step-derived peptides for brain injury treatment

    公开(公告)号:JP2014505010A

    公开(公告)日:2014-02-27

    申请号:JP2013529343

    申请日:2011-09-15

    CPC classification number: C12N9/16 A61K38/00 A61K38/465 C12Y301/03048

    Abstract: 【構成】ニューロン特異性チロシンホスファターゼの修飾誘導体である新規なペプチド配列に関する。 この新規なペプチド配列は、具体的には線条体リッチ化チロシンホスファターゼ(STEP)の修飾誘導体である。 過剰なグルタメート放出および/または酸化的ストレスから発症する脳損傷を緩和および治療できるように上記ペプチド配列を修飾する。 本発明のペプチド配列により有効に治療できる脳損傷タイプの実例は、発作から発症する急性脳損傷、外傷性脳損傷、およびハンティントン舞踏病や統合失調症などの慢性疾患である。 さらに、本発明のペプチド配列は、PTDSなどの恐怖体験記憶に関連する疾患の治療および緩和に有効である。
    【選択図】図6

    Fuel cell
    53.
    发明专利
    Fuel cell 有权
    燃料电池

    公开(公告)号:JP2013048066A

    公开(公告)日:2013-03-07

    申请号:JP2011186500

    申请日:2011-08-29

    CPC classification number: Y02E60/521

    Abstract: PROBLEM TO BE SOLVED: To provide a fuel cell showing excellent power generation performance, the fuel cell using as a fuel a compound containing at least hydrogen and nitrogen, and an anion exchange membrane as an electrolyte layer.SOLUTION: A fuel cell 1 comprises: an electrolyte layer 4 composed of an anion exchange membrane; and a fuel-side electrode 2 and an oxygen-side electrode 3, facing each other across the electrolyte layer. The fuel-side electrode contains nickel, zinc, and rare-earth element as a metal catalyst, the percentage of a nickel content being equal to or more than 20 mol%, a zinc content being 10 to 60 mol%, and a rare-earth element content being equal to or less than 50 mol% with respect to the total number of moles of the nickel, zinc, and rare-earth element. A compound, containing at least hydrogen and nitrogen, such as hydrazine is used as a fuel.

    Abstract translation: 要解决的问题:为了提供一种具有优异的发电性能的燃料电池,使用至少含有氢和氮的化合物作为燃料的燃料电池和作为电解质层的阴离子交换膜。 解决方案:燃料电池1包括:由阴离子交换膜组成的电解质层4; 以及在电解质层上彼此相对的燃料侧电极2和氧气侧电极3。 燃料侧电极含有作为金属催化剂的镍,锌和稀土元素,镍含量的百分比等于或大于20摩尔%,锌含量为10至60摩尔% 土元素含量相对于镍,锌,稀土元素的总摩尔数为50摩尔%以下。 使用至少含有氢和氮的化合物,例如肼,作为燃料。 版权所有(C)2013,JPO&INPIT

    Method and apparatus for integrating optical and interferometric lithography to produce complex pattern
    56.
    发明专利
    Method and apparatus for integrating optical and interferometric lithography to produce complex pattern 有权
    用于整合光学和干涉计算以生产复杂图案的方法和装置

    公开(公告)号:JP2010199594A

    公开(公告)日:2010-09-09

    申请号:JP2010069006

    申请日:2010-03-24

    Abstract: PROBLEM TO BE SOLVED: To provide a method and apparatus for defining a single structure (11) on a semiconductor wafer by spatial frequency components. SOLUTION: Some of the spatial frequency components (12-16) are derived by optical lithography and some by interferometric lithography technology. Interferometric lithography images the high frequency components while optical lithography images the low frequency components. Optics collects many spatial frequencies and the interferometry shifts the spatial frequencies to high spatial frequencies. Thus, because a mask does not need to provide high spatial frequencies, the masks are configured to create only low frequency components. Thereby fabrication of simpler masks having larger structures is allowed. These methods and apparatus facilitate writing of more complex repetitive as well as non-repetitive patterns in a single exposure with a resolution which is higher than that currently available using known optical lithography alone. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题:提供一种用于通过空间频率分量在半导体晶片上定义单个结构(11)的方法和装置。 解决方案:一些空间频率分量(12-16)是通过光学光刻技术得到的,一些通过干涉光刻技术得到。 干涉光刻成像高频分量,而光刻成像低频分量。 光学收集许多空间频率,干涉测量将空间频率移动到高空间频率。 因此,由于掩模不需要提供高空间频率,所以掩模被配置为仅产生低频分量。 从而允许制造具有较大结构的更简单的掩模。 这些方法和装置便于在单一曝光中以更高复杂度的重复和非重复图案的写入,该分辨率高于目前仅使用已知光刻技术的分辨率。 版权所有(C)2010,JPO&INPIT

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