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公开(公告)号：BR0312664A
公开(公告)日：2005-05-03
申请号：BR0312664
申请日：2003-07-16
Applicant: HELIX BIOPHARMA CORP
Inventor： CHAO HERMAN , WONG WAH , SEGAL DONALD , MCELROY JERRY , DOCHERTY JOHN , DICKSTEIN JODI
Abstract: A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject.
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公开(公告)号：TR200500108T2
公开(公告)日：2005-04-21
申请号：TR200500108
申请日：2003-07-16
Applicant: HELIX BIOPHARMA CORP
Inventor： CHAO HERMAN , WONG WAH , SEGAL DONALD , MCELROY JERRY , DOCHERTY JOHN , DICKSTEIN JODI
Abstract: A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject.
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公开(公告)号：CA2483150A1
公开(公告)日：2003-11-06
申请号：CA2483150
申请日：2003-04-24
Applicant: HELIX BIOPHARMA CORP
Inventor： SEGAL DONALD , CHAO HEMAN , TIAN BAOMIN , MCELROY JERRY , WONG WAH
IPC: G01N27/62 , C12M1/00 , C12N15/09 , C12P21/02 , C40B30/04 , C40B40/10 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/68 , G01N37/00
Abstract: A protein interaction method and composition are described. The method and composition are useful for a number of purposes including: reconstituting multisubunit protein complexes, identifying known binding subunits, detrmini ng the kinetics and order of self assembly of a multsubunit protein complex, an d drug screening. The method involves contacting a conjugate with a solid surface having an immobilized first coil-forming peptide characterized by a selected charge and an ability to interact with a second, oppositely carged coil-forming peptide to form a stable .alpha.-helical coiled-coil heterodime r, where the conjugate comprises (a) the second, oppositely charged coil-formin g peptide, and (b) a first subunit polypeptide which is one of a plurality of subunit polypeptides in a multisubunit complex. By said contacting the conjugate is bound to the solid surface. Other subunit of the complex are added under conditions effective to promote self-assembly of the subunit complex or the solid surface.
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公开(公告)号：AU8745101A
公开(公告)日：2002-03-13
申请号：AU8745101
申请日：2001-08-30
Applicant: HELIX BIOPHARMA CORP
Inventor： WONG WAH Y , CHAO HEMAN , MCELROY JERRY , SEGAL DONALD
IPC: G01N33/543
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公开(公告)号：CA2877505C
公开(公告)日：2020-09-22
申请号：CA2877505
申请日：2013-06-11
Applicant: HELIX BIOPHARMA CORP , AMORFIX LIFE SCIENCES LTD
Inventor： UGER MARNI DIANE , CHAI VIENGTHONG , CIOLFI VERONICA , CASHMAN NEIL R , WONG WAH YAU , CHAO HEMAN LAP-MAN , TIAN BAOMIN
IPC: C07K16/18 , A61K39/395 , A61P35/00 , G01N33/53 , G01N33/574
Abstract: Human prion protein, PrP, selectively presents the epitope MDEYSNQNN (SEQ ID No. 14) when PrP misfolds. The misfolded form of human PrP is associated with various disease states. The present invention provides an antibody useful to detect and treat such diseases, including cancer such as ovarian cancer and lymphomas, and transmissible spongiform encephalopathies such as CJD. Also provided is an immunoconjugate in which the antibody is conjugated with urease as cytotoxin.
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Patent Agency Ranking56.发明专利
公开(公告)号：CA2493282C
公开(公告)日：2020-05-12
申请号：CA2493282
申请日：2005-01-31
Applicant: HELIX BIOPHARMA CORP
Inventor： SEGAL DONALD , MCELROY JERRY , CHAO HEMAN , WONG WAH Y , DOCHERTY JOHN , DICKSTEIN JODI
IPC: A61K47/68 , A61K31/135 , A61K31/17 , A61K31/475 , A61K31/513 , A61K31/704 , A61K38/50 , A61P35/00
Abstract: Improvements in methods of treating cancer with weakly basic anti-cancer compounds are provided. In one aspect, the invention provides an improvement in a method of treating cancer cells whose extracellular environment contains 1-8 mM urea, by exposing the cells to a weakly basic anti-cancer compound which is effective in inhibiting the growth of the cells. The improvement includes (a) exposing the cells to a urease enzyme composition and, (b) by step (a), reducing the amount of anti- cancer compound required to produce a given extent of inhibition in the growth of the cells when the cells are exposed to the anti-cancer agent. Methods of potentiating the specific therapeutic activity of a weakly basic anti-cancer compound in the treatment of a given mammalian cancer which is responsive to the compound are provided as are pharmaceutical compositions for use in intravenous administration to a subject are also provided.
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公开(公告)号：AU2016210551B2
公开(公告)日：2019-03-07
申请号：AU2016210551
申请日：2016-01-22
Applicant: HELIX BIOPHARMA CORP
Inventor： CHAO HEMAN , WONG WAH YAU , TIAN BAOMIN , GASPAR KIMBERLY JAYNE , KUMAR PRAVEEN
Abstract: Pharmaceutical compositions comprising antibody-urease conjugates and substantially free of unconjugated urease are disclosed. These compositions are prepared by a method that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy wherein the urease converts endogenous urea into ammonia in situ to induce cytotoxicity.
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公开(公告)号：CA3049276A1
公开(公告)日：2018-07-12
申请号：CA3049276
申请日：2018-01-04
Applicant: HELIX BIOPHARMA CORP
Inventor： CHAO HEMAN , WONG WAH YAU , TIAN BAOMIN , UGER MARNI DIANE
IPC: C12N15/13 , A61K35/17 , A61P35/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/0783 , C12N5/10 , C12N15/62 , C12N15/85
Abstract: Compositions and methods for treating cancer in humans are provided using CARs. The invention includes engineered CARs (chimeric receptor antigens) and genetically modified immune cells that express such a CAR with a high affinity for VEGFR. More specifically, the cells are CAR-T cells recognizing VEGFR-2 on solid tumors, uses thereof, compositions thereof and methods of making. The invention includes therapeutic methods to treat VEGFR-2 dependent cancers targeting tumor angiogenesis. A chimeric antigen receptor (CAR) that binds to VEGFR-2, an epitope or fragment thereof, or a variant thereof.
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公开(公告)号：MX2017009537A
公开(公告)日：2018-04-10
申请号：MX2017009537
申请日：2016-01-22
Applicant: HELIX BIOPHARMA CORP
Inventor： HEMAN CHAO , WAH YAU WONG , BAOMIN TIAN , KIMBERLY JAYNE GASPAR , PRAVEEN KUMAR
Abstract: Se describen composiciones farmacéuticas que comprenden conjugados ureasa-anticuerpo, y sustancialmente libres de ureasa no conjugada. Estas composiciones se preparan mediante un método que no requiere purificación cromatográfica. Estas composiciones farmacéuticas tienen utilidad en el tratamiento contra el cáncer mediante un tratamiento con profármaco de enzima con especificidad de objetivo al anticuerpo en donde la ureasa convierte in situ a la urea endógena en amoniaco para inducir citotoxicidad.
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公开(公告)号：CY1114754T1
公开(公告)日：2016-12-14
申请号：CY141100021
申请日：2014-01-10
Applicant: HELIX BIOPHARMA CORP
Inventor： CHAO HEMAN , WONG WAH , SEGAL DONALD , MCELROY JERRY , DOCHERTY JOHN , DICKSTEIN JODI
Abstract: Αποκαλύπτονταιφαρμακευτικήσύνθεσηκαιμέθοδοςχρήσηςστηναναστολήανάπτυξηςτωνκαρκινικώνκυττάρωνσεέναυποκείμενοθηλαστικό. Ησύνθεσηπεριλαμβάνειένζυμοουρεάσηκαισυνδυασμένημεαυτό, χημικήοντότητααποτελεσματικήγιατηνενίσχυσητηςαπελευθέρωσηςτουενζύμουσεκαρκινικάκύτταρα, ότανη σύνθεσηχορηγείταιστουποκείμενο. Αποκαλύπτονταιεπίσηςμέθοδοςενίσχυσηςτηςαποτελεσματικότηταςασθενώςβασικώναντικαρκινικώνενώσεων, μέθοδοςαξιολόγησηςτηςπαρουσίας, μεγέθουςή κατάστασηςσυμπαγούςόγκουσεέναυποκείμενοκαισύνθεσηγονιδιακήςθεραπείαςγιαθεραπείακαρκίνουσεέναυποκείμενο.
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