公开(公告)号：US20230152227A1

公开(公告)日：2023-05-18

申请号：US18156846

申请日：2023-01-19

Applicant: Illumina, Inc.

Inventor： Rui JIANG ,  Joseph PINTO

IPC: G01N21/64 ,  C12Q1/6869 ,  G01J3/10 ,  G02B27/09

CPC classification number: G01N21/6428 ,  C12Q1/6869 ,  G01J3/10 ,  G01N21/6452 ,  G01N21/6456 ,  G02B27/0994 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/08 ,  G01N2201/0638 ,  G01N2201/0806 ,  H01L27/14612

Abstract: There is set forth herein a light energy exciter that can include one or more light sources. A light energy exciter can emit excitation light directed toward a detector surface that can support biological or chemical samples.

公开(公告)号：US20170370842A1

公开(公告)日：2017-12-28

申请号：US15598236

申请日：2017-05-17

Applicant: TAIGEN BIOSCIENCE CORPORATION

Inventor： HUNG-JEN KAO

IPC: G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6428 ,  C12Q1/686 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2201/0627 ,  G01N2201/0806

Abstract: The present invention provides a multi-channel fluorescence detecting system for detecting a plurality of fluorescence labeled analytes. The multi-channel fluorescence detecting system comprises a light source, a light filter device, a dual branch light guide tube, and a detector. The light source comprises a plurality of sub light sources for respectively providing an excitation light. The plurality of sub light sources are a plurality of single color Light emitting diodes (LEDs) which can be selectively turned on or off. The light source generates a plurality of lights with full width at half maximum (FWHM) wavelengths formed in a non-overlap manner. With the disposition of the plurality of sub light sources, the accuracy for detecting the specific analytes is raised, the light flux with a specific wavelength band is effectively raised (without raising the light flux of the full wavelength band), the structure is simplified, and the manufacturing cost is decreased.

公开(公告)号：US20150153285A1

公开(公告)日：2015-06-04

申请号：US14558417

申请日：2014-12-02

Applicant: ATEXON OY

Inventor： Mika VANNAS

IPC: G01N21/67

CPC classification number: G01N21/67 ,  G01J5/0014 ,  G01J5/043 ,  G01J5/0806 ,  G01J5/0818 ,  G01J5/089 ,  G01N2201/0806 ,  G08B17/12

Abstract: The invention relates to the detection of sparks in a channel where material flows. A spark sensing device is positioned in connection with channel where material flows in a flowing direction. The spark sensing device comprises a sensor element and an optical element that transfers a radiation of a spark to the sensor element. The optical element is made of optically transparent material. The optical element is such that it shapes the collection beam of the sensor element to be asymmetrical whereby the viewing angle of the sensor element is wider in a direction transverse to the flowing direction than in the flowing direction.

Abstract translation: 本发明涉及在材料流动的通道中检测火花。 火花感测装置与材料沿流动方向流动的通道相连。 火花检测装置包括传感器元件和将火花辐射传递到传感器元件的光学元件。 光学元件由光学透明材料制成。 光学元件使传感器元件的收集束成形为不对称，由此传感器元件的视角在横向于流动方向的方向上比在流动方向上更宽。

公开(公告)号：US20140093948A1

公开(公告)日：2014-04-03

申请号：US14042096

申请日：2013-09-30

Applicant: Roche Molecular Systems, Inc.

Inventor： Fabian Durrer ,  Alan Furlan ,  Joachim Wietzorrek

IPC: F21K99/00 ,  G01N21/17

CPC classification number: G01N21/17 ,  F21K9/61 ,  G01N21/6452 ,  G01N2021/015 ,  G01N2021/6419 ,  G01N2201/024 ,  G01N2201/0627 ,  G01N2201/0806

Abstract: A light source module for use in an analytical instrument for analyzing at least one sample is disclosed. The light source module includes at least one light-emitting diode and at least one light guiding rod adapted to guide and shape light emitted by the light-emitting diode. The light source module further includes at least one memory device. The memory device has stored therein at least one driving parameter set, for driving the light-emitting diode in such a way that desired emission properties of light provided by the light source module are generated.

Abstract translation: 公开了用于分析至少一个样品的分析仪器的光源模块。 光源模块包括至少一个发光二极管和适于引导和形成由发光二极管发射的光的至少一个导光棒。 光源模块还包括至少一个存储器件。 存储器件中存储有至少一个驱动参数组，用于以这样的方式驱动发光二极管，使得产生由光源模块提供的光的期望的发射特性。

公开(公告)号：US20110049385A1

公开(公告)日：2011-03-03

申请号：US12738843

申请日：2008-10-08

Applicant: Jyrki Laitinen ,  Petri Kivelä

Inventor： Jyrki Laitinen ,  Petri Kivelä

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/18 ,  G01J3/4406 ,  G01N21/253 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0806

Abstract: The invention relates to an apparatus and method for optically analysing samples contained in sample sites of a sample holder by means of fluorescence. The apparatus comprises a first light source comprising a plurality of individual light sources having narrow wavelength bands, means for further limiting wavelength bands of the light emitted by the individual light sources, means for guiding the reduced-wavelength light to the sample sites of the sample holder, and a detector for detecting light from the sample sites. According to the invention said means for further reducing the wavelength bands emitted by the individual light sources comprise a wavelength-tunable single monochromator. The invention allows manufacturing of a microplate reader having the capability for fluorescence measurements at a continuous wavelength range, while maintaining the cost of the device at a reasonable level.

Abstract translation: 本发明涉及一种用于通过荧光光学分析样品保持器的样品位点中包含的样品的装置和方法。 该装置包括：第一光源，其包括具有窄波长带的多个单独的光源;用于进一步限制由各个光源发射的光的波长带的装置;用于将所述还原波长的光引导到所述样品的样品位置的装置 支架和用于检测来自样品位点的光的检测器。 根据本发明，用于进一步减少由各个光源发射的波长带的装置包括波长可调单色器。 本发明允许制造具有在连续波长范围内的荧光测量能力的酶标仪，同时将装置的成本保持在合理的水平。

公开(公告)号：US20070181818A1

公开(公告)日：2007-08-09

申请号：US11350240

申请日：2006-02-08

Applicant: Robert Austin

Inventor： Robert Austin

IPC: G01J1/42

CPC classification number: G01N21/03 ,  G01N21/33 ,  G01N23/227 ,  G01N2201/0806

Abstract: A device for detecting impurities in a noble gas includes a detection chamber and a source of pulsed ultraviolet light. The pulse of the ultraviolet light is transferred into the detection chamber and onto a photocathode, thereby emitting a cloud of free electrons into the noble gas within the detection chamber. The cloud of electrons is attracted to the opposite end of the detection chamber by a high positive voltage potential at that end and focused onto a sensing anode. If there are impurities in the noble gas, some or all of the electrons within the cloud will bond with the impurity molecules and not reach the sensing anode. Therefore, measuring a lower signal at the sensing anode indicates a higher level of impurities while sensing a higher signal indicates fewer impurities. Impurities in the range of one part per billion can be measured by this device.

Abstract translation: 用于检测惰性气体中的杂质的装置包括检测室和脉冲紫外光源。 紫外光的脉冲被传送到检测室和光电阴极上，从而将自由电子云发射到检测室内的惰性气体中。 电子云被吸收到检测室的另一端，在该端处具有高的正电压电位并聚焦到感测阳极上。 如果稀有气体中存在杂质，云中的部分或全部电子将与杂质分子结合，而不会到达感应阳极。 因此，在感测阳极处测量较低的信号指示较高水平的杂质，同时感测较高的信号表示较少的杂质。 该装置可以测量十亿分之一的杂质。

公开(公告)号：US20060000219A1

公开(公告)日：2006-01-05

申请号：US11210095

申请日：2005-08-23

Applicant: Douglas Myhre

Inventor： Douglas Myhre

IPC: F02C7/00

CPC classification number: F23M11/045 ,  F01D17/02 ,  F01D21/003 ,  F02C9/28 ,  F05D2270/083 ,  F05D2270/301 ,  F05D2270/303 ,  F05D2270/304 ,  F23N5/082 ,  F23N2029/00 ,  F23N2029/04 ,  F23N2029/08 ,  F23N2041/20 ,  F23R3/28 ,  F23R2900/00013 ,  G01N21/15 ,  G01N21/3518 ,  G01N21/766 ,  G01N2021/3531 ,  G01N2201/08 ,  G01N2201/0806

Abstract: A fuel injector for a gas turbine combustor is disclosed which includes a feed arm having a flange for mounting the injector within the combustor and a fuel nozzle depending from the feed arm for injecting fuel into the combustor for combustion. An optical sensor array is operatively associated with the fuel nozzle for observing combustor flame characteristics. The optical sensor array includes a plurality of sapphire rods positioned to be close enough to the combustor flame to oxidize soot deposits thereon.

公开(公告)号：US5288991A

公开(公告)日：1994-02-22

申请号：US985390

申请日：1992-12-04

Applicant: Mark R. King ,  William H. Vonderhaar

Inventor： Mark R. King ,  William H. Vonderhaar

IPC: G01B11/00 ,  G01N21/88 ,  G02B6/42 ,  G02B6/04 ,  G02B27/00

CPC classification number: G02B6/4298 ,  G01B11/00 ,  G01N21/8806 ,  G01N2201/0806

Abstract: An inspection system in which the surface of a substrate is continuously scanned by a linear CCD. The surface is illuminated in a narrowly focused strip from a broad-band light source that is selectively wavelength filtered to optimize image contrast to the optical characteristics of the surface under inspection. A channel integrator in the light source optical system provides illumination homogeneity at the surface of the substrate.

Abstract translation: 一种检查系统，其中基片的表面被线性CCD连续地扫描。 该表面在狭窄聚焦的条带中从宽带光源照射，该宽带光源被选择性地波长过滤以优化与检查中的表面的光学特性的图像对比度。 光源光学系统中的通道积分器在衬底的表面提供照明均匀性。

公开(公告)号：US4909990A

公开(公告)日：1990-03-20

申请号：US92177

申请日：1987-09-02

Applicant: Myron J. Block ,  Steve J. Lackie ,  Thomas R. Glass

Inventor： Myron J. Block ,  Steve J. Lackie ,  Thomas R. Glass

IPC: G01N21/01 ,  G01N21/64

CPC classification number: G01N21/648 ,  G01N21/01 ,  G01N2201/0806 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/827

Abstract: An assay apparatus employing total internal reflection of excitation radiation at the interface between a replaceable optically conductive rod or fiber and a surrounding liquid phase of lower index of refraction. Immobilized on the surface of the fiber is a component of a complex formed in an immunological-type specific reaction. A fluorophore that can be excited into fluorescence by the excitation radiation is attached to another component of the complex. The rod is coaxially mounted within a tube that is sized with respect to said rod so that a fluid sample may be introduced into said tube.The rod and tubing are supported in a mounting assembly that is attachable to an optical assembly for transmitting excitation radiation into the proximal end of the rod and receiving fluorescent radiation emitted from the proximal end of the rod. Included in the apparatus is a mounting assembly for centering the rod within tube and for biasing the rod in a first direction against an annular seat. The latter is designed to support one end of the rod so that none of the radiation introduced into the rod is intercepted by the seat. The apparatus also includes a seal arrangement for preventing a fluid sample from escaping from the tube. Additionally, a tapered fiber may be included in the optical system of the assay apparatus for increasing the power and numerical aperture of radiation input into the optical rod.

Abstract translation: 一种测定装置，其在可替代的光学导电棒或纤维与较低折射率的周围液相之间的界面处采用激发辐射的全内反射。 固定在纤维表面上的是在免疫型特异性反应中形成的复合物的成分。 可以通过激发辐射激发成荧光的荧光团附着到复合物的另一组分。 杆同轴地安装在相对于所述杆的尺寸的管中，使得流体样品可以被引入所述管中。 杆和管被支撑在可附接到光学组件的安装组件中，用于将激发辐射传送到杆的近端并接收从杆的近端发射的荧光辐射。 该设备中包括一个安装组件，用于将杆定位在管内并用于将杆沿第一方向偏压抵靠环形座。 后者被设计成支撑杆的一端，使得没有引入到杆中的辐射被座椅拦截。 该装置还包括用于防止流体样品从管中逸出的密封装置。 此外，锥形光纤可以包括在测量装置的光学系统中，用于增加输入到光棒中的辐射的功率和数值孔径。

公开(公告)号：US4865456A

公开(公告)日：1989-09-12

申请号：US238586

申请日：1988-08-31

Applicant: Fred Mast ,  Jean A. Knus

Inventor： Fred Mast ,  Jean A. Knus

IPC: G01J3/02 ,  G01J3/42 ,  G01J3/46 ,  G01J3/50 ,  G01N21/27 ,  G01N21/47 ,  G01N21/84 ,  G01N21/89

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0291 ,  G01N21/474 ,  G01N2021/4757 ,  G01N2201/0806 ,  Y10T137/86823 ,  Y10T137/88022 ,  Y10T137/8803

Abstract: A measuring head for the determination of the optical reflectance properties of color measuring fields co-printed with color sheets includes an optical illuminating device having two Mangin mirrors and an aplanar system located in alignment with the Mangin mirrors in a central opening. The light emitted by a light source and reflected by the measuring area arrives in a glass rod and is fed through an optical measuring device into a light waveguide, through which the reflected light is fed into a spectrometer for spectral analysis.

Abstract translation: 用于确定与彩色片共同印刷的彩色测量场的光学反射特性的测量头包括具有两个Mangin镜的光学照明装置和在中央开口中与Mangin镜对准的平面系统。 由光源发射并由测量区域反射的光到达玻璃棒，并通过光学测量装置馈送到光波导中，反射光通过该光波导进入光谱仪进行光谱分析。