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公开(公告)号：EP2282754A2
公开(公告)日：2011-02-16
申请号：EP09726377.6
申请日：2009-03-24
Applicant: Orthologic Corp. , The Texas A&M University System
Inventor： CARNEY, Darrell, H. , OLSZEWSKA-PAZDRAK, Barbara , FOSSUM, Theresa, W.
Abstract: An agonist of a non-proteolytically activated thrombin receptor can be used in a method for treating peripheral arterial disease. The agonist can be a thrombin peptide derivative. In some embodiments, the peripheral arterial disease is characterized by intermittent claudication. The thrombin peptide derivatives to be used in the methods can have amino acid sequences similar to a region of thrombin. Usually, the thrombin peptide derivatives are 12-23 amino acid residues in length. In some cases, the thrombin peptide derivatives are dimers, and in particular, dimers that result from formation of a disulfide bond between two cysteine residues of peptide monomers.
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公开(公告)号：EP2063910A2
公开(公告)日：2009-06-03
申请号：EP07861354.4
申请日：2007-09-21
Applicant: Orthologic Corp. , THE TEXAS A & M UNIVERSITY SYSTEM
Inventor： CARNEY, Darrell, H. , OLSZEWSKA-PAZDRAK, Barbara , FOSSUM, Theresa, W.
CPC classification number: A61K38/10 , A61K38/16 , A61K38/18 , A61K38/4833 , C12N9/6429 , C12Y304/21005
Abstract: Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.
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公开(公告)号：EP1934262A1
公开(公告)日：2008-06-25
申请号：EP06803588.0
申请日：2006-09-14
Inventor： FULLER, Gerald, M. , CARNEY, Darrell, H. , BERGMANN, John, S.
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/2863 , C07K2317/34 , C07K2317/75 , C12N9/6429 , C12Y304/21005
Abstract: Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subj ect in need of such treatment are disclosed.
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公开(公告)号：EP1559431B1
公开(公告)日：2007-03-28
申请号：EP04258191.8
申请日：2004-12-30
Applicant: Orthologic Corp.
Inventor： Hobson, David M. , Crowther, Roger S. , Carney, Darrell H. , Tang, Andrew Po Kwan
IPC: A61K38/48 , A61K47/12 , A61K31/198 , A61P17/02
CPC classification number: A61K47/12 , A61K9/06 , A61K31/198 , A61K38/4833 , A61K47/10 , A61K47/16 , A61K47/18 , A61K47/183 , A61K47/20 , A61K2300/00
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55.发明授权
公开(公告)号：EP1414487B1
公开(公告)日：2006-06-07
申请号：EP02703130.1
申请日：2002-01-16
Applicant: Orthologic Corp.
Inventor： CARNEY, Darrell, H.
CPC classification number: A61K38/4833
Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.
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Patent Agency Ranking
公开(公告)号：EP0843573A4
公开(公告)日：1999-07-21
申请号：EP95937426
申请日：1995-10-04
Applicant: ORTHOLOGIC CORP
Inventor： KAUFMAN JONATHAN J , CHIABRERA ALLESSANDRO E
CPC classification number: A61N7/00 , A61B2017/0015 , A61B2017/00172 , A61F2002/2864
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公开(公告)号：CA2663547C
公开(公告)日：2020-08-25
申请号：CA2663547
申请日：2007-09-21
Applicant: ORTHOLOGIC CORP , TEXAS A & M UNIV SYS
Inventor： CARNEY DARRELL H , OLSZEWSKA-PAZDRAK BARBARA , FOSSUM THERESA W
Abstract: Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.
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公开(公告)号：CA2722621A1
公开(公告)日：2009-10-01
申请号：CA2722621
申请日：2009-03-24
Applicant: ORTHOLOGIC CORP , TEXAS A & M UNIV SYS
Inventor： CARNEY DARRELL H , OLSZEWSKA-PAZDRAK BARBARA , FOSSUM THERESA W
Abstract: Agonists of a non-proteolytically activated thrombin receptor, and more particularly, thrombin peptide derivatives, can be used in methods to cause smooth muscle relaxation. Compositions comprising thrombin peptide derivatives can be administered to a subject with a disease or disorder that can be ameliorated by relaxation of smooth muscle. Such compositions can also be administered to a subject to facilitate medical, diagnostic or surgical procedures.
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公开(公告)号：DE60313982T2
公开(公告)日：2008-01-17
申请号：DE60313982
申请日：2003-07-01
Applicant: ORTHOLOGIC CORP
Inventor： CARNEY DARRELL H
Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.
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公开(公告)号：DK1414487T3
公开(公告)日：2006-10-09
申请号：DK02703130
申请日：2002-01-16
Applicant: ORTHOLOGIC CORP
Inventor： CARNEY DARRELL H
Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.
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