公开(公告)号：EP2486122B1

公开(公告)日：2018-06-13

申请号：EP10822576.4

申请日：2010-10-06

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory, G.

IPC: C12N1/12 ,  C12M3/02 ,  C12M1/04 ,  C12P7/06 ,  C12P5/02

CPC classification number: C12M21/12 ,  C12M21/02 ,  C12M45/02 ,  C12N1/066 ,  C12N1/12 ,  Y02E50/17

Abstract: A method for culturing algae comprising, forming an emulsion comprising a gaseous stream and a media utilizing a high shear device, wherein the emulsion comprises gas bubbles, and wherein the high shear device comprises at least one toothed rotor and at least one stator; introducing the emulsion into a bioreactor; and introducing an algae into the bioreactor for growing the algae culture. Additionally, a method for producing liquids from an algae culture, the method comprising forming an emulsion comprising a buffer and algal components, wherein the emulsion comprises algal component globules; separating algal hydrocarbons; and processing algal hydrocarbons to form liquid hydrocarbons. Additionally, a system for producing liquids from an algae culture comprising at least one high shear device.

公开(公告)号：EP2563426B1

公开(公告)日：2018-01-03

申请号：EP11777787.0

申请日：2011-04-08

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G.

IPC: A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  A61J3/00 ,  A61K9/10 ,  A61K9/00 ,  B01F7/00 ,  B01F13/10

CPC classification number: A61J3/00 ,  A61K9/0019 ,  A61M5/142 ,  B01F7/00766 ,  B01F7/008 ,  B01F13/1016

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

公开(公告)号：EP2542336B1

公开(公告)日：2016-11-23

申请号：EP11751253.3

申请日：2011-03-02

Applicant: H R D Corporation

Inventor： HASSAN, Abass ,  HASSAN, Aziz ,  ANTHONY, Rayford, G. ,  BORSINGER, Greg, G. ,  VISWANATHAN, Krishan

IPC: B01J19/18 ,  C07B39/00 ,  C07B45/00 ,  C07B63/00

CPC classification number: B01J19/1806 ,  B01F7/00766 ,  B01F13/1013 ,  B01F13/1027 ,  C07C17/10 ,  C07C303/06 ,  C07C19/01 ,  C07C309/62

公开(公告)号：EP2970745A1

公开(公告)日：2016-01-20

申请号：EP14760698.2

申请日：2014-03-07

Applicant: H R D Corporation

Inventor： Hassan, Abbas ,  Hassan, Aziz ,  Borsinger, Gregory G.

IPC: C09K8/035 ,  E21B43/22

CPC classification number: B01F15/065 ,  B01F3/2078 ,  B01F7/00766 ,  B01F13/1016 ,  C09K8/035

Abstract: Herein disclosed is a method for producing a predispersed wax product comprising: operating a high shear device having at least one rotor/stator, configurable for a shear rate of at least 20,000 s
-1 ; introducing wax and a carrier liquid into said high shear device; and forming a dispersion of wax in a carrier liquid, wherein the wax comprises globules with an average diameter less than 5 mm.

公开(公告)号：EP2916948A1

公开(公告)日：2015-09-16

申请号：EP13853313.8

申请日：2013-11-04

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G. ,  BORSINGER, Gregory G.

IPC: B01J23/882 ,  B01J23/75 ,  C01B31/18 ,  C01B31/20

CPC classification number: B01J23/8993 ,  B01J8/009 ,  B01J8/025 ,  B01J8/10 ,  B01J12/007 ,  B01J19/0073 ,  B01J19/2495 ,  B01J19/28 ,  B01J23/8892 ,  B01J23/8986 ,  B01J27/24 ,  B01J2208/0053 ,  B01J2208/00911 ,  B01J2219/00159 ,  C01B3/40 ,  C01B2203/0233 ,  C01B2203/062 ,  C01B2203/1241 ,  C07C29/153 ,  C10G2/33 ,  C10G50/00 ,  Y02P20/149 ,  Y02P20/52 ,  C07C31/04

Abstract: Herein disclosed is a catalyst composition for producing organic compounds comprising (a) a catalyst that promotes the oxidative coupling of methane (OCM) and a methane steam reforming (MSR) catalyst, wherein the catalyst composition causes oxidative dehydrogenation to form reactive species and oligomerization of the reactive species to produce the organic compounds; or (b) a catalyst that promotes syngas generation (SG) and a Fischer-Tropsch (FT) catalyst wherein the catalyst composition causes non-oxidative dehydrogenation to form reactive species and oligomerization of the reactive species to produce the organic compounds; or (c) a SG catalyst, a MSR catalyst, and a FT catalyst wherein the catalyst composition causes non-oxidative dehydrogenation to form reactive species and oligomerization of the reactive species to produce the organic compounds; or (d) a FT catalyst and a MSR catalyst wherein the catalyst composition causes reforming reactions and chain growing reactions to produce the organic compounds.

公开(公告)号：EP2834333A1

公开(公告)日：2015-02-11

申请号：EP13772671.7

申请日：2013-03-06

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G.

IPC: C11B1/00 ,  C11B3/16

CPC classification number: B01F3/04 ,  A23D9/02 ,  B01F3/04531 ,  B01F7/00766 ,  B01F13/1016 ,  C11B1/00 ,  C11B1/02 ,  C11B1/10 ,  C11B3/00 ,  C11B3/14

Abstract: Herein disclosed is a method of processing oil, comprising providing a high shear device comprising at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; contacting a gas with an oil in the high shear device, wherein the gas is an inert gas or a reactive gas; and forming a product, wherein the product is a solution, a dispersion, or combination thereof. Herein also disclosed is a high shear system for processing oil, comprising; at least one high shear device, having an inlet and at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; a gas source fluidly connected to the inlet; an oil source fluidly connected to the inlet; and a pump positioned upstream of a high shear device, the pump in fluid connection with the inlet and the oil source.

公开(公告)号：EP2827982A2

公开(公告)日：2015-01-28

申请号：EP13764217.9

申请日：2013-03-19

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G. ,  HASSAN, Alishah

IPC: B01J19/18 ,  B01F7/16

CPC classification number: C01B23/00 ,  B01F7/00766 ,  B01F13/1016 ,  B01J19/1806 ,  G21G5/00

Abstract: A system for converting a first substance into a second substance, the system including a mixing reactor configured to provide a reactant mixture comprising a first reactant, a second reactant, and a solvent; and a high shear device fluidly connected to the mixing reactor, wherein the high shear device comprises at least one rotor/stator set comprising a rotor and a complementarily-shaped stator symmetrically positioned about an axis of rotation and separated by a shear gap, wherein the shear gap is in the range of from about 10 microns to about 250 microns; and a motor configured for rotating the rotor about the axis of rotation, whereby energy can be transferred from the rotor to the reactants thereby inducing reactions between the first reactant and the second reactant to form a product.

公开(公告)号：EP2294296B1

公开(公告)日：2015-01-28

申请号：EP09773987.4

申请日：2009-06-02

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory ,  HASSAN, Aziz ,  BAGHERZADEH, Ebrahim

IPC: F02B45/10 ,  B01F3/00 ,  B01F7/16 ,  C10L1/32

CPC classification number: F02B43/00 ,  C10L1/32 ,  F02M29/02

公开(公告)号：EP2563426A2

公开(公告)日：2013-03-06

申请号：EP11777787.0

申请日：2011-04-08

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G.

IPC: A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  A61J3/00 ,  A61K9/10

CPC classification number: A61J3/00 ,  A61K9/0019 ,  A61M5/142 ,  B01F7/00766 ,  B01F7/008 ,  B01F13/1016

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

公开(公告)号：EP2563338A2

公开(公告)日：2013-03-06

申请号：EP11777788.8

申请日：2011-04-08

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G.

IPC: A61K9/16 ,  A61K9/08 ,  A61K9/107 ,  A61J3/00 ,  A61M5/14

CPC classification number: A61J3/00 ,  A61K9/0019 ,  A61M5/142 ,  B01F7/00766 ,  B01F7/008 ,  B01F13/1016

Abstract: In this disclosure, methods and systems for drug delivery utilizing high shear are disclosed. In an embodiment, a method comprises (1) subjecting a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug in nano-size. In an embodiment, a method comprises (1) subjecting a drug carrier and a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug carrier loaded with the drug. In an embodiment, a method comprises (1) applying high shear to a drug carrier and a therapeutic fluid containing a drug; (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug-loaded carrier; and (3) modifying the drug-loaded carrier with a targeting moiety to obtain a modified drug-loaded carrier.