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公开(公告)号：TW201446261A
公开(公告)日：2014-12-16
申请号：TW103110360
申请日：2014-03-19
Applicant: 環球免疫公司 , GLOBEIMMUNE, INC. , 美國衛生與公眾服務部 , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： 羅迪爾 提摩西C , RODELL, TIMOTHY C. , 艾佩連 大衛 , APELIAN, DAVID , 潘拉娜 克勞蒂雅 , PALENA, CLAUDIA , 史庫倫 傑佛瑞 , SCHLOM, JEFFREY
IPC: A61K38/16 , A61K39/00 , C07K14/435 , A61P35/00
CPC classification number: A61K39/0011 , A61K2039/521 , A61K2039/545
Abstract: 本發明揭示治療或預防索脊瘤之方法，其包括投與以酵母菌為基礎之免疫治療組合物之步驟。以酵母菌為基礎之免疫治療組合物較佳包含短尾突變體抗原。
Abstract in simplified Chinese: 本发明揭示治疗或预防索嵴瘤之方法，其包括投与以酵母菌为基础之免疫治疗组合物之步骤。以酵母菌为基础之免疫治疗组合物较佳包含短尾突变体抗原。
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公开(公告)号：WO2007100584A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/004506
申请日：2007-02-16
Applicant: THE GOVERMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE GOVERMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , NABEL, Gray, J. , KONG, Wing-pui , YANG, Zhi-yong , TUMPEY, Terrence
Inventor： NABEL, Gray, J. , KONG, Wing-pui , YANG, Zhi-yong , TUMPEY, Terrence
IPC: C07K14/435 , C12N15/86
CPC classification number: C07K14/005 , A61K38/00 , A61K39/12 , A61K39/145 , A61K2039/53 , C07K2319/21 , C07K2319/70 , C12N2710/10343 , C12N2740/16043 , C12N2740/16134 , C12N2760/16122 , C12N2760/16134
Abstract: These vaccines target H5N1, H1, H3 and other subtypes of influenza and are designed to elicit neutralizing antibodies, as well as cellular immunity. The DNA vaccines express hemagglutinin (HA) or nucleoprotein (NP) proteins from influenza which are codon optimized and/or contain modifications to protease cleavage sites of HA which affect the normal function of the protein. Adenoviral constructs expressing the same inserts have been engineered for prime boost strategies. Protein-based vaccines based on protein production from insect or mammalian cells using foldon trimerization stabilization domains with or without cleavage sites to assist in purification of such proteins have been developed. Another embodiment of this invention is the work with HA pseudotyped lentiviral vectors which would be used to screen for neutralizing antibodies in patients and to screen for diagnostic and therapeutic antivirals such as monoclonal antibodies.
Abstract translation: 这些疫苗靶向H5N1，H1，H3和其他亚型亚型，旨在引发中和抗体以及细胞免疫。 DNA疫苗表达来自流感的血凝素（HA）或核蛋白（NP）蛋白，其密码子优化和/或含有影响蛋白质正常功能的HA蛋白酶切割位点的修饰。 表达相同插入片段的腺病毒构建体已被设计用于主要的增强策略。 已经开发了基于使用具有或不具有切割位点的折叠三聚稳定结构域的昆虫或哺乳动物细胞蛋白质产生的基于蛋白质的疫苗，以帮助纯化这些蛋白质。 本发明的另一个实施方案是具有HA假型慢病毒载体的工作，其将用于筛选患者中的中和抗体并筛选诊断和治疗性抗病毒剂，例如单克隆抗体。
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公开(公告)号：RS61594B1
公开(公告)日：2021-04-29
申请号：RSP20210207
申请日：2012-07-17
Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： BUCK CHRISTOPHER B , PASTRANA DIANA V
IPC: C07K16/08
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54.发明专利
公开(公告)号：AU2017233716B2
公开(公告)日：2020-10-29
申请号：AU2017233716
申请日：2017-03-08
Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： NEWMAN AMY HAUCK , KUMAR VIVEK , SHAIK ANVER BASHA
IPC: C07D209/42 , A61K31/404 , A61P25/18 , A61P25/24 , C07D307/85 , C07D471/04 , C07D513/04
Abstract: Disclosed herein novel dopamine D3 receptor selective antagonists/partial agonists compounds with high affinity and metabolic stability useful for the treatment of psychiatric and neurological disorders and as research and diagnostic tools. Also disclosed are methods of making the compounds.
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公开(公告)号：AU2018251788A1
公开(公告)日：2019-11-28
申请号：AU2018251788
申请日：2018-04-11
Applicant: AURA BIOSCIENCES INC , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： DE LOS PINOS ELISABET , SCHILLER JOHN TODD , KINES RHONDA C
Abstract: Some embodiments of the present disclosure are directed to methods and compositions for the treatment of tumors, using a combination of immunotherapeutic agents and tumor-targeting viral capsid protein assemblages comprising anti-cancer molecules conjugated to viral capsid proteins.
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Patent Agency Ranking56.发明专利
公开(公告)号：AU2018201544B2
公开(公告)日：2019-07-18
申请号：AU2018201544
申请日：2018-03-02
Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： MARUGAN JUAN JOSE , ZHENG WEI , XIAO JINGBO , MCKEW JOHN
IPC: C07D311/72 , A61K31/555 , A61P43/00
Abstract: The subject invention relates to improved tocopheryl quinone derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorders, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.
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公开(公告)号：AU2014253919B2
公开(公告)日：2019-06-20
申请号：AU2014253919
申请日：2014-04-17
Applicant: GENZYME CORP , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： WADSWORTH SAMUEL , SCARIA ABRAHAM , CHAN CHI-CHAO
Abstract: Compositions and methods for treating macular degeneration are disclosed. The methods utilize IL17 inhibitors, such as IL17 receptors, as well as fusion proteins including an IL17 receptor fused with a multimerization domain, and recombinant viral vectors encoding such fusions.
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公开(公告)号：AU2017359330A1
公开(公告)日：2019-05-23
申请号：AU2017359330
申请日：2017-11-08
Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： BHARTI KAPIL , SONG MIN JAE , QUINN RUSSELL LOUIS
Abstract: Methods are disclosed for fabricating a three-dimensional engineered blood retinal barrier (BRB) comprising a choroid and retinal pigment epithelial cells. The methods include the use of bioprinting. Also disclosed is a three-dimensional engineered BRB, and its use. Methods are also disclosed for using the three-dimensional engineered BRB, such as for the treatment of retinal degeneration in a subject or screening. A three-dimensional printing insert that is adapted for bioprinting on a culture substrate sheet that is securely retained within and exposed through a printing frame is also disclosed.
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59.发明专利
公开(公告)号：AU2016302237A1
公开(公告)日：2018-03-01
申请号：AU2016302237
申请日：2016-08-03
Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： SCHLOM JEFFREY , PALENA CLAUDIA M
IPC: A61K39/00
Abstract: The invention provides Brachyury deletion mutant polypeptides, nucleic acids encoding the polypeptides, non-yeast vectors comprising the nucleic acids, non-yeast cells, and methods of use.
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公开(公告)号：AU2012347453B2
公开(公告)日：2017-11-23
申请号：AU2012347453
申请日：2012-12-10
Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： KWONG PETER D , NABEL GARY J , RUDICELL REBECCA S , MASCOLA JOHN , CONNORS MARK , GEORGIEV IVELIN , ZHU JIANG , KWON YOUNG DO , ZHOU TONGQING , YANG YONGPING , ZHANG BAOSHAN , CHUANG GWO-YU , WU XUELING , YANG ZHI-YONG , SHI WEI
IPC: C07K16/10 , A61K39/42 , A61P31/18 , C12N15/13 , G01N33/569
Abstract: Monoclonal neutralizing antibodies that specifically bind to HIV-1 gpl20 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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