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    POROUS MATERIAL AND METHOD FOR FABRICATING SAME
    42.
    发明申请
    POROUS MATERIAL AND METHOD FOR FABRICATING SAME 审中-公开
    多孔材料及其制造方法

    公开(公告)号：US20130171443A1

    公开(公告)日：2013-07-04

    申请号：US13774245

    申请日：2013-02-22

    Applicant: PPD MEDITECH

    Inventor： DANIEL MORRISSETTE ,  PATRICK CROTEAU

    IPC: B32B5/14 ,  B32B5/22 ,  B32B27/00

    CPC classification number: B32B5/145 ,  A61L27/18 ,  A61L27/48 ,  A61L27/56 ,  B32B5/22 ,  B32B27/00 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249981 ,  Y10T428/249991 ,  C08L71/00

    Abstract: A composite structure comprising a first porous portion comprising a plurality of interconnected pores and a second solid portion having a first surface, said first surface secured to said first portion wherein said first and second portions are fabricated from a polymer material. The material may be suitable for implant, illustratively vertebral or spinal implants, comprising a rigid biocompatible polymer such as PEEK comprising a plurality of interconnected pores. The polymer illustratively has a porosity of between 50% and 85% by volume and in a particular embodiment is able to withstand pressures of up to 20 MPa. The porous PEEK material may also have a minimum thickness in any dimension of one (1) inch.

    Abstract translation: 一种复合结构，包括包括多个互连孔的第一多孔部分和具有第一表面的第二固体部分，所述第一表面固定到所述第一部分，其中所述第一和第二部分由聚合物材料制成。 该材料可适用于植入物，例如脊椎或脊髓植入物，其包含刚性生物相容性聚合物，例如包含多个互连孔的PEEK。 该聚合物示例性地具有50体积％至85体积％之间的孔隙率，并且在特定实施方案中能够承受高达20MPa的压力。 多孔PEEK材料也可以具有一（1）英寸的任何尺寸的最小厚度。

    Compositions containing poly(lactic acid), bacteriocin(s), plasticizers(s), and optionally pore forming agent(s), and methods or making
    43.
    发明授权
    Compositions containing poly(lactic acid), bacteriocin(s), plasticizers(s), and optionally pore forming agent(s), and methods or making 有权
    包含聚（乳酸），细菌素，增塑剂和任选的成孔剂的组合物，以及方法或制备

    公开(公告)号：US08268905B1

    公开(公告)日：2012-09-18

    申请号：US12583110

    申请日：2009-08-14

    Applicant: LinShu Liu ,  David R. Coffin ,  Kevin B. Hicks ,  Zhonglin T. Jin

    Inventor： LinShu Liu ,  David R. Coffin ,  Kevin B. Hicks ,  Zhonglin T. Jin

    IPC: C08J9/00

    CPC classification number: C08L67/04 ,  C08J3/203 ,  C08J9/0023 ,  C08J9/26 ,  C08J2201/0422 ,  C08J2201/0446 ,  C08J2201/0464 ,  C08J2367/04 ,  C08J2489/00 ,  C08K5/0058 ,  C08K5/103 ,  C08L89/00

    Abstract: A composition containing poly(lactic acid), at least one bacteriocin (e.g., nisin, generally in the form of Nisaplin®), and at least one plasticizer (e.g., lactic acid, lactide, triacetin, glycerol triacetate), and optionally at least one pore forming agent. A method of making the composition, involving mixing about 100% of the total of the poly(lactic acid), about 50% to about 90% of the total of the at least one plasticizer, and optionally at least one pore forming agent at a first temperature of about 150° to about 170° C. to form a mixture, cooling the mixture to a second temperature of about 115° to about 125° C., adding at least one bacteriocin and about 10% to about 50% of the total of the at least one plasticizer and the remainder of the total of the poly(lactic acid) to the mixture and mixing to form the composition.

    Abstract translation: 含有聚（乳酸），至少一种细菌素（例如通常为Nisaplin的形式的乳链菌肽）和至少一种增塑剂（例如乳酸，丙交酯，甘油三乙酸酯，甘油三乙酸酯）和任选地至少 一种成孔剂。 一种制备该组合物的方法，包括混合约100％的聚（乳酸），约50％至约90％的至少一种增塑剂和任选的至少一种成孔剂 第一温度为约150℃至约170℃以形成混合物，将混合物冷却至约115℃至约125℃的第二温度，加入至少一种细菌素和约10％至约50％的 将总共​​至少一种增塑剂和剩余的聚（乳酸）的总量混合并混合以形成组合物。

    Silicone foam and method for making it
    44.
    发明授权
    Silicone foam and method for making it 失效
    硅胶泡沫及其制作方法

    公开(公告)号：US4859712A

    公开(公告)日：1989-08-22

    申请号：US256648

    申请日：1988-10-12

    Applicant: James E. Cox

    Inventor： James E. Cox

    IPC: A61L27/00 ,  A61L27/34 ,  A61L27/56 ,  C08J9/26

    CPC classification number: C08J9/26 ,  A61L27/34 ,  A61L27/56 ,  C08J2201/0446 ,  C08J2383/04

    Abstract: A method to make a silicone foam. A layer of crystalline material is embedded in a layer of uncured silicone. The crystalline material is closely packed in crystal-to-crystal contact, the crystals being provided in a plurality of sizes or ranges of size to increase the packing ratio of the crystals as a group. The silicone is cured and then the crystals are dissolved out with a solvent that dissolves them but does not dissolve the silicone.

    Abstract translation: 一种制造硅氧烷泡沫的方法。 将一层结晶材料嵌入未固化的硅树脂层中。 结晶材料紧密地堆积在晶体与晶体之间，晶体以多个尺寸或尺寸范围提供，以提高晶体作为一组的填充率。 硅氧烷固化，然后用溶解它们但不溶解硅氧烷的溶剂溶出晶体。

    Aromatic polyimide particles from polycyclic diamines
    45.
    发明授权
    Aromatic polyimide particles from polycyclic diamines 失效
    来自多环二胺的芳族聚酰亚胺颗粒

    公开(公告)号：US3179631A

    公开(公告)日：1965-04-20

    申请号：US16910762

    申请日：1962-01-26

    Applicant: DU PONT

    Inventor： LASZLO ENDREY ANDREW

    IPC: C08G73/10 ,  C08J3/12 ,  C08J9/26

    CPC classification number: C08J9/26 ,  C08G73/1003 ,  C08G73/1007 ,  C08G73/1032 ,  C08J3/12 ,  C08J2201/0446 ,  C08J2379/08

    Abstract: A process for making a polyamide-acid powder comprises reacting at least one diamine of the formula H2N-R1-NH2, where R is a divalent polycyclic aromatic radical in which no more than one NH2 group is substituted in any one aromatic ring, with at least one tetracarboxylic acid dianhydride of the formula where R is a tetravalent radical containing at least one 6-carbon atom ring having benzenoid unsaturation and wherein the four carbonyl groups are attached to different carbon atoms in a ring of the R radical and wherein each pair of carbonyl groups is attached to adjacent carbon atoms in a 6-membered benzenoid ring of the R radical, in an organic solvent for at least one of the reactants, the solvent being inert to the reactants, at a temperature below 75 DEG C., to form a solution of a polymer containing polyamide-acid having an inherent viscosity of at least 0.1, and then mixing the solution with a precipitant for the polyamide-acid to precipitate a particulate, polymeric solid. The precipitate may be converted to the corresponding polyimide by (1) reacting with a lower fatty monobasic acid preferably in the presence of a tertiary amine and/or (2) heating at a temperature above 50 DEG C. The inherent viscosity is measured at 35 DEG C. at a concentration of 0.5% by weight of the polymer in N:N-dimethyl acetamide. Many diamines, tetracarboxylic acid dianhydrides, solvents and precipitants are specified. The examples describe the preparation of polyamide-acid powders from:-(1) 4:41-diamino diphenyl ether and pyromellitic dianhydride and (2) bis-(3:4-dicarboxyphenyl) ether dianhydride and 1:3-bis-(p-amino-phenoxy) benzene.

    PROCESS FOR THE MANUFACTURE OF POROUS CELLULOSE MATRICES
    50.
    发明公开
    PROCESS FOR THE MANUFACTURE OF POROUS CELLULOSE MATRICES 失效
    工艺，一种生产多孔ZELLULOSENMATRIZEN。

    公开(公告)号：EP0532611A1

    公开(公告)日：1993-03-24

    申请号：EP91910979.0

    申请日：1991-06-05

    Applicant: KABI PHARMACIA AB

    Inventor： EK, Bo, Ragnar ,  ERIKSSON, Kjell, Gunnar ,  NYQVIST, Per, Gustaf, Hakan ,  RAGNARSSON, Gert, Anders

    IPC: A61K9 ,  A61K47 ,  C08B15 ,  C08J9 ,  C08L1

    CPC classification number: C08J9/26 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2081 ,  C08B15/02 ,  C08J2201/0446 ,  C08J2301/02 ,  C08L1/02

    Abstract: L'invention se rapporte à un procédé de fabrication de particules de cellulose poreuses, qui ont une forme régulière et une capacité de sorption de l'eau de 1,5 à 9 fois leur propre poids, ainsi qu'une masse volumique apparente après tassement inférieure à 0,85 g/ml. Le procédé de fabrication de ces matrices cellulosiques poreuses consiste à traiter mécaniquement la cellulose hydraulisée dans une phase à voie humide. Les matrices celluylosiques ont de préférence une grandeur d'au moins 0,1 mm et une masse volumique apparente après tassement de 0,1 à 0,7 g/ml. Une substance bioactive ou des substances bioactives peuvent être sorbées, précipitées ou sublimées dans la structure poreuse des matrices. Ces matrices peuvent être mélangées avec des médicaments ou avec des granulés contenant des médicaments, afin d'en améliorer la mise en tablettes et les propriétés des tablettes obtenues, et elles peuvent ensuite être comprimées. Des matrices dans lesquelles il est incorporé un médicament peuvent être utilisée pour permettre la compression directe des tablettes.

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