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    METHODS AND SYSTEMS FOR PURE DYE INSTRUMENT NORMALIZATION
    41.
    发明公开
    METHODS AND SYSTEMS FOR PURE DYE INSTRUMENT NORMALIZATION 审中-公开
    纯染料仪器正常化的方法和系统

    公开(公告)号：EP3254082A1

    公开(公告)日：2017-12-13

    申请号：EP16707298.2

    申请日：2016-02-05

    Applicant: Life Technologies Corporation

    Inventor： MARKS, Jeffrey

    IPC: G01N21/27 ,  G01N21/64

    CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/068 ,  G01N2201/12746

    Abstract: The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.

    Calibration method for photometry
    42.
    发明公开
    Calibration method for photometry 审中-公开
    KalibrierverfahrenfürFotometrie

    公开(公告)号：EP2813839A1

    公开(公告)日：2014-12-17

    申请号：EP13171586.4

    申请日：2013-06-12

    Applicant: Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

    Inventor： Horstmann, Martin ,  Lang, Fridl

    IPC: G01N21/25 ,  G01N21/27 ,  G01N35/00

    CPC classification number: G01N33/96 ,  G01J1/0295 ,  G01N21/274 ,  G01N21/75 ,  G01N33/487 ,  G01N35/00693 ,  G01N2201/12746 ,  G01N2496/00

    Abstract: The invention provides for a method of determine a physical property of a biological sample. The method comprises the steps of: acquiring (100) a set of preliminary calibration signals (306) of a first lot (208') of a reagent using an automatic analyzer (202) with a first photometry module (210); acquiring (102) a reference set of signals (310) of the first lot of the reagent using a calibration analyzer (302) with a second photometry module (210'); determining (104) a set of module specific components (224) by subtracting the reference set of signals (310) from the preliminary calibration signals (306); acquiring (106) a lot specific set of signals (226) of a second lot (208) of the reagent using the second photometry module (210'); determining (108) a lot calibration (228) for the first photometry module (210) using the set of module specific components (224) and the lot specific set of signals (226); and acquiring (110) a measurement signal (230) of the biological sample using the first photometry module (210) and the second lot (208) of the reagent; and determining (112) a physical property (232) of the biological sample using the measurement signal (230) and the lot calibration (228).

    Abstract translation: 本发明提供了确定生物样品的物理性质的方法。 该方法包括以下步骤：使用具有第一测光模块（210）的自动分析器（202）获取（100）试剂的第一批（208'）的一组初步校准信号（306）; 使用具有第二测光模块（210'）的校准分析器（302）获取（102）所述第一批试剂的参考信号组（310）; 通过从所述初步校准信号（306）中减去参考信号集（310）来确定（104）一组模块特定组件（224）; 使用所述第二测光模块（210'）获取（106）所述试剂的第二批次（208）的许多特定信号集合（226）; 使用所述一组模块特定组件（224）和所述批量特定信号集合（226）来确定（108）所述第一测光模块（210）的批量校准（228）。 以及使用所述试剂的第一测色模块（210）和所述第二批（208）获取（110）所述生物样品的测量信号（230） 以及使用所述测量信号（230）和批次校准（228）确定（112）所述生物样品的物理性质（232）。

    OPTICAL AUTO-CALIBRATION METHOD
    43.
    发明公开
    OPTICAL AUTO-CALIBRATION METHOD 审中-公开
    光学自动校准

    公开(公告)号：EP2344863A2

    公开(公告)日：2011-07-20

    申请号：EP09822620.2

    申请日：2009-10-21

    Applicant: Bayer HealthCare LLC

    Inventor： MICINSKI, Russell, J. ,  DOSMANN, Andrew, J. ,  CHARLTON, Steven, C.

    IPC: G01N21/27

    CPC classification number: A61B5/1495 ,  G01N21/274 ,  G01N21/8483 ,  G01N27/4163 ,  G01N33/48771 ,  G01N2021/8494 ,  G01N2021/8645 ,  G01N2201/12746

    Abstract: A method of determining auto-calibrating information of a test sensor includes providing an optical read head that includes a light source, a light guide and a detector. The read head forms an opening that is sized to receive a test sensor. The detector includes a linear-detector array or single detector. A test sensor is provided having apertures formed therein. The test sensor is placed in the opening of the optical read head. Light is transmitted from the light source through the apertures. The light transmitted through the apertures using the detector or detecting the absence of light being transmitted through the test sensor using the detector is detected. The detected light or the absence of detected light information from the detector is used to determine the auto-calibration information of the test sensor.

    Method for controlling one or more parameters of a flow cytometer type measurement system
    44.
    发明公开
    Method for controlling one or more parameters of a flow cytometer type measurement system 审中-公开
    一种用于控制Durchflusszytometermesssystems的一个或多个参数的方法

    公开(公告)号：EP2275799A1

    公开(公告)日：2011-01-19

    申请号：EP10183127.9

    申请日：2004-08-13

    Applicant: Luminex Corporation

    Inventor： Roth, Wayne D. ,  Moore, Douglas E.

    IPC: G01N15/14

    CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

    Abstract: A method for controlling one or more parameters of a flow cytometer type measurement system, is disclosed. The comprises the following steps
    - measuring a time in which a microsphere (10) travels from a first detection window of the flow cytometer type measurement system to a second detection window of the measurement system; and
    - altering an applied pressure of the measurement system such that the time is substantially constant.

    Abstract translation: 一种用于控制流式细胞计型测量系统的流程的一个或多个参数的方法，是游离缺失盘。 该方法包括以下步骤 - 测量时间，其中，微球（10）从流流式细胞计型测量系统的测量系统的第二探测窗口的第一检测窗口行进; 和 - 检测所述测量系统的施加压力的改变做的时间基本上是恒定的。

    Methods for controlling one or more parameters of a flow cytometer type measurement system
    45.
    发明公开
    Methods for controlling one or more parameters of a flow cytometer type measurement system 有权
    用于控制流式细胞仪类型测量系统的一个或多个参数的方法

    公开(公告)号：EP1754965A3

    公开(公告)日：2007-03-07

    申请号：EP06022210.6

    申请日：2004-08-13

    Applicant: Luminex Corporation

    Inventor： Roth, Wayne D. ,  Moore, Douglas E.

    IPC: G01N15/10 ,  G01N15/14

    CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

    Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

    Abstract translation: 提供了用于控制流式细胞仪类型测量系统的一个或多个参数的各种方法。 一个实施例包括在测量样本微球体期间监测测量系统的参数。 该方法还包括基于监测实时改变参数。 另一种方法包括监测接近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体的温度，其中设置有样本微球体。 该方法还包括根据温度下流体的粘度确定测量系统中样品微球的速度。

    Methods for controlling one or more parameters of a flow cytometer type measurement system
    46.
    发明公开
    Methods for controlling one or more parameters of a flow cytometer type measurement system 有权
    一种用于控制Durchflusszytometermesssystems的一个或多个参数的方法

    公开(公告)号：EP1754965A2

    公开(公告)日：2007-02-21

    申请号：EP06022210.6

    申请日：2004-08-13

    Applicant: Luminex Corporation

    Inventor： Roth, Wayne D. ,  Moore, Douglas E.

    IPC: G01N15/14

    CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

    Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

    Abstract translation: 提供了用于控制流式细胞计型测量系统的流程的一个或多个参数的各种方法。 一个实施例包括在样本微球体的测量的测量系统的监控参数（一个或多个）。 因此，该方法包括改变在基于所述监视实时参数（一个或多个）。 另一种方法包括监测最接近于测量系统的温度。一种搜索方法包括改变雪崩光电二极管的偏置电压响应于使用经验得出的数据的温度。 不同的搜索方法包括：使用特性曲线改变的光电倍增管的输出信号响应于所述温度。 一些方法包括监测流体的温度，其中样本微球体被布置，thatwill流经流式细胞计型测量系统的流量，该方法因此包括确定性采矿从在流体的粘度在测量系统中的样本微球体的速度 温度。

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