公开(公告)号：US06844464B2

公开(公告)日：2005-01-18

申请号：US10388302

申请日：2003-03-13

Applicant: Ryoji Sugise ,  Shuji Tanaka ,  Hirofumi Ii ,  Kazuaki Mii

Inventor： Ryoji Sugise ,  Shuji Tanaka ,  Hirofumi Ii ,  Kazuaki Mii

IPC: C07C201/04 ,  C07C203/00 ,  C07C203/02

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: An alkyl nitrite is produced with high efficiency by bringing a nitrogen monoxide gas into contact with an aqueous solution of an alkyl alcohol and nitric acid in a reactor 2, which aqueous solution may be a liquid fraction generated in an alkyl nitrite-production process in which an alkyl alcohol is reacted with nitrogen monoxide and oxygen in a reaction column 1.

公开(公告)号：US20030149292A1

公开(公告)日：2003-08-07

申请号：US10240319

申请日：2003-01-21

Inventor： Philippe Karrer ,  Sebastien Balzano

IPC: C07C203/00

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: The invention concerns a method for preparing alkyl nitrites of formula (I) R ONO (I) ONO wherein R represents a C1-C20, advantageously C2-C10 linear or branched alkyl group. The invention is characterised in that it consists in gradually and continuously adding in an aqueous medium, an alcohol of formula (II) R OH, R being as defined above, a nitrite of formula (III) M NO2, wherein M represents a metal cation, and a strong acid, so as to form continuously said alkyl nitrite, and in continuously drawing off said alkyl nitrite thus formed from the reaction medium.

Abstract translation: 本发明涉及一种制备式（I）的烷基亚硝酸酯R ONO（I）ONO的方法，其中R表示C1-C20，有利地为C2-C10直链或支链烷基。 本发明的特征在于其在水性介质中逐渐和连续地加入式（II）的醇R OH，R如上定义，式（III）的亚硝酸根M NO 2，其中M表示金属阳离子 和强酸，从而连续形成亚硝酸烷基酯，并连续地从反应介质中除去由此形成的亚硝酸烷基酯。

公开(公告)号：US3649665A

公开(公告)日：1972-03-14

申请号：US3649665D

申请日：1969-04-23

Applicant: TEXACO INC

Inventor： CHAFETZ HARRY ,  BLACKLEY WILLIAM D ,  KREUZ KENNETH L

IPC: C07C45/33 ,  C07C45/36 ,  C07C51/31 ,  C07C201/02 ,  C07C201/04 ,  C07C203/00 ,  C07C205/02 ,  C07C205/06 ,  C07C77/00 ,  C07C77/02 ,  C07C79/02

CPC classification number: C07C201/02 ,  C07C45/33 ,  C07C45/36 ,  C07C51/316 ,  C07C201/04 ,  C07C201/06 ,  C07C2601/14 ,  C07C203/02 ,  C07C203/00 ,  C07C205/06 ,  C07C205/02

Abstract: THIS INVENTION RELATES TO THE RELATIVELY LOW TEMPERATURE TREATMENT OF HYDROCARBONS WITH NITRIC OIDE (NO) AND OXYGEN TO RPODUCE NITRATES, NITRITES AND KETONES AND OTHER OXIDATION PRODUCTS. THROUGH THE USE OF ALKALINE INHIBITORS SUCH AS ALKALI METAL BICARBONATES, THE PRODUCTION OF KETONES AND OTHER NON-NITROGEN CONTAINING OXIDATION PRODUCTS CAN BE MINIMIZED WHILE THE PRODUCTION OF ITRATES AND NITRIES ARE MAXIMIZED.

公开(公告)号：US2474903A

公开(公告)日：1949-07-05

申请号：US2474903D

CPC classification number: C07C201/00 ,  C07C201/04 ,  C07C207/00

公开(公告)号：WO2017046118A1

公开(公告)日：2017-03-23

申请号：PCT/EP2016/071620

申请日：2016-09-14

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  MAYERHOEFFER, Ulrich ,  GIRARD, Christophe ,  BITTEL, Michael ,  KALBERMATTEN, Rolf ,  ARNOLD, Claudio ,  GARMS, Stefan ,  SCHNIDER, Christian ,  TILLE, Stefan ,  FAVRE, Manuel ,  RABOUD, Guy ,  SCHNYDRIG, Kilian ,  VENETZ, Martin ,  EGGEL, Thomas

IPC: C07C201/04 ,  C07C203/00

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO 2 in a continuous way, in which the n-butanol, an acid and NaNO 2 are mixed in a mixing device which provides for a pressure drop of at least 1 bar; the acid is selected from the group consisting of HCI, H 2 SO 4 , formic acid, methanesulfonic acid, and mixtures thereof; and the amount of HCI is at least 1.02 molar equivalent based on the molar amount of n-butanol.

Abstract translation: 本发明公开了一种连续制备正丁醇含量低的正丁基亚硝酸正丁酯的方法，包括正丁醇，酸和NaNO 2的连续反应，其中正丁醇，酸和NaNO 2 在混合装置中混合，该混合装置提供至少1巴的压降; 酸选自HCl，H 2 SO 4，甲酸，甲磺酸及其混合物; 并且基于正丁醇的摩尔量，HCl的量为至少1.02摩尔当量。

公开(公告)号：WO2012128515A9

公开(公告)日：2012-12-20

申请号：PCT/KR2012001928

申请日：2012-03-16

Applicant: LG CHEMICAL LTD ,  IUCF HYU ,  HAN YANG-KYOO ,  CHO JIN ,  LEE SANG-MI ,  SHIN SEUNG-HOON

Inventor： HAN YANG-KYOO ,  CHO JIN ,  LEE SANG-MI ,  SHIN SEUNG-HOON

IPC: C08F20/54 ,  B01J27/26 ,  C07C245/00 ,  C08F12/08 ,  C08F20/56

CPC classification number: C07C291/08 ,  B01J31/06 ,  B01J2231/641 ,  C07C201/04 ,  C07C207/02 ,  C07C209/36 ,  C07C209/38 ,  C07C209/40 ,  C07C213/02 ,  C07C245/08 ,  C08F20/54 ,  C08F212/08 ,  C08F220/56 ,  Y02P20/582 ,  C08F220/54 ,  C08F212/36 ,  C07C211/46 ,  C07C211/47

Abstract: The present invention relates to a polymer supported reagent comprising a novel crosslinked mesoporous polymer, enabling a simple and easy production of an azoxy compound or an azo compound from an aromatic nitro compound, and a method of selectively reducing an aromatic nitro compound by using the same. The polymer supported reagent comprises a certain acrylamide mesoporous crosslinked polymer.

Abstract translation: 本发明涉及包含新颖的交联介孔聚合物的聚合物负载型试剂，能够简单且容易地从芳族硝基化合物制备偶氮化合物或偶氮化合物，以及通过使用其来选择还原芳族硝基化合物的方法 。 聚合物负载的试剂包括某种丙烯酰胺介孔交联聚合物。

公开(公告)号：WO2014111957A1

公开(公告)日：2014-07-24

申请号：PCT/IN2014/000033

申请日：2014-01-17

Applicant: SATYAM, Apparao

Inventor： SATYAM, Apparao

IPC: C07C203/04 ,  A61K31/216 ,  A61K31/621 ,  A61P35/00 ,  A61P29/00 ,  A61P29/02 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P1/04 ,  A61P25/24 ,  A61P25/08 ,  A61P31/04 ,  A61P33/06 ,  A61P39/06

CPC classification number: A61K47/542 ,  A61K31/21 ,  A61K31/216 ,  A61K31/60 ,  A61K47/55 ,  C07C201/04 ,  C07C203/04 ,  C07C227/18 ,  C07C229/42

Abstract: The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these prodrugs.

Abstract translation: 本发明涉及已知药物或治疗剂的一氧化氮释放前药，其中药物或治疗剂含有至少一个羧酸基团。 本发明还涉及制备这些一氧化氮释放前药的方法，含有它们的药物组合物和使用这些前药的方法。

公开(公告)号：WO01074754A1

公开(公告)日：2001-10-11

申请号：PCT/FR2001/000999

申请日：2001-04-03

IPC: C07B61/00 ,  C07C201/04 ,  C07C203/00

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: The invention concerns a method for preparing alkyl nitrites of formula (I) R ONO wherein R represents a C1-C20, advantageously C2-C10 linear or branched alkyl group. The invention is characterised in that it consists in gradually and continuously adding in an aqueous medium, an alcohol of formula (II) R OH, R being as defined above, a nitrite of formula (III) M NO2, wherein M represents a metal cation, and a strong acid, so as to form continuously said alkyl nitrite, and in continuously drawing off said alkyl nitrite thus formed from the reaction medium.

Abstract translation: 本发明涉及一种制备式（I）的亚硝酸烷基酯的方法，其中R代表C1-C20，有利地为C2-C10直链或支链烷基。 本发明的特征在于其在水性介质中逐渐和连续地加入式（II）的醇R OH，R如上定义，式（III）的亚硝酸根M NO 2，其中M表示金属阳离子 和强酸，从而连续形成亚硝酸烷基酯，并连续地从反应介质中除去由此形成的亚硝酸烷基酯。

公开(公告)号：WO2012128515A3

公开(公告)日：2013-02-07

申请号：PCT/KR2012001928

申请日：2012-03-16

Applicant: LG CHEMICAL LTD ,  IUCF HYU ,  HAN YANG-KYOO ,  CHO JIN ,  LEE SANG-MI ,  SHIN SEUNG-HOON

Inventor： HAN YANG-KYOO ,  CHO JIN ,  LEE SANG-MI ,  SHIN SEUNG-HOON

IPC: C08F20/54 ,  B01J27/26 ,  C07C245/00 ,  C08F12/08 ,  C08F20/56

CPC classification number: C07C291/08 ,  B01J31/06 ,  B01J2231/641 ,  C07C201/04 ,  C07C207/02 ,  C07C209/36 ,  C07C209/38 ,  C07C209/40 ,  C07C213/02 ,  C07C245/08 ,  C08F20/54 ,  C08F212/08 ,  C08F220/56 ,  Y02P20/582 ,  C08F220/54 ,  C08F212/36 ,  C07C211/46 ,  C07C211/47

Abstract: The present invention relates to a polymer supported reagent comprising a novel crosslinked mesoporous polymer, enabling a simple and easy production of an azoxy compound or an azo compound from an aromatic nitro compound, and a method of selectively reducing an aromatic nitro compound by using the same. The polymer supported reagent comprises a certain acrylamide mesoporous crosslinked polymer.

Abstract translation: 本发明涉及包含新颖的交联介孔聚合物的聚合物负载型试剂，能够简单且容易地从芳族硝基化合物制备偶氮化合物或偶氮化合物，以及通过使用其来选择还原芳族硝基化合物的方法 。 聚合物负载的试剂包括某种丙烯酰胺介孔交联聚合物。

公开(公告)号：WO2012128515A2

公开(公告)日：2012-09-27

申请号：PCT/KR2012/001928

申请日：2012-03-16

Applicant: LG CHEM, LTD. ,  IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) ,  HAN, Yang-Kyoo ,  CHO, Jin ,  LEE, Sang-Mi ,  SHIN, Seung-Hoon

Inventor： HAN, Yang-Kyoo ,  CHO, Jin ,  LEE, Sang-Mi ,  SHIN, Seung-Hoon

IPC: C08F20/54 ,  C08F20/56 ,  C08F12/08 ,  C07C245/00 ,  B01J27/26

CPC classification number: C07C291/08 ,  B01J31/06 ,  B01J2231/641 ,  C07C201/04 ,  C07C207/02 ,  C07C209/36 ,  C07C209/38 ,  C07C209/40 ,  C07C213/02 ,  C07C245/08 ,  C08F20/54 ,  C08F212/08 ,  C08F220/56 ,  Y02P20/582 ,  C08F220/54 ,  C08F212/36 ,  C07C211/46 ,  C07C211/47

Abstract: The present invention relates to a polymer supported reagent comprising a novel crosslinked mesoporous polymer, enabling a simple and easy production of an azoxy compound or an azo compound from an aromatic nitro compound, and a method of selectively reducing an aromatic nitro compound by using the same. The polymer supported reagent comprises a certain acrylamide mesoporous crosslinked polymer.

Abstract translation: 本发明涉及一种包含新型交联中孔聚合物的聚合物载体试剂，其能够简单且容易地由芳族硝基化合物制备氧化偶氮化合物或偶氮化合物，以及选择性还原 通过使用它们的芳香族硝基化合物。 聚合物载体试剂包含特定的丙烯酰胺中孔交联聚合物。