公开(公告)号：WO2011140508A1

公开(公告)日：2011-11-10

申请号：PCT/US2011/035630

申请日：2011-05-06

Applicant: ALPS, LLC ,  PY, Daniel

Inventor： PY, Daniel

IPC: F16K31/12

CPC classification number: F16K15/145 ,  B65D47/2018 ,  B65D47/2031 ,  B65D77/065 ,  B65D83/0055 ,  F16K15/02 ,  F16K15/142 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/4245 ,  Y10T137/7879 ,  Y10T137/7889 ,  Y10T137/86895

Abstract: A one-way valve is connectable in fluid communication with a fluid-receiving chamber, such as a dilution chamber or a mixing chamber for diluting or mixing a perishable food product, such as a milk product or chocolate product, and forming a substantially fluid-tight seal therebetween. The valve comprises a relatively rigid valve seat, and a relatively flexible valve member overlying the valve seat and forming an axially-elongated, normally-closed valve opening therebetween defining an inlet at one end of the valve seat, an outlet at an opposite end of the valve seat, and an axially-extending seal therebetween that forms a fluid-tight seal between the inlet and outlet of the normally-closed valve opening. An axially-extending valve body is radially spaced relative to the valve member and forms a space therebetween allowing fluid-flow therethrough for cleaning the valve and the fluid-receiving chamber.

Abstract translation: 单向阀可连接到流体接收室，例如用于稀释或混合易腐食品（例如牛奶制品或巧克力制品）的稀释室或混合室，并形成基本上流体连通的流体 - 密封。 所述阀包括相对刚性的阀座和相对柔性的阀构件，该阀构件覆盖在阀座上并且形成一个轴向细长的常闭阀门开口，在其间限定出阀座一端的入口， 阀座和其间的轴向延伸的密封件，其在常闭阀开口的入口和出口之间形成流体密封。 轴向延伸的阀体相对于阀构件径向间隔开并在其间形成一个空间，允许流体流过其中以清洁阀和流体接收室。

公开(公告)号：WO2009055830A1

公开(公告)日：2009-04-30

申请号：PCT/US2008/081393

申请日：2008-10-27

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  ARKINS, Thomas, Daniel ,  CHAN, Julian ,  TULLEY, Bryan ,  WILLEY, Jeffrey

Inventor： PY, Daniel ,  ARKINS, Thomas, Daniel ,  CHAN, Julian ,  TULLEY, Bryan ,  WILLEY, Jeffrey

IPC: A61J11/00

CPC classification number: B65D47/36 ,  A61J1/202 ,  A61J9/00 ,  A61J9/008 ,  A61J11/04 ,  B65B3/04 ,  B65D47/063 ,  B65D47/265 ,  B65D47/32 ,  B65D51/002

Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.

Abstract translation: 一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及容器盖，该容器封闭件包括用于在储存期间气密地密封室内的产品的主密封件。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。 容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到 允许产品从腔室通过流出口并进入分配构件以分配产品。

公开(公告)号：WO2007050970A2

公开(公告)日：2007-05-03

申请号：PCT/US2006/042159

申请日：2006-10-26

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  FLAMENBAUM, Miles, J. ,  HARTMAN, Eric, E. ,  HOULE, Nathaniel

Inventor： PY, Daniel ,  FLAMENBAUM, Miles, J. ,  HARTMAN, Eric, E. ,  HOULE, Nathaniel

IPC: B67D5/00

CPC classification number: B65D51/227 ,  B65D47/205 ,  B65D2251/0025 ,  B65D2251/0093

Abstract: A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the first passageway relative to the storage chamber, and a first threaded connecting portion located at one end of the body for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and a piercing portion mounted within the valve body and engageable with the pierceable wall of the container. At least one of the piercing portion and the pierceable wall is movable relative to the other between a first position wherein the pierceable portion is not piercing the pierceable wall, and a second position wherein the pierceable portion is piercing the pierceable wall and the first passageway of the container is in fluid communication with the second passageway of the valve body for allowing the flow of substance from the storage chamber therethrough. The valve assembly includes a second threaded connecting portion that is threadedly connectable to the first threaded connecting portion of the container for fixedly securing the valve assembly to the container when the valve assembly and container are located in the second position. A manually-engageable and removable member is disposed intermediate the valve body and the container that prevents movement of at least one of the piercing portion and pierceable wall to the second position until the removable member is removed. The valve assembly includes a valve seat and at least one flow aperture extending through the valve body adjacent to the valve seat and in fluid communication with the second passageway for receiving the substance from the storage chamber there through.

Abstract translation: 用于存储和分配物质的装置包括具有在其中限定有用于接收和存储物质的储存室的主体的容器。 容器包括与主体的储存室流体连通并限定其间的流路的第一通道。 所述容器还包括位于所述第一通道相对于所述储存室的相对侧上的可穿透壁，以及位于所述主体的一端的第一螺纹连接部分，用于将另一部件连接到所述第一螺纹连接部分。 该装置还包括单向阀组件，该单向阀组件包括阀体，阀体包括限定第二通道的主体基座和安装在阀体内并与容器的可刺穿壁接合的刺穿部分。 所述穿刺部分和所述可刺穿壁中的至少一个在所述可刺穿部分不穿透所述可刺穿壁之间的第一位置和第二位置之间可相对于另一个移动，其中所述可刺穿部分穿透所述可刺破壁和所述第一通道 容器与阀体的第二通道流体连通，用于允许物质从储存室流过。 阀组件包括第二螺纹连接部分，其螺纹连接到容器的第一螺纹连接部分，用于当阀组件和容器位于第二位置时将阀组件固定地固定到容器。 手动接合和可拆卸构件设置在阀体和容器之间，防止至少一个刺穿部分和可刺穿的壁移动到第二位置，直到可移除构件被移除。 阀组件包括阀座和至少一个流动孔，其延伸穿过与阀座相邻的阀体，并与第二通道流体连通，用于从存储室接收物质。

公开(公告)号：WO2006063000A2

公开(公告)日：2006-06-15

申请号：PCT/US2005/044167

申请日：2005-12-05

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  CHAN, Julian, V. ,  ADAMO, Benoit

Inventor： PY, Daniel ,  CHAN, Julian, V. ,  ADAMO, Benoit

IPC: G06Q10/00

CPC classification number: B67D1/0004 ,  B65B39/004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/10 ,  B67D1/108 ,  B67D1/1279 ,  B67D3/04 ,  B67D2001/0827 ,  F04B43/1238 ,  F04B53/1037 ,  Y10T137/7761

Abstract: An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variable­volume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.

Abstract translation: 装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。 该设备的阀盖由弹性材料形成，并且包括安装在阀体上并且固定地防止相对于其移动的盖基座以及覆盖阀座的阀门部分。 阀部分限定预定的径向厚度并与阀座形成过盈配合。 阀部分和阀座在它们之间限定了常闭的轴向延伸的阀开口。 阀部分可在阀部分与阀座接合的常闭位置和打开位置之间移动，其中阀部分的至少一段与阀座隔开以将阀开口与流动孔口流体连通地连接 从而允许流体从流动孔通过阀开口。 密封的可变容积存储腔室在其中存储流体的多个部分并且可与单向阀组件流体连通地连接。 泵联接在可变容积存储腔室和单向阀组件之间，并且被配置为从可变容积存储腔室抽出离散的部分流体，穿过流动孔并且通过阀门开口以分配部分 流体通过阀门组件。

公开(公告)号：WO2005115282A2

公开(公告)日：2005-12-08

申请号：PCT/US2005/018890

申请日：2005-05-24

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61F9/00

CPC classification number: A61F9/0061

Abstract: An apparatus and method are provided for applying and removing contact lenses. The apparatus has an actuator and two tissue-engaging surfaces drivingly coupled to the actuator for engaging tissue adjacent to the eye in connection with actuating the actuator and to facilitate retaining the eye open during removal of the contact lens therefrom. A support surface supports the apparatus adjacent to the eye, and a lens removing member is drivingly coupled to the actuator for movement between an extended position and a retracted position for removing the contact lens from the eye. The actuator actuates the tissue-engaging surface to facilitate retaining the eye open during removal of the contact lens therefrom, and substantially simultaneously actuates the lens removing member to remove the contact lens from the open eye.

Abstract translation: 提供了一种用于施加和去除隐形眼镜的装置和方法。 该装置具有致动器和驱动地连接到致动器的两个组织接合表面，用于与邻近眼睛的组织接合以致动致动器，并且有助于在从其移除隐形眼镜期间保持眼睛张开。 支撑表面支撑邻近眼睛的装置，并且透镜去除构件驱动地联接到致动器，用于在延伸位置和缩回位置之间移动，以从眼睛移除隐形眼镜。 致动器致动组织接合表面以有助于在从其中移除隐形眼镜期间保持眼睛打开，并且基本上同时致动透镜去除构件以从露出眼睛去除隐形眼镜。

公开(公告)号：WO2005087592A1

公开(公告)日：2005-09-22

申请号：PCT/US2005/007916

申请日：2005-03-08

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: B65B07/28

CPC classification number: B29C67/004 ,  B29C45/006 ,  B29C45/1701 ,  B29C45/42 ,  B29C65/16 ,  B29C65/1616 ,  B29C66/001 ,  B29C66/0018 ,  B29C66/71 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91221 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/961 ,  B29C2791/005 ,  B29L2031/565 ,  B65B3/003 ,  B65B3/022 ,  B65B55/06 ,  B29C65/00 ,  B29K2023/38

Abstract: A stopper (22) and container body (18) are molded in the same molding machine (28). An assembly device(24), such as a pick and place robot, transfers the stopper from one mold cavity (20) into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper (22) and the container body (18). Then, the assembled container body and stopper are removed from the molding machine(28) and transported to a needle filling and laser resealing station (36) for filling and laser resealing. A laminar flow source (33) directs a substantially laminar flow of air (35) or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 在相同的成型机（28）中模制止动器（22）和容器主体（18）。 诸如拾放机器人的组装装置（24）将止动器从一个模腔（20）转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器（22）和 容器主体（18）。 然后，将组装的容器主体和止动件从成型机（28）中取出并运送到用于填充和激光重新密封的针填充和激光再密封台（36）。 层流源（33）将大致层流的空气（35）或无菌气体引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：WO2005046755A2

公开(公告)日：2005-05-26

申请号：PCT/US2004/037341

申请日：2004-11-08

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  ADAMO, Benoit ,  GUTHY, John

Inventor： PY, Daniel ,  ADAMO, Benoit ,  GUTHY, John

IPC: A61M

CPC classification number: B65B3/006 ,  A61L2/10 ,  A61M5/1782 ,  B29C66/80 ,  B65B3/003 ,  B65B43/00 ,  B65B51/00 ,  Y10T29/49716

Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one needle assembly and is adjustable to receive a plurality of needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of vials that are to be filled concurrently and adjusting an assembly to include at least one needle assembly and at least one seal assembly. A number of the needle assemblies and the seal assemblies equals the number of vials.

Abstract translation: 组件包括支撑和驱动组件，第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个针组件，并且可调节以接收多个针组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的小瓶的数量并且调整组件以包括至少一个针组件和至少一个密封组件。 许多针组件和密封组件等于小瓶的数量。

公开(公告)号：WO2004101027A2

公开(公告)日：2004-11-25

申请号：PCT/US2004/014823

申请日：2004-05-12

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  CHAN, Julian, V.

Inventor： PY, Daniel ,  CHAN, Julian, V.

IPC: A61M

CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

公开(公告)号：WO2004032989A2

公开(公告)日：2004-04-22

申请号：PCT/US2003/022612

申请日：2003-07-16

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61M

CPC classification number: A61M5/3287 ,  A61M5/3202 ,  A61M5/3272 ,  A61M5/46 ,  A61M2005/2073 ,  A61M2005/3261 ,  A61M2005/3267

Abstract: An intradermal delivery device for injecting a substance into the skin has a housing including a base defining a radially-extending mounting surface for releasably engaging the skin, and a needle aperture formed therethrough and defining a substantially planar needle penetration region on the skin. A pressure-sensitive adhesive is superimposed over the mounting surface for releasably securing the mounting surface to the skin and preventing relative movement of the needle penetration region of the skin and the mounting surface. A syringe body is reciprocally mounted within the housing and a plunger is reciprocally mounted within the syringe body. A needle is mounted to the syringe body and is movable through the needle aperture to penetrate the needle penetration region of the skin. A needle cap is mounted over the needle and forms an approximately airtight seal therebetween, and is penetrable by the needle upon passage through the needle aperture and into the skin.

Abstract translation: 用于将物质注射到皮肤中的皮内递送装置具有壳体，该壳体包括限定用于可释放地接合皮肤的径向延伸的安装表面的基部和穿过其中形成的针孔，并且在皮肤上限定基本上平面的穿刺区域。 压敏粘合剂叠加在安装表面上，用于将安装表面可释放地固定到皮肤上，并防止皮肤的穿刺区域和安装表面的相对运动。 注射器主体相互安装在壳体内，柱塞往复地安装在注射器主体内。 针头安装到注射器主体上并且能够穿过针孔移动以穿透皮肤的穿刺区域。 针帽安装在针上并在其间形成大致气密的密封，并且当针穿过针孔并进入皮肤时可以穿透针头。

公开(公告)号：WO2003041763A2

公开(公告)日：2003-05-22

申请号：PCT/US2002/036617

申请日：2002-11-14

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  CHAN, Julian, V.

Inventor： PY, Daniel ,  CHAN, Julian, V.

IPC: A61M

CPC classification number: A61M5/425 ,  A61M5/24 ,  A61M5/3158 ,  A61M5/31591 ,  A61M5/3287 ,  A61M5/46

Abstract: The subject intradermal delivery device provides for penetration to a fixed depth without requiring special expertise by the user. The device consists of a syringe nested inside an inner shell and an outer shell. An elongated annular channel is formed between the inner shell and the outer shell. A housing receives the syringe and concentric shells in a sliding engagement. A first seal on the distal end of the housing forms a variable length channel in communication with the elongated annular channel via a port formed in the outer shell. When the device is applied to the skin, the housing and syringe are slid towards the skin, and the variable length channel generates a vacuum which forces the skin to bulge into the elongated annular channel. As a result, the skin is tensioned across the inner shell to form a substantially planar, taut target area of skin. The taut target area of skin in combination with a stop on the housing determines the insertion depth of the syringe.

Abstract translation: 受试者皮内递送装置提供穿透至固定深度，而不需要用户的专门知识。 该装置由嵌套在内壳和外壳内的注射器组成。 在内壳和外壳之间形成细长的环形通道。 壳体以滑动接合的方式接收注射器和同心壳体。 在壳体的远端上的第一密封件通过形成在外壳中的端口形成与细长环形通道连通的可变长度通道。 当将该装置应用于皮肤时，壳体和注射器朝向皮肤滑动，并且可变长度通道产生迫使皮肤凸起进入细长环形通道的真空。 结果，皮肤被横跨内壳张紧，以形成基本上平坦的，拉紧的皮肤目标区域。 与壳体上的止动件组合的皮肤的拉紧目标区域决定了注射器的插入深度。