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    KIT FOR THE IMPLANTATION OF A DENTAL IMPLANT
    52.
    发明公开
    KIT FOR THE IMPLANTATION OF A DENTAL IMPLANT 审中-公开
    植入种植牙的套件

    公开(公告)号：EP3193772A1

    公开(公告)日：2017-07-26

    申请号：EP14777392.3

    申请日：2014-09-19

    Applicant: Stichting VU-VUmc

    Inventor： KOOPS, Daniël

    IPC: A61C1/08 ,  A61C8/00

    CPC classification number: A61C8/0089 ,  A61C1/084 ,  A61C8/0087

    Abstract: The kit comprises a stop element comprising a first part and a second part, wherein the first part and the second part are configured to be movable between a first state, in which the first part and the second part are spaced at a first distance, and a second state, in which the first part and the second part are spaced at a second distance, wherein the first distance is smaller than the second distance, and wherein the first and second parts are biased to the first state, wherein the second distance is the same or larger than a distance between diametrically opposite sides of the outer surface of the implant guide, such that, before implantation, the first part and the second part can be arranged, in the second state, on diametrically opposite sides of the outer surface, and that during movement in the implantation direction of the dental implant into the jaw, the stop surface of the implantation channel will push the stop element towards the groove until the groove will allow the first and second part to move towards the first state and the stop element will be caught by the groove, therewith blocking further movement of the implant guide in the implantation direction.

    Abstract translation: 本发明提供了一种用于植入牙科植入物的套件，其包括植入物引导件，该植入物引导件包括近端和远端，其中远端被构造成可拆卸地附接到牙植入物，所述植入物引导件包括圆柱形 其中所述圆柱形主体包括圆柱形外表面和在所述外表面中的周向凹槽，以及模板，所述模板被构造成相对于钳口布置在预定位置处，其中所述模板包括至少一个植入通道，以引导所述圆柱形 在植入颌骨期间的植入物引导件的期望植入方向上的植入物导向件和植入通道的端部处的止动表面。 该套件包括止动元件，该止动元件包括第一部分和第二部分，其中第一部分和第二部分构造成可在第一状态和第二部分之间移动，在第一状态下第一部分和第二部分以第一距离间隔开， 第二状态，其中所述第一部分和所述第二部分以第二距离间隔开，其中所述第一距离小于所述第二距离，并且其中所述第一和第二部分偏置到所述第一状态，其中所述第二距离是 所述第一部分和所述第二部分可以在所述植入引导件的外表面的径向相对侧之间的距离相同或大于所述植入引导件的外表面的径向相对侧之间的距离，使得在植入之前，所述第一部分和所述第二部分可以在所述第二状态中布置在所述外表面 并且在牙科植入物植入颌中的植入方向移动期间，植入通道的止动表面将朝向凹槽推动止动元件，直到凹槽将允许冷杉 第一部分和第二部分向第一状态移动，并且止动元件将被凹槽卡住，从而阻止植入引导件在植入方向上的进一步移动。

    SYSTEM AND METHOD FOR NETWORK SYNCHRONIZATION AND FREQUENCY DISSEMINATION
    53.
    发明公开
    SYSTEM AND METHOD FOR NETWORK SYNCHRONIZATION AND FREQUENCY DISSEMINATION 审中-公开
    系统和方法进行网络同步和频率分布

    公开(公告)号：EP2715955A1

    公开(公告)日：2014-04-09

    申请号：EP12725889.5

    申请日：2012-05-24

    Applicant: Stichting VU-VUmc ,  Nuijts, Roeland Johannus Marie Wilhelm

    Inventor： NUIJTS, Roeland Johannus Marie Wilhelm ,  KOELEMEIJ, Jeroen Cornelis Jean

    IPC: H04J3/06 ,  H04J14/02

    CPC classification number: H04L7/0075 ,  H04J3/0682 ,  H04J14/02 ,  H04J14/0272 ,  H04J14/0275

    Abstract: Distribution of reference frequency and timing information in a network involves determining latency between a first and second node from time delay between transmission of a reference frequency and timing signal and reception of an optical return timing signal in response. In a network with pairs of first and second optical fibers in optical fiber connections between network nodes, for transmission of optical data signals separately in mutually opposite directions between the network nodes respectively, provisions are made to transmit the reference frequency and timing signal and the resulting optical return signal via the same fiber, one in the same direction as the unidirectional data signal over that fiber and the other upstream. Repeaters between the nodes may be modified to pass such signals upstream and downstream. In an embodiment wherein the network provides for an optical supervisory channel, the optical filters for combining the optical supervisory channel signal with the unidirectional data signal and separating the optical supervisory channel signal from the unidirectional data signal are used to combine and separate the reference frequency and timing signal and to pass the optical return timing signal. For this purpose, further optical filters may be added outside the main optical data channel to combine and separate the reference frequency and timing signal and the optical supervisory channel and to pass the optical return signal back to the filter that separates the optical supervisory channel signal from the data signal.

    Fiber endoscope
    54.
    发明授权
    Fiber endoscope 有权

    公开(公告)号：US11963663B2

    公开(公告)日：2024-04-23

    申请号：US17042488

    申请日：2019-03-28

    Applicant: Stichting VU

    Inventor： Fabio Feroldi ,  Johannes Fitzgerald De Boer

    IPC: A61B1/00 ,  A61B5/00 ,  G02B6/28

    CPC classification number: A61B1/00167 ,  A61B1/0017 ,  A61B5/0062 ,  A61B5/0084 ,  G02B6/2821

    Abstract: A fibre endoscope system (100) comprises a catheter (10) with a probe head (10a) for entering into a body cavity (C) adjacent or near a sample region (S). A source fiber (11) has a first fiber ending (11a) and a signal fiber (12) has a second fiber ending (12a) both remote from the probe head (10a) but separate. A sampling fiber (13) has a third fiber ending (13a) disposed at the probe head (10a). A fiber coupler (15) is configured to optically couple at least the source fiber (11) to the sampling fiber (13), and the sampling fiber (13) to the signal fiber (12). A sampling fiber length (L13) of the sampling fiber (13) between a fiber coupler (15) and the third fiber ending (13a) is shorter than a source fiber length (L11) of the source fiber (11) between the fiber coupler (15) and the first fiber ending (11a).

    SPECTROSCOPY APPARATUS
    57.
    发明公开
    SPECTROSCOPY APPARATUS 审中-公开

    公开(公告)号：US20230324298A1

    公开(公告)日：2023-10-12

    申请号：US18023172

    申请日：2021-08-19

    Applicant: STICHTING VU

    Inventor： Alfred Holzwarth ,  Jacopo URBANI ,  Lukas JASMONTAS

    IPC: G01N21/64

    CPC classification number: G01N21/6408 ,  G01N2021/635

    Abstract: There is provided a spectroscopy apparatus for measuring fluorescence signals from a photosynthetic object. The spectroscopy apparatus comprises:



    one or more light excitation sources (26,28) operable to carry out time-varying excitation of the fluorescence from the photosynthetic object; and
    one or more fluorescence-sensitive detection channels (36,38,44,46) configured to simultaneously record the fluorescence as a function of time with a microsecond to millisecond time resolution and as a function of wavelength with a wavelength resolution of 10 nm or better, responsive to the excitation of the fluorescence from the photosynthetic object by the or each light excitation source (26,28).

    Identification and Elimination of HCMV-Infected Cells
    59.
    发明申请
    Identification and Elimination of HCMV-Infected Cells 有权

    公开(公告)号：US20220324947A1

    公开(公告)日：2022-10-13

    申请号：US17632023

    申请日：2020-08-05

    Applicant: Stichting VU ,  Cambridge Enterprise Limited

    Inventor： Martine Joyce Smit ,  Timo Werner Marcella De Groof ,  Raimond Heukers ,  John Sinclair ,  Elizabeth Elder

    IPC: C07K16/08 ,  C12N7/00 ,  G01N33/50

    Abstract: The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.

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