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公开(公告)号：JP2007109402A
公开(公告)日：2007-04-26
申请号：JP2007018172
申请日：2007-01-29
Inventor： KISHIMA KOICHIRO , SAITO KIMIHIRO
Abstract: PROBLEM TO BE SOLVED: To transmit write light or read light for read/write of a first recording layer 3 without decreasing thickness of a second recording layer 5 disposed in a side where the write light or the read light is incident in an optical recording medium having at least two recording layers. SOLUTION: An optical recording medium having at least two recording layers includes a first recording layer 3; a second recording layer 5 disposed at a side, at which write light or read light is incident, than the first recording layer 3 with an intermediate layer 4 being interposed between the recording layers; and a dielectric layer 7 between the intermediate layer 4 and the second recording layer 5, which makes higher the transmittance of light transmitted through the second recording layer with increase in incident angle of the light. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：为了发送用于第一记录层3的读/写的写入光或读取光，而不减少设置在写入光或读取光入射在一侧的第二记录层5的厚度 具有至少两个记录层的光学记录介质。 解决方案：具有至少两个记录层的光学记录介质包括第一记录层3; 设置在写入光或读取光的一侧的第二记录层5比第一记录层3具有介于记录层之间的中间层4; 以及在中间层4和第二记录层5之间的电介质层7，其随着光的入射角的增加而使透过第二记录层的光的透射率更高。 版权所有（C）2007，JPO＆INPIT
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42.发明专利
公开(公告)号：JP2006216135A
公开(公告)日：2006-08-17
申请号：JP2005026541
申请日：2005-02-02
Inventor： TAKEMOTO SADAHIRO , KAI SHINICHI , KISHIMA KOICHIRO
Abstract: PROBLEM TO BE SOLVED: To provide an optical pickup having a phase-modulating liquid crystal element which can perform a desired aberration correction even if the thickness of a liquid crystal layer is different from a designed thickness due to a change of environmental temperature, an error in production of liquid crystal elements, or the like. SOLUTION: Signal voltages VS1, VS2 and VS3 which drive a phase-modulating device mounted on an optical pickup are generated as follows. Firstly, a VSamp is generated in accordance with an aberration correction value, and a first signal voltage VS1 and a second signal voltage VS2 are generated from a reference driving signal VS0 and the VSamp. Then, a VSoffset is generated so that it may be equal to a third signal voltage VS3 when an equation ¾VS2¾=¾VS1¾ is established, and the third signal voltage VS3 is generated from the VS1, k (a constant), the VSamp and the VSoffset. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 要解决的问题：为了提供一种具有相位调制液晶元件的光学拾取器，即使由于环境温度的变化而导致液晶层的厚度与设计厚度不同，其也可以执行期望的像差校正 ，液晶元件的制造误差等。 解决方案：驱动安装在光学拾取器上的相位调制装置的信号电压VS1，VS2和VS3如下生成。 首先，根据像差校正值生成VSamp，并且从参考驱动信号VS0和VSamp生成第一信号电压VS1和第二信号电压VS2。 然后，当等式¾VS2¾=¾VS1¾建立时，产生VSoffset，使得其可以等于第三信号电压VS3，并且从VS1，k（常数），VSamp和VSoffset生成第三信号电压VS3 。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2005339712A
公开(公告)日：2005-12-08
申请号：JP2004159392
申请日：2004-05-28
Inventor： KISHIMA KOICHIRO
IPC: G11B7/0055 , G11B7/135
Abstract: PROBLEM TO BE SOLVED: To stably initialize each recording layer in an optical recording medium having a plurality of recording layers while stabilizing an initialization condition without having an adverse effect on the other recording layers. SOLUTION: A ring-shaped laser flux 200 is converged on a recording layer L0 of the optical recording medium 10 by an objective lens 4 to initialize a recording material. In that case, since reflected light from a recording layer L1 is dispersed because all the ring-shaped laser flux 200 is made incident on the recording layer L0 obliquely, the adverse effects made by the reflected light on the initialization condition is almost eliminated. In addition, in the case of converging the ring-shaped light flux 200 on the recording layer L1 to perform initialization, an adverse effect is eliminated in a similar manner because heat escapes to the outer and inner sides of the laser flux 200, so that the recording layer L0 can not reach initialization temperature, even though the ring-shaped laser flux 200 passes through the recording layer L0. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 要解决的问题：在稳定初始化状态的同时，在具有多个记录层的光记录介质中稳定地初始化每个记录层，而不会对其它记录层产生不利影响。 解决方案：环形激光束200通过物镜4会聚在光记录介质10的记录层L0上，以初始化记录材料。 在这种情况下，由于所有环形激光束200倾斜地入射到记录层L0上，所以由于记录层L1的反射光分散，所以几乎消除了反射光对初始化条件的不利影响。 此外，在将环形光束200会聚在记录层L1上以进行初始化的情况下，由于热量逸出到激光束200的外侧和内侧，因此以类似的方式消除了不利影响，使得 即使环形激光束200通过记录层L0，记录层L0也不能达到初始化温度。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2017083263A
公开(公告)日：2017-05-18
申请号：JP2015210980
申请日：2015-10-27
Inventor： KISHIMA KOICHIRO
Abstract: 【課題】流路を流れる微粒子に照射されなかった励起光の利用効率を高める。【解決手段】本開示に係る微粒子検出装置は、微粒子が流れる流路に励起光を照射して前記微粒子から蛍光光を励起させる第1の照射部と、前記第1の照射部によって前記流路に照射された光から励起光と蛍光光を分離する第1の分離部と、前記第1の分離部によって分離された蛍光光を検出する第1の検出部と、前記第1の分離部によって分離された励起光を前記流路に照射して前記微粒子から蛍光光を励起させる第2の照射部と、前記第2の照射部によって前記流路に照射された光から励起光と蛍光光を分離する第2の分離部と、前記第2の分離部によって分離された蛍光光を検出する第2の検出部と、を備える。【選択図】図3
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公开(公告)号：JP2014098575A
公开(公告)日：2014-05-29
申请号：JP2012249208
申请日：2012-11-13
Inventor： KISHIMA KOICHIRO
CPC classification number: G01N21/6428 , G01N21/6458
Abstract: PROBLEM TO BE SOLVED: To provide an image acquisition device and an image acquisition method capable of efficiently photograph a biological sample having a fluorescent marker.SOLUTION: The image acquisition device includes: a light source that generates an excitation light for causing a fluorescent marker on a biological sample to emit light; an imaging element for focusing an image; an optical system that irradiates at least a part of a region including the fluorescent marker on the biological sample with the excitation light from the light source and focuses a fluorescent image of the region on the imaging element; a movement control section that controls the optical system to move the focus point in an optical axis direction of the optical system and in a direction perpendicular to the optical axis; a generation section that exposes the imaging element continuously during the movement of the focus point of the optical system to generate a long-time exposure image of the region; and a calculation section that analyzes the frequency of the generated long-time exposure image to calculate a piece of positional information in the optical axis direction of the fluorescent marker using at least the analysis result.
Abstract translation: 要解决的问题：提供能够有效地拍摄具有荧光标记物的生物样品的图像获取装置和图像获取方法。解决方案：图像获取装置包括：产生用于使荧光标记物上的激发光的光源 生物样品发光; 用于聚焦图像的成像元件; 光学系统，其利用来自光源的激发光将包含荧光标记的区域的至少一部分照射在生物样品上，并将该区域的荧光图像聚焦在成像元件上; 移动控制部，其控制所述光学系统使所述聚焦点沿所述光学系统的光轴方向和与所述光轴垂直的方向移动; 生成部，其在所述光学系统的所述焦点的移动期间连续地使所述摄像元件曝光，以产生所述区域的长时间曝光图像; 以及计算部分，其分析所生成的长时间曝光图像的频率，以至少使用分析结果来计算荧光标记的光轴方向上的位置信息。
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Patent Agency Ranking46.发明专利Image acquisition device, image acquisition method and image acquisition program 审中-公开图像获取装置，图像采集方法和图像采集程序
公开(公告)号：JP2013114042A
公开(公告)日：2013-06-10
申请号：JP2011260271
申请日：2011-11-29
Inventor： KISHIMA KOICHIRO , NARISAWA TATSU , SUZUKI FUMIYASU
CPC classification number: H04N7/18 , G02B21/16 , G02B21/365
Abstract: PROBLEM TO BE SOLVED: To provide an image acquisition device which allows an organism sample with a fluorescent label attached to be efficiently imaged, an image acquisition method and an image acquisition program.SOLUTION: The image acquisition device includes a light source, an optical system, an imaging element, a movement control unit and a data processing unit. The light source irradiates an organism sample with a fluorescent label attached with excitation light for the fluorescent label. The optical system includes an object lens for magnifying an imaging object of the organism sample. An image of the imaging object magnified by the object lens is formed on the imaging element. The movement control unit moves a focal position of the optical system within in an imaging range including at least a range of the thickness of the imaging object. The data processing unit acquires a fluorescent image of the organism sample by exposing the imaging element while the focal position is moved within the imaging range, and calculates distribution information of the fluorescent label in the thickness direction of the imaging object on the basis of the fluorescent image.
Abstract translation: 要解决的问题：提供一种允许具有附着的荧光标签的生物体样品被有效成像的图像获取装置，图像获取方法和图像获取程序。 解决方案：图像采集装置包括光源，光学系统，成像元件，移动控制单元和数据处理单元。 光源用具有荧光标记的激发光的荧光标签照射生物体样品。 光学系统包括用于放大生物体样品的成像对象的物镜。 在成像元件上形成由物镜放大的成像对象的图像。 运动控制单元在包括成像对象的厚度的至少一个范围的成像范围内移动光学系统的焦点位置。 数据处理单元通过在焦点位置在成像范围内移动而使成像元件曝光而获取有机体样品的荧光图像，并且基于荧光体计算成像对象的厚度方向上的荧光标签的分布信息 图片。 版权所有（C）2013，JPO＆INPIT
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47.发明专利Focal position information detector, microscope device and focal position information detection method 有权焦点位置信息检测器，显微镜装置和焦点位置信息检测方法
公开(公告)号：JP2012108184A
公开(公告)日：2012-06-07
申请号：JP2010254770
申请日：2010-11-15
Inventor： KISHIMA KOICHIRO , NARISAWA TATSU
Abstract: PROBLEM TO BE SOLVED: To provide a focal position information detector, a microscope device and a focal position information detection method which enable accurate detection of focal position information.SOLUTION: A focal position information detector 1 includes an image sensor 2, a stage 4, a light source 6, a light source control section 9, and a focal position information acquisition section 10. The image sensor 2 includes plural pixel lines and operates in a rolling shutter mode. The stage 4 faces the image sensor 2 via a microscopic optical system 3 and is movable in the optical axis direction of the microscopic optical system 3. The light source 6 lights the stage 4. The light source control section 9 makes the light source 6 emit light intermittently at an interval longer than light reception time of the pixel lines. The focal position information acquisition section 10 acquires focal position information on the microscopic optical system 3 based on an image imaged by the image sensor 2 while moving the stage 4.
Abstract translation: 要解决的问题：提供一种能够准确检测焦点位置信息的焦点位置信息检测器，显微镜装置和焦点位置信息检测方法。 解决方案：焦点位置信息检测器1包括图像传感器2，平台4，光源6，光源控制部分9和焦点位置信息获取部分10.图像传感器2包括多个像素线 并以滚动快门模式操作。 舞台4通过微观光学系统3面对图像传感器2，并且可在微观光学系统3的光轴方向上移动。光源6照亮舞台4.光源控制部9使光源6发射 以比像素线的光接收时间长的间隔间歇地发光。 焦点位置信息获取部分10在移动舞台4的同时基于由图像传感器2成像的图像获取关于微观光学系统3的焦点位置信息。（C）2012，JPO和INPIT
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48.发明专利Image processing apparatus, image processing system and image processing method, and program 审中-公开图像处理设备，图像处理系统和图像处理方法及程序
公开(公告)号：JP2012013804A
公开(公告)日：2012-01-19
申请号：JP2010148280
申请日：2010-06-29
Inventor： KISHIMA KOICHIRO
CPC classification number: G02B21/367 , G06T5/50 , G06T2207/20221
Abstract: PROBLEM TO BE SOLVED: To provide an image processing apparatus capable of detecting a depth position of a target in a sample without requiring a large-capacity memory.SOLUTION: An image processing apparatus 20 exposes an imaging element 30 while moving a stage 11 in a Z-direction to obtain a first image of a sample SPL including a first bright point representing a fluorescent marker M; and exposes the imaging element 30 while moving the stage 11 at a first constant speed in the Z-direction as well as in an X-direction at a second constant speed to obtain a second image including a second bright point representing the fluorescent marker M. A distance D between a first bright point and a second bright point within a composite image of the first image and the second image is calculated; and thus, a height h of the fluorescent marker M in the sample SPL is calculated based on the distance D and the first speed and the second speed.
Abstract translation: 要解决的问题：提供一种能够在不需要大容量存储器的情况下检测样本中的目标的深度位置的图像处理装置。 解决方案：图像处理装置20在沿着Z方向移动台11的同时曝光摄像元件30，以获得包括表示荧光标记M的第一亮点的样本SPL的第一图像; 并且在Z方向以X方向以及第二恒定速度的第一恒定速度移动台11的同时露出成像元件30，以获得包括表示荧光标记M的第二亮点的第二图像。 计算第一图像和第二图像的合成图像内的第一亮点和第二亮点之间的距离D; 因此，基于距离D和第一速度和第二速度来计算样本SPL中的荧光标记M的高度h。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2011158273A
公开(公告)日：2011-08-18
申请号：JP2010018002
申请日：2010-01-29
Inventor： KISHIMA KOICHIRO
IPC: G01M11/02
Abstract: PROBLEM TO BE SOLVED: To provide a chromatic aberration measuring method, capable of efficiently measuring the chromatic aberration.
SOLUTION: An image of light of each wavelength is reflected in the fluorescent sample image with an inclination conforming to a difference in the chromatic aberration by moving relative positions of a fluorescent sample SPE and an image sensor 30 while the focal point of an objective lens 12 is moved in the direction of the optical axis so that the moving directions may be varied in a surface direction intersecting the moving direction of the focal point at right angles to acquire a fluorescent sample image by making the image sensor 30 exposed in the meantime, thereby a microscope device 1 can measure the chromatic aberration, based on this inclination. Accordingly, the number of sheets of the fluorescent sample images can be lessened in comparison with that of conventional ones. Consequently, an imaging time can be shortened and thus the chromatic aberration can be measured efficiently.
COPYRIGHT: (C)2011,JPO&INPITAbstract translation: 要解决的问题：提供能够有效地测量色差的色差测量方法。 解决方案：通过移动荧光样品SPE和图像传感器30的相对位置，通过移动荧光样品SPE和图像传感器30的相对位置，以适合于色差的倾斜的方式将每个波长的光的图像反射在荧光样品图像中 物镜12沿光轴方向移动，使得移动方向可以在与焦点的移动方向成直角相交的表面方向上变化，以通过使图像传感器30暴露在 同时，显微镜装置1可以基于该倾斜度来测量色差。 因此，与常规荧光样品图像相比，荧光样品图像的片数可以减少。 因此，可以缩短成像时间，从而有效地测量色像差。 版权所有（C）2011，JPO＆INPIT
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50.发明专利Fluorescent image-obtaining device, fluorescent image-obtaining method, and fluorescent image-obtaining program 有权荧光图像获取装置，荧光图像获取方法和荧光图像获取程序
公开(公告)号：JP2011070140A
公开(公告)日：2011-04-07
申请号：JP2009244874
申请日：2009-10-23
Inventor： HAYASHI NOBUHIRO , YAMAGOSHI TAKAMICHI , KISHIMA KOICHIRO , KIHARA NOBUHIRO , YAMAMOTO TAKASHI , SUZUKI FUMIYASU , NARISAWA TATSU , HIRONO YU
CPC classification number: G01N21/6458 , G01N21/6428
Abstract: PROBLEM TO BE SOLVED: To obtain the image of a fluorescent-stained biological sample, without degrading image quality.
SOLUTION: Exciting light for making a fluorescent material marked on a target in a biological sample SPL lie in a non-excited state and for making a fluorescent material marked on a control with the probe lie in an excited state is emitted from an exciting light source 51, to take the image of the entire slide glass SG including the biological sample SPL as a dark field thumbnail image by a thumbnail camera 14, so that the dark field thumbnail image including the entire fluorescent-stained biological sample SPL can be obtained without degrading the image quality.
COPYRIGHT: (C)2011,JPO&INPITAbstract translation: 要解决的问题：为了获得荧光染色的生物样品的图像，而不降低图像质量。 解决方案：用于制造标记在生物样品SPL中的靶上的荧光材料的激发光处于非激发状态，并且使用探针处于激发状态的在控制上标记的荧光材料从 激发光源51，通过缩略图相机14将包括生物样本SPL的整个载玻片SG的图像作为暗视野缩略图图像，使得包括整个荧光染色的生物样本SPL的暗视野缩略图可以是 获得而不降低图像质量。 版权所有（C）2011，JPO＆INPIT
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