公开(公告)号：EP4433818A1

公开(公告)日：2024-09-25

申请号：EP22839045.6

申请日：2022-11-18

Applicant: Waters Technologies Corporation

Inventor： FOGWILL, Michael O. ,  MICHIENZI, Joseph D. ,  BESNER, Sebastien ,  COOK, Brett G. ,  O'BRIEN, Peter

IPC: G01N30/74 ,  G01N21/05

CPC classification number: G01N30/74 ,  B01L3/502715 ,  B01L2300/065420130101 ,  B01L2300/087720130101

公开(公告)号：EP2748504B1

公开(公告)日：2015-12-09

申请号：EP12828696.0

申请日：2012-08-23

Applicant: Waters Technologies Corporation

Inventor： MICHIENZI, Joseph D.

IPC: G01N30/60 ,  F16L19/02

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

公开(公告)号：EP2748599A2

公开(公告)日：2014-07-02

申请号：EP12826759.8

申请日：2012-08-23

Applicant: Waters Technologies Corporation

Inventor： MICHIENZI, Joseph D.

IPC: G01N30/60

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

Abstract translation: 描述了包括微流体衬底，耦合器和密封配件的层析色谱装置。 微流体基底可以包括一个或多个色谱柱，例如分析柱或捕获柱，以及与一个或多个色谱柱连通的入口。 耦合器扩散结合到微流体衬底的表面，使得耦合器中的开口与微流体衬底中的入口对齐。 密封配件包括设置在耦合器的开口中并与衬底表面接触的耐热密封剂。 该耦合器和密封配件能够实现与微流体基底的入口紧密流体密封连接，该微流体基底具有高拉伸和扭转强度，并且不需要使用粘合剂。

公开(公告)号：EP2747861A1

公开(公告)日：2014-07-02

申请号：EP12828910.5

申请日：2012-08-23

Applicant: Waters Technologies Corporation

Inventor： MICHIENZI, Joseph D. ,  FADGEN, Keith ,  LEVEILLE, SR., Wade P. ,  FISK, Raymond P. ,  MARZALKOWSKI, JR., Frank John

IPC: B01D15/08 ,  B23P19/00

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

Abstract translation: 描述了色谱柱组件，其包括可永久变形的外管，中间管，内管和设置在内管内的吸附剂床。 吸附剂床可以是填充色谱颗粒或多孔整体结构的形式。 通过在组件上的纵向位置处的一个或多个均匀的径向卷曲提供径向密封。 均匀的径向卷曲将外管和下面的中间管压缩到内管上，以实现三个管之间的高压液密密封。 每个卷边的长度和深度都精确地形成以适应特定应用的要求。 防止沿着管道组件的泄漏并且减少或消除空隙体积。 不需要外部套圈或套圈模锻机构; 因此色谱柱组件很容易适用于各种色谱柱配置。

公开(公告)号：EP2747860A1

公开(公告)日：2014-07-02

申请号：EP12826799.4

申请日：2012-08-23

Applicant: Waters Technologies Corporation

Inventor： MICHIENZI, Joseph D.

IPC: B01D15/08

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

Abstract translation: 用于化学分离的装置包括具有用于输出样品的洗脱液的出口孔的微流体衬底。 发射器组件包括具有可变形的端部部分，在可变形端部附近的入口，以从微流体衬底接收样品洗脱液，以及导电出口部分以发射样品洗脱液的喷雾。 力施加单元向发射器组件施加力，其促使可变形端部与微流体衬底接触。 可变形端部比微流体衬底更具弹性，使得微流体衬底和可变形端部之间的接触在微流体衬底的出口孔与发射器组件的入口之间产生基本上流体密封的密封。

公开(公告)号：EP2747859A1

公开(公告)日：2014-07-02

申请号：EP12825812.6

申请日：2012-08-22

Applicant: Waters Technologies Corporation

Inventor： MICHIENZI, Joseph D. ,  MURPHY, James P. ,  KEENE, Russell L.

IPC: B01D15/08

CPC classification number: G01N30/06 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1827 ,  G01N30/16 ,  G01N30/6095 ,  G01N30/88 ,  G01N33/49 ,  G01N2001/383 ,  G01N2030/009 ,  G01N2030/062

Abstract: An apparatus for use in a chromatography system includes a first microfluidic substrate having a first fluidic channel. One end of the first fluidic channel terminates at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first fluidic channel terminates at a second fluidic port on a second side of the first microfluidic substrate. A second microfluidic substrate has a second fluidic channel. One end of the second fluidic channel terminates at a first fluidic port on a first side of the second microfluidic substrate. The first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the fluidic port of the second microfluidic substrate aligns with one of the fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second fluidic channels.

公开(公告)号：EP4244613A1

公开(公告)日：2023-09-20

申请号：EP22705213.1

申请日：2022-01-25

Applicant: Waters Technologies Corporation

Inventor： CORMIER, Sylvain Gilles ,  MURPHY, Charles T. ,  MICHIENZI, Joseph D.

IPC: G01N30/20 ,  B01L3/00 ,  F16K99/00 ,  F16K11/072 ,  G01N30/46

公开(公告)号：EP4237841A1

公开(公告)日：2023-09-06

申请号：EP21811633.3

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： LEVEILLE, Wade P. ,  CORMIER, Sylvain G. ,  FOGWILL, Michael O. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  ANTOCCI, Joseph D.

IPC: G01N30/60 ,  G01N30/46

公开(公告)号：EP4153988A1

公开(公告)日：2023-03-29

申请号：EP21732731.1

申请日：2021-05-20

Applicant: Waters Technologies Corporation

Inventor： CORMIER, Syvlain Gilles ,  MURPHY, Charles T. ,  MICHIENZI, Joseph D.

IPC: G01N30/20

公开(公告)号：EP3030351A1

公开(公告)日：2016-06-15

申请号：EP14834260.3

申请日：2014-08-04

Applicant: Waters Technologies Corporation

Inventor： MICHIENZI, Joseph D. ,  MURPHY, James P. ,  FOGWILL, Michael O. ,  FADGEN, Keith ,  GERHARDT, Geoff ,  BERTONE, Gary W.

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L7/54 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0883 ,  B01L2300/1805 ,  B01L2300/1811 ,  B01L2300/1894

Abstract: A microfluidic device, for use in separation systems, includes a substrate having a fluidic channel. One or more heaters made of a thick film material are integrated with the substrate and in thermal communication with the fluidic channel of the substrate. The one or more heaters produce a thermal gradient within the fluidic channel in response to a current flowing through the one or more heaters. A plurality of electrically conductive taps can be in electrically conductive contact with the one or more heaters. The plurality of electrically conductive taps provides an electrically conductive path to the one or more heaters by which an electrical supply can produce the current flowing through the one or more heaters. Alternatively, the thick film material can be ferromagnetic, and the electrical supply can use induction to cause the current to flow through the one or more heaters.