公开(公告)号：EP2393941A2

公开(公告)日：2011-12-14

申请号：EP10705038.7

申请日：2010-02-09

Applicant: Zenhausern, Frederic ,  Nordquist, Alan ,  Lenigk, Ralf ,  Hurth, Cedric ,  Yang, Jianing

Inventor： Zenhausern, Frederic ,  Nordquist, Alan ,  Lenigk, Ralf ,  Hurth, Cedric ,  Yang, Jianing

IPC: C12Q1/68 ,  G01N35/00 ,  G02B7/00

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/502738 ,  B01L7/52 ,  B01L7/525 ,  C12Q1/6806 ,  C25B9/00 ,  G01N1/10 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44791 ,  G01N2021/6484 ,  G01N2201/062 ,  G01N2201/0846 ,  Y10T436/143333

Abstract: Analysis methods and apparatus are provided for inspecting a channel, such as a capillary electrophoresis channel, in a device. Configuration and alignment systems are provided, together with optical systems and temperature control.

Abstract translation: 分析方法和装置被提供用于检查装置中的通道，例如毛细管电泳通道。 提供配置和校准系统，以及光学系统和温度控制。

公开(公告)号：EP2338405A1

公开(公告)日：2011-06-29

申请号：EP10252186.1

申请日：2010-12-22

Applicant: McNeil-PPC, Inc.

Inventor： Binner, Curt

IPC: A61B1/24 ,  A61B5/00 ,  A61C17/00 ,  A61C19/04 ,  G01N21/64

CPC classification number: A61B1/24 ,  A61B1/00165 ,  A61B1/0646 ,  A61B1/0676 ,  A61B5/0088 ,  G01N21/645 ,  G01N2021/6484 ,  G01N2201/0846

Abstract: The present invention regards methods and devices for detecting plaque on a surface in the oral cavity to which a fluorescent agent capable of binding to plaque has been applied, whereby a radiation source emits incident radiation for contacting the surface, reflected light and fluorescent emission resulting from contact of the radiation with the surface is collected by an optical collector and conveyed by an optical pathway in the device, where the optical light signal of the reflected light and fluorescent emission is converted to an electrical signal, and where the electrical signals of the fluorescent emission and the reflected light are then mathematically manipulated to provide a compensated plaque value as a function of the distance from the optical collector and the surface of the oral cavity to which the fluorescent agent has been applied.

Abstract translation: 本发明涉及用于检测口腔中表面上能够结合斑块的荧光剂已经被施加到其上的斑块的方法和装置，由此辐射源发射用于接触表面的入射辐射，反射光和由 辐射与表面的接触由光学收集器收集并通过设备中的光学路径传送，其中反射光和荧光发射的光信号被转换为电信号，并且其中荧光 然后数学地操纵发射和反射光，以提供补偿的斑块值作为与光学收集器和已经施加荧光剂的口腔表面的距离的函数。

公开(公告)号：EP2332460A1

公开(公告)日：2011-06-15

申请号：EP11000358.9

申请日：2006-03-07

Applicant: Olympus Medical Systems Corp.

Inventor： Gono, Kazuhiro ,  Amano, Shoichi ,  Takahashi, Tomoya ,  Ohshima, Mutsumi

IPC: A61B1/045

CPC classification number: G01J3/50 ,  A61B1/00186 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/7203 ,  G01J3/32 ,  G01J3/501 ,  G01J3/513 ,  G01J2003/1213 ,  G01J2003/1221 ,  G01N21/255 ,  G01N2201/08 ,  G01N2201/0846 ,  G02B23/2446 ,  G02B23/2469 ,  H04N2005/2255

Abstract: A biological observation apparatus comprising: an illuminating section that irradiates light to a living body that is a subject to be examined; an image pickup section that photoelectrically converts light reflected from the living body based on the irradiating light and creates an image pickup signal; and a signal processing control section that controls operations of the illuminating section and/or the image pickup section and outputs the image pickup signal to a display device, wherein the signal processing control section includes: a spectral signal creating section that creates a spectral signal corresponding to an optical wavelength narrowband image from the image pickup signal through signal processing; and a color adjusting section that, when outputting the spectral signal to the display device, allocates a different color tone for each of a plurality of bands forming the spectral signal, further wherein the biological observation apparatus further comprises an image quality adjusting section that adjusts an image quality of a signal to be outputted to the display device, or, with the exception of at least the spectral signal creating section and the color adjusting section, the other signal processing sections are shared for respective signal processing on the image pickup signal and on the spectral signal.

Abstract translation: 一种生物观察装置，其特征在于，包括：照射部，其对作为被检查体的生物进行光照射; 摄像部，其根据所述照射光对从所述生物体反射的光进行光电转换，并产生摄像信号; 以及信号处理控制部，其控制所述照明部和/或所述图像拾取部的操作，并将所述摄像信号输出到显示装置，其中所述信号处理控制部包括：频谱信号生成部，其生成相应的频谱信号 通过信号处理从图像拾取信号到光波长窄带图像; 以及颜色调整部，其在向所述显示装置输出所述分光信号时，为形成所述频谱信号的多个频带中的每一个分配不同的色调，其中，所述生物观察装置还包括图像质量调整部， 要输出到显示装置的信号的图像质量，或者除了至少频谱信号产生部分和颜色调整部分之外，其他信号处理部分被共享用于对摄像信号的各个信号处理， 光谱信号。

公开(公告)号：EP2198273A2

公开(公告)日：2010-06-23

申请号：EP08843195.2

申请日：2008-10-10

Applicant: Mauna Kea Technologies

Inventor： VIELLEROBE, Bertrand ,  LACOMBE, François ,  BOULAROT, Nicolas ,  DOUSSOUX, François ,  LAVILLONNIERE, Nicolas

IPC: G01N21/64 ,  A61B1/07 ,  G02B21/00 ,  A61B1/00 ,  G01N21/63 ,  A61B5/00 ,  G02B26/10 ,  G02B23/14

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

公开(公告)号：EP1895289A2

公开(公告)日：2008-03-05

申请号：EP07023438.0

申请日：2000-04-06

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： Walt, David R. ,  Dickinson, Todd A.

IPC: G01N21/77 ,  G01N33/543

CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可以携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比的实质性改进。

公开(公告)号：EP1895289B1

公开(公告)日：2018-03-14

申请号：EP07023438.0

申请日：2000-04-06

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： Walt, David R. ,  Dickinson, Todd A.

IPC: C12Q1/68 ,  G01N33/543 ,  G01N21/77 ,  G06F19/00

CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

公开(公告)号：EP3168661A4

公开(公告)日：2017-11-22

申请号：EP14897252

申请日：2014-08-05

Applicant: SHANGHAI INST OPTICS & FINE MECH CAS

Inventor： CAI HAIWEN ,  CHEN ZEHENG ,  HUANG CHONGDE ,  GENG JIANXIN ,  CHEN DIJUN ,  CHEN WEIBIAO

IPC: G02B6/38 ,  G01N21/01 ,  G01N21/39 ,  G02B6/02 ,  G02B6/42 ,  H01S3/139 ,  H01S5/0687 ,  H01S5/14

CPC classification number: G02B6/02323 ,  G01N21/03 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0846 ,  G02B6/02328 ,  G02B6/02385 ,  G02B6/255 ,  G02B6/38 ,  G02B6/4203 ,  G02B6/4207

Abstract: A hollow-core photonic crystal fiber gas cell and method for preparing the same. The hollow-core photonic crystal fiber gas cell comprises a single-mode fiber, a fiber splicing protection sleeve, a hollow-core photonic crystal fiber, and a photoelectric detector. One end of the single-mode fiber is fusion spliced with one end of the hollow-core photonic crystal fiber to form a fusion splice and seal one end of the hollow-core photonic crystal fiber gas cell. The fiber splicing protection sleeve covers and protects the fusion splice. The other end of the hollow-core photonic crystal fiber is processed into an output end by fusion sealing, and the surface of the output end faces, but is not parallel to, a detection surface of the photoelectric detector.

公开(公告)号：EP3182099A1

公开(公告)日：2017-06-21

申请号：EP15200489.1

申请日：2015-12-16

Applicant: rap.ID Particle Systems GmbH

Inventor： GOEDE, Karsten ,  HOLZ, Lothar ,  LANKERS, Markus ,  VALET, Oliver K.

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/03 ,  G01J3/44 ,  G01N21/65 ,  G01N33/483 ,  G01N2021/0385 ,  G01N2021/0389 ,  G01N2201/0846 ,  G01N2201/10

Abstract: The invention relates to a system (1) for confocal Raman-spectroscopic measurements, comprising at least the following components:
- a sample chamber (10), wherein said sample chamber (10) is configured to house a sample (2) in a closed chamber volume (12) of the sample chamber (10),
- an excitation light source (3),
- an objective lens (4), configured to focus excitation light (32) of the excitation light source (3) through a ceiling portion (11) of the sample chamber (10) in a focal volume (31) in the chamber volume (12) and to collect inelastically scattered light (33) stemming from the focal volume (31),
- a confocal detection arrangement (20), comprising means for a confocal detection (22, 23) of a Raman signal comprised in the inelastically scattered light (33) from the focal volume (31), and a detector (21) that is configured to detect and to record said Raman signal,
wherein the distance (5) between the ceiling portion (11) of the sample chamber (10) and the focal volume (31) is greater than one millimetre during operation of the system (1).

Abstract translation: 本发明涉及用于共焦拉曼光谱测量的系统（1），其至少包括以下组件： - 样品室（10），其中所述样品室（10）被配置为将样品（2） （10）的腔室容积（12）， - 激励光源（3）， - 物镜（4），其配置为将激励光源（3）的激励光（32）聚焦通过天花板部分 （12）中的聚焦体积（31）中的样本室（10）的样本（11），并且收集源自所述聚焦容积（31）的非弹性散射光（33）， - 共焦检测装置（20） ，包括用于包括在来自所述聚焦容积（31）的所述非弹性散射光（33）中的拉曼信号的共焦检测（22,23）的装置，以及配置成检测并记录所述拉曼信号 ，其中样品室（10）的顶部（11）与聚焦体积（31）之间的距离（5）为i 在系统（1）的操作期间大于1毫米。

公开(公告)号：EP3136086A1

公开(公告)日：2017-03-01

申请号：EP16180465.3

申请日：2016-07-21

Applicant: Otsuka Electronics Co., Ltd.

Inventor： SHIRAIWA, Hisashi

IPC: G01N21/64 ,  G02B21/00 ,  G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC classification number: G01J3/28 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/0846 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0064

Abstract: A microspectroscope (101) includes: a light source (11, 17); a plurality of light projecting optical fibers (12) that receive light from the light source (11, 17); a spectroscope (1); a plurality of light receiving optical fibers (22) for guiding received light to the spectroscope (1); and a confocal optical system (5) for causing each of a plurality of beams from the plurality of light projecting optical fibers (12) to be condensed and irradiated onto a sample, and forming images of a plurality of beams from a plurality of condensing points on the sample, respectively on the plurality of light receiving optical fibers (22).

Abstract translation: 显微光谱仪（101）包括：光源（11,17）; 多个从所述光源（11,17）接收光的投光光纤（12）; 分光仪（1）; 多个光接收光纤（22），用于将接收的光引导到所述分光器（1）; 以及共焦光学系统（5），用于使来自所述多个投光光纤（12）的多个光束中的每一个被聚集并照射到样本上，并且从多个聚光点形成多个光束的图像 分别在多个受光光纤（22）上。

公开(公告)号：EP2584339A1

公开(公告)日：2013-04-24

申请号：EP11795568.2

申请日：2011-06-02

Applicant: Nitto Denko Corporation

Inventor： KONTANI, Tomohiro

IPC: G01N21/27

CPC classification number: G02B6/036 ,  G01N21/553 ,  G01N2201/08 ,  G01N2201/0846

Abstract: An SPR sensor cell is an SPR sensor cell including an optical waveguide to be brought into contact with a sample. The optical waveguide includes an under clad layer, a core layer provided in the under clad layer such that at least a part thereof is exposed from the under clad layer, and a metal particle layer covering the core layer exposed from the under clad layer to be brought into contact with the sample.

Abstract translation: SPR传感器单元是包括要与样品接触的光波导的SPR传感器单元。 光波导包括下包层，芯层层设置在下包层中，使得其至少一部分从下包覆层露出，覆盖从下包层暴露的芯层的金属颗粒层为 与样品接触。