公开(公告)号：US20080095839A1

公开(公告)日：2008-04-24

申请号：US10594436

申请日：2005-03-23

Applicant: Takashi Yoshitake ,  Mitsuru Mizuno ,  Kenji Moroshima ,  Shigeru Aoki

Inventor： Takashi Yoshitake ,  Mitsuru Mizuno ,  Kenji Moroshima ,  Shigeru Aoki

IPC: A61K9/52 ,  A61K31/44 ,  A61K9/24

CPC classification number: A61K9/2886 ,  A61K31/4439

Abstract: It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax.

Abstract translation: 本发明的目的是在含有不稳定的生理活性物质的控释药物组合物，特别是脉冲释放药物组合物的情况下，提供溶解滞后时间几乎没有变化的药物组合物， 溶解特性可靠性高。 本发明公开了一种控释药物组合物，其包含：1）含有酸不稳定的生理活性物质和崩解剂的核心; 和2）覆盖核心并且含有水不溶性聚合物，肠溶聚合物和疏水性蜡的释放控制涂层。

公开(公告)号：US20070120255A1

公开(公告)日：2007-05-31

申请号：US11599268

申请日：2006-11-15

Applicant: Kiyonori Oyu ,  Shigeru Aoki

Inventor： Kiyonori Oyu ,  Shigeru Aoki

IPC: H01L23/48

CPC classification number: H01L23/562 ,  H01L21/306 ,  H01L21/30604 ,  H01L21/3065 ,  H01L21/308 ,  H01L21/78 ,  H01L23/26 ,  H01L23/3128 ,  H01L29/0657 ,  H01L2924/0002 ,  H01L2924/00

Abstract: The present invention has an object to provide a semiconductor chip of high reliability with less risk of breakage. Specifically, the present invention provides a semiconductor chip having a semiconductor silicon substrate including a semiconductor device layer and a porous silicon domain layer, the semiconductor device layer being provided in a main surface region on one surface of the semiconductor silicon substrate, the porous silicon domain layer being provided in a main surface region on a back surface which is the other surface of the semiconductor silicon substrate, and the porous silicon domain layer having porous silicon domains dispersed like islands in the back surface of the semiconductor silicon substrate.

Abstract translation: 本发明的目的是提供一种具有较高可靠性的半导体芯片，具有较小的破损风险。 具体而言，本发明提供一种半导体芯片，具有包括半导体器件层和多孔硅畴层的半导体硅衬底，半导体器件层设置在半导体硅衬底的一个表面上的主表面区域中，多孔硅区域 层设置在作为半导体硅衬底的另一表面的背面上的主表面区域中，并且在半导体硅衬底的背面中具有分散成岛状的多孔硅畴的多孔硅畴层。

公开(公告)号：US20070110806A1

公开(公告)日：2007-05-17

申请号：US11543991

申请日：2006-10-06

Applicant: Takashi Yoshitake ,  Mitsuru Mizuno ,  Kenji Moroshima ,  Shigeru Aoki

Inventor： Takashi Yoshitake ,  Mitsuru Mizuno ,  Kenji Moroshima ,  Shigeru Aoki

IPC: A61K9/26

CPC classification number: A61K9/2886 ,  A61K31/4439

Abstract: It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax.

Abstract translation: 本发明的目的是在含有不稳定的生理活性物质的控释药物组合物，特别是脉冲释放药物组合物的情况下，提供溶解滞后时间几乎没有变化的药物组合物， 溶解特性可靠性高。 本发明公开了一种控释药物组合物，其包含：1）含有酸不稳定的生理活性物质和崩解剂的核心; 和2）覆盖核心并且含有水不溶性聚合物，肠溶聚合物和疏水性蜡的释放控制涂层。

公开(公告)号：US06794847B2

公开(公告)日：2004-09-21

申请号：US10059196

申请日：2002-01-31

Applicant: Masaharu Hosoda ,  Masaaki Kaizuka ,  Kazunari Takahashi ,  Shigeru Aoki

Inventor： Masaharu Hosoda ,  Masaaki Kaizuka ,  Kazunari Takahashi ,  Shigeru Aoki

IPC: H02J700

CPC classification number: B60K6/28 ,  B60K6/485 ,  B60K6/54 ,  B60L3/0046 ,  B60L11/14 ,  B60L2210/10 ,  B60L2210/40 ,  B60L2270/20 ,  H02J7/1423 ,  H02J7/1492 ,  H02J2001/008 ,  Y02T10/6226 ,  Y02T10/70 ,  Y02T10/7077 ,  Y02T10/7216 ,  Y02T10/7241 ,  Y02T10/92 ,  Y10S903/903 ,  Y10S903/907 ,  Y10S903/917

Abstract: The charging system for a vehicle includes: a motor generator which operates as a generator to generate an alternating current when the motor generator is driven by an internal combustion engine, and operates as a motor when an alternating current is supplied thereto; a switching circuit for converting the alternating current generated by the motor generator into a direct current; a first accumulator accumulating therein the direct current converted by the switching circuit; a second accumulator accumulating therein the direct current converted by the switching circuit and having a smaller accumulation voltage than that of the first accumulator; a first opening/closing unit interposed between the first accumulator and the switching circuit; a second opening/closing unit interposed between the second accumulator and the switching circuit; and, a control unit for controlling the opening and closing of the first and second opening/closing units.

Abstract translation: 车辆的充电系统包括：电动发电机，其在电动发电机由内燃机驱动时作为发电机进行动作以产生交流电流，并且当提供交流电时作为电动机动作; 用于将由电动发电机产生的交流电转换为直流的开关电路; 第一累加器累积由开关电路转换的直流电流; 第二累加器累积由所述开关电路转换的直流电并且具有比所述第一累加器的累积电压更小的累积电压; 插入在所述第一蓄电池和所述开关电路之间的第一开闭单元; 插入在所述第二蓄电池和所述开关电路之间的第二开闭单元; 以及控制单元，用于控制第一和第二打开/关闭单元的打开和关闭。

公开(公告)号：US06629515B1

公开(公告)日：2003-10-07

申请号：US09679145

申请日：2000-10-05

Applicant: Kazuhisa Yamamoto ,  Yusuke Tatara ,  Shigeru Aoki

Inventor： Kazuhisa Yamamoto ,  Yusuke Tatara ,  Shigeru Aoki

IPC: F02N1100

CPC classification number: B60W10/06 ,  B60K6/485 ,  B60K6/543 ,  B60L7/18 ,  B60L15/2045 ,  B60L2240/62 ,  B60L2240/68 ,  B60W2510/244 ,  B60W2540/12 ,  B60W2550/20 ,  B60W2550/22 ,  B60W2550/402 ,  F02D2200/701 ,  F02D2200/702 ,  F02N11/0814 ,  F02N11/0837 ,  F02N2200/061 ,  F02N2200/0802 ,  F02N2200/0806 ,  F02N2200/0807 ,  F02N2200/104 ,  F02N2200/123 ,  F02N2200/125 ,  F02N2300/306 ,  G08G1/096725 ,  G08G1/096758 ,  G08G1/096783 ,  Y02T10/48 ,  Y02T10/6226 ,  Y02T10/645 ,  Y02T10/72 ,  Y02T10/7283 ,  Y02T10/7291 ,  Y02T90/16 ,  Y02T90/162 ,  Y10S903/903 ,  Y10S903/918

Abstract: An engine control device is provided, capable of restarting the engine when starting the vehicle rapidly and without giving any feeling of unease to the driver at the time of starting the vehicle by restarting the engine from the idle stop state. The engine control device comprises an engine stop determination device for determining the propriety of stopping the engine; an engine stop device for stopping the engine based on the determination of the engine stop determination device; an engine start determination device for determining the propriety of starting the engine; an engine starting device for starting the engine based on the determination of the engine start determination device; and a vehicle forward signal state detecting device for detecting the state of the traffic light directly ahead in the vehicle travelling direction; wherein said engine start determination device determines whether it is appropriate to start the engine based on the change of the traffic light state detected by said vehicle forward signal state detecting device, when the engine is stopped by the determination of said engine stop determination device while the vehicle stops during driving.

Abstract translation: 提供了一种发动机控制装置，能够在起动车辆时快速地起动发动机，并且在通过从怠速停止状态重新起动发动机而在起动车辆时不给驾驶员带来不舒服的感觉。 发动机控制装置包括用于确定停止发动机的适当性的发动机停止确定装置; 发动机停止装置，用于根据所述发动机停止判定装置的判定来停止所述发动机; 用于确定起动发动机的适当性的发动机起动确定装置; 发动机起动装置，用于基于所述发动机起动判定装置的判定来起动所述发动机; 以及车辆前方信号状态检测装置，用于检测车辆前进方向上的交通信号灯的状态; 其特征在于，所述发动机起动判定装置根据由所述车辆前方信号状态检测装置检测到的交通灯状态的变化，判定是否适合起动所述发动机，当所述发动机由所述发动机停止判定装置的判定停止时， 车辆停在驾驶中。

公开(公告)号：US06377596B1

公开(公告)日：2002-04-23

申请号：US09043384

申请日：1998-03-18

Applicant: Toshiaki Tanaka ,  Shigeru Aoki

Inventor： Toshiaki Tanaka ,  Shigeru Aoki

IPC: H01S520

CPC classification number: H01L33/025 ,  B82Y20/00 ,  H01L21/02378 ,  H01L21/02381 ,  H01L21/02387 ,  H01L21/0242 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02639 ,  H01L33/007 ,  H01L33/16 ,  H01L33/20 ,  H01S5/0202 ,  H01S5/0205 ,  H01S5/0207 ,  H01S5/0208 ,  H01S5/0213 ,  H01S5/18319 ,  H01S5/18338 ,  H01S5/18341 ,  H01S5/1835 ,  H01S5/2077 ,  H01S5/223 ,  H01S5/227 ,  H01S5/2272 ,  H01S5/3202 ,  H01S5/32341 ,  H01S5/34333 ,  H01S5/423 ,  H01S2304/12

Abstract: An insulating member (4) of an amorphous structure partially opened to expose a substrate (1; 1, 2, 3) is formed on the substrate. At least a compound semiconductor (5, 51, 52) containing at least nitrogen as a constituent element is deposited on the insulating member (4) and the substrate (40) exposed by the opening thereby to form a semiconductor material (1, 5, 51, 52). A semiconductor material (6, 7) configured of the first semiconductor material or configured of the first semiconductor material and another semiconductor material grown on the first semiconductor material is processed thereby to form a semiconductor device.

Abstract translation: 在基板上形成有部分开放以露出基板（1; 1,2,3）的非晶结构的绝缘构件（4）。 至少含有氮作为构成元素的化合物半导体（5,51,52）沉积在由开口露出的绝缘构件（4）和基板（40）上，形成半导体材料（5,5， 51，52）。 由第一半导体材料构成或由第一半导体材料构成的半导体材料和在第一半导体材料上生长的另一半导体材料进行处理，从而形成半导体器件。

公开(公告)号：US5632250A

公开(公告)日：1997-05-27

申请号：US530525

申请日：1995-09-19

Applicant: Atsushi Kato ,  Yoshikazu Ohshima ,  Eisaku Gosho ,  Kazuhiro Ueda ,  Shigeo Hidai ,  Akira Murakami ,  Toshiyuki Nishida ,  Shigeru Aoki ,  Ryuichi Noseyama ,  Kenichiro Ishibashi ,  Katsunori Nakamura ,  Nobuo Arai

Inventor： Atsushi Kato ,  Yoshikazu Ohshima ,  Eisaku Gosho ,  Kazuhiro Ueda ,  Shigeo Hidai ,  Akira Murakami ,  Toshiyuki Nishida ,  Shigeru Aoki ,  Ryuichi Noseyama ,  Kenichiro Ishibashi ,  Katsunori Nakamura ,  Nobuo Arai

IPC: F02D19/02 ,  F02D41/00 ,  F02D41/06 ,  F02D41/22 ,  F02M51/02 ,  F02M69/28 ,  F02M69/46 ,  F02M51/00

CPC classification number: F02M69/462 ,  F02D19/022 ,  F02D19/024 ,  F02D19/025 ,  F02D19/027 ,  F02D41/0027 ,  F02D41/064 ,  F02D41/22 ,  F02M21/0224 ,  F02M21/029 ,  F02M51/02 ,  F02M69/28 ,  F02D2041/224 ,  F02M21/0215 ,  F02M21/0278 ,  Y02T10/32

Abstract: Supply of fuel is stopped when fuel pressure sensed by a pressure sensor provided upstream of a regulator is at a predetermined value or less to avoid abnormal combustion caused by improper adjustment of air/fuel ratio. Even slight variation of the fuel pressure is sensed by monitoring the fuel pressure in an interval after closing a fuel shut-off valve once opened to re-opening of it. In addition, an abnormal state in the fuel system is detected by comparing an accumulated value of amount of injected fuel and an estimated value of fuel consumption in the tank. Furthermore, the peak current value of the fuel injection valve is controlled so that, when the engine at a low temperature is started, lift load of the injection valve is larger than sticking force of the injection valve, thereby preventing such situation where the injection valve is frozen so that it cannot supply fuel to the engine. In this case, the engine can be smoothly started by simultaneously controlling the valve open time. Furthermore, the temperature of the regulator is properly maintained so that optimum function can be exhibited by controlling the flow rate of cooling water flowing through a water passage provided in the regulator for regulating the fuel gas pressure.

Abstract translation: 在设置在调节器上游的压力传感器检测到的燃料压力为预定值以下时，停止供给燃料，以避免由于空气/燃料比的不当调整引起的异常燃烧。 通过在关闭燃料切断阀一旦打开以重新打开之后的间隔中监视燃料压力来检测燃料压力的轻微变化。 另外，燃料系统中的异常状态是通过比较燃料喷射量的累积值和燃料消耗的估计值来检测的。 此外，控制燃料喷射阀的峰值电流值，使得当低温发动机开始时，喷射阀的升程负荷大于喷射阀的粘附力，从而防止了喷射阀 被冻结，使其不能向发动机供应燃料。 在这种情况下，可以通过同时控制阀打开时间来平稳地起动发动机。 此外，适当地保持调节器的温度，从而通过控制流过设置在用于调节燃料气体压力的调节器中的水通道的冷却水的流量来显示最佳功能。

公开(公告)号：US5035899A

公开(公告)日：1991-07-30

申请号：US332731

申请日：1989-04-04

Applicant: Yasuharu Saeki ,  Noritoshi Koyama ,  Sumio Watanabe ,  Shigeru Aoki

Inventor： Yasuharu Saeki ,  Noritoshi Koyama ,  Sumio Watanabe ,  Shigeru Aoki

IPC: A61K9/30 ,  A61K9/20 ,  A61K9/28 ,  A61K31/415 ,  A61K31/44 ,  A61K47/00 ,  A61K47/02 ,  A61P1/04

CPC classification number: A61K31/44 ,  A61K9/2009 ,  A61K9/2886

Abstract: A peroral preparation of an acid-unstable compound comprises (1) a core containing the acid-unstable compound, (2) a first layer, coated on the core, comprising a hardly water-soluble, film-forming material and fine particles of a hardly water-soluble substance, suspended in the material, and (3) a second layer, coated on the first layer, of enteric film. The acid-unstable compound is a benzimidazole compound.

公开(公告)号：US4002666A

公开(公告)日：1977-01-11

申请号：US516963

申请日：1974-10-22

Applicant: Tadashi Shirai ,  Yasuhisa Tashiro ,  Shigeru Aoki

Inventor： Tadashi Shirai ,  Yasuhisa Tashiro ,  Shigeru Aoki

IPC: C07B57/00 ,  C07B31/00 ,  C07C19/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/20 ,  C07C227/34 ,  C07C229/36 ,  C07C231/00 ,  C07C231/12 ,  C07C231/20 ,  C07C233/47 ,  C07C103/46 ,  C07C103/84 ,  C07C125/06

CPC classification number: C07C271/06

Abstract: Optically active p-hydroxyphenylglycine is prepared by reacting a racemic compound of a specified p-hydroxyphenylglycine derivative with optically active .alpha.-phenylethylamine to form a corresponding salt, obtaining two types of optically active salts therefrom by fractional crystallization, and obtaining optically active p-hydroxyphenylglycine by decomposition and hydrolysis of at least one of the optically active salts.

Abstract translation: 通过使特定的对羟基苯基甘氨酸衍生物的外消旋化合物与光学活性α-苯乙胺反应形成相应的盐，通过分级结晶获得两种类型的光学活性盐，得到光学活性对羟基苯基甘氨酸，制备光学活性对羟基苯基甘氨酸 通过至少一种光学活性盐的分解和水解。

公开(公告)号：US3994962A

公开(公告)日：1976-11-30

申请号：US544899

申请日：1975-01-28

Applicant: Tadashi Shirai ,  Yasuhisa Tashiro ,  Shigeru Aoki

Inventor： Tadashi Shirai ,  Yasuhisa Tashiro ,  Shigeru Aoki

IPC: C07C143/28

Abstract: Optically active p-hydroxyphenylglycine is manufactured by inoculating a supersaturated solution of a p-hydroxyphenylglycine sulfonic acid derivative salt comprising a mixture of the two optically active enantiomers of said salt with an optically active enantiomer of the same salt, said mixture being either racemic or else one in which the predominant enantiomer is that of the inoculant. In this manner the enantiomer having the form of the inoculant is selectively crystallized. The selectively crystallized salt is thereafter treated for removal of the sulfonic acid derivative.

Abstract translation: 通过将包含所述盐的两种光学活性对映异构体的混合物的对羟基苯基甘氨酸磺酸衍生物盐的过饱和溶液与相同盐的光学活性对映体接触来制备光学活性对羟基苯基甘氨酸，所述混合物是外消旋的 其中主要的对映异构体是孕育剂的对映异构体。 以这种方式，具有孕育剂形式的对映体被选择性结晶。 然后处理选择性结晶的盐以除去磺酸衍生物。