公开(公告)号：JP2010223655A

公开(公告)日：2010-10-07

申请号：JP2009069471

申请日：2009-03-23

Applicant: PANASONIC CORP

Inventor： OSHIMA AKIYOSHI ,  NAKATANI MASAYA ,  TAKAHASHI MAKOTO

IPC: G01N33/543 ,  C12M1/00 ,  G01N33/553

Abstract: PROBLEM TO BE SOLVED: To provide a sensor enhanced in sensitivity. SOLUTION: The sensor includes a base material 5, the vapor deposition layer 6 comprising a plurality of the particles 8 accumulated on the base material 5 in a branched state to be integrally bonded to each other and a plurality of the functional molecules 7 joined to the surfaces of the particles 8 of the vapor deposition layer 6, and the surfaces of the respective particles 8 contains aluminum oxide as the main component. By this constitution, the surface area of the base material 5 is magnified and the functional molecules 7 can be fixed in high density. As a result, the sensitivity of the sensor is enhanced. COPYRIGHT: (C)2011,JPO&INPIT

公开(公告)号：JP2009168794A

公开(公告)日：2009-07-30

申请号：JP2008194473

申请日：2008-07-29

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： USHIO KOJI ,  NAKATANI MASAYA ,  TAKAHASHI MAKOTO

IPC: G01N27/28 ,  C12M1/42

CPC classification number: G01N33/48728

Abstract: PROBLEM TO BE SOLVED: To aim at manufacturing of a cellular electrophysiological sensor with high measurement precision.
SOLUTION: In order to achieve the purpose, following processes are included in the present invention: the process of holding sensor chips 14; the process of holding glass tubes 13 enclosing the outer circumference of the lateral surface of the sensor chips 14; and the process of melting the glass tubes 13 to glass-deposit with the lateral surface of the sensor chip 14, while giving wind pressure towards the lateral surface of the glass tube 13 from outside of the glass tube 13. Thereby, the present invention allows to encircle the outer circumference of the sensor chips 14 with the glass tube 13 of high hydrophilicity, resulted in possible manufacturing of cellular electrophysiological sensor with high measurement precision.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：针对制造具有高测量精度的细胞电生理传感器。 解决方案：为了实现该目的，本发明包括以下处理：保持传感器芯片14的过程; 保持包围传感器芯片14的侧表面的外周的玻璃管13的过程; 以及熔融玻璃管13以与传感器芯片14的侧表面玻璃沉积的过程，同时从玻璃管13的外部向玻璃管13的侧表面施加风压。由此，本发明允许 以高亲水性的玻璃管13环绕传感器芯片14的外周，导致可能制造具有高测量精度的细胞电生理传感器。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009072130A

公开(公告)日：2009-04-09

申请号：JP2007244828

申请日：2007-09-21

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： USHIO KOJI ,  NAKATANI MASAYA ,  TAKAHASHI MAKOTO

IPC: C12M1/34 ,  G01N27/28 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To improve the measuring precision of a cellular electrophysiological sensor. SOLUTION: This device for the cellular electrophysiological sensor is equipped with a holding plate 11, a storage vessel 12 installed above the holding plate 11, a flow passage 13 installed below the holding plate 11, a tubular chip-holding part 15 inserted into the perforation 14 of the holding plate 11 and a sensor chip 16 inserted into the lower end of the chip-holding part 15, and the sensor chip 16 has a cell-holding plate 17 formed with a conductive hole 20. The lower surface 17A of the cell-holding plate is positioned below the lower surface 11A of the holding plate. Thereby, the sensor can flow bubbles off by the flow of liquid even if the bubbles attach in the vicinity of the conductive hole 20 on the side of the flow passage 13, and as a result, the measuring precision of the cellular electrophysiological sensor is improved. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提高细胞电生理传感器的测量精度。 解决方案：用于细胞电生理传感器的装置配备有保持板11，安装在保持板11上方的储存容器12，安装在保持板11下方的流动通道13，插入的管状芯片保持部15 进入保持板11的穿孔14和插入芯片保持部15的下端的传感器芯片16，并且传感器芯片16具有形成有导电孔20的电池保持板17.下表面17A 位于保持板的下表面11A的下方。 因此，即使气泡附着在流路13一侧的导电孔20附近，传感器也能够通过液体流动气泡，结果提高了细胞电生理传感器的测定精度 。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009058461A

公开(公告)日：2009-03-19

申请号：JP2007227734

申请日：2007-09-03

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： NAKATANI MASAYA ,  USHIO KOJI ,  HIRAOKA SOICHIRO ,  OSHIMA AKIYOSHI ,  TAKAHASHI MAKOTO

IPC: G01N1/00 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a dispensing apparatus capable of dispensing prescribed liquid and solid components while extracting/moving the solid component into other liquid in approximate synchronism with its dispensing operation.
SOLUTION: The dispensing apparatus is composed of a component separating section and a pipette section 11. The component separating section includes an introducing channel 7 for introducing a first solution 6 containing solid particles 4, a flow channel 2 for introducing a second solution 9, concentration gradient generating means 3 for generating a concentration gradient of the solid particles 4 in the middle portion of the flow channel 2, and a lead-out channel 8 for leading out the first solution 6. The pipette section 11 is disposed so as to communicate with an end of the flow channel 2 from which the second solution 9 containing separated solid particles 4 moved from the first solution 6 into the second solution 9 by the concentration gradient generating means 3 is discharged.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种能够在与其分配操作大致同步地提取/移动固体组分到其它液体的同时分配规定的液体和固体组分的分配装置。 分配装置由分离部分和移液管部分11组成。部件分离部分包括用于引入含有固体颗粒4的第一溶液6的引入通道7，用于引入第二溶液的流动通道2 如图9所示，用于产生固体颗粒4在流动通道2的中间部分的浓度梯度的浓度梯度产生装置3以及用于引出第一溶液6的引出通道8.移液管部分11设置成 与通过浓度梯度发生装置3将分离的固体颗粒4从第一溶液6移动到第二溶液9的第二溶液9从该流路2的一端排出。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2008306968A

公开(公告)日：2008-12-25

申请号：JP2007157213

申请日：2007-06-14

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： USHIO KOJI ,  NAKATANI MASAYA ,  HIRAOKA SOICHIRO ,  OSHIMA AKIYOSHI ,  TAKAHASHI MAKOTO

IPC: C12M1/34 ,  G01N27/28 ,  G01N27/327

Abstract: PROBLEM TO BE SOLVED: To improve the measuring accuracy of a cell electrophysiological sensor. SOLUTION: A device for the cell electrophysiological sensor is equipped with a cell-holing chip 11 and a substrate 9 for covering the sides of the cell-holding chip 11 so as to attain the objectives. Furthermore, the cell-holing chip 11 is provided with a conducting hole 14 connecting the upper and the lower surfaces thereof. The cell-holding chip 11 comprises silicon as the principal component. The substrate 9 is formed of glass and a hydrophilic film 16, composed of at least either silicon oxide or silicon nitride, is formed on each side of the cell-holing chip 11. The substrate 9 is heat-fused to the hydrophilic film 16. Thus, gaps between the sides of the cell-holding chip 11 and the substrate 9 can be reduced to raise airtightness and as a result, improve the measurement accuracy of the cell electrophysiological sensor. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提高细胞电生理传感器的测量精度。 解决方案：用于细胞电生理传感器的装置配备有电池保持芯片11和用于覆盖电池保持芯片11的侧面的基板9，以达​​到目的。 此外，电池开孔芯片11设置有连接其上表面和下表面的导电孔14。 电池保持片11包含硅作为主要成分。 基板9由玻璃形成，并且在电池孔洞芯片11的每一侧形成由至少一种氧化硅或氮化硅构成的亲水性膜16.基板9被热熔合到亲水膜16。 因此，可以减小电池保持用芯片11和基板9的两侧之间的间隙，以提高气密性，结果提高电池电生理传感器的测量精度。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2014232055A

公开(公告)日：2014-12-11

申请号：JP2013113447

申请日：2013-05-29

Applicant: 株式会社島津製作所 ,  Shimadzu Corp ,  パナソニック株式会社 ,  Panasonic Corp

Inventor： SHIMADA TAKASHI ,  AOKI TOMOKAGE ,  SATO TAKAAKI ,  NAKATANI MASAYA ,  HAYAMA MASAAKI

IPC: G01N27/64 ,  G01N27/62

CPC classification number: H01J49/0418 ,  G01N33/6851

Abstract: 【課題】MALDI質量分析において、測定対象物質やマトリックスの不均一性に起因する検出精度の低下を最小限に抑えることのできる測定基板を提供する。【解決手段】MALDI質量分析用測定基板10を、上面を有するベース板11と、前記上面の少なくとも一部に敷設された、配向方向が前記上面の面内にある高配向性グラファイトシートから成るカーボンシート12で構成する。高配向性グラファイトシートは面内方向において高い熱伝導率を有し、それに垂直な方向には低い熱伝導率を有するため、レーザ照射によりマトリックス物質において生成された熱エネルギーは、前記高配向性グラファイトシートを通じて速やかに面内方向に伝達される。これにより、レーザ照射箇所において熱エネルギーは均一となり、マトリックス物質による測定対象試料の昇華及びイオン化の反応が均等に行われるようになって、検出精度の低下が防止される。【選択図】図1

Abstract translation: 要解决的问题：提供一种能够使MALDI质量分析中测量对象材料和基质的不均匀性导致的检测精度的劣化最小化的测量板。解决方案：用于MALDI质量分析的测量板10由以下部分构成：基板 11具有顶面; 以及由顶板的平面中的取向方向为高取向性的石墨片构成的碳片12，至少布置在顶面的一部分。 由于高取向性石墨片在面内方向上具有高导热性，并且在垂直于面内方向的方向上具有低导热性，所以通过激光照射在基体材料中产生的热能迅速地在内部传播， 平面方向穿过高取向石墨片。 因此，激光照射部的热能变得均匀，能够均匀地进行基体材料的测定对象样品的升华和离子化的反应，能够防止检测精度的恶化。

公开(公告)号：JP2013124861A

公开(公告)日：2013-06-24

申请号：JP2011271903

申请日：2011-12-13

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： OKA TAKUYA ,  NAKANO YUSUKE ,  NAKATANI MASAYA

IPC: G01N27/28 ,  G01N27/327 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To provide a sensor chip on which a specimen cell can be caught longer than a conventional sensor chip and in which, since electric noise is reduced, even a weaker electric signal can be measured accurately.SOLUTION: In a sensor chip, a hydrocarbon film or an organic silicon film is formed in a part of a substrate or in a part of a through hole. Thus, an examinee cell can be prevented from being destroyed by passing the through hole and since electric capacitance of the sensor chip is reduced, electric noise is extremely reduced, such that high-accuracy cell electrophysiological measurement can be performed for a long time. Thus, pharmacological effects can be evaluated efficiently.

Abstract translation: 要解决的问题：为了提供一种传感器芯片，其上可以比常规传感器芯片捕获更长的样品池，并且由于电噪声降低，即使能够精确地测量较弱的电信号。 解决方案：在传感器芯片中，在基板的一部分或通孔的一部分中形成烃膜或有机硅膜。 因此，通过使通孔能够防止受检细胞的破坏，并且由于传感器芯片的电容减少，电噪声极度降低，能够长时间进行高精度的细胞电生理测定。 因此，可以有效地评价药理作用。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2011205995A

公开(公告)日：2011-10-20

申请号：JP2010078441

申请日：2010-03-30

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： OKA TAKUYA ,  NAKATANI MASAYA ,  USHIO KOJI ,  TAKAHASHI MAKOTO ,  TANEMURA AKINA

IPC: C12M1/34 ,  G01N27/28 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To provide an electrophysiological measurement device capable of suppressing an effect of a compound secreted from a subject during measurement or the subject nearby without damage thereof.SOLUTION: The electrophysiological measurement device includes: a sensor chip 3 including at least one conduction hole 5 capturing the subject; a retaining plate 4 retaining the sensor chip 3; and a well including a through-hole 2 joined to an upper surface of the retaining plate 4. The electrophysiological measurement device for measuring electrophysiology of the subject 7 by filling the upper surface and a lower surface of the sensor chip 3 with a solution, includes a secretion absorber 6 absorbing the secretion of the subject 7, at a part filled with the solution.

Abstract translation: 要解决的问题：提供一种电生理测量装置，其能够抑制测量期间从受试者分泌的化合物对受试者的影响，而不损害其对象。解决方案：电生理测量装置包括：传感器芯片3，其包括至少一个导电 捕获被摄体的孔5; 保持传感器芯片3的保持板4; 以及包括连接到保持板4的上表面的通孔2的阱。通过用溶液填充传感器芯片3的上表面和下表面来测量被检体7的电生理学的电生理测量装置包括 吸收受试者7的分泌物的分泌吸收器6。

公开(公告)号：JP2011191241A

公开(公告)日：2011-09-29

申请号：JP2010059054

申请日：2010-03-16

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： OKA TAKUYA ,  NAKATANI MASAYA ,  USHIO KOJI ,  TAKAHASHI MAKOTO

IPC: G01N27/28 ,  C12M1/34 ,  G01N27/02 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To achieve electrophysiological measurement corresponding to a polarity of a specimen having the polarity, and to perform simultaneous electrophysiological measurement of different domains of the same specimen. SOLUTION: In order to attain the purpose, this electrophysiological measuring device includes a substrate 1 on which a channel groove 4 having an inner wall for the flow of a solution containing the specimen is formed, a specimen capturing part 6 for capturing the specimen in the channel groove 4, and a conduction hole 5 for communicating a solution not containing the specimen with the channel groove 4 in order to measure an electrophysiological phenomenon of the specimen. The specimen capturing part 6 is allowed to capture the specimen so that the polarity carried by the specimen itself introduced into the channel groove 4 is oriented, and electrophysiological measurement is performed corresponding to the polarity of the specimen. Hereby, cell electrophysiological measurement can be performed efficiently corresponding to the polarity on the cell membrane of a cell. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：实现对应于具有极性的样本的极性的电生理测量，并且对同一样本的不同结构域进行同时电生理测量。 解决方案：为了达到这一目的，该电生理测量装置包括：衬底1，形成有用于包含试样的溶液流的内壁的通道槽4，用于捕获 通道槽4中的试样和用于将不含试样的溶液与通道槽4连通的导电孔5，以测量试样的电生理现象。 允许样本捕获部分6捕获样本，使得被引入到沟槽4中的样本本身携带的极性取向，并且对应于样本的极性进行电生理测量。 因此，可以相应于细胞的细胞膜上的极性有效地进行细胞电生理测量。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010008399A

公开(公告)日：2010-01-14

申请号：JP2009019157

申请日：2009-01-30

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： USHIO KOJI ,  NAKATANI MASAYA ,  TAKAHASHI MAKOTO

IPC: G01N27/28 ,  G01N27/02 ,  G01N27/327 ,  G01N27/416 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a cell electrophysiologic sensor of high productive efficiency. SOLUTION: This cell electrophysiologic sensor includes a mounting substrate 12 having through-holes 11, sensor chips 9 held at the lower end of the through-holes 11 and having a conductive hole 19, and tape 20 stuck to the lower surface of the mounting substrate 12 via an adhesive layer. The tape 20 has holes positioned inside the through-holes 11 in a part facing the through-holes 11. Thus, a cell electrophysiologic sensor can reduce exposing area of the adhesive layer, and has low cell toxicity and high measurement accuracy. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供高生产效率的细胞电生理传感器。 解决方案：该细胞电生理传感器包括具有通孔11的安装基板12，保持在通孔11的下端的传感器芯片9，并且具有导电孔19，并且带20粘附在通孔11的下表面 安装基板12经由粘合剂层。 胶带20在面向通孔11的部分中具有位于通孔11内的孔。因此，细胞电生理传感器可以减少粘合剂层的暴露面积，并且具有低细胞毒性和高测量精度。 版权所有（C）2010，JPO＆INPIT