳腺癌的治疗剂的方法，治疗乳腺癌的方法和用于针对乳腺癌接种受试者的方法。

公开(公告)号：WO2004031411A3

公开(公告)日：2004-09-30

申请号：PCT/JP0311713

申请日：2003-09-12

Applicant: ONCOTHERAPY SCIENCE INC ,  JAPAN AS REPRESENTED BY THE PR ,  NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574 ,  C07K14/82

CPC classification number: G01N33/57438 ,  A61K38/00 ,  C07K14/47 ,  C07K14/82 ,  C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y02A90/26

Abstract: The present application provides novel human genes C1958V1 or C1958V2 whose expression is markedly elevated in pancreatic cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of pancreatic cancer, and as target molecules for developing drugs against the disease.

Abstract translation: 本申请提供了新的人类基因C1958V1或C1958V2，与相应的非癌性组织相比，其表达在胰腺癌中显着升高。 由这些基因编码的基因和多肽可以用于例如胰腺癌的诊断以及作为开发针对该疾病的药物的靶分子。