公开(公告)号：NO950374L

公开(公告)日：1995-03-29

申请号：NO950374

申请日：1995-02-01

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：AU6830094A

公开(公告)日：1994-12-12

申请号：AU6830094

申请日：1994-05-10

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M

IPC: C07D333/58 ,  A61K31/38 ,  A61K31/381 ,  A61P1/00 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P27/16 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00

Abstract: Methods are disclosed utilizing optically pure (-)-zileuton for the treatment of asthma in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of zileuton.

公开(公告)号：AU6098094A

公开(公告)日：1994-08-15

申请号：AU6098094

申请日：1994-01-27

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： GRAY NANCY M ,  WOOSLEY RAYMOND L

IPC: A61K31/495 ,  A61K31/50

公开(公告)号：AU5955094A

公开(公告)日：1994-07-19

申请号：AU5955094

申请日：1993-12-17

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M

IPC: A61K31/495

Abstract: Methods and compositions are disclosed utilizing the optically pure (-) isomer of ketoconazole. This compound is a potent drug for the treatment of local and systemic fungal, yeast, and dermatophyte infections, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ketoconazole.

公开(公告)号：CA2141572A1

公开(公告)日：1994-02-17

申请号：CA2141572

申请日：1993-08-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: C07D211/22 ,  A61K9/48 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: A pharmaceutical composition comprising a compound of formula (I): wherein Z is COOH, COOCH3 or CH2OH, or a pharmaceutically acceptable salt thereof, for use in an anti-histaminic treatment which does not induce any significant cardiac arrhythmia, comprising administering a therapeutically effective amount of a compound of formula (I) to a human patient.

公开(公告)号：HK1045806B

公开(公告)日：2008-03-14

申请号：HK02106014

申请日：2002-08-17

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K20060101 ,  A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P20060101 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

公开(公告)号：DK1214937T3

公开(公告)日：2007-09-17

申请号：DK02006356

申请日：1993-08-03

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M ,  CHEN YIWANG ,  WOOSLEY RAYMOND L ,  YOUNG JAMES W

IPC: A61K31/445 ,  A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：AT363283T

公开(公告)日：2007-06-15

申请号：AT02006356

申请日：1993-08-03

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K31/445 ,  C07D211/22 ,  A61K9/48 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：DE69334008T2

公开(公告)日：2006-10-19

申请号：DE69334008

申请日：1993-08-03

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K31/445 ,  A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：AU2003204192B2

公开(公告)日：2005-11-03

申请号：AU2003204192

申请日：2003-05-14

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M

IPC: A61K31/4184 ,  A61P1/04 ,  A61K031/4184 ,  A61P001/04